0.75x 1x 1.25x 1.5x 2x 0:0033:09 151 – Detecting and Quantifying Peptide Doping Agents and Developing Smart Samplers – Trine Halvorsen, PhD Apple PodcastsGoogle PodcastsPlayer EmbedShare Leave a Revie...

Background Doping remains an ongoing threat to clean competition. To date, global preventive initiatives have not addressed critical psychosocial antecedents of doping thoroughly due to the scarcity of knowledge regarding its psychosocial mechanisms from a harmonised cross-country perspective. We, therefore, conducted a multi-country investigation testing the interplay of two important yet overlooked attributes, namely narcissism and self-compassion, and examined their psychosocial mechanisms underpinning doping. Methods Using a sample of 499 high-performing athletes (80% competing at national level or above) from the UK, US, and China, we performed a series of multi-variate multi-group moderation models to test the narcissism × compassion interaction on doping and examined potential psychosocial mechanisms underlying such effects. In all analyses, we applied cluster control to adjust for coach-/team-level confounds and compared fixed vs. random effects models for cross-country comparisons. Results We found an identical interaction across study countries showing self-compassion alleviates narcissism-related doping willingness (especially that vulnerable narcissism drives). Grandiose narcissism’s protective effect on vulnerable narcissism-related doping moral disengagement was invariant across countries. Resilient coping appears to be a consistent mechanism across study countries that explains narcissism-related risk and compassion-related protection. Fear of failure manifested varied mechanistic effects in different study countries, inferring potential cross-cultural differences. Conclusion Vulnerable narcissism is a critical person-level correlate of doping. Grandiose narcissism, in the presence of self-compassion, can alleviate such risk thanks to enhanced resilient coping. Future education and interventions should tackle these important person-level attributes for anti-doping.

0.75x 1x 1.25x 1.5x 2x 0:0053:38 159 – The 13-Year Battle for Olympic Bronze and the Impacts of Doping on Clean Athletes – Shannon Rowbury Apple PodcastsGoogle PodcastsPlayer EmbedShare Leave a Review...

Rationale This work introduces an alternative experimental approach by integrating high-resolution mass spectrometry (HRMS) with multivariate statistical analysis for metabolite detection and identi...

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In vitro metabolic models provide a means to circumvent the ethical concerns associated with human administration research, allowing for preliminary predictions of human metabolism while generating high concentrations of metabolites for characterization. As S1.1-class anabolic androgenic steroids on the World Anti-Doping Agency (WADA) Prohibited List, oxymetholone and methasterone have consistently appeared in the top 20 substances identified in adverse analytical findings (AAFs) in recent years, reflecting their persistent abuse patterns in sports. Given their exogenous nature, the metabolites of these steroid hormones fall within the scope of doping control, making metabolic studies a crucial aspect of anti-doping research. In this study, human liver S9 fractions were employed as a model for the characterization and metabolic profiling of oxymetholone and methasterone via gas chromatography-orbitrap-high-resolution mass spectrometry (GC-Orbitrap-HRMS). The full scan mode of GC-Orbitrap-HRMS was utilized to detect free and two conjugated fractions of metabolites, comparing these with control groups to confirm the metabolites during in vitro incubation. Possible metabolite structures were inferred from EI mass spectra, and the metabolic pathways for both drugs were discussed. In vitro, three oxymetholone and five methasterone metabolites were identified, and among them, two metabolites, OMT-M3 (2α,17α-methyl-5ξ-androstan-3α,6β,17β-triol) and MTS-M3 (2α,17α-dimethyl-5ξ-androstane-3α,12ξ,16ξ,17β-tetrol), were characterized as novel metabolites based on recent human in vivo metabolic studies. These metabolites exhibited diverse metabolic pathways, and their structures were corroborated through complementary in vitro and in vivo metabolic analyses. This study provides a comprehensive evaluation of the applicability of the human liver S9 model in the metabolic studies of anabolic steroids in vitro, verifying novel human metabolites and providing valuable insights for future research in this field. Graphical Abstract

The Partnership for Clean Competition (PCC) is thrilled to announce that Rusty Smith has been hired as the new Head of Research Programs. The Head of Research Programs is responsible for developing, d...

0.75x 1x 1.25x 1.5x 2x 0:0036:17 90 – Investigating Ion Mobility-Mass Spectrometry for Anti-Doping – Chris Chouinard, PhD Apple PodcastsGoogle PodcastsPlayer EmbedShare Leave a ReviewListen in a New W...

A new machine learning model for plasma volume (PV) estimation was applied within the ABP framework. PV estimation was applied through visual displays or corrected ABP thresholds. With a favorable as...

Today's #AskUSADA question is: "My friend got an Adverse Analytical Finding (AAF). What is that?" Listen in to hear what USADA's Chief Legal & Operations Officer Jeff Cook has to say!🤔🗯️ Learn more....

0.75x 1x 1.25x 1.5x 2x 0:0053:29 158 – Leading Efforts to Advance Public Health, Drug Control Policy, and Drug Discovery – Rahul Gupta, MD Apple PodcastsGoogle PodcastsPlayer EmbedShare Leave a Review...

Purpose Anabolic–androgenic steroids (AAS) enhance athletic performance, giving athletes an unfair advantage and disrupting fair competition. Banned in sports and listed by World Anti-Doping Agency, t...