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Nimesh Chahare @onenimesa.bsky.social · 9d

Congratulations Isabela 🎉 🎉

Reposted by Nimesh Chahare

Isabela Corina Fortunato, PhD @icfortunato.bsky.social · 12d

Happy to share that my PhD has finally taken the shape of a paper! ✨

Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.

🧵👇

David Brückner @davidbrueckner.bsky.social · 12d

How do cells navigate up gradients of adhesive proteins?
🤔

Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood

We show that passive friction directs cells & explains complex trajectories on gradients

👉 www.nature.com/articles/s41...

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Reposted by Nimesh Chahare

Sara Wickstrom @sarawickstrom.bsky.social · 10d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Reposted by Nimesh Chahare

Surojit Sural @surojitsural.bsky.social · 15d

Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.

www.science.org/doi/10.1126/...

Thread ⬇️

(1/n)

Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes

Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.

www.science.org

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Reposted by Nimesh Chahare

andreuion.bsky.social @andreuion.bsky.social · 16d

1/ Link: www.biorxiv.org/content/10.1...
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.

Mechanosensitive and Reversible Chromatin-Lamina Dewetting Triggers Cellular Contraction During Wound Healing

Tissue wounding causes rapid mechanical changes in the epithelium, but how these changes affect intracellular organization remains unclear. Using the Drosophila embryonic epidermis, we show that wound...

www.biorxiv.org

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Nimesh Chahare @onenimesa.bsky.social · 15d

👀🚨 Fantastic preprint from @andreuion.bsky.social

There's a lot going on inside the nucleus. #EpithelialMechanics

andreuion.bsky.social @andreuion.bsky.social · 16d

We know tissue mechanics matter in healing, but what happens at the chromatin level?
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌

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Reposted by Nimesh Chahare

andreuion.bsky.social @andreuion.bsky.social · 16d

We know tissue mechanics matter in healing, but what happens at the chromatin level?
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌

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Reposted by Nimesh Chahare

epithelial mechanics fan club @epimechfc.bsky.social · 18d

If you are interested in cell compression in general (not only in epithelial systems) in how to control it in vitro, in the associated mechanotransduction mechanisms and on their consequences, you can check our latest review!
bsky.app/profile/epim...

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Reposted by Nimesh Chahare

epithelial mechanics fan club @epimechfc.bsky.social · 18d

We believe that the combination of various in vitro tools, can complement in vivo observations. By doing so, Conti et al. showed that stem vs differentiated cancer cells present different mechano-phenotypes, suggesting a differential metastatic potential.
bsky.app/profile/epim...

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Reposted by Nimesh Chahare

epithelial mechanics fan club @epimechfc.bsky.social · 18d

Ever wondered how to control stretch/compression in your epithelial system? Do you know why it’s important, which mechanotransduction mechanisms could be involved? I am @valeriaventurini.bsky.social and today I will guide you through this journey.

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Nimesh Chahare @onenimesa.bsky.social · 21d

Incredible!!! 😍

Daniel J. Cohen (Princeton) @djcohen.bsky.social · 22d

SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N

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Reposted by Nimesh Chahare

Daniel J. Cohen (Princeton) @djcohen.bsky.social · 22d

It allows shaping the electric field, from single cells (first video) to sculpting whole tissues (movie below). This was several years of Yubin and Jeremy's lives; it's now changing what we know and do with electricity to control cell behaviors. It's so cool--please use it, we will help/share!

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Reposted by Nimesh Chahare

Daniel J. Cohen (Princeton) @djcohen.bsky.social · 22d

SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N

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Reposted by Nimesh Chahare

Yu-Chiun Wang @yuchiunwang.bsky.social · 24d

Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.

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Reposted by Nimesh Chahare

epithelial mechanics fan club @epimechfc.bsky.social · 26d

How can we use cell shapes and geometry to study mechanics of tissues?

