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pbilleke.bsky.social
Pablo Billeke
@pbilleke.bsky.social
120 followers 93 following 20 posts
MD, PhD, Neuroscientist. How does the 🧠 works? How does our 🧠 make us beings who live, socialize, make decisions, learn and develop? How our 🧠 make us humans?
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pbilleke.bsky.social
Pablo Billeke @pbilleke.bsky.social · Nov 20
Happy 🎉 to share that our article 🚨, "Lateral Prefrontal Theta Oscillations Causally Drive a Computational Mechanism Underlying Conflict Expectation and Adaptation," has been published 📚 today in NatureComms. (1/8)
doi.org/10.1038/s414....
Lateral prefrontal theta oscillations causally drive a computational mechanism underlying conflict expectation and adaptation - Nature Communications
Martínez-Molina et al. utilized fMRI, EEG-TMS, and cognitive modeling to reveal the mechanisms behind expectation and adaptation to upcoming conflicting events, demonstrating the causal role of theta ...
doi.org
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Reposted by Pablo Billeke
neurocics.bsky.social
neuroCICS @neurocics.bsky.social · Aug 20
Te invitamos a la charla Estimulación cerebral no invasiva y ejercicio en dolor crónico con la Dra. Edith Elgueta. 🗓 21/08/25 | ⏰ 14:30 hrs | 📍 UDD, modalidad híbrida.
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pbilleke.bsky.social
Pablo Billeke @pbilleke.bsky.social · Aug 3
Integrating and interpreting brain maps: Trends in Neurosciences www.cell.com/trends/neuro...
Integrating and interpreting brain maps
Tangled molecular, cellular, and dynamic undercurrents shape brain organization. An emerging paradigm across neuroscience domains is to comprehensively measure the spatial patterning of multiple biolo...
www.cell.com
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pbilleke.bsky.social
Pablo Billeke @pbilleke.bsky.social · Aug 3
Integrating and interpreting brain maps: Trends in Neurosciences www.cell.com/trends/neuro...
Integrating and interpreting brain maps
Tangled molecular, cellular, and dynamic undercurrents shape brain organization. An emerging paradigm across neuroscience domains is to comprehensively measure the spatial patterning of multiple biolo...
www.cell.com
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Reposted by Pablo Billeke
neurocics.bsky.social
neuroCICS @neurocics.bsky.social · Jun 30
Marcela Díaz, alumna del Doctorado en Neurociencias UC y del laboratorio NeuroCICS, representó nuestro trabajo en el Human Brain Mapping 2025 en Brisbane, Australia. 🧠🌏 #NeuroCICS #HBM2025
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pbilleke.bsky.social
Pablo Billeke @pbilleke.bsky.social · Jun 30
Is criticality a unified setpoint of brain function?: Neuron www.cell.com/neuron/fullt...
Is criticality a unified setpoint of brain function?
Hengen and Shew propose that criticality—a state with scale-invariant dynamics—is a universal computational setpoint of healthy brains. Their meta-analysis of two decades of research reconciles contra...
www.cell.com
pbilleke.bsky.social
Pablo Billeke @pbilleke.bsky.social · Jun 24
Stimulation of the human ventral tegmental area increases strategic betting url: academic.oup.com/brain/articl...
Stimulation of the human ventral tegmental area increases strategic betting
Hirschbichler et al. examine the effects of DBS-induced inhibition of the VTA on learning and decision-making. They find that while VTA inhibition does not
academic.oup.com
Reposted by Pablo Billeke
neurocics.bsky.social
neuroCICS @neurocics.bsky.social · May 30
📅 30 de mayo | Día Mundial de la Esclerosis Múltiple
Nos sumamos a “Navegando juntos la EM” para visibilizar esta enfermedad.
🧡 18 h | Iluminación en La Moneda #iluminEMosChile
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Reposted by Pablo Billeke
neurocics.bsky.social
neuroCICS @neurocics.bsky.social · Jun 4
🧠 Seminario de Neurociencia y Neuroimágenes | 6 de junio, 12:00 h | U. de Concepción. Inscríbete 👉 forms.gle/uvrHQQz62zK6... 🍕 ¡Habrá coffee break con pizza! #Neurocics
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Reposted by Pablo Billeke
pessoabrain.bsky.social
PessoaBrain @pessoabrain.bsky.social · May 30
𝗕𝗿𝗮𝗶𝗻-𝘄𝗶𝗱𝗲 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝗼𝗳 𝗮𝗻 𝗲𝗺𝗼𝘁𝗶𝗼𝗻𝗮𝗹 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲

Looks like an interesting paper about brain-wide processes.
Sure to generate discussion.
www.science.org/doi/10.1126/...
#neuroscience #neuroskyence
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pbilleke.bsky.social
Pablo Billeke @pbilleke.bsky.social · May 20
7/7 🧵 Our findings could inform better diagnostics and treatments 💙, including brain stimulation ⚡or cognitive rehabilitation.
Understanding the neural basis of fatigue is key to improving quality of life in MS.
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pbilleke.bsky.social
Pablo Billeke @pbilleke.bsky.social · May 20
6/7 🧵 Cognitive fatigue—not physical fatigue—was consistently associated with these white matter patterns in PwRMS.
This suggests that fatigue in MS may arise from early, subtle disruptions in cognitive control and sensory integration networks.
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pbilleke.bsky.social
Pablo Billeke @pbilleke.bsky.social · May 20
5/7 🧵 Importantly, white matter microstructure (FA) 🧠 in short-range fibers connecting these areas, especially the left inferior frontal gyrus, was altered in PwRMS. This supports a distinct neuroanatomical basis for fatigue in PwMS 🌟
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pbilleke.bsky.social
Pablo Billeke @pbilleke.bsky.social · May 20
4/7 🧵
Regions linked to fatigue include:
🧠 Cingulate gyrus
🧠 Inferior frontal gyrus
🧠 Superior temporal sulcus
🧠 Insula
🧠 Transverse temporal gyrus
These are key areas for language, decision-making, emotional and social processing.
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pbilleke.bsky.social
Pablo Billeke @pbilleke.bsky.social · May 20
3/7 🧵 Using Bayesian regression models 📉(LASSO and Spike-and-Slab), we identified a specific pattern of white matter alterations that correlated with total and cognitive fatigue only in PwRMS.
@rodrigohch.bsky.social
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pbilleke.bsky.social
Pablo Billeke @pbilleke.bsky.social · May 20
2/7 🧵 Fatigue is one of the most disabling symptoms in MS. We compared 32 PwRMS and 29 healthy controls—both groups experiencing similar levels of fatigue—to explore brain-based differences using 🧠 MRI and diffusion imaging. @alejandrafigueroa.bsky.social @neurocics.bsky.social
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pbilleke.bsky.social
Pablo Billeke @pbilleke.bsky.social · May 20
Why do we fatigue? Fatigue is very frequent in people with some pathologies as #MultipleSclerosis (MS). In our new paper, we show that white matter structure and connectivity in the brain are linked to cognitive fatigue. 🧵1/7🔗 www.nature.com/articles/s41...
‪@multiplesclerosis.bsky.social‬
White matter volume and microstructural integrity are associated with fatigue in relapsing multiple sclerosis - Scientific Reports
Scientific Reports - White matter volume and microstructural integrity are associated with fatigue in relapsing multiple sclerosis
www.nature.com
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Reposted by Pablo Billeke
neurocics.bsky.social
neuroCICS @neurocics.bsky.social · May 19
El PPPD afecta la orientación espacial. Este estudio revela fallas en la navegación cerebral y mayor desorganización en pacientes. Lee más aquí: doi.org/10.3389/fneu... @pbilleke.bsky.social
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Reposted by Pablo Billeke
neurocics.bsky.social
neuroCICS @neurocics.bsky.social · Apr 7
¡𝐒𝐞 𝐚𝐛𝐫𝐢𝐞𝐫𝐨𝐧 𝐥𝐚𝐬 𝐩𝐨𝐬𝐭𝐮𝐥𝐚𝐜𝐢𝐨𝐧𝐞𝐬!
Inscríbete en la II versión del Diplomado en Investigación Clínica 𝟏𝟎𝟎% 𝐨𝐧𝐥𝐢𝐧𝐞.
𝐈𝐧𝐢𝐜𝐢𝐨: 𝟐 𝐝𝐞 𝐣𝐮𝐧𝐢𝐨 𝟐𝟎𝟐𝟓
👉 medicina.udd.cl/ver-diplomad...
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Reposted by Pablo Billeke
neurocics.bsky.social
neuroCICS @neurocics.bsky.social · May 13
¡Nuevo artículo de Alejandra Figueroa! Un gran avance en nuestro laboratorio cambios en sustancia blanca y fatiga en EM. ¡Felicitaciones! #EsclerosisMúltiple #NeuroCICS #InvestigaciónUDD #CienciaConImpacto #AvancesEnNeurociencia
📌 www.nature.com/articles/s41...
White matter volume and microstructural integrity are associated with fatigue in relapsing multiple sclerosis - Scientific Reports
Scientific Reports - White matter volume and microstructural integrity are associated with fatigue in relapsing multiple sclerosis
www.nature.com
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Reposted by Pablo Billeke
neurocics.bsky.social
neuroCICS @neurocics.bsky.social · Apr 21
¡Felicitamos a Nicolás Ferrer por aprobar su defensa de tesis! Celebramos este gran hito académico y le deseamos mucho éxito en sus próximos desafíos.
#neurocics #neurocicsudd #udd #neurociencias @pbilleke.bsky.social
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Reposted by Pablo Billeke
natureportfolio.nature.com
Nature Portfolio @natureportfolio.nature.com · Apr 21
Nature reports on how researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases. 🧪
Cells are swapping their mitochondria. What does this mean for our health?
Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
go.nature.com
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Reposted by Pablo Billeke
antropomemoria.bsky.social
Adriana Goñi @antropomemoria.bsky.social · Apr 19
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Reposted by Pablo Billeke
nicolecrust.bsky.social
Nicole Rust @nicolecrust.bsky.social · Apr 15
THIS IS ONE NEURON! Jaw dropping.

It distributes a particular neurotransmitter (norepinephrine) across the mouse brain; it’s a locus coeruleus neuron.

@jeremiahycohen.bsky.social and colleagues at the @alleninstitute.bsky.social are using new biotech to see things never seen before.
Jeremiah Cohen standing in front of a giant green neuron.
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Reposted by Pablo Billeke
lavidaenvinetas.bsky.social
La vida en viñetas @lavidaenvinetas.bsky.social · Apr 9
Quino
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Reposted by Pablo Billeke
nataliepeluso.com
Natalie Peluso 🧠​🫁😊 @nataliepeluso.com · Apr 1
Age-related differences in 1/f aperiodic EEG/MEG signals can be driven by cardiac rather than brain activity 👇

#interoception 🧠🫀 #neuroskyence

elifesciences.org/reviewed-pre...
Age-related changes in “cortical” 1/f dynamics are linked to cardiac activity
elifesciences.org
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