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Reposted by Padmanee (Pam) Sharma, MD, PhD

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Sara Bruschini @sara-bruschini.bsky.social · Dec 10

What a pleasure and honor to have the Nobel Prize @jimallisonphd.bsky.social and the brilliant @pamsharmamdphd.bsky.social at Regina Elena National Cancer Institute in Rome, for the Raffaele Tecce memorial lecture. Immuno past and future! #savelife

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Keystone Symposia @keystonesymposia.bsky.social · Dec 10

Submit your abstract by Dec. 19 (11:59pm MST) to secure a poster presentation spot at our Precision Oncology meeting. Connect with experts such as @pamsharmamdphd.bsky.social in precision medicine, cancer treatment, and health equity! hubs.ly/Q02_9vH10 #KSPrecisionOnc25
@mdanderson.bsky.social

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Host Microbe interactions @hostmicrobelit.bsky.social · Dec 9

Spatial Proteomics named ‘Method of the year’ by @naturemethods.bsky.social .

Very exciting technology 🔬 #science #research #omics

www.nature.com/articles/s41...

Method of the Year 2024: spatial proteomics - Nature Methods

Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

www.nature.com

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Marla Polk @marlajp.bsky.social · Dec 8

Jim Allison, amazing leader and inspiration!

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Aria Vaishnavi, PhD @drariav.bsky.social · Dec 8

Let’s see… David Baker and Victor Ambros! And Jim 🤓🧐

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Padmanee (Pam) Sharma, MD, PhD @pamsharmamdphd.bsky.social · Dec 9

De novo protein synthesis for specific recognition of peptide-MHC complex! This represents the potential for significant advancement in the development of immunotherapies!

doi: doi.org/10.1101/2024...

doi.org

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Padmanee (Pam) Sharma, MD, PhD @pamsharmamdphd.bsky.social · Dec 8

How many Nobel Laureates can you name? It was an absolute pleasure to spend time with friends, including Sid Mukherjee & Doug Hanahan & Sabeena Merchant, and to hear stories of science, dedication & teamwork that led to the Nobel Prize for these brilliant, compassionate, fun & badass individuals!

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Padmanee (Pam) Sharma, MD, PhD @pamsharmamdphd.bsky.social · Dec 8

Nobel Prize Lecture in Chemistry with incredible promise for the future to use AlphaFold & development of new proteins to improve treatments for diseases and provide sustainability for our planet! Congratulations to David Baker, John Jumper & Demis Hassabis @demishassabis.bsky.social

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Rebekah Jones @georebekah.bsky.social · Dec 7

Working on my end-of-year analysis for public health and came across this shocking statistic:

The percent of Ameircans vaccinated for the flu has dropped from 67% in 2019 (pre-COVID) to 38% today.

Influenza has been a leading cause of death in America almost every year since at least 1980.

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Padmanee (Pam) Sharma, MD, PhD @pamsharmamdphd.bsky.social · Dec 8

This show took the concept of work-life balance to a whole other level & left me unsure of how to answer questions from students & junior faculty about how they can achieve work-life balance in academic medicine… looking forward to season 2 for some answers!

Reposted by Padmanee (Pam) Sharma, MD, PhD

Ben Stiller @benstiller.redhour.com · Dec 7

#SEVERANCE

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youtu.be/_UXKlYvLGJY

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Petter Brodin @petterbrodin.bsky.social · Dec 7

Nobel prize week, a yearly celebration of science.
Great to catch up with @jimallisonphd.bsky.social & @pamsharmamdphd.bsky.social back again in Stockholm.

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Padmanee (Pam) Sharma, MD, PhD @pamsharmamdphd.bsky.social · Dec 7

Brilliant lectures today by Victor Ambros & Gary Ruvkun for 2024 Nobel Prize in Medicine! I learned a lot about the Worm Breeders Gazette 🪱

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Bruce Levine, Ph.D. 🇺🇦 @bllphd.bsky.social · Dec 6

🚨2024 VinFuture Special Prize for Innovators with Outstanding Achievements has been awarded to Professors Zelig Eshhar (Israel), Carl H. June, and Michel Sadelain (United States) @PennMedicine @vinfutureprize www.accesswire.com/951373/the-2...

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Padmanee (Pam) Sharma, MD, PhD @pamsharmamdphd.bsky.social · Dec 6

Back in Stockholm to celebrate Nobel Week with @jimallisonphd.bsky.social
Always so much fun!! 🤩❤️🥰💕

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Bruce Levine, Ph.D. 🇺🇦 @bllphd.bsky.social · Dec 5

#Science 🔭 is awesome
First Ever Image of a Multi-Planet System around a Sun-like Star Captured by ESO Telescope
www.eso.org/public/news/...

First Ever Image of a Multi-Planet System around a Sun-like Star Captured by ESO Telescope

The European Southern Observatory’s Very Large Telescope (ESO’s VLT) has taken the first ever image of a young, Sun-like star accompanied by two giant exoplanets. Images of systems with multiple exopl...

www.eso.org

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Hind Hussein, PhD @hindhussein.bsky.social · Dec 4

Intro time! I'm Hind, a mucosal #immunologist working in KU Leuven on mast cells in health and in gut disease.
Speaking of, I can finally show what I have been working on for the last 4 years, ie characterizing human mast cells in layers of the colon via scRNAseq
www.biorxiv.org/content/10.1...

Single cell transcriptomics reveal mast cell heterogeneity in the human gut

Gut mast cells are key players in infection and inflammation, as well as in homeostasis. Mast cells regulate gastrointestinal (GI) function by controlling vascular and epithelial permeability, and int...

www.biorxiv.org

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Rob Patro @robp.bsky.social · Dec 2

Noor (@noorpratap.bsky.social) has been working on this for quite some time! It took a bit of work to figure out, but now you can map your scATAC-seq reads directly to the genome and sort and dedup them with alevin-fry-atac. You get a BED file with counts ready for downstream analysis! 1/

bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · Dec 2

Alevin-fry-atac enables rapid and memory frugal mapping of single-cell ATAC-seq data using virtual colors for accurate genomic pseudoalignment https://www.biorxiv.org/content/10.1101/2024.11.27.625771v1

Ultrafast mapping of short reads to transcriptomic and metagenomic references via lightweight mappin

www.biorxiv.org

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Betty Kim @bettykimmdphd.bsky.social · Dec 1

Our new tradition every Thanksgiving. watching Jim Allison: Breakthrough movie. Must-watch, especially students interested in science and medicine. Modern day #superman (cape missing) who saves millions of lives. Inspirational
@jimallisonphd.bsky.social @pamsharmamdphd.bsky.social
amzn.to/4gdxXaR

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Rod Rahimi @rodrahimi.bsky.social · Nov 29

Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪

go.bsky.app/PY5tCas

go.bsky.app/FmERUoD

go.bsky.app/6aT6qDS

go.bsky.app/QSEPDoj

Rod Rahimi @rodrahimi.bsky.social · Nov 19

Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network

Below are the links

If you're an immunologist and I have missed you so far, let me know 🧪

go.bsky.app/PY5tCas

go.bsky.app/FmERUoD

go.bsky.app/6aT6qDS

Rod Rahimi @rodrahimi.bsky.social · Nov 15

Wonderful to see the #immunology community growing here.

The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added

go.bsky.app/PY5tCas

go.bsky.app/FmERUoD

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Reposted by Padmanee (Pam) Sharma, MD, PhD

danapeer.bsky.social @danapeer.bsky.social · Nov 28

Sometimes I read a pre-print that moves the needle, typically on bioRxiv where all the good new stuff first appears. Two first class tech-dev pioneers and their fearless postdocs collaborate creating tour de-force methods -->
www.biorxiv.org/content/10.1...

A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function

Organ function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the...

www.biorxiv.org

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Vivek Subbiah, MD @viveksubbiah.bsky.social · Nov 28

Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer
www.nejm.org/doi/full/10....

Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer | NEJM

Patients with microsatellite-instability–high (MSI-H) or mismatch-repair–deficient (dMMR) metastatic colorectal cancer have poor outcomes with standard chemotherapy with or without targeted therapi...

www.nejm.org

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Padmanee (Pam) Sharma, MD, PhD @pamsharmamdphd.bsky.social · Nov 27

Great work! Congrats!

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Reposted by Padmanee (Pam) Sharma, MD, PhD

Anna Obenauf @obenaufa.bsky.social · Nov 27

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

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