@paulschanda.bsky.social
Passionate for integrated structural biology, including NMR and many more. Particularly interested in protein dynamics, and therefore chaperones, enzymes and mitochondrial protein import.
Fortunate to lead a great research team at IST Austria.
Fortunate to lead a great research team at IST Austria.
Very nice preprint that shows that protein crystallographic structures can be used to reveal the entropy of ligand binding.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 23, 2026 at 5:21 AM
Very nice preprint that shows that protein crystallographic structures can be used to reveal the entropy of ligand binding.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
A recent podcast by Stephanie Wankowicz and James @fraserlab.com picked up our work (with Alex Bronstein & coworkers) on Guiding AlphaFold3 with experimental data (cryoEM, X-ray, NMR) to generate protein ensembles. (Thanks for the kind words 🙂)
👉 creators.spotify.com/pod/profile/... (from 35:50)
👉 creators.spotify.com/pod/profile/... (from 35:50)
Episode 8: Open Science in a Changing Academic World by The Tortured Proteins Department
Topics:Compact for Academic Excellence in Higher EducationGovernment ShutdownHHMI's new open science policiesShrinking PhD poolsThe Nobel PrizesThe BearTLOS ReactionsPreprint: Experiment-guided AlphaF...
creators.spotify.com
January 21, 2026 at 2:14 PM
A recent podcast by Stephanie Wankowicz and James @fraserlab.com picked up our work (with Alex Bronstein & coworkers) on Guiding AlphaFold3 with experimental data (cryoEM, X-ray, NMR) to generate protein ensembles. (Thanks for the kind words 🙂)
👉 creators.spotify.com/pod/profile/... (from 35:50)
👉 creators.spotify.com/pod/profile/... (from 35:50)
📢 Check out Ben Tatman's talk in the Magnetic Resonance Seminar series online (see details below). He will talk about methods to probe protein dynamics by magic-angle spinning #NMR. Friday, Jan 23, noon CET.
January 20, 2026 at 8:06 AM
📢 Check out Ben Tatman's talk in the Magnetic Resonance Seminar series online (see details below). He will talk about methods to probe protein dynamics by magic-angle spinning #NMR. Friday, Jan 23, noon CET.
📢 New preprint alert!
How do proteins enter mitochondria? We uncovered a surprising mechanism at the mitochondrial entry gate—using #NMR, in vivo single-particle tracking, yeast experiments, and MD simulations to crack the code.
www.biorxiv.org/content/10.6...
#StructuralBiology #Mitochondria
🧵 1/8
How do proteins enter mitochondria? We uncovered a surprising mechanism at the mitochondrial entry gate—using #NMR, in vivo single-particle tracking, yeast experiments, and MD simulations to crack the code.
www.biorxiv.org/content/10.6...
#StructuralBiology #Mitochondria
🧵 1/8
A dynamic displacement mechanism drives protein import into mitochondria
Most mitochondrial proteins are produced in the cytosol and imported through the translocase of the outer mitochondrial membrane (TOM) to reach their final destination. Although this protein entry gat...
www.biorxiv.org
January 14, 2026 at 7:16 PM
📢 New preprint alert!
How do proteins enter mitochondria? We uncovered a surprising mechanism at the mitochondrial entry gate—using #NMR, in vivo single-particle tracking, yeast experiments, and MD simulations to crack the code.
www.biorxiv.org/content/10.6...
#StructuralBiology #Mitochondria
🧵 1/8
How do proteins enter mitochondria? We uncovered a surprising mechanism at the mitochondrial entry gate—using #NMR, in vivo single-particle tracking, yeast experiments, and MD simulations to crack the code.
www.biorxiv.org/content/10.6...
#StructuralBiology #Mitochondria
🧵 1/8
📢 Join us at the first Austrian #NMR meeting.
Organised by a fantastic group of young international NMR researchers, this meeting is great opportunity for postdocs and students to contribute their science with a talk or poster. And to see great invited speakers.
austrian-nmr-meeting.pages.ist.ac.at
Organised by a fantastic group of young international NMR researchers, this meeting is great opportunity for postdocs and students to contribute their science with a talk or poster. And to see great invited speakers.
austrian-nmr-meeting.pages.ist.ac.at
Next Austrian NMR Meeting 2026
austrian-nmr-meeting.pages.ist.ac.at
January 12, 2026 at 4:22 PM
📢 Join us at the first Austrian #NMR meeting.
