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pccantidoping.bsky.social
Partnership for Clean Competition
@pccantidoping.bsky.social
200 followers 51 following 620 posts
We support analytical/social scientists doing anti-doping research via grants, postdoctoral fellowships, tech transfer, & working groups. PIs worldwide may apply.
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pccantidoping.bsky.social
Dr. John Eiler is using #massspectrometry technology to identify the exact locations of isotopes in atoms in a PCC-funded research project to detect the molecular isotopic structures of substances in #antidoping samples.

Learn more in our latest podcast episode:
cleancompetition.org/anti-doping-...
There is a photo of Dr. John Eiler in the lower left. His name and titles are included in the bottom right. The text logo of the Partnership for Clean Competition appears at the top above the words, "The Anti-Doping Podcast". Below, there is a quote from Dr. Eiler's episode: "When you study in this way, you first of all have a highly specific fingerprint. Something that can’t be faked. Second, you have a very mechanistic fingerprint. It tells you how the system was being dysregulated. And third… it’s a persistent change that may be very easy to detect later than some of the more familiar tests. When they stop working, maybe our test will keep working.”
November 25, 2025 at 5:19 PM
pccantidoping.bsky.social
Performance-enhancing drugs compromise the integrity of sport, and they can cause a wide range of negative health effects. This recent review article examines the latest evidence surrounding the negative cardiovascular effects of doping.

www.minervamedica.it/en/journals/...
#antidoping #science
The cardiovascular risk of doping and substance abuse in athletes - The Journal of Sports Medicine and Physical Fitness 2025 October;65(10):1401-12
The cardiovascular risk of doping and substance abuse in athletes
www.minervamedica.it
November 24, 2025 at 7:22 PM
pccantidoping.bsky.social
An increasing body of research supports that tDCS impacts endurance, strength, skill acquisition & perceived exertion. This recent editorial discusses how tDCS works, what we know about its ergogenic effects, & how it may fit within the framework of “neurodoping”. 🧪
pubmed.ncbi.nlm.nih.gov/41078301/
This image provides details about the open access article linked in the post. It was published in the journal Advances in Clinical and Experimental Medicine, and the title of the article is, "Transcranial direct current stimulation (tDCS): A new, (still) legal form of "neurodoping" in sports?"
November 21, 2025 at 5:04 PM
pccantidoping.bsky.social
The synthetic steroidal SARM S42 is prohibited in sport due to potential performance-enhancing effects. To improve detection of S42 misuse, the PCC funded a research project, led by Dr. Mario Thevis, to investigate the metabolism of S42 to inform the development of new #antidoping detection methods.
The text reads, "PCC-Funded Research Spotlight, Grant Title: Investigations into the metabolism and detection of the novel SARM S42, Dr. Mario Thevis, German Sort University Cologne". There is a photo of Dr. Thevis on the right, above the text logo for the Partnership for Clean Competition.
November 21, 2025 at 4:51 PM
pccantidoping.bsky.social
Authors developed a rapid method using a CRISPR/CAS-based assay & double emulsion droplets to detect human erythropoietin gene doping. They validated the approach in spiked serum samples, & their results show excellent sensitivity & specificity. 🚫💊 🧪

advanced.onlinelibrary.wiley.com/doi/10.1002/...
This image shows more details about the paper linked in the post. It was published in the journal Advanced Science, and the title is, "Osmotically Tunable Microdroplets Enable Amplification-Free CRISPR Detection of Gene Doping".
November 19, 2025 at 6:16 PM
pccantidoping.bsky.social
How can approaches from geosciences advance #antidoping? Dr. John Eiler discusses his research, a recent PCC-funded project examining use of molecular isotopic structure for doping forensics, promising new results, and the potential impacts of this work. 🚫💊 🧪

cleancompetition.org/anti-doping-...
162 - Leveraging Molecular Isotopic Structure in Anti-Doping Analyses - John Eiler, PhD - PCC - Global Anti-Doping Research Grants for Scientists and Researchers
0.75x 1x 1.25x 1.5x 2x 0:0056:13 162 – Leveraging Molecular Isotopic Structure in Anti-Doping Analyses – John Eiler, PhD Apple PodcastsGoogle PodcastsPlayer EmbedShare Leave a ReviewListen in a New Wi...
cleancompetition.org
November 18, 2025 at 4:25 PM
pccantidoping.bsky.social
SARMs are increasingly detected in #antidoping analyses, & in-depth drug characterization can help understand health risks & improve detection. Authors examined the absorption, distribution, metabolism, & excretion of the novel non-steroidal SARM ACP-105. 🧪

