Paul Baker
@pauljbaker.bsky.social
Cells go in, western blots come out. Autoinflammatory diseases, Innate immunology, Molecular biology, Cytokines
Congratulations to @shouyafeng.bsky.social @sethlucianmasters.bsky.social and the entire team on our lab’s latest publication out now in @natimmunol.bsky.social!
#autoinflammation #autoinflammatory
#autoinflammation #autoinflammatory
A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis.
rdcu.be/d9iRG
rdcu.be/d9iRG
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants
Nature Immunology - Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform...
rdcu.be
February 11, 2025 at 7:11 PM
Congratulations to @shouyafeng.bsky.social @sethlucianmasters.bsky.social and the entire team on our lab’s latest publication out now in @natimmunol.bsky.social!
#autoinflammation #autoinflammatory
#autoinflammation #autoinflammatory
Reposted by Paul Baker
#JanuaryIssue | Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus
Goldbach-Mansky and colleagues propose a pathogenesis-based classification of #autoinflammatory interferonopathies in this #Review
bit.ly/4gLCpOx
Goldbach-Mansky and colleagues propose a pathogenesis-based classification of #autoinflammatory interferonopathies in this #Review
bit.ly/4gLCpOx
Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus - Nature Reviews Rheumatology
This Review provides a comprehensive update on dysregulated type I interferon production and signalling in autoinflammatory interferonopathies, monogenic systemic lupus erythematosus and conditio...
bit.ly
December 20, 2024 at 9:22 AM
#JanuaryIssue | Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus
Goldbach-Mansky and colleagues propose a pathogenesis-based classification of #autoinflammatory interferonopathies in this #Review
bit.ly/4gLCpOx
Goldbach-Mansky and colleagues propose a pathogenesis-based classification of #autoinflammatory interferonopathies in this #Review
bit.ly/4gLCpOx
Reposted by Paul Baker
Looks like a great inflammazoom coming up Dec 16 with @inflammasomelab.bsky.social and Si Ming Man! These talks are great for everyone interested in autoinflammation.
Register here to access the live session as well as on-demand talks from past sessions: events.abcam.com/AnYVL?rt=Qlp...
Register here to access the live session as well as on-demand talks from past sessions: events.abcam.com/AnYVL?rt=Qlp...
InflammaZoom
Join me online at the next InflammaZoom webinar!
events.abcam.com
December 14, 2024 at 10:48 PM
Looks like a great inflammazoom coming up Dec 16 with @inflammasomelab.bsky.social and Si Ming Man! These talks are great for everyone interested in autoinflammation.
Register here to access the live session as well as on-demand talks from past sessions: events.abcam.com/AnYVL?rt=Qlp...
Register here to access the live session as well as on-demand talks from past sessions: events.abcam.com/AnYVL?rt=Qlp...
Reposted by Paul Baker
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Link: rdcu.be/d2mjm
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...
rdcu.be
December 9, 2024 at 1:39 AM
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Link: rdcu.be/d2mjm
Excited to share this paper from my post-doc at @niaidnews.bsky.social out now in Science Immunology! We show that recent or ongoing 🫁 infections or other pulmonary environmental exposures at the time of infection with SARSCoV2 can vastly influence early replication of the virus in mice.
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication
Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.
www.science.org
December 7, 2024 at 11:47 PM
Excited to share this paper from my post-doc at @niaidnews.bsky.social out now in Science Immunology! We show that recent or ongoing 🫁 infections or other pulmonary environmental exposures at the time of infection with SARSCoV2 can vastly influence early replication of the virus in mice.
Reposted by Paul Baker
The December issue of #Science #Immunology is out now! This week: #MAITcell plasticity in #antibacterial immunity; how #inflammatory status of #lung before #COVID19 infection impacts #viral control; & #helminths utilize glutamate dehydrogenase to prevent #AAMs & #TH2 activation!
bit.ly/SI_DEC_24
bit.ly/SI_DEC_24
December 6, 2024 at 7:13 PM
The December issue of #Science #Immunology is out now! This week: #MAITcell plasticity in #antibacterial immunity; how #inflammatory status of #lung before #COVID19 infection impacts #viral control; & #helminths utilize glutamate dehydrogenase to prevent #AAMs & #TH2 activation!
bit.ly/SI_DEC_24
bit.ly/SI_DEC_24