Organised by a fantastic group of young international NMR researchers, this meeting is great opportunity for postdocs and students to contribute their science with a talk or poster. And to see great invited speakers.
austrian-nmr-meeting.pages.ist.ac.at
Organised by a fantastic group of young international NMR researchers, this meeting is great opportunity for postdocs and students to contribute their science with a talk or poster. And to see great invited speakers.
austrian-nmr-meeting.pages.ist.ac.at
The PhD call at @istaresearch.bsky.social is open.
Get a glimpse on the work of Jakob, a PhD student in our group www.instagram.com/reel/DSjvCo4...
Applications:
phd.pages.ista.ac.at/phd-applicat...
Get a glimpse on the work of Jakob, a PhD student in our group www.instagram.com/reel/DSjvCo4...
Applications:
phd.pages.ista.ac.at/phd-applicat...
ISTAustria on Instagram: "A day in the life of a biochemistry PhD student at ISTA.
Meet Jakob from the Schanda group, and see what a typical day of a structural biologist looks like.
Interested in c...
30 likes, 0 comments - istaresearch on December 22, 2025: "A day in the life of a biochemistry PhD student at ISTA.
Meet Jakob from the Schanda group, and see what a typical day of a structural biolo...
www.instagram.com
December 22, 2025 at 8:55 AM
The PhD call at @istaresearch.bsky.social is open.
Get a glimpse on the work of Jakob, a PhD student in our group www.instagram.com/reel/DSjvCo4...
Applications:
phd.pages.ista.ac.at/phd-applicat...
Get a glimpse on the work of Jakob, a PhD student in our group www.instagram.com/reel/DSjvCo4...
Applications:
phd.pages.ista.ac.at/phd-applicat...
#NMR spectroscopists in and around Austria: join us for this meeting.
A few great keynote speakers, and lots of space for contributed talks from students and postdocs. Taking place at ISTA @istaresearch.bsky.social in February 2026
A few great keynote speakers, and lots of space for contributed talks from students and postdocs. Taking place at ISTA @istaresearch.bsky.social in February 2026
So excited to announce the first 🧲 Next Austrian NMR Meeting 🧲, happening @ ISTA, Feb 26–27, 2026! Plus a satellite workshop, 💊 “ #NMR in #DrugDiscovery” 🧭 on Feb 25!
📅 Registration: Dec 1, 2025
🌐 Program, venue: austrian-nmr-meeting.pages.ist.ac.at
#NMRchat #Austria 1/4
📅 Registration: Dec 1, 2025
🌐 Program, venue: austrian-nmr-meeting.pages.ist.ac.at
#NMRchat #Austria 1/4
November 17, 2025 at 1:22 PM
#NMR spectroscopists in and around Austria: join us for this meeting.
A few great keynote speakers, and lots of space for contributed talks from students and postdocs. Taking place at ISTA @istaresearch.bsky.social in February 2026
A few great keynote speakers, and lots of space for contributed talks from students and postdocs. Taking place at ISTA @istaresearch.bsky.social in February 2026
Reposted
So excited to announce the first 🧲 Next Austrian NMR Meeting 🧲, happening @ ISTA, Feb 26–27, 2026! Plus a satellite workshop, 💊 “ #NMR in #DrugDiscovery” 🧭 on Feb 25!
📅 Registration: Dec 1, 2025
🌐 Program, venue: austrian-nmr-meeting.pages.ist.ac.at
#NMRchat #Austria 1/4
📅 Registration: Dec 1, 2025
🌐 Program, venue: austrian-nmr-meeting.pages.ist.ac.at
#NMRchat #Austria 1/4
November 17, 2025 at 1:00 PM
So excited to announce the first 🧲 Next Austrian NMR Meeting 🧲, happening @ ISTA, Feb 26–27, 2026! Plus a satellite workshop, 💊 “ #NMR in #DrugDiscovery” 🧭 on Feb 25!