link.springer.com/article/10.1...
First multifaceted ADME profile of ACP-105 (CAS: 1048998-11-3): a novel non-steroidal selective androgen receptor modulator used as doping in sports—integrative in silico toxicological studies for cli...
ACP-105 (CAS: 1048998-11-3) is a novel non-steroidal selective androgen receptor modulator (SARM), increasingly detected in anti-doping analyses, yet lacking a comprehensive ADME profile. This study p...
link.springer.com
November 17, 2025 at 5:18 PM
pccantidoping.bsky.social
Roxadustat has erythropoietic, cardioprotective, and metabolic regulatory effects and is prohibited in sport. This review details what we know about its mechanisms of action, legitimate clinical uses, how it can be detected in #antidoping analyses, and more. 🧪

pmc.ncbi.nlm.nih.gov/articles/PMC...
This image provides details about the paper linked in the post. It was published in Current Issues in Molecular Biology, and the title of the paper is, "Roxadustat as a Hypoxia-Mimetic Agent: Erythropoietic Mechanisms, Bioanalytical Detection, and Regulatory Considerations in Sports Medicine".
November 14, 2025 at 4:33 PM
pccantidoping.bsky.social
PCC-funded research, led by Dr. Michael Polet, produced the 1st gas chromatography mass spectrometry (GCMS) initial testing procedure using an open high-resolution acquisition. Now labs can sensitively test for more prohibited substances w/ 1 method.

Learn more:
cleancompetition.org/anti-doping-...
The text reads, "PCC-Funded Research Spotlight, Grant Title: Comprehensive Detection of Doping Agents by Low Energy EI GCQTOF, Dr. Michaël Polet, Doping Control Laboratory, Ghent University". There is a photo of Dr. Polet on the right, and the text logo for the Partnership for Clean Competition is displayed below.
November 13, 2025 at 6:35 PM
pccantidoping.bsky.social
Gene doping is prohibited in sport, but it can be tough to detect. Authors found quantitative real-time PCR assays can detect transgenic human EPO (hEPO), but not when the hEPO gene has codon changes. Un-biased, sequencing-based detection tools are needed. #antidoping

www.nature.com/articles/s41...
Codon changes challenge PCR-based gene doping detection - Gene Therapy
Gene Therapy - Codon changes challenge PCR-based gene doping detection
www.nature.com
November 12, 2025 at 4:25 PM
pccantidoping.bsky.social
Time matters when an #antidoping lab has to process 100s or 1,000s of samples quickly for large sporting events. Biotage is innovating their products to increase efficiency and address customers' needs. Learn more from Esraa AboJasser & Dr. Lee Williams.

cleancompetition.org/anti-doping-podcast/161
There is a photo and quote from Esraa AboJasser, Market and Applications Manager in Analytical Testing at Biotage. This was from her episode of the Partnership for Clean Competition's Anti-Doping Podcast episode, "Biotage has long pioneered a diverse portfolio of advanced polymers and specialized chemistries. And today we continue to refine these technologies and innovate in the space... The innovation process at Biotage is really directly driven by the voice and the feedback of our customers. So we continue to focus on developing high quality solutions that are robust and reliable workflows that streamline the sample prep process for analysts, reducing any process bottlenecks and helping them save time."
November 11, 2025 at 9:06 PM
pccantidoping.bsky.social
Electroceuticals like spinal cord stimulation (SCS) may have great clinical benefits, but how do these technologies impact fair sport? Authors discuss SCS for people with spinal cord injury, evidence for performance enhancement, potential health risks, and more. 🧪

link.springer.com/article/10.1...
Electroceuticals for Paralympic Athletes: A Fair Play and Classification Concern? - Sports Medicine
Electroceuticals such as brain computer interfaces and spinal cord stimulation (SCS) represent transformative strategies for neuromodulation. Research has demonstrated that SCS can ameliorate motor an...
link.springer.com
November 10, 2025 at 5:51 PM
pccantidoping.bsky.social
Prior data shows plant steroids 20E and DSG improve performance, but this study found no performance-enhancing effects of a combined 20E & DSG supplement given 3x/day for 12 weeks, likely due to low concentrations of the steroids & lack of biological activity. 🧪

www.tandfonline.com/doi/10.1080/...
How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study
Phytosteroids like 20-hydroxyecdysone (20E) and diosgenin (DSG) have shown promising anabolic and performance-enhancing effects in in vitro, animal, and human studies. Combining phytosteroids is co...
www.tandfonline.com
November 7, 2025 at 5:53 PM
pccantidoping.bsky.social
hCG can ⬆️ performance by ⬆️ testosterone, & biotin can interfere with hCG lab tests. The PCC funded Dr. Miller to examine if biotin could be used as a masking agent in #antidoping tests. This work led to the discovery that biotin supplements can substantially ⬇️ urinary hCG values in immunoassays. 🧪
The text reads, "PCC-Funded Research Spotlight, Grant Title: Biotin as a masking agent for hCG use - a follow-up administration study, Dr. Geoffrey Miller, Sports Medicine Research & testing Laboratory". On the right there is a photo of Dr. Miller. Below, the text logo for the Partnership for Clean Competition appears.
November 6, 2025 at 6:30 PM
pccantidoping.bsky.social
Authors compared the anabolic androgenic steroid (AAS) detection abilities of 2 dried blood spot (DBS) devices to urine analysis. The DBS devices were sensitive for detecting prohibited AAS use & showed benefits vs. urine analysis. 🧪

analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
Detection of Anabolic Androgenic Steroids and Steroid Esters—Comparing Dried Blood Spots Collection Devices and Urine Samples
DBS (Capitainer-B50 and Tasso-M20) enabled detection of testosterone esters in all participants, whereas urine testing (T/E) missed cases including potential UGT2B17 del/del carriers and individuals ...
analyticalsciencejournals.onlinelibrary.wiley.com
November 5, 2025 at 4:25 PM
pccantidoping.bsky.social
In episode 2 of our 2-episode feature on @biotage.bsky.social, Esraa AboJasser & Dr. Lee Williams discuss their consumable products, activities in North America, educational endeavors, future goals, preparations for the LA28 Olympic & Paralympic Games, & more. 🧪

cleancompetition.org/anti-doping-...
161 - How Biotage Supports Scientists and Advances Anti-Doping in the North America - Esraa AboJasser and Dr. Lee Williams - PCC - Global Anti-Doping Research Grants for Scientists and Researchers
0.75x 1x 1.25x 1.5x 2x 0:0031:34 161 – How Biotage Supports Scientists and Advances Anti-Doping in the North America – Esraa AboJasser and Dr. Lee Williams Apple PodcastsGoogle PodcastsPlayer EmbedSha...
cleancompetition.org
November 4, 2025 at 3:08 PM
pccantidoping.bsky.social
Researchers examined the excretion of metabolites of the anabolic androgenic steroid metandienone (MD). They identified new metabolites & detected E3, a metabolite that could increase the detection window for MD in #antidoping analyses. 🧪

linkinghub.elsevier.com/retrieve/pii/S0960-0760(25)00129-3
The image shows details about the paper linked in the post. It was published in The Journal of steroid Biochemistry and Molecular Biology. The title of the article is, "Reduced and rearranged metabolite structures after metandienone administration: New promising metabolites for potential long-term detection."
November 3, 2025 at 4:46 PM
pccantidoping.bsky.social
Limitations in ABP biomarkers make it essential to identify new complimentary biomarkers. Researchers identified hypoxanthine and inosine as 2 novel metabolite biomarkers that showed significant increases after EPO administration. 🧪

analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
Identification of Candidate Blood Biomarkers of Recombinant Human Erythropoietin Administration Using Targeted Polar Metabolomics by HILIC‐MS/MS
Using targeted HILIC-MS/MS metabolomics, inosine and hypoxanthine were identified as potential biomarkers of EPO administration. Their consistent and sensitive plasma responses highlight their promis....
analyticalsciencejournals.onlinelibrary.wiley.com
October 31, 2025 at 3:48 PM
pccantidoping.bsky.social
Every lab is different, and Biotage serves a wide range of labs around the world, including many #antidoping labs. Developing solutions that work for each lab's unique situation & needs is key for enhancing and advancing #cleansport.

Learn more in this episode:
cleancompetition.org/anti-doping-...
The text logo for the Partnership for Clean Competition appears at the top above the words, "The Anti-Doping Podcast". Below, there is a headshot photo of Monika Vezse, EMEA Market Segment & Application Lab Manager for Analytical Testing & Diagnostics at Biotage, as well as a quote from her that reads, "We are working with highly advanced centralized laboratories, while also partnering with emerging labs that face really different resource and infrastructure challenges. And our job here is to support both ends of that spectrum. And not just with the technology, but also the training, and method development, and long-term partnership to make sure that they can really rely on consistent and efficient workflows, whatever their situation is."
October 30, 2025 at 5:33 PM
pccantidoping.bsky.social
Authors retrospectively analyzed anabolic androgenic steroids (AAS) in non-sport samples & reanalyzed 310 samples for additional AAS. Understanding patterns of drug use helps inform #antidoping education & public health policies. 🧪

analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
The image shows details about the open access paper linked in the post. It was published in the journal Drug Testing and Analysis, and the article title is, "Prevalence of AAS-Positive Samples at Drug Abuse Laboratory Sweden Between 2014 and 2023 and Sub-Study of Dual Use of AAS and Narcotics".
October 29, 2025 at 5:15 PM
pccantidoping.bsky.social
Partnerships and collaborations are critical for advancing #antidoping approaches & analyses. Dr. Lee Williams and Monika Vezse from @biotage.bsky.social discuss how they work closely with customers to develop solutions & drive innovation in anti-doping & beyond.
cleancompetition.org/anti-doping-...
The text logo for the Partnership for Clean Competition appears at the top above the words "The Anti-Doping Podcast". There is a quote below from guest Lee Williams, PhD, Director of R&D for Analytical Consumables and Applications at Biotage. The quote reads, "Quite often, we’ve got more than one option to get the desired result, so I think it’s really working with the customer to see what fits and what’s best for what they want to achieve ultimately." There is a photo of Lee in the lower left corner.
October 28, 2025 at 3:16 PM
pccantidoping.bsky.social
Over-the-counter topical products may contain the steroid clostebol. Authors examined the metabolism of oral vs. topical clostebol & propose using ratios between metabolites as a method to distinguish between administration routes. 🧪
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
Clostebol Metabolism by Different Routes of Administration: Selection of Diagnostic Urinary Markers
The metabolism of clostebol after oral and transdermal applications was described. Ten metabolites were detected after oral administration (M1–M10), but only five (M1–M4 and M9) could be detected aft...
analyticalsciencejournals.onlinelibrary.wiley.com
October 27, 2025 at 4:56 PM
pccantidoping.bsky.social
Anti-doping analyses for steroids can be costly & time-intensive. Authors developed & validated an efficient & effective method using liquid chromatography-(low-resolution)-MS3 that detected 17 steroidal esters from dried blood spots.
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
This image shows details about the paper linked in the post. It was published in the journal of Mass Spectrometry. The title is, "Simplified Analysis of Native Steroid Esters in Dried Blood Spots by LC-MS3".
October 24, 2025 at 6:26 PM
pccantidoping.bsky.social
Through his 2021 PCC Research Grant, Prof. Nikos Ntoumanis conducted a review and meta-analysis of 200+ studies of psychosocial predictors and correlates of doping intention, use, and inadvertent doping in sport and exercise. 🚫💊 🧪

The results were published last year: bjsm.bmj.com/content/bjsp...
The text on the image reads, "PCC-Funded Research Spotlight, Grant Title: A meta-analysis of psychosocial predictors of doping intentions and use, Dr. Nikos Ntoumanis, University of Southern Denmark." There is a photo of Nikos on the right above the text logo for the Partnership for Clean Competition.
October 23, 2025 at 5:41 PM
pccantidoping.bsky.social
Can serum testosterone-to-luteinizing hormone ratio, measured w/ an automated immunoassay platform, benefit routine #antidoping analysis to detect testosterone abuse? Results showed serum ratio was sensitive & may improve detection.

analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
Evaluating the Testosterone‐to‐Luteinizing Hormone Ratio in Male Anti‐Doping Serum Samples: Results From a Transdermal Testosterone Administration Trial and Field Collected Samples
Practicality of serum T/LH ratio was investigated in the context of a transdermal testosterone administration study and a field study where the T/LH ratio was measured using an automated immunoassay ...
analyticalsciencejournals.onlinelibrary.wiley.com
October 22, 2025 at 3:50 PM