Surojit Sural
@surojitsural.bsky.social
C. elegans researcher | Studies how the worm brain responds to stress in http://hobertlab.org http://hhmi.org @Columbia | @UMich & @IISERPune alum | (he/him)
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Surojit Sural
@surojitsural.bsky.social
· Sep 24
Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes
Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.
www.science.org
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.
www.science.org/doi/10.1126/...
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Machine learning predicts lifespan and suggests underlying causes of death in aging C. elegans
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Machine learning predicts lifespan and suggests underlying causes of death in aging C. elegans - Communications Biology
Data-driven machine learning sheds light on how genes, environment and sexual dimorphism shapes aging in the model organism C. elegans.
www.nature.com
November 25, 2025 at 5:07 PM
Machine learning predicts lifespan and suggests underlying causes of death in aging C. elegans
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Surojit Sural
As pharma ramps up efforts on disorders of aging, a new era of disease prevention comes into focus go.nature.com/49aN7gR
November 25, 2025 at 3:13 PM
As pharma ramps up efforts on disorders of aging, a new era of disease prevention comes into focus go.nature.com/49aN7gR
Reposted by Surojit Sural
We have a new postdoc position available in the Promislow lab at the HNRCA at #Tufts in #Boston, to work on the #systemsbiology of #aging in #Drosophila. Come join us! For info on the position and to apply, see promislowlab.org/wp-content/u...
promislowlab.org
November 25, 2025 at 2:12 AM
We have a new postdoc position available in the Promislow lab at the HNRCA at #Tufts in #Boston, to work on the #systemsbiology of #aging in #Drosophila. Come join us! For info on the position and to apply, see promislowlab.org/wp-content/u...
From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism - a perspective written by 11 scientists, six of whom are Nobel laureates
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
November 24, 2025 at 11:08 PM
From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism - a perspective written by 11 scientists, six of whom are Nobel laureates
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Surojit Sural
Form and function of actin impacts actin health and aging. https://www.biorxiv.org/content/10.1101/2025.11.22.689949v1
November 23, 2025 at 3:30 PM
Form and function of actin impacts actin health and aging. https://www.biorxiv.org/content/10.1101/2025.11.22.689949v1
Reposted by Surojit Sural
A gene expression atlas of a juvenile nervous system https://www.biorxiv.org/content/10.1101/2025.11.21.689793v1
November 23, 2025 at 12:15 AM
A gene expression atlas of a juvenile nervous system https://www.biorxiv.org/content/10.1101/2025.11.21.689793v1
Reposted by Surojit Sural
She found something surprising to us - that removal from chronic alcohol, as close as we can get to withdrawal in the worm, was not so great for their ability to remember. She then went on to chase down the genetic why - read her paper here to find out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Altered glr-1 expression is linked to EtOH cessation-mediated behavior deficits in C. elegans.
Chronic ethanol (EtOH) exposure and withdrawal are linked to worsened memory and cognitive outcomes. One target of EtOH is the glutamatergic alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid r...
www.biorxiv.org
November 21, 2025 at 11:41 PM
She found something surprising to us - that removal from chronic alcohol, as close as we can get to withdrawal in the worm, was not so great for their ability to remember. She then went on to chase down the genetic why - read her paper here to find out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Surojit Sural
If you want to know more - as I hope you do, here is the link! www.biorxiv.org/content/10.1...
INS-17, an insulin-receptor ligand, confers specificity in adult IIS-regulated phenotypes in C. elegans
Insulin/IGF growth factor (IGF) signaling (IIS) is a pleiotropic signaling pathway that functions across tissues to coordinate phenotypic changes in response to nutrient status. Thus, the ubiquity of ...
www.biorxiv.org
November 21, 2025 at 11:41 PM
If you want to know more - as I hope you do, here is the link! www.biorxiv.org/content/10.1...
Analysis of categorical data from biological experiments with logistic regression and CMH tests
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
Analysis of categorical data from biological experiments with logistic regression and CMH tests
The choice of appropriate statistical tests in experimental biology is critical for scientific rigor and can be challenging in the case of categorical data analysis. Using example datasets from Caenor...
journals.plos.org
November 23, 2025 at 4:53 PM
Analysis of categorical data from biological experiments with logistic regression and CMH tests
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
What makes a killer? How nervous system evolution can give rise to predatory behavior
biology.columbia.edu/news/what-ma...
biology.columbia.edu/news/what-ma...
What makes a killer? How nervous system evolution can give rise to predatory behavior | Biology
biology.columbia.edu
November 21, 2025 at 6:04 PM
What makes a killer? How nervous system evolution can give rise to predatory behavior
biology.columbia.edu/news/what-ma...
biology.columbia.edu/news/what-ma...
Reposted by Surojit Sural
Altered glr-1 expression is linked to EtOH cessation-mediated behavior deficits in C. elegans. https://www.biorxiv.org/content/10.1101/2025.11.19.689356v1
November 20, 2025 at 5:45 PM
Altered glr-1 expression is linked to EtOH cessation-mediated behavior deficits in C. elegans. https://www.biorxiv.org/content/10.1101/2025.11.19.689356v1
Reposted by Surojit Sural
As an international scholar, my academic dreams belong to my family, too
"When I feel overwhelmed, I pause and remind myself that I’m not just chasing a degree—I’m trying to solve scientific problems that matter beyond myself, and I’m honoring my family."
www.science.org/content/arti...