📅 Registration: Dec 1, 2025
🌐 Program, venue: austrian-nmr-meeting.pages.ist.ac.at
#NMRchat #Austria 1/4
📅 Registration: Dec 1, 2025
🌐 Program, venue: austrian-nmr-meeting.pages.ist.ac.at
#NMRchat #Austria 1/4
Wichtig für Klosterneuburg. Und auch für alle am @istaresearch.bsky.social
Bitte hier unterzeichnen: mein.aufstehn.at/petitions/ra...
Bitte hier unterzeichnen: mein.aufstehn.at/petitions/ra...
Jetzt unterzeichnen: Radwegeausbau in Klosterneuburg!
Klosterneuburg muss das Radwegenetz ausbauen. Nur so steigen mehr Menschen auf das klimafreundliche Verkehrsmittel Rad um — ein wichtiger Schritt zur Bewältigung der Klimakrise.
mein.aufstehn.at
November 17, 2025 at 1:21 PM
Wichtig für Klosterneuburg. Und auch für alle am @istaresearch.bsky.social
Bitte hier unterzeichnen: mein.aufstehn.at/petitions/ra...
Bitte hier unterzeichnen: mein.aufstehn.at/petitions/ra...
I had the pleasure to work with amazing students at @istaresearch.bsky.social on a nice "side project": Understanding the travel-related carbon emissions of our institute, and how much planes pollute (compared to trains) -- and then applying all this to analyze the footprint of #NMR conferences.
->🧵
->🧵
“In-person meetings have a quality that online conferences simply cannot provide,” says ISTA professor @paulschanda.bsky.social.
But can we make conference travel more sustainable?
Read more: ista.ac.at/en/news/carb...
But can we make conference travel more sustainable?
Read more: ista.ac.at/en/news/carb...
Carbon Footprint of Conference Travel
International meetings offer researchers worldwide the chance to explore the cutting edge of science, generate new ideas, and strike up collaborations. Having a wide geographical distribution of atten...
ista.ac.at
November 10, 2025 at 11:34 AM
I had the pleasure to work with amazing students at @istaresearch.bsky.social on a nice "side project": Understanding the travel-related carbon emissions of our institute, and how much planes pollute (compared to trains) -- and then applying all this to analyze the footprint of #NMR conferences.
->🧵
->🧵
Looking forward to hosting Kresten Lindorff-Larsen's talk tomorrow.
I am looking forward to seeing ISTA's main lecture hall of full, and hearing the latest developments of tools to predict, design and study intrinsically disordered proteins.
@istaresearch.bsky.social
I am looking forward to seeing ISTA's main lecture hall of full, and hearing the latest developments of tools to predict, design and study intrinsically disordered proteins.
@istaresearch.bsky.social
Looking forward to visit colleagues in Vienna and Graz 🇦🇹
If you’re in Vienna I’m speaking on:
Prediction and Design of Intrinsically Disordered Proteins and Condensates (27/10 ISTA)
&
Understanding the Effects of Missense Variants Using Analyses of Protein Stability and Conservation (30/10 VBC)
If you’re in Vienna I’m speaking on:
Prediction and Design of Intrinsically Disordered Proteins and Condensates (27/10 ISTA)
&
Understanding the Effects of Missense Variants Using Analyses of Protein Stability and Conservation (30/10 VBC)
October 26, 2025 at 6:38 PM
Looking forward to hosting Kresten Lindorff-Larsen's talk tomorrow.
I am looking forward to seeing ISTA's main lecture hall of full, and hearing the latest developments of tools to predict, design and study intrinsically disordered proteins.
@istaresearch.bsky.social
I am looking forward to seeing ISTA's main lecture hall of full, and hearing the latest developments of tools to predict, design and study intrinsically disordered proteins.
@istaresearch.bsky.social
Reposted
here is the correct link: ista.ac.at/en/job/tenur...
Tenure-based Research Staff Scientist Position in Computational Structural Biology
ISTA (www.ista.ac.at) is seeking a highly skilled Staff Scientist in Computational Structural Biology to support and advance the Institute’s structural biology research through the development and imp...
ista.ac.at
October 15, 2025 at 12:44 PM
here is the correct link: ista.ac.at/en/job/tenur...
