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Reposted by Li-Kun Phng

RIKEN Center for Biosystems Dynamics Research (BDR) @riken-bdr.bsky.social · 20d

🪰Yu-Chiun Wang’s team & Univ. of Hohenheim group discovered how fly embryos solve the “tissue tectonic collision” that occurs in morphogenetic movements between tissues and why the #cephalicfurrow evolved, a longstanding mystery to developmental biologists.
In @nature.com
doi.org/10.1038/s415...

Divergent evolutionary strategies pre-empt tissue collision in gastrulation - Nature

Flies have evolved two distinct strategies for managing mechanical stresses during embryogenesis: out-of-plane cell division in midges and transient out-of-plane tissue folding in fruit flies.

doi.org

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Reposted by Li-Kun Phng

Yu-Chiun Wang @yuchiunwang.bsky.social · 23d

Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.

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Li-Kun Phng @phnglab.bsky.social · 29d

@mvikkula.bsky.social

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Li-Kun Phng @phnglab.bsky.social · 29d

Another successful #leducq #ReVAMP meeting held at Orford, Canada! Great science, food and friendship... Thanks @ondinecleaver.bsky.social for hosting us and showing us the way up the mountain! A la prochaine!

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Reposted by Li-Kun Phng

eLife @elife.bsky.social · 29d

Tiny molecular spirals in cells can scale up to control the twist and turn of entire tissues, an important step towards understanding left-right symmetry in tissues and organs.
buff.ly/2pSf3xS

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Reposted by Li-Kun Phng

Julia Eckert @juliaeckert.bsky.social · Aug 15

Now published in @natcomms.nature.com! 🥳

👉 rdcu.be/eATn3

We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.

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Reposted by Li-Kun Phng

Julia Eckert @juliaeckert.bsky.social · Jul 11

A fantastic week at the Mechanobiology Conference in Vietnam, filled with fascinating talks, fruitful discussions, and amazing people.

Huge thanks to the organizers and ICISE for making it all possible!

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Li-Kun Phng @phnglab.bsky.social · Jun 2

Missing @yuchiunwang.bsky.social in the group photo!

Li-Kun Phng @phnglab.bsky.social · Jun 2

And many thanks to speakers from Japan: @satsawai.bsky.social, @ashindo.bsky.social, @sugimuralab.bsky.social, Takashi Hiiragi, Fumio Motegi, Tatsuo Shibata, Hirokazu Tanimoto, Satoshi Toda and Fumiko Toyoshima

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Li-Kun Phng @phnglab.bsky.social · Jun 2

Special thanks to @ybellaichelab.bsky.social, @nicolettapetridou.bsky.social, @herveturlier.bsky.social, Lance Davidson, Elisabeth Fischer-Friedrich, Madan Rao, Yusuke Toyama and Fengzhu Xiong for making the long journey to Japan. And to @rashmi-priya.bsky.social for making a special appearance!

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Li-Kun Phng @phnglab.bsky.social · Jun 2

Thanks to the generosity of #FujiharaFoundation and the excellent organization of Fumio Motegi and his team, the ' #Mechanics of Life Across Scales' symposium was held successfully at beautiful Awaji. We had 3 days of fantastic #mechanobiology talks with speakers from Japan, India, Europe and US.

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Li-Kun Phng @phnglab.bsky.social · Apr 22

Had the absolute pleasure of hosting the Leducq ReVAMP biannual meeting @riken-bdr.bsky.social in Kobe this spring! #endothelial #mechanobiology #vascularmalformations See you all again in Fall @ondinecleaver.bsky.social @mvikkula.bsky.social

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Li-Kun Phng @phnglab.bsky.social · Apr 15

Check us out @the-node.bsky.social !

the Node @the-node.bsky.social · Apr 14

Lab Meeting with the Phng Lab

Meet the lab of @phnglab.bsky.social, based @riken-bdr.bsky.social, Kobe, Japan. The lab is interested in vascular #morphogenesis, in particular, endothelial cell mechanobiology in #zebrafish 🐟

Find out more about the lab and what it's like working at RIKEN BDR:

Lab Meeting with the Phng Lab - the Node

Meet the Phng Lab, based at the RIKEN Center for Biosystems Dynamics Research, Japan. The lab is interested in vascular morphogenesis and, in particular, endothelial cell mechanobiology.

thenode.biologists.com

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Reposted by Li-Kun Phng

Institut Jacques Monod @ijmonod.bsky.social · Jan 21

📢 Mechanobiology Conference III: From Fundamental Research to Applications

📅 July 06-12
📍 ICISE Quy Nhon, central Vietnam

The registration and abstract submission is now open!

