Lightnews — Scholar-powered news

Reposted by Yu-Chiun Wang

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · 18h

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews

Black and white portrait of John Gurdon, 1971

2 33 91

Reposted by Yu-Chiun Wang

Jain_Akanksha_ @akanksha-jain.bsky.social · 1d

🧠 Join us @uzh-ch.bsky.social ! We are a new lab looking for PhDs, Postdocs & Master’s students interested in studying how human neural systems emerge & go awry using brain organoids, light-sheet imaging & genomics. 🚀 Deadline for LSZGS 1st Nov! www.lifescience-graduateschool.uzh.ch/en.html.

11 19

Yu-Chiun Wang @yuchiunwang.bsky.social · 11d

How nice! Mechanochemical feedback that shuts it self off below threshold. That is THE frontier of developmental mechanisms. Congrats!

Akankshi Munjal @akankshi.bsky.social · 12d

Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd

1 6

Reposted by Yu-Chiun Wang

Rashmi Priya @rashmi-priya.bsky.social · 19d

Development does not happen in isolation! Material properties, geometry, stiffness, fluid flows...can all steer how development unfolds. If you’re exploring these kinds of questions, we’d love to see your work @dev-journal.bsky.social
More info below ⬇️

Development @dev-journal.bsky.social · Sep 1

📢Call for papers. Submit your latest research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells

Guest Editors: Alex Hughes and Rashmi Priya

📅 Deadline: 1 March 2026

journals.biologists.com/dev/pages/ex...

#DevBio

22 31

Yu-Chiun Wang @yuchiunwang.bsky.social · 19d

Many thanks to @riken-bdr.bsky.social press team for publicizing our work.

RIKEN Center for Biosystems Dynamics Research (BDR) @riken-bdr.bsky.social · 20d

🪰Yu-Chiun Wang’s team & Univ. of Hohenheim group discovered how fly embryos solve the “tissue tectonic collision” that occurs in morphogenetic movements between tissues and why the #cephalicfurrow evolved, a longstanding mystery to developmental biologists.
In @nature.com
doi.org/10.1038/s415...

Divergent evolutionary strategies pre-empt tissue collision in gastrulation - Nature

Flies have evolved two distinct strategies for managing mechanical stresses during embryogenesis: out-of-plane cell division in midges and transient out-of-plane tissue folding in fruit flies.

doi.org

3

Reposted by Yu-Chiun Wang

Daniel Alber @danielalber.bsky.social · 20d

A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis!

Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)

3 22 68

Reposted by Yu-Chiun Wang

Giulia Paci @giuliapaci.bsky.social · Aug 11

Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️

5 40 100

Yu-Chiun Wang @yuchiunwang.bsky.social · 23d

Thanks, Sebastian! Glad that you’re interested in our work and great to reconnect. Hope all is well!

Reposted by Yu-Chiun Wang

Camilla Autorino @cami-autorino.bsky.social · Jun 11

🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨

“A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶

🔗 www.biorxiv.org/content/10.1...

#devbio #biophysics

🧵⤵️

3 31 98

Reposted by Yu-Chiun Wang

bipashadey29.bsky.social @bipashadey29.bsky.social · 26d

Super thrilled to see our review out! It was a great experience to put this together with @sameerthukral.bsky.social and @yuchiunwang.bsky.social. Use it as a primer to the field or as inspiration to brainstorm how rigidity transitions can bridge scales!

sameerthukral.bsky.social @sameerthukral.bsky.social · 26d

Excited to share our new review in Development, Growth and Differentiation(DGD) Journall!

With the amazing @yuchiunwang.bsky.social & @bipashadey29.bsky.social,we explore how rigidity transitions bridge cytoplasmic & tissue scales.

Read the full review: onlinelibrary.wiley.com/doi/full/10....

Integrating Tissue and Cytoplasmic Rigidity Transitions During Morphogenesis

Multicellular organisms generate organizational complexity through morphogenesis, in which mechanical forces orchestrate the movements and deformations of cells and tissues, while chemical signals re...

onlinelibrary.wiley.com

4 8

Reposted by Yu-Chiun Wang

sameerthukral.bsky.social @sameerthukral.bsky.social · 26d

Thanks to @liamholt.bsky.social @fredchanglab.bsky.social for inspiration during the 2023 RIKEN symposium & @itaiyanai.bsky.social @nightsciencepod.bsky.social for encouraging us to blend day & night science,using a review not only to recap but also generate new perspectives!

1 1 1

Reposted by Yu-Chiun Wang

sameerthukral.bsky.social @sameerthukral.bsky.social · 26d

From crowded cytoplasm to flowing tissues:how material properties changes across scales shaping development,especially during transitions?
We provide primers on tissue scale & cytoplasmic rigidity,control parameters,new hypotheses on possible cross-scale feedback,linking scales rarely integrated.

1 1 1

Yu-Chiun Wang @yuchiunwang.bsky.social · 24d

Although direct evidence remains ahead of us, smoking guns are all over the place. Cross-scale feedback of material properties could be the next frontier in #mechanobiology. A harbinger of exciting work to come from @sameerthukral.bsky.social and @bipashadey29.bsky.social.

