Petr Znamenskiy
@petrznam.bsky.social
Neuroscientist at the Crick studying cortical microcircuits and cell types.
www.znamlab.org
www.znamlab.org
Pinned
Petr Znamenskiy
@petrznam.bsky.social
· Jul 21
Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits
Sequencing of oligonucleotide barcodes holds promise as a high-throughput approach for reconstructing synaptic connectivity at scale. Rabies viruses can act as a vehicle for barcode transmission, than...
www.biorxiv.org
1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Registration for the 3rd Senses in Motion meeting taking place 18-21 May in Berlin is now open! If you work on sensation in freely moving animals and would like to participate, submit an abstract by Dec 19!
sensesinmotion.org
Please share!
sensesinmotion.org
Please share!
Senses in Motion: Sensory Processing in Freely Moving Animals
Senses in Motion: Sensory Processing in Freely Moving Animals.
sensesinmotion.org
November 20, 2025 at 2:32 PM
Registration for the 3rd Senses in Motion meeting taking place 18-21 May in Berlin is now open! If you work on sensation in freely moving animals and would like to participate, submit an abstract by Dec 19!
sensesinmotion.org
Please share!
sensesinmotion.org
Please share!
The Crick is hiring Early Career Group Leaders!
Core funding for PhD studentships, postdocs, and staff scientists, phenomenal facilities and a wonderful community of early career GLs!
Please share widely and feel free to get in touch with any questions!
www.crick.ac.uk/careers-stud...
Core funding for PhD studentships, postdocs, and staff scientists, phenomenal facilities and a wonderful community of early career GLs!
Please share widely and feel free to get in touch with any questions!
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 10:13 AM
The Crick is hiring Early Career Group Leaders!
Core funding for PhD studentships, postdocs, and staff scientists, phenomenal facilities and a wonderful community of early career GLs!
Please share widely and feel free to get in touch with any questions!
www.crick.ac.uk/careers-stud...
Core funding for PhD studentships, postdocs, and staff scientists, phenomenal facilities and a wonderful community of early career GLs!
Please share widely and feel free to get in touch with any questions!
www.crick.ac.uk/careers-stud...
We are looking for a postdoctoral fellow to join the lab to study how cortical microcircuits are organised at the single cell level using high throughput molecular methods. Please share and get in touch if interested!
www.crick.ac.uk/careers-stud...
www.crick.ac.uk/careers-stud...
October 10, 2025 at 10:08 AM
We are looking for a postdoctoral fellow to join the lab to study how cortical microcircuits are organised at the single cell level using high throughput molecular methods. Please share and get in touch if interested!
www.crick.ac.uk/careers-stud...
www.crick.ac.uk/careers-stud...
Applications for Doctoral Clinical Fellowships at the Crick, including a project in my lab, are now open! Please share widely!
We're looking for clinicians who are passionate about research to join our 3-year fully funded clinical PhD programme. 🔬🩺
Apply by 14 November 2025. 👇
www.crick.ac.uk/careers-stud...
Apply by 14 November 2025. 👇
www.crick.ac.uk/careers-stud...
Doctoral clinical fellows
The Crick's clinical PhD programme.
www.crick.ac.uk
October 2, 2025 at 8:47 AM
Applications for Doctoral Clinical Fellowships at the Crick, including a project in my lab, are now open! Please share widely!
We use high refresh rate "gaming" monitors to present closed-loop visual stimuli with low latency. They have various "gaming modes" and response time options that are poorly documented. So @antblot.bsky.social tested every possible setting to find out what they do.
znamlab.org/hardware-con...
znamlab.org/hardware-con...
Which gaming mode will please my mice?
We use VR setups, see for instance this study, which require fast monitors. We recently got some cheap gaming monitors from MSI
znamlab.org
August 12, 2025 at 8:06 PM
We use high refresh rate "gaming" monitors to present closed-loop visual stimuli with low latency. They have various "gaming modes" and response time options that are poorly documented. So @antblot.bsky.social tested every possible setting to find out what they do.
znamlab.org/hardware-con...
znamlab.org/hardware-con...
How does the brain blend what we see with what we hear? In collaboration with @flor-iacaruso.bsky.social lab, we find new anatomical and functional rules that govern how auditory and visual cortices talk to each other.
Led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social.
Led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social.
1/N What are the organizational principles underlying crossmodal cortical connections?
We address this in this new preprint, led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social in collab w/ @petrznam.bsky.social @crick.ac.uk
www.biorxiv.org/content/10.1...
We address this in this new preprint, led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social in collab w/ @petrznam.bsky.social @crick.ac.uk
www.biorxiv.org/content/10.1...
August 1, 2025 at 11:50 AM
How does the brain blend what we see with what we hear? In collaboration with @flor-iacaruso.bsky.social lab, we find new anatomical and functional rules that govern how auditory and visual cortices talk to each other.
Led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social.
Led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social.
One way - it detects inputs of the starter neurons.
July 21, 2025 at 6:34 PM
One way - it detects inputs of the starter neurons.