"When I feel overwhelmed, I pause and remind myself that I’m not just chasing a degree—I’m trying to solve scientific problems that matter beyond myself, and I’m honoring my family."
www.science.org/content/arti...
As an international scholar, my academic dreams belong to my family, too
When this scientist’s father fell ill far away, he had to reconsider how best to honor his family’s sacrifice
www.science.org
November 14, 2025 at 2:28 PM
As an international scholar, my academic dreams belong to my family, too
"When I feel overwhelmed, I pause and remind myself that I’m not just chasing a degree—I’m trying to solve scientific problems that matter beyond myself, and I’m honoring my family."
www.science.org/content/arti...
"When I feel overwhelmed, I pause and remind myself that I’m not just chasing a degree—I’m trying to solve scientific problems that matter beyond myself, and I’m honoring my family."
www.science.org/content/arti...
The mind-bending power of placebo
Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought.
www.nature.com/articles/s41...
Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought.
www.nature.com/articles/s41...
The mind-bending power of placebo - Nature Medicine
Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought.
www.nature.com
November 14, 2025 at 5:43 PM
The mind-bending power of placebo
Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought.
www.nature.com/articles/s41...
Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought.
www.nature.com/articles/s41...
Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
JCI Insight -
Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health
insight.jci.org
November 14, 2025 at 5:01 PM
Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
Chemical modulation of gut bacterial metabolism induces colanic acid and extends the lifespan of nematode and mammalian hosts
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Chemical modulation of gut bacterial metabolism induces colanic acid and extends the lifespan of nematode and mammalian hosts
Gut microbes can influence aging, but how can this effect be chemically induced? This study shows that a low dose of cephaloridine triggers colanic acid production in commensal E. coli, extending the ...
journals.plos.org
November 14, 2025 at 5:00 PM
Chemical modulation of gut bacterial metabolism induces colanic acid and extends the lifespan of nematode and mammalian hosts
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Surojit Sural
Our lab’s paper spearheaded by Keni and pushed to completion (and satisfaction by the reviewers) by Satish is finally out www.nature.com/articles/s41.... Was so fortunate to contribute to this project and learned a lot in both neuronal cell biology and cryoET. Also, Satish is on the job market!
November 12, 2025 at 5:35 PM
Our lab’s paper spearheaded by Keni and pushed to completion (and satisfaction by the reviewers) by Satish is finally out www.nature.com/articles/s41.... Was so fortunate to contribute to this project and learned a lot in both neuronal cell biology and cryoET. Also, Satish is on the job market!
Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons | PNAS
How mutations in histone modifying enzymes lead to neurodevelopmental defects is unknown.
To address this question, we took advantage of the invari...
www.pnas.org
November 10, 2025 at 6:04 PM
Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Surojit Sural
Make males live more than 400% longer and prevent sexual disfunction late in life?! We're down with it. Our latest preprint: Disruption of the insulin signaling pathway in C. elegans dramatically increases male longevity and enhances reproductive health late in life. www.biorxiv.org/content/10.1...
November 6, 2025 at 11:14 PM
Make males live more than 400% longer and prevent sexual disfunction late in life?! We're down with it. Our latest preprint: Disruption of the insulin signaling pathway in C. elegans dramatically increases male longevity and enhances reproductive health late in life. www.biorxiv.org/content/10.1...
Reposted by Surojit Sural
We’re excited to expand our partnership with @reviewcommons.org in a new collaborative model reshaping scientific publishing to streamline peer review, reduce redundancy, and improve the author and reviewer experience. Read more: buff.ly/h6SfMXF
And meet our Editorial Board! 👋
And meet our Editorial Board! 👋
November 5, 2025 at 2:01 PM
We’re excited to expand our partnership with @reviewcommons.org in a new collaborative model reshaping scientific publishing to streamline peer review, reduce redundancy, and improve the author and reviewer experience. Read more: buff.ly/h6SfMXF
And meet our Editorial Board! 👋
And meet our Editorial Board! 👋
Reposted by Surojit Sural
HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.31.685810v1
November 3, 2025 at 6:30 PM
HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.31.685810v1
Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance
Tardigrade Dsup extends C. elegans life span by reducing mitochondrial activity and enhancing stress resistance.
www.science.org
November 4, 2025 at 4:10 PM
Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Insulin and epidermal signals independently shape sexually dimorphic neurite branching in C. elegans
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Insulin and epidermal signals independently shape sexually dimorphic neurite branching in C. elegans | EMBO reports
imageimageSexual state-regulated insulin signaling and vulval epithelial cues engage distinct
pathways to remodel the F-actin cytoskeleton, thereby sculpting sexually dimorphic
PVP branches that are i...
www.embopress.org
November 4, 2025 at 4:01 PM
Insulin and epidermal signals independently shape sexually dimorphic neurite branching in C. elegans
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Surojit Sural
The study “Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration” in Nature Cell Biology 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration - Nature Cell Biology
Li et al. uncover a connection between metabolic cues and mitochondrial protein degradation, showing that specifically leucine stabilizes outer mitochondrial membrane proteins by inhibiting ubiquityla...
www.nature.com
October 31, 2025 at 1:33 PM
The study “Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration” in Nature Cell Biology 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
www.science.org/doi/full/10....
www.science.org/doi/full/10....
www.science.org
November 2, 2025 at 8:58 PM
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
www.science.org/doi/full/10....
www.science.org/doi/full/10....