Yu-Chiun Wang @yuchiunwang.bsky.social · 24d

Taking advantage of organizing the often intellectually disjointed BDR symposium, we hijacked a session & turned it into a coherent & stimulating session with Kinneret Keren, @heisenbergcplab.bsky.social, @liamholt.bsky.social, and @fredchanglab.bsky.social, who inspired us to write this review.

1

Yu-Chiun Wang @yuchiunwang.bsky.social · 24d

Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.

2 8 20

Reposted by Yu-Chiun Wang

Xavier Trepat @xaviertrepat.bsky.social · Sep 1

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌
@IBECBarcelona
www.biorxiv.org/content/10.1...

3 28 88

Reposted by Yu-Chiun Wang

Benoit Ladoux @bladoux.bsky.social · 28d

Very happy to share our new study from CAM team @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social (MPZPM) on the unanticipated “hidden fluidity” in jammed epithelia. Congrats to Yuan Shen and great collaboration with Walter Kob.
www.biorxiv.org/content/10.1...

The complex microscopic dynamics of cells in high-density epithelial tissues

Epithelial tissues line the surfaces of vital organs and are often densely packed in a disordered, mechanically arrested state, referred to as jammed or glassy state. While collective migration at low...

www.biorxiv.org

9 29

Reposted by Yu-Chiun Wang

Nature @nature.com · 29d

A long-standing mystery in the development of fly embryos has been resolved

go.nature.com/4nhVxaa

Flies evolved a shock-absorber tissue used during embryonic development

The role of tissue that forms between the head and trunk of a fly embryo has been unclear. It turns out that it absorbs forces when nearby cells move and divide.

go.nature.com

8 18

Reposted by Yu-Chiun Wang

Nature @nature.com · 29d

Nature research paper: Patterned invagination prevents mechanical instability during gastrulation

go.nature.com/420lbIj

Patterned invagination prevents mechanical instability during gastrulation - Nature

In Drosophila, the cephalic furrow counteracts mechanical stress as the developing head and the trunk tissues meet, providing evidence for how mechanical forces influence the evolution of morphogenetic innovations in early development.

go.nature.com

5 15

Reposted by Yu-Chiun Wang

Nature @nature.com · 29d

Nature research paper: Divergent evolutionary strategies pre-empt tissue collision in gastrulation

go.nature.com/4m3exrU

Divergent evolutionary strategies pre-empt tissue collision in gastrulation - Nature

Flies have evolved two distinct strategies for managing mechanical stresses during embryogenesis: out-of-plane cell division in midges and transient out-of-plane tissue folding in fruit flies.

go.nature.com

3 9

Yu-Chiun Wang @yuchiunwang.bsky.social · 29d

Thanks so much. Super nice to have you here and such a great talk. So many things to talk about. I hope the conversation continues!

1 1

Yu-Chiun Wang @yuchiunwang.bsky.social · 29d

Fascinating observations and beautiful physical modeling from our very own @tomokiishibashi.bsky.social and Tatsuo Shibata. Do check it out.

eLife @elife.bsky.social · 29d

Tiny molecular spirals in cells can scale up to control the twist and turn of entire tissues, an important step towards understanding left-right symmetry in tissues and organs.
buff.ly/2pSf3xS

3 11

Yu-Chiun Wang @yuchiunwang.bsky.social · Sep 8

@bipashadey29.bsky.social we wouldn’t have pulled it off without you. So lucky to have you head our effort.

Yu-Chiun Wang @yuchiunwang.bsky.social · Sep 4

Our heroes: Bipasha Dey in my lab, Verena Kaul and @girishkalephd.bsky.social in Steffen's lab. PI search committees: be on the look out for Bipasha and Girish. They do wonders. But not after Bipasha does some additional cool things with Pavel. Stay tuned! (6/9)

1

Yu-Chiun Wang @yuchiunwang.bsky.social · Sep 7

One of my all time favorite quotes, “Nothing in biology makes sense except in the light of evolution”, since the tender age of a skinny undergrad. (I’m still kind of skinny…) 🤣

paveltomancak.bsky.social @paveltomancak.bsky.social · Sep 4

The moral of the story is that building the #bridge between #evolution & #morphogenesis is hard. I still think it needs a concerted push, because, to paraphrase the classic: "Everything in biology, even the #CF, starts making sense in the light of evolution." I add, it is #stuff_that_matters (12/12)

1 2

Yu-Chiun Wang @yuchiunwang.bsky.social · Sep 7

Thanks so much, Juan. Steffen and I are very lucky to count you as our friend. We are rooting for you to bring #mechanobiology and #morphogenesis to the next level with #Brillouin microscopy and #proteomics with embryos.

Juan Manuel Gomez Elliff @gomezjm-devmech.bsky.social · Sep 6

Great work from two great scientists that happen to be my friends too, so I am double happy, for Developmental Biology and for them and their groups!

Congratulations!!!!!! 🎉🎉Yu Chiun Wang and Steffen Lemke!!!!! @yuchiunwang.bsky.social

Yu-Chiun Wang @yuchiunwang.bsky.social · Sep 4

Tissue 'tectonic' collision is detrimental, but flies found two distinct solutions! Gratifying and grateful to be included in this collective effort, w/ Steffen Lemke, to crack the (or 'a') code of #cephalicfurrow, now out in @nature.com, all with @paveltomancak.bsky.social at the helm. (1/9)

1