Lightnews — Scholar-powered news

Reposted by Psychiatric Genomics Consortium (PGC)

Joseph D. Deak, PhD @josephdeak.bsky.social · 16d

Some recent work led by @peterjonghona.bsky.social and myself at @yaleschoolofmed.bsky.social looks at environmental, psychiatric, and genetic predictors of alcohol use disorder.

Online today at The American Journal of Psychiatry (@apapsychiatric.bsky.social):

psychiatryonline.org/doi/10.1176/...

3 5

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 16d

People with schizophrenia are underrepresented in volunteer-based biobanks. A new UK Biobank study shows that those who do participate tend to have milder symptoms, lower polygenic risk scores, lower rates of copy-number variants, and higher levels of education and employment.

Genetic and Phenotypic Features of Schizophrenia in the UK Biobank

This cross-sectional study compares genetic liability to psychiatric disorders in individuals with schizophrenia in the UK Biobank with individuals in the Psychiatric Genomics Consortium and compares ...

jamanetwork.com

2

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 16d

A new preprint reports the largest genetic study of schizophrenia in people of African ancestry, identifying 3 genetic signals unique to this group using data from the Million Veteran Program (MVP) and the All of Us Research Program: pubmed.ncbi.nlm.nih.gov/39252912/

Biological Insights from Schizophrenia-associated Loci in Ancestral Populations - PubMed

Large-scale genome-wide association studies of schizophrenia have uncovered hundreds of associated loci but with extremely limited representation of African diaspora populations. We surveyed electroni...

pubmed.ncbi.nlm.nih.gov

1 2

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 23d

Schizophrenia is often misunderstood and highly complex. Learn about its prevalence and health impact in the WHO Fact Sheet 💡:
www.who.int/news-room/fa...

Schizophrenia

Fact sheet on schizophrenia: key facts, symptoms, causes, support, WHO response

www.who.int

3

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 23d

4/ Want to help advance schizophrenia research? 🔬You can contribute by sharing data to the newest meta-analysis via our Data Receiving Committee!
pgc.unc.edu/about-us/joi...

Submit data/join PGC – PGC

pgc.unc.edu

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 23d

3/ The study identified 287 regions in the genome associated with schizophrenia, and follow-up analyses highlighted 120 likely involved genes.

1

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 23d

2/ In 2022, we published our largest study yet, a global effort that analyzed DNA from 76,755 individuals affected by schizophrenia. www.nature.com/articles/s41...

Mapping genomic loci implicates genes and synaptic biology in schizophrenia - Nature

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-m...

www.nature.com

1 1

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 23d

1/ 🧵 For 10+ years, the Schizophrenia Working Group of the PGC has been dedicated to understanding the genetic risk factors for schizophrenia.

1 1 2

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 24d

Hi from the PGC Schizophrenia working group! During the next 2 weeks, we will be posting about schizophrenia genetics and related topics. Stay tuned!

2

Reposted by Psychiatric Genomics Consortium (PGC)

WHO @who.int · Sep 10

Today is #WorldSuicidePreventionDay.

Worried someone might be struggling with suicidal thoughts?

Your presence can be powerful. A simple check-in could be the lifeline they need. 💙

Learn more about #SuicidePrevention 👉 bit.ly/4phPYKi

110 240

Reposted by Psychiatric Genomics Consortium (PGC)

Gabriel R. Fries @friesgabriel.bsky.social · Jun 17

Latin America has experienced an increase in suicide rate, contrasting with a global decline. We review possible reasons for this here: www.sciencedirect.com/science/arti...
Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.

6 6

Reposted by Psychiatric Genomics Consortium (PGC)

International Association for Suicide Prevention @iaspinfo.bsky.social · Sep 8

On 10 September, the world comes together for #WorldSuicidePreventionDay under the theme, Changing the Narrative on Suicide. This year, we’re making resources more accessible than ever - translated into more languages, to reach more communities worldwide. bit.ly/469incZ

2 5

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · Sep 8

Brenda Cabrera-Mendoza, postdoctoral associate at Yale Psychiatry, has been awarded a MQ US Fellow grant from MQ Mental Health Research. Her project will integrate genetic and clinical data to improve suicide risk stratification.

2

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · Sep 8

Over the next couple of tweets, we will highlight some of the funded research projects in the PGC SUI Workgroup, which are working toward understanding the genetics of suicide. #PGCSUI #suicidegenetics

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · Sep 4

This fall members of the PGC Suicide Workgroup will be presenting at the upcoming IASR/AFSP International Summit on Suicide Research and the World Congress of Psychiatric Genetics. We look forward to sharing our latest findings with the scientific community.
#WCPG2025 #IASR2025

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · Sep 4

📢 For the next two weeks, the Suicide Working Group is taking over this space.
September is Suicide Prevention Awareness Month — a time to break stigma, share resources, and highlight research and action that can save lives.
#SuicidePrevention #SuicideAwarenessMonth

Reposted by Psychiatric Genomics Consortium (PGC)

Emma Johnson @ecjohnson.bsky.social · Aug 20

Excited to share that our manuscript describing a multi-ancestry GWAS of nicotine dependence has now been published: doi.org/10.1017/S003...

1 4 20

Reposted by Psychiatric Genomics Consortium (PGC)

Joseph D. Deak, PhD @josephdeak.bsky.social · Jul 21

"A contextual genomic perspective on physical activity and its relationship to health, well being and illness" led by Marco Galimberti at @yaleschoolofmed.bsky.social and US Dept. of Veterans Affairs is now online at Nature Genetics (@natureportfolio.nature.com)

Link: www.nature.com/articles/s41...

2 5

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · Jun 21

1 2

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · Jun 21

‪Attending the 2025 @behaviorgenetic.bsky.social Meeting in Atlanta? Be sure to check out some exciting work from members of the PGC-SUD working group:

1 2 5

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · Jun 21

1

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · Jun 21

1

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · Jun 21

‪Attending the @rsaofficial.bsky.social meeting in New Orleans? Be sure to check out some exciting work from members of the PGC-SUD working group:

1 3 3

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · Jun 19

New preprint alert 📢: First genome-wide significant loci identified for panic attacks and panic disorder

Gerome Breen @psychgenomics.bsky.social · Jun 17

Excited about our new preprint: 1st successful genome-wide study of >61,000 panic attack and 29,000 panic disorder cases. www.medrxiv.org/content/10.1... We find 17 associations & evidence that peripheral neurons in eye, lungs and heart are involved in panic & other psychiatric disorders 1/n

5