📢 New preprint:
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
October 18, 2025 at 6:59 PM
📢 New preprint:
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Reposted
ISTA @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology, to develop tools for cryo-EM, cryo-ET, structural prediction methods and protein interaction analysis!
Please spread the word!
ista.ac.at/en/job/tenur...
Please spread the word!
ista.ac.at/en/job/tenur...
Tenure-based Research Staff Scientist Position in Computational Structural Biology
ISTA (www.ista.ac.at) is seeking a highly skilled Staff Scientist in Computational Structural Biology to support and advance the Institute’s structural biology research through the development and imp...
ista.ac.at
October 15, 2025 at 2:08 PM
ISTA @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology, to develop tools for cryo-EM, cryo-ET, structural prediction methods and protein interaction analysis!
Please spread the word!
ista.ac.at/en/job/tenur...
Please spread the word!
ista.ac.at/en/job/tenur...
Today, teaching again our sustainability course at @istaresearch.bsky.social, we discussed about the "addiction" of humanity to fossil fuels. The promise of carbon capture and storage ("we'll solve it later") is so convenient, and who cares today that it probably won't ever work ...?
This is exactly what scientists have been saying for years:
oilprice.com/Energy/Energ...
oilprice.com/Energy/Energ...
The Collapse of Confidence in Carbon Capture | OilPrice.com
Carbon Capture and Storage, once seen as a lifeline for the oil and gas industry, is facing mounting doubts as delays, high costs, and poor performance cast serious doubts on its future viability.
oilprice.com
October 8, 2025 at 6:42 PM
Today, teaching again our sustainability course at @istaresearch.bsky.social, we discussed about the "addiction" of humanity to fossil fuels. The promise of carbon capture and storage ("we'll solve it later") is so convenient, and who cares today that it probably won't ever work ...?
🌟 Huge congrats to Darja Rohden for winning the L’Oréal For Women in Science Award 2025! 🎓
Darja works in our group @istaresearch.bsky.social and at @univie.ac.at, funded by @fwf-at.bsky.social on chemical synthesis of amino acids and protein #nmr.
👉 Get more details in the thread.
1/n
Darja works in our group @istaresearch.bsky.social and at @univie.ac.at, funded by @fwf-at.bsky.social on chemical synthesis of amino acids and protein #nmr.
👉 Get more details in the thread.
1/n
4 Forscherinnen erhalten den L'Oré[email protected] Förderpreis "For Women in #Science" 2025, 2 davon von der #univie: Nida Ali der Fakultät für Psychologie und Darja Rohden vom Institut für Biologische Chemie! 🥳 Herzliche Gratulation an die Preisträgerinnen! Mehr dazu 👉 www.ots.at/presseaussen...
October 8, 2025 at 6:09 PM
🌟 Huge congrats to Darja Rohden for winning the L’Oréal For Women in Science Award 2025! 🎓
Darja works in our group @istaresearch.bsky.social and at @univie.ac.at, funded by @fwf-at.bsky.social on chemical synthesis of amino acids and protein #nmr.
👉 Get more details in the thread.
1/n
Darja works in our group @istaresearch.bsky.social and at @univie.ac.at, funded by @fwf-at.bsky.social on chemical synthesis of amino acids and protein #nmr.
👉 Get more details in the thread.
1/n
Reposted
Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social!
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
September 15, 2025 at 9:37 AM
Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social!
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
ISTA's Science Experience Center opens with a nice festival.
If you are in the Vienna area, come and enjoy.
If you are in the Vienna area, come and enjoy.
Keynote “In defense of wonder - science communication in an age of misinformation” by @michaeljohngorman.bsky.social of the @mit.edu museum about current challenges in science communication.
October 3, 2025 at 5:52 PM
ISTA's Science Experience Center opens with a nice festival.
If you are in the Vienna area, come and enjoy.
If you are in the Vienna area, come and enjoy.
📢 New paper: a combination of a new isotope labelling with solution-NMR, allowing to assign methyl groups even in large proteins -- we've tested it with our favourite ~130 kDa enzyme and a 70 kDa receptor.
->see thread
1/n
@istaresearch.bsky.social @univie.ac.at
www.sciencedirect.com/science/arti...