6/ As BRISC does not depend on the availability of transgenic animals, it is readily applicable across brain areas and species to systematically investigate how microcircuit organization varies across the brain and the evolutionary tree.
Preprint at www.biorxiv.org/content/10.1...
Preprint at www.biorxiv.org/content/10.1...
Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits
Sequencing of oligonucleotide barcodes holds promise as a high-throughput approach for reconstructing synaptic connectivity at scale. Rabies viruses can act as a vehicle for barcode transmission, than...
www.biorxiv.org
July 21, 2025 at 7:58 AM
6/ As BRISC does not depend on the availability of transgenic animals, it is readily applicable across brain areas and species to systematically investigate how microcircuit organization varies across the brain and the evolutionary tree.
Preprint at www.biorxiv.org/content/10.1...
Preprint at www.biorxiv.org/content/10.1...
\5 Long-range inputs onto single V1 neurons reveal the topography of feedback projections from higher visual areas, which mirrors the retinotopic organisation of the visual cortex.
July 21, 2025 at 7:58 AM
\5 Long-range inputs onto single V1 neurons reveal the topography of feedback projections from higher visual areas, which mirrors the retinotopic organisation of the visual cortex.
4/ We apply BRISC in the mouse primary visual cortex, mapping 7,814 putative synaptic connections of 385 starter neurons and identifying layer- and cell-type-specific connectivity rules.
July 21, 2025 at 7:58 AM
4/ We apply BRISC in the mouse primary visual cortex, mapping 7,814 putative synaptic connections of 385 starter neurons and identifying layer- and cell-type-specific connectivity rules.
3/ Barcodes are read out from intact tissue sections using in situ sequencing, thus reconstructing presynaptic ensembles of individual starter neurons while preserving spatial information.
July 21, 2025 at 7:58 AM
3/ Barcodes are read out from intact tissue sections using in situ sequencing, thus reconstructing presynaptic ensembles of individual starter neurons while preserving spatial information.
2/ BRISC uses random molecular barcodes transsynaptically transmitted by rabies viruses to map inputs of many neurons simultaneously, while maintaining single cell resolution. Connections between individual neurons are then identified by matching their barcode sequences.
July 21, 2025 at 7:58 AM
2/ BRISC uses random molecular barcodes transsynaptically transmitted by rabies viruses to map inputs of many neurons simultaneously, while maintaining single cell resolution. Connections between individual neurons are then identified by matching their barcode sequences.
1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits
Sequencing of oligonucleotide barcodes holds promise as a high-throughput approach for reconstructing synaptic connectivity at scale. Rabies viruses can act as a vehicle for barcode transmission, than...
www.biorxiv.org
July 21, 2025 at 7:58 AM
1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Petr Znamenskiy
Agree. Cuts in UKRI funded PhD places, is about government funding and prioritisation. We need work force planning with joined up thinking
A PhD is not about an academic career, its an apprenticeship for the knowledge economy. "Europe's Silicon Valley" will not exist without PhDs
A PhD is not about an academic career, its an apprenticeship for the knowledge economy. "Europe's Silicon Valley" will not exist without PhDs
This is (a) obvious and (b) has been discussed for decades. Don't blame UKRI. What is really needed is workforce planning at a national level. What should the HE/FE sector look like for research and training, and therefore how many PhD places do we need?
UKRI planned for dramatic drop in #PhD places.
UKRI anticipated that raising the PhD stipend in the face of the cost of living crisis could have dropped the number of new postgraduate research students it funds by up to 50 per cent. #PhDchat
www.researchprofessionalnews.com/rr-news-uk-r...
UKRI anticipated that raising the PhD stipend in the face of the cost of living crisis could have dropped the number of new postgraduate research students it funds by up to 50 per cent. #PhDchat
www.researchprofessionalnews.com/rr-news-uk-r...
January 29, 2025 at 1:35 PM
Agree. Cuts in UKRI funded PhD places, is about government funding and prioritisation. We need work force planning with joined up thinking
A PhD is not about an academic career, its an apprenticeship for the knowledge economy. "Europe's Silicon Valley" will not exist without PhDs
A PhD is not about an academic career, its an apprenticeship for the knowledge economy. "Europe's Silicon Valley" will not exist without PhDs
Reposted by Petr Znamenskiy
Save the date!
UK Neural Computation 2025 will be at Imperial College London
9 July: ECR day
10-11 July: main meeting
9 invited speakers, 4 talks from abstracts and many posters
Abstract & registration opening soon
Pls share!
neuralcomputation.uk
UK Neural Computation 2025 will be at Imperial College London
9 July: ECR day
10-11 July: main meeting
9 invited speakers, 4 talks from abstracts and many posters
Abstract & registration opening soon
Pls share!
neuralcomputation.uk
UKNC25 |
neuralcomputation.uk
January 24, 2025 at 10:47 AM
Save the date!
UK Neural Computation 2025 will be at Imperial College London
9 July: ECR day
10-11 July: main meeting
9 invited speakers, 4 talks from abstracts and many posters
Abstract & registration opening soon
Pls share!
neuralcomputation.uk
UK Neural Computation 2025 will be at Imperial College London
9 July: ECR day
10-11 July: main meeting
9 invited speakers, 4 talks from abstracts and many posters
Abstract & registration opening soon
Pls share!
neuralcomputation.uk
Reposted by Petr Znamenskiy
Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro
Apply by: February 16th!