🔗 icisequynhon.com/conferences/...

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Li-Kun Phng @phnglab.bsky.social · Apr 2

Thank you @the-node.bsky.social‬ for inviting me to write a 'Behind the Story' piece on our recent study!

Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis thenode.biologists.com/exploring-th...

Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis - the Node

Behind the Paper Story of “Combined forces of hydrostatic pressure and actin polymerisation drive endothelial tip cell migration and sprouting angiogenesis”.

thenode.biologists.com

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Reposted by Li-Kun Phng

Rashmi Priya @rashmi-priya.bsky.social · Mar 10

Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...

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Li-Kun Phng @phnglab.bsky.social · Mar 10

At #RIKEN BDR, women represent 10% of PIs, 31% of researchers, 38% of students and 74% of technical staff. On #IDWGIS last month, we celebrated their achievements and contributions to research at BDR. www.bdr.riken.jp/en/news/bdr-... #internationalwomensday

Careers in Science—Perspectives of Women Researchers and Technical Staff

www.bdr.riken.jp

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Reposted by Li-Kun Phng

Biomedical Picture of the Day BPoD @bpodaily.bsky.social · Mar 6

Zebrafish study reveals that, along with actin polymerisation, hydrostatic pressure underlies the push of endothelial tip cells into new territory

📹: Igor Kondrychyn et al RIKEN Center for Biosystems Dynamics Research, Kobe, Japan in @elife.bsky.social

➡️: bpod.org.uk/archive/2025...

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Li-Kun Phng @phnglab.bsky.social · Mar 5

Chuffed to find out that our work was featured as an Insight article in @elife.bsky.social elifesciences.org/articles/106.... Thank you Sean Sun and colleague for highlighting our work!

Morphogenesis: Fluid transport comes to the fore

Proteins that allow water to move in and out of cells help shape the development of new blood vessels.

elifesciences.org

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Reposted by Li-Kun Phng

eLife @elife.bsky.social · Mar 3

Proteins that allow water to move in and out of cells help shape the development of new blood vessels.
buff.ly/41n6ii0

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Reposted by Li-Kun Phng

sameerthukral.bsky.social @sameerthukral.bsky.social · Feb 22

What an honor to host @itaiyanai.bsky.social at RIKEN-BDR, Kobe! From learning Night Science creativity, to see them come alive with Day Science rigor, Itai truly demonstrated the "yes, and" attitude in person! Thank you for your great energy, passion and generosity! Can't wait to have you back!

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Li-Kun Phng @phnglab.bsky.social · Feb 21

Read the Research Highlight here! www.riken.jp/en/news_pubs... @RIKEN BDR

Water gives cells a push in blood vessel formation

RIKEN researchers have shown that that hydrostatic pressure is one of two mechanisms that control endothelial cell migration during angiogenic sprouting in zebrafish

www.riken.jp

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Li-Kun Phng @phnglab.bsky.social · Feb 21

Happy to announce that the final version of our paper on #endothelial cell #migration #mechanobiology, #angiogenesis, #hydrostaticpressure is out on @elife.bsky.social doi.org/10.7554/eLif... !! In our revised paper, we show that disrupted osmotic gradient and water inflow impair tip cell migration!

Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

Investigation of Aquaporin water channels unveils water inflow and build-up of hydrostatic pressure in endothelial tip cells as a novel mechanism of endothelial cell migration and blood vessel formati...

doi.org

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Reposted by Li-Kun Phng

sameerthukral.bsky.social @sameerthukral.bsky.social · Feb 18

Excited to host @itaiyanai.bsky.social at RIKEN BDR, Kobe over the next few days! Looking forward to learning about "Tails" and how to use Night Science "Tales" to supercharge creativity in science! Thank you Itai for accepting our invitation!

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Li-Kun Phng @phnglab.bsky.social · Jan 21

Excited to announce that we will be holding another #mechanobiology across scales symposium this year in beautiful Awaji Island #Japan! We have a star-studded lineup of speakers and it's free participation (free accommodation and food!)! Register here: www.igm.hokudai.ac.jp/85th-fujihar...

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