I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics

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Reposted by Nimesh Chahare

Jesse Veenvliet @jesseveenvliet.bsky.social · 27d

📣 New preprint! We present SpinePy, a modular framework that enables automated 3D spatiotemporal quantification of #gastruloids & other multicellular in vitro systems. Spearheaded by @cryaaa.bsky.social @mpi-cbg.de. Check out his thread 👇 & the paper:
www.biorxiv.org/content/10.1...

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Reposted by Nimesh Chahare

David Brückner @davidbrueckner.bsky.social · Aug 25

🤔 Can migrating cells 'remember' their past trajectories?

In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question:

Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history!

www.nature.com/articles/s41...

The actin cortex acts as a mechanical memory of morphology in confined migrating cells - Nature Physics

Cells often navigate through confined spaces. Now it is shown that cells retain a mechanical memory of previous confinement events, which makes them more efficient at migrating through narrow microenv...

www.nature.com

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Reposted by Nimesh Chahare

Barbara Marte @barbmarte.bsky.social · Sep 6

new out in Nature www.nature.com/articles/d41...

Compression causes cancer cells to start spreading

The switch between proliferation and invasion is triggered by mechanical force.

www.nature.com

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Reposted by Nimesh Chahare

David Brückner @davidbrueckner.bsky.social · Sep 4

Super excited that our group will be supported by an ERC Starting Grant!

In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions.

We'll have PhD and Postdoc positions available, please get in touch if interested!

Biozentrum, University of Basel @biozentrum.unibas.ch · Sep 4

Why do some cells become neurons and others muscle?
Physicist Prof. David Brückner @davidbrueckner.bsky.social @biozentrum.unibas.ch @unibas.ch receives a prestigious #ERCStartingGrant to uncover how cells make life-shaping decisions. @erc.europa.eu
www.biozentrum.unibas.ch/news/detail/...

ERC Starting Grant for Physicist David Brückner

How do cells decide which role to take on in the body? Prof. David Brückner from the Biozentrum of the University of Basel is investigating this and similar questions. Over the next five years, a Star...

www.biozentrum.unibas.ch

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Reposted by Nimesh Chahare

Julia Eckert @juliaeckert.bsky.social · Sep 5

The last paper from my PhD is now online! 🥳

👉 pubs.aip.org/aip/rsi/arti...

We have designed a new device based on the elastic micropillar array assay to measure the detachment forces between spread cells.

@leidenphysics.bsky.social

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Nimesh Chahare @onenimesa.bsky.social · Sep 2

Congratulations Tom!!! 😍🎉🎉

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Reposted by Nimesh Chahare

Tom Golde @tomgolde.bsky.social · Sep 2

Check out the preprint of my main work in the lab of @xaviertrepat.bsky.social @IBECBarcelona. Many thanks to all the people involved!

Xavier Trepat @xaviertrepat.bsky.social · Sep 1

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌
@IBECBarcelona
www.biorxiv.org/content/10.1...

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Reposted by Nimesh Chahare

Xavier Trepat @xaviertrepat.bsky.social · Sep 1

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌
@IBECBarcelona
www.biorxiv.org/content/10.1...

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Nimesh Chahare @onenimesa.bsky.social · Aug 31

🚨wonderful thread by @benswedlund.bsky.social!
Tissue engineering via self assembly 👀

epithelial mechanics fan club @epimechfc.bsky.social · Aug 31

Are different cell types like oil and water? Over a century ago, researchers found that dissociated sponges and embryonic tissues can self-assemble into functional structures. Join me, @benswedlund.bsky.social to explore the differential adhesion hypothesis & its applications in tissue engineering!

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Reposted by Nimesh Chahare

epithelial mechanics fan club @epimechfc.bsky.social · Aug 31

Are different cell types like oil and water? Over a century ago, researchers found that dissociated sponges and embryonic tissues can self-assemble into functional structures. Join me, @benswedlund.bsky.social to explore the differential adhesion hypothesis & its applications in tissue engineering!

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