->see thread
1/n
@istaresearch.bsky.social @univie.ac.at
www.sciencedirect.com/science/arti...
A Novel HMBC-CC-HMQC NMR Strategy for Methyl Assignment Using Triple-13C-Labeled α-Ketoisovalerate Integrated with UCBShift 2.0
In this study, we describe an integrated approach for methyl group assignment comprising precursor-based selective methyl group labeling, a novel puls…
www.sciencedirect.com
October 3, 2025 at 4:29 AM
📢 New paper: a combination of a new isotope labelling with solution-NMR, allowing to assign methyl groups even in large proteins -- we've tested it with our favourite ~130 kDa enzyme and a 70 kDa receptor.
->see thread
1/n
@istaresearch.bsky.social @univie.ac.at
www.sciencedirect.com/science/arti...
->see thread
1/n
@istaresearch.bsky.social @univie.ac.at
www.sciencedirect.com/science/arti...
Reposted
The VISTA Science Experience Center Opening Festival offers a free, diverse program for science, art & music lovers. Several activities, incl. exhibition tours, keynotes, and panel discussions, will also be accessible with sign language interpretation.
Join us from Oct 3-5!
https://bit.ly/4mnJ3Ne
Join us from Oct 3-5!
https://bit.ly/4mnJ3Ne
September 22, 2025 at 3:11 PM
The VISTA Science Experience Center Opening Festival offers a free, diverse program for science, art & music lovers. Several activities, incl. exhibition tours, keynotes, and panel discussions, will also be accessible with sign language interpretation.
Join us from Oct 3-5!
https://bit.ly/4mnJ3Ne
Join us from Oct 3-5!
https://bit.ly/4mnJ3Ne
Check out these thoughts about reviewing preprints. I agree, a change in the culture and practices would be very welcome.
Why hasn't Preprint Peer Review caught on more?
I discovered a small, but simple reason - authors are missing out on the JOY of getting feedback because they aren't notified when feedback occurs.
more in thread below!
I discovered a small, but simple reason - authors are missing out on the JOY of getting feedback because they aren't notified when feedback occurs.
more in thread below!
September 8, 2025 at 5:16 PM
Check out these thoughts about reviewing preprints. I agree, a change in the culture and practices would be very welcome.
Reposted
@Bruker #NMR User Meetings are coming to the US. Join us either in Washington DC on Oct. 28. or in La Jolla CA on Nov. 4. 2025. You can see the agenda and register here. www.bruker.com/en/news-and-...
September 5, 2025 at 12:23 PM
@Bruker #NMR User Meetings are coming to the US. Join us either in Washington DC on Oct. 28. or in La Jolla CA on Nov. 4. 2025. You can see the agenda and register here. www.bruker.com/en/news-and-...
Check out Fede's and Darja's MAS #NMR / isotope-labeling paper.
Team effort with @darjarohden.bsky.social 💪🏼👩🔬 targeting my second favourite amino acid by solid-state NMR. Many motion timescales accessible. And the next amino acid is already in the crosshairs (my third favourite 😏).
share.google/Q1ZzwJwDjjwA...
(yeah nothing beats tryptophan)
share.google/Q1ZzwJwDjjwA...
(yeah nothing beats tryptophan)
Arginine dynamics probed by magic-angle spinning NMR with a specific isotope-labeling scheme
The specific introduction of 1H-13C or 1H-15N moieties into otherwise deuterated proteins holds great potential for high-resolution solution and magic…
share.google
September 2, 2025 at 4:30 PM
Check out Fede's and Darja's MAS #NMR / isotope-labeling paper.
Reposted
I’m carrying out a short survey of NMR TITAN users - if you’ve made use of this tool in your research, or have suggestions for its future development, I’d be grateful for your input: forms.gle/MMXYwSozszhi... #nmrchat
NMR TITAN user survey
This survey aims to assess the impact of NMR TITAN on biomolecular research and identify priorities for future development. The form should take approximately 5 minutes to complete. Your responses may...
forms.gle
August 28, 2025 at 2:13 PM
I’m carrying out a short survey of NMR TITAN users - if you’ve made use of this tool in your research, or have suggestions for its future development, I’d be grateful for your input: forms.gle/MMXYwSozszhi... #nmrchat