Apply by: February 16th!
January 14, 2025 at 4:58 AM
Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro
Apply by: February 16th!
Apply by: February 16th!
Reposted by Petr Znamenskiy
We're hiring - a lab tech and fully funded (UK rate) PhD student! Join us at to figure out how the brain constructs auditory space! Adverts here (tech : shorturl.at/hmrFY) and here (PhD studentship : shorturl.at/adoJN). #neuroscience #hearing
October 30, 2023 at 5:37 PM
We're hiring - a lab tech and fully funded (UK rate) PhD student! Join us at to figure out how the brain constructs auditory space! Adverts here (tech : shorturl.at/hmrFY) and here (PhD studentship : shorturl.at/adoJN). #neuroscience #hearing
🚀 Don't miss your chance join @thecrick.bsky.social PhD programme, including projects in my lab! Interested in how neuronal activity, connectivity and gene expression all relate to each other in vivo?
Learn more and apply at crick.ac.uk/careers-stud...
🗓️ Deadline Nov 9! Please repost!
Learn more and apply at crick.ac.uk/careers-stud...
🗓️ Deadline Nov 9! Please repost!
October 31, 2023 at 9:55 AM
🚀 Don't miss your chance join @thecrick.bsky.social PhD programme, including projects in my lab! Interested in how neuronal activity, connectivity and gene expression all relate to each other in vivo?
Learn more and apply at crick.ac.uk/careers-stud...
🗓️ Deadline Nov 9! Please repost!
Learn more and apply at crick.ac.uk/careers-stud...
🗓️ Deadline Nov 9! Please repost!
Mouse cortical neurons have ~5,000 spines, but how many different presynaptic cells do they get input from? What is the average number of synaptic contacts between connected neurons in the mouse neocortex? I was hoping that there is a good estimate based on EM but I cannot find one.
October 9, 2023 at 9:55 AM
Mouse cortical neurons have ~5,000 spines, but how many different presynaptic cells do they get input from? What is the average number of synaptic contacts between connected neurons in the mouse neocortex? I was hoping that there is a good estimate based on EM but I cannot find one.
Wow! End of an era indeed! Once a few years ago I tried to crossreference the timing of your and BGB's tweets but there was no clear signal.
October 6, 2023 at 4:54 PM
Wow! End of an era indeed! Once a few years ago I tried to crossreference the timing of your and BGB's tweets but there was no clear signal.
Reposted by Petr Znamenskiy
ICYMI for neuro Twitter expats, a long standing mystery is solved.
October 6, 2023 at 1:35 AM
ICYMI for neuro Twitter expats, a long standing mystery is solved.
Reposted by Petr Znamenskiy
Delighted to see this in print from my @TheCrick colleagues in Jonny Kohl's lab
How pregnancy (in mice) changes the behaviour of a population of hypothalamic neurons & initiates parental behaviour before birth
www.science.org/doi/10.1126/...
How pregnancy (in mice) changes the behaviour of a population of hypothalamic neurons & initiates parental behaviour before birth
www.science.org/doi/10.1126/...
Hormone-mediated neural remodeling orchestrates parenting onset during pregnancy
Work in mice suggests that hormonal remodeling of distinct hypothalamic neurons during pregnancy promotes parental behavior.
www.science.org
October 6, 2023 at 8:37 AM
Delighted to see this in print from my @TheCrick colleagues in Jonny Kohl's lab
How pregnancy (in mice) changes the behaviour of a population of hypothalamic neurons & initiates parental behaviour before birth
www.science.org/doi/10.1126/...
How pregnancy (in mice) changes the behaviour of a population of hypothalamic neurons & initiates parental behaviour before birth
www.science.org/doi/10.1126/...
(3) We are also looking for a Doctoral Clinical Fellow to join us to map synaptic connections in human brain tissue using high throughput molecular methods, in partnership with Dimitri Kullmann at UCL:
www.crick.ac.uk/careers-stud...
www.crick.ac.uk/careers-stud...
October 5, 2023 at 9:26 AM
(3) We are also looking for a Doctoral Clinical Fellow to join us to map synaptic connections in human brain tissue using high throughput molecular methods, in partnership with Dimitri Kullmann at UCL:
www.crick.ac.uk/careers-stud...
www.crick.ac.uk/careers-stud...
(2) Joint studentship with Laura Andreae at KCL to understand mechanisms of development of corticocortical connections:
www.crick.ac.uk/careers-stud...
www.crick.ac.uk/careers-stud...
Znamenskiy & Andreae | Mechanisms of development of corticocortical connections in the visual cortex
www.crick.ac.uk
October 5, 2023 at 9:25 AM
(2) Joint studentship with Laura Andreae at KCL to understand mechanisms of development of corticocortical connections:
www.crick.ac.uk/careers-stud...
www.crick.ac.uk/careers-stud...