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Jon Humphries @jdhl18.bsky.social · 6d

Therapeutic Use of Integrin Signaling in Melanoma Cells: Physical Link with the Extracellular Matrix (ECM)
www.mdpi.com/2072-6694/17...

www.mdpi.com

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CERN @cern.bsky.social · 8d

Why engage youth in science? 🧑‍🎓

Hear from the directors and special guests – #CERN Director-General Fabiola Gianotti, architect Renzo Piano, and John Elkann, President of Fondazione Agnelli – on why it is important to get the young generation interested in science.

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Josh Hardy @joshuamhardy.bsky.social · 13d

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign

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Naba Lab UIC @nabalabuic.bsky.social · 16d

“The integrin odyssey – a journey full of fundamental discoveries” by Fässler and Sonnenberg in @jcellsci.bsky.social, worth a read!
journals.biologists.com/jcs/article/...

The integrin odyssey – a journey full of fundamental discoveries

Summary: This Perspective highlights the key discoveries in integrin research that laid the foundation for a successful field.

journals.biologists.com

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Journal of Cell Biology @jcb.org · 16d

Kowalczyk et al. provide a historical perspective on the discovery of #desmosomes and how imaging technologies have advanced our understanding of this adhesive intercellular junction. rupress.org/jcb/article/...

📕 In our Intermediate Filaments collection: rupress.org/jcb/collecti...

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Liz Kurtz @liz-kurtz.bsky.social · 28d

When you had quals & published your first paper!✨behind✨SO PROUD to share we published our first piece of the CasL story!! journals.biologists.com/jcs/article/... The scaffold protein CasL restrains membrane blebbing and promotes T cell migration | Journal of Cell Science | The Company of Biologists

The scaffold protein CasL restrains membrane blebbing and promotes T cell migration

Highlighted Article: The scaffold CasL restricts membrane blebbing by controlling the balance of actin polymerization and myosin contractility during integrin-dependent T cell migration.

journals.biologists.com

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cryoEM papers @cryoempapers.bsky.social · 28d

BaR-based cryo-EM of platelet integrin αIIbβ3 pubmed.ncbi.nlm.nih.gov/40938611/ #cryoem

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Instruct-ERIC @instruct-eric.bsky.social · 29d

Have you applied for the Instruct-ERIC Industry Co-fund R&D call?

Get up to €30,000 matched by industrial partners for your technology development project in structural biology.

Find out more about the call and apply here - instruct-eric.org/submit-call/...

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Jon Humphries @jdhl18.bsky.social · Sep 11

Basement membranes at a glance
journals.biologists.com/jcs/article/...

Basement membranes at a glance

Summary: Basement membranes (BMs) are dynamic assemblies of secreted proteins uniquely tailored for diverse tissue supporting roles. Here, we review our current understanding of BM composition, format...

journals.biologists.com

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Jeremy Hollis @jeremyahollis.bsky.social · Sep 10

So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work

Molecular exaptation by the integrin αI domain

An ancient protein domain insertion seamlessly preserved conformational signaling while providing a novel surface for adaptation.

www.science.org

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Jon Agirre @glycojones.bsky.social · Sep 3

Just a few days left to register for the next Diamond/CCP4 Data Collection and Structure Solution Workshop! This is an excellent training course delivered at a unique location and close to the most wonderful time of the year. It also has LOTS of tutors per student! www.ccp4.ac.uk/schools/DLS-...

DLS/CCP4 Workshop 2025

www.ccp4.ac.uk

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Thomas Iskratsch @tiskratsch.bsky.social · Sep 5

🎉It's finally out! Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling | Science Advances www.science.org/doi/10.1126/... - Amazing work Emilie, Ioannis and all co-authors and collaborators!

Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling

Cardiomyocytes’ sensing of extracellular matrix stiffness is imprinted in the talin interactome and regulates their phenotype.

www.science.org

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Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · Sep 5

Honored to receive the 2026 DeLano Award from @asbmb.bsky.social. Warren wrote PyMOL which I spend several hours a day with -- a hero for open & accessible software. Helen Berman, another of my heroes, nominated me (with help from Ruth Nussinov & Janet Thornton), three women I admire tremendously.

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cryoEM papers @cryoempapers.bsky.social · Sep 2

Cryo-EM structures of CRAF/MEK1/14-3-3 complexes in autoinhibited and open-monomer states reveal features of RAF regulation pubmed.ncbi.nlm.nih.gov/40890113/ #cryoem

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Structural Biology @actacrystd.iucr.org · Aug 28

M. Carmen Salinas-Garcia et al.: Understanding domain swapping in the c-Src SH3 domain through hinge-loop mutagenesis ##SH3Domains##DDomainSwapping##HingeLoop@ualmeria@canalugr...##IUCrhttps://journals.iucr.org/paper?S2059798325006977

Understanding domain swapping in the c-Src SH3 domain through hinge-loop mutagenesis

The role of the hinge loop and the open interface in the 3D domain swapping of the c-Src SH3 domain is reported.

journals.iucr.org

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Ben Goult @bengoult.bsky.social · Aug 28

Excited to share our new preprint in @biorxiv-neursci.bsky.social

"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"

Instead of a 🧵 the paper is summarised in this video.

www.biorxiv.org/content/10.1...

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Martin Pacesa @martinpacesa.bsky.social · Aug 27

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.

www.nature.com/articles/s41...

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IRNASA-CSIC @irnasa.bsky.social · Aug 25

📰 New paper out in 'The FEBS Journal'! This study by Mónica Balsera, from #IRNASA-CSIC, reveals a novel mechanism in cyanobacteria.

🔗 febs.onlinelibrary.wiley.com/doi/10.1111/...

#Cyanobacteria #RedoxBiology #StructuralBiology #Microbiology #Biochemistry

FEBS Press

Ferredoxin-dependent flavin thioredoxin reductases (FFTRs) regenerate reduced thioredoxin, sustaining dithiol–disulfide exchange reactions that regulate protein activity in select organisms. In cyano...

febs.onlinelibrary.wiley.com

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Journal of Cell Science @jcellsci.bsky.social · Aug 15

Why would anyone want to be a scientist?

Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...

Screenshot of Essay from Martin Schwartz on 'Why would anyone want to be a scientist'. An anniversary article from The Company of Biologists published in Journal of Cell Science.

The first few lines are: It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection. But, strange even to myself, I not only don't question the unfavorable risk-to-reward ratio but consider myself astonishingly lucky to be a scientist. There are three fundamental pleasures that have sustained me through 50 years of this madness.

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Eric Topol @erictopol.bsky.social · Aug 14

Platelets sequester and harbor cell-free tumor DNA, which could enhance our ability to make early, microscopic diagnosis of cancer
@science.org

science.org/doi/10.1126/...
science.org/doi/10.1126/...

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cryoEM papers @cryoempapers.bsky.social · Aug 7

Structural basis of MPL activation by thrombopoietin pubmed.ncbi.nlm.nih.gov/40766813/ #cryoem

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Instruct-ERIC @instruct-eric.bsky.social · Aug 7

We are delighted to announce that Instruct has added a Centre in Germany, and expanded its existing Centre in Spain with new facilities, services, and technologies!

See the list below - all new services will be available for funded access soon!
Watch this space!
instruct-eric.org/news/new-ger...

New German Centre and Expanded Spanish Centre Approved

Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.

instruct-eric.org

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MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Aug 4

The LMB recently hosted a symposium to mark 50 years since Richard Henderson and Nigel Unwin published the structure of bacteriorhodopsin, the first 3D structure of a protein determined by #cryoEM.

Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur...

#LMBNews 🧪🔬

Attendees of the recent bacteriorhopsin symposium, photographed from above.

Black and white photograph of Nigel Unwin and Richard Henderson sitting outside the LMB, 1991

Symposium attendees applauding in the LMB's Max Perutz Lecture Theatre.

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Basil Greber @bjgreber.bsky.social · Jul 30

Now out in Structure: Paper on high-resolution #cryoEM using the 100 kV Tundra cryo-TEM by Dimple Karia, Adrian Koh, @abhaykot.bsky.social, @lingboyu.bsky.social, @landerlab.bsky.social and many others. Happy to have contributed to this effort. Check it out:
www.sciencedirect.com/science/arti...

Sub-3 Å resolution protein structure determination by single-particle cryo-EM at 100 keV

Cryoelectron microscopy (cryo-EM) has transformed structural biology by providing high-resolution insights into biological macromolecules. We report s…

www.sciencedirect.com

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