Psychiatric Genomics Consortium (PGC)
@pgcgenetics.bsky.social
With 1700+ international scientists & 900,000 participants, the PGC is the largest biological investigation in the history of psychiatry 🧬
We are deeply saddened by the passing of Professor Dan Stein, an internationally respected leader in psychiatry and neuroscience, and chair of the Department of Psychiatry and Mental Health at @UCT_news.
December 16, 2025 at 1:57 PM
We are deeply saddened by the passing of Professor Dan Stein, an internationally respected leader in psychiatry and neuroscience, and chair of the Department of Psychiatry and Mental Health at @UCT_news.
❗Join us to discuss: ‘Scientifically accurate and ethically responsible science communication in psychiatric genetics’ on 14th Jan !
Organised by the PGC Outreach Committee, BGA Public Science Committee @behaviorgenetic.bsky.social, and @ibangs.bsky.social
Register: us02web.zoom.us/webinar/regi...
Organised by the PGC Outreach Committee, BGA Public Science Committee @behaviorgenetic.bsky.social, and @ibangs.bsky.social
Register: us02web.zoom.us/webinar/regi...
December 15, 2025 at 11:33 AM
❗Join us to discuss: ‘Scientifically accurate and ethically responsible science communication in psychiatric genetics’ on 14th Jan !
Organised by the PGC Outreach Committee, BGA Public Science Committee @behaviorgenetic.bsky.social, and @ibangs.bsky.social
Register: us02web.zoom.us/webinar/regi...
Organised by the PGC Outreach Committee, BGA Public Science Committee @behaviorgenetic.bsky.social, and @ibangs.bsky.social
Register: us02web.zoom.us/webinar/regi...
🌟It has been great to learn the full breadth of @pgc_fg #genes #cells #omics #mentalhealth and the bright 🧠👨🎓 behind the work ! The second year has been a wonderful experience and get's us excited for the next 🍾🥂🎉
December 15, 2025 at 11:26 AM
🌟It has been great to learn the full breadth of @pgc_fg #genes #cells #omics #mentalhealth and the bright 🧠👨🎓 behind the work ! The second year has been a wonderful experience and get's us excited for the next 🍾🥂🎉
Looking forward to meeting in-person again at #WCPG2026 in Glasgow, Scotland! 🏴 #functionalgenomics #mentalhealth
December 14, 2025 at 7:57 AM
Looking forward to meeting in-person again at #WCPG2026 in Glasgow, Scotland! 🏴 #functionalgenomics #mentalhealth
👩🔬👨🔬in October, we @fg-pgc.bsky.social had our in-person meeting at #WCPG2025 in Cancun, Mexico ! We loved strategizing about how we can make #functionalgenomics #tools and #datasets in #mentalhealth useful for all, to understand the biology of genetic risk ! 🧬🧠
December 14, 2025 at 7:52 AM
👩🔬👨🔬in October, we @fg-pgc.bsky.social had our in-person meeting at #WCPG2025 in Cancun, Mexico ! We loved strategizing about how we can make #functionalgenomics #tools and #datasets in #mentalhealth useful for all, to understand the biology of genetic risk ! 🧬🧠
🌟for our last portrait, @fg-pgc.bsky.social is back in Germany @unibonn.bsky.social, where Dr EVA BEINS @evabeins.bