Jon Humphries
@jdhl18.bsky.social
Cell Biologist. Manchester Metropolitan University.
Cell-ECM adhesion and proteomics, often in the context of cancer.
Google Scholar: https://scholar.google.com/citations?user=h9DWslsAAAAJ&hl=en
Orcid: https://orcid.org/0000-0002-8953-7079
Cell-ECM adhesion and proteomics, often in the context of cancer.
Google Scholar: https://scholar.google.com/citations?user=h9DWslsAAAAJ&hl=en
Orcid: https://orcid.org/0000-0002-8953-7079
Pinned
Jon Humphries
@jdhl18.bsky.social
· Oct 14
Just flagging up this conference that I'm helping with.
There will be fantastic speakers in sessions covering Melanoma evolution, microenvironment, host cell interactions, precision immunotherapy, emerging therapeutics and clinical trials / real-world data.
Scan the QR code for full details.
There will be fantastic speakers in sessions covering Melanoma evolution, microenvironment, host cell interactions, precision immunotherapy, emerging therapeutics and clinical trials / real-world data.
Scan the QR code for full details.
The integrin odyssey – a journey full of fundamental discoveries
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
The integrin odyssey – a journey full of fundamental discoveries
Summary: This Perspective highlights the key discoveries in integrin research that laid the foundation for a successful field.
journals.biologists.com
November 24, 2025 at 4:46 PM
The integrin odyssey – a journey full of fundamental discoveries
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Reposted by Jon Humphries
In agreement with my friend @kkjetelina.bsky.social who writes today: "I suggest the general public avoid the CDC website."
yourlocalepidemiologist.substack.com/p/cdc-false-...
www.wsj.com/health/healt...
yourlocalepidemiologist.substack.com/p/cdc-false-...
www.wsj.com/health/healt...
November 21, 2025 at 3:39 PM
In agreement with my friend @kkjetelina.bsky.social who writes today: "I suggest the general public avoid the CDC website."
yourlocalepidemiologist.substack.com/p/cdc-false-...
www.wsj.com/health/healt...
yourlocalepidemiologist.substack.com/p/cdc-false-...
www.wsj.com/health/healt...
Mechanobiology:
Microtubules provide a mechanical link for YAP/TAZ signalling
www.nature.com/articles/s41...
Microtubules provide a mechanical link for YAP/TAZ signalling
www.nature.com/articles/s41...
Microtubules provide a mechanical link for YAP/TAZ signalling - Nature Reviews Molecular Cell Biology
A study finds that mechanical activation leads to microtubule rearrangement, facilitating the proteasomal degradation of an inhibitor of YAP/TAZ, thus promoting YAP/TAZ nuclear translocation.
www.nature.com
November 20, 2025 at 7:53 AM
Mechanobiology:
Microtubules provide a mechanical link for YAP/TAZ signalling
www.nature.com/articles/s41...
Microtubules provide a mechanical link for YAP/TAZ signalling
www.nature.com/articles/s41...
Reposted by Jon Humphries
Excited to share our new preprint in @biorxiv-neursci.bsky.social
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
August 28, 2025 at 10:25 AM
Excited to share our new preprint in @biorxiv-neursci.bsky.social
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
Reposted by Jon Humphries
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 5, 2025 at 9:18 AM
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Jon Humphries
The project is now live on FindaPhD and open for applications. Deadline December 4th
*Fully funded 4-year PhD studentship available*
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpool on FindAPhD...
PhD Project - MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpo...
www.findaphd.com
October 31, 2025 at 10:07 AM
The project is now live on FindaPhD and open for applications. Deadline December 4th
Reposted by Jon Humphries
An exciting project to understand cellular ageing in health and disease.
Deadline for applications is 4th Dec.
www.findaphd.com/phds/project...
Pls see also our group websites:
TobiasZech: tzech6.wixsite.com/zechlab
• Chris Toseland: www.toseland-
lab.com
Deadline for applications is 4th Dec.
www.findaphd.com/phds/project...
Pls see also our group websites:
TobiasZech: tzech6.wixsite.com/zechlab
• Chris Toseland: www.toseland-
lab.com
www.findaphd.com
November 19, 2025 at 12:13 PM
An exciting project to understand cellular ageing in health and disease.
Deadline for applications is 4th Dec.
www.findaphd.com/phds/project...
Pls see also our group websites:
TobiasZech: tzech6.wixsite.com/zechlab
• Chris Toseland: www.toseland-
lab.com
Deadline for applications is 4th Dec.
www.findaphd.com/phds/project...
Pls see also our group websites:
TobiasZech: tzech6.wixsite.com/zechlab
• Chris Toseland: www.toseland-
lab.com
Reposted by Jon Humphries
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
Anoikis resistance and cancer
bmccancer.biomedcentral.com/articles/10....
bmccancer.biomedcentral.com/articles/10....
Anoikis resistance and cancer - BMC Cancer
Normal epithelial cells detach from extracellular matrix during normal homeostasis by a selective process called epithelial extrusion. Thereafter, they undergo apoptosis, in a phenomenon called anoiki...
bmccancer.biomedcentral.com
November 17, 2025 at 11:42 PM
Anoikis resistance and cancer
bmccancer.biomedcentral.com/articles/10....
bmccancer.biomedcentral.com/articles/10....
Vinculin Y822 phosphorylation regulates adhesion remodeling during cardiomyocyte maturation
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Vinculin Y822 phosphorylation regulates adhesion remodeling during cardiomyocyte maturation
In the heart, cardiomyocyte cell-matrix and cell-cell adhesions reorganize in response to increased cardiac demand and growth. Vinculin (VCL), a mechanosensitive adaptor protein, links filamentous act...
journals.biologists.com
November 17, 2025 at 11:39 PM
Vinculin Y822 phosphorylation regulates adhesion remodeling during cardiomyocyte maturation
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
USP7 inhibitor P5091 enhances the antitumor efficacy of vemurafenib in BRAFV600E-mutant thyroid cancer via ferroptosis
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
USP7 inhibitor P5091 enhances the antitumor efficacy of vemurafenib in BRAFV600E-mutant thyroid cancer via ferroptosis
Resistance to the BRAF inhibitor vemurafenib (PLX4032) limits its efficacy in thyroid cancer. Ubiquitin-specific peptidase 7 (USP7), a key regulator o…
www.sciencedirect.com
November 17, 2025 at 11:37 PM
USP7 inhibitor P5091 enhances the antitumor efficacy of vemurafenib in BRAFV600E-mutant thyroid cancer via ferroptosis
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Extracellular matrix stiffness regulates the proliferation and migration capacities of lymphatic endothelial cells via FAT1
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Frontiers | Extracellular matrix stiffness regulates the proliferation and migration capacities of lymphatic endothelial cells via FAT1
IntroductionThe extracellular matrix (ECM) stiffness serves as a critical biomechanical regulator of cellular behavior. However, its specific roles on lympha...
www.frontiersin.org
November 17, 2025 at 11:31 PM
Extracellular matrix stiffness regulates the proliferation and migration capacities of lymphatic endothelial cells via FAT1
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Spatial-proteomics reveals recombinant human laminin-111 restores adhesion-signaling to laminin-α2 deficient muscle
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
JCI Insight -
Spatial-proteomics reveals recombinant human laminin-111 restores adhesion-signaling to laminin-α2 deficient muscle
insight.jci.org
November 9, 2025 at 12:45 PM
Spatial-proteomics reveals recombinant human laminin-111 restores adhesion-signaling to laminin-α2 deficient muscle
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer - Cell Death Discovery
Cell Death Discovery - FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer
www.nature.com
November 9, 2025 at 12:41 PM
FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
from abstract: 'Degrading cell-surface αv integrins, rather than merely blocking their interactions with the extracellular matrix (ECM), produces a stronger anti-proliferative effect by more robustly modulating oncogenic signaling pathways.'
Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling
Integrins play a critical role in signaling events that regulate cell adhesion, migration, and proliferation, processes that, when dysregulated, contribute to cancer progression. Recently, innovati...
www.tandfonline.com
November 9, 2025 at 12:37 PM
from abstract: 'Degrading cell-surface αv integrins, rather than merely blocking their interactions with the extracellular matrix (ECM), produces a stronger anti-proliferative effect by more robustly modulating oncogenic signaling pathways.'
Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling
Integrins play a critical role in signaling events that regulate cell adhesion, migration, and proliferation, processes that, when dysregulated, contribute to cancer progression. Recently, innovati...
www.tandfonline.com
November 9, 2025 at 12:36 PM
Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Ligand and integrin-independent mechano-sensitive EGFR activation in lung cancer cells
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Ligand and integrin-independent mechano-sensitive EGFR activation in lung cancer cells
Epidermal Growth Factor Receptor (EGFR) is a transmembrane receptor tyrosine kinase that plays important roles in cell proliferation, differentiation, and migration. EGFR overexpression or mutation is...
journals.biologists.com
November 9, 2025 at 12:33 PM
Ligand and integrin-independent mechano-sensitive EGFR activation in lung cancer cells
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition - Oncogene
Oncogene - A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition
www.nature.com
November 9, 2025 at 12:27 PM
A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells
This study uncovers a previously unknown crosstalk between two major ubiquitin ligases, CRL5 and APC/C. The authors identify APC11 as a binding partner of CUL5, showing that their interaction regulat...
advanced.onlinelibrary.wiley.com
November 9, 2025 at 12:21 PM
The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Very pleased to see this published and to have played a (minor) role. Congrats to all authors and in particular corresponding author Prof Tris McKay @manmetuni.bsky.social
CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival - Cell Death & Disease
Cell Death & Disease - CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival
www.nature.com
November 6, 2025 at 2:59 PM
Very pleased to see this published and to have played a (minor) role. Congrats to all authors and in particular corresponding author Prof Tris McKay @manmetuni.bsky.social
CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival - Cell Death & Disease
Cell Death & Disease - CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival
www.nature.com
November 6, 2025 at 2:50 PM
CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mechanochemical waves in focal adhesions during cell migration
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Mechanochemical waves in focal adhesions during cell migration
Traction force and FAK signaling exhibit oscillatory temporal coupling in adhesive structures.
www.science.org
November 3, 2025 at 11:56 AM
Mechanochemical waves in focal adhesions during cell migration
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Piezo1 regulates the mechanotransduction of soft matrix viscoelasticity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Piezo1 regulates the mechanotransduction of soft matrix viscoelasticity - Nature Communications
Matrix viscoelasticity regulates cell behavior in a stiffness-dependent manner. Here, the authors reveal that the mechanosensitive channel Piezo1 transduces soft matrix viscoelastic cues, through a co...
www.nature.com
November 3, 2025 at 11:55 AM
Piezo1 regulates the mechanotransduction of soft matrix viscoelasticity
www.nature.com/articles/s41...
www.nature.com/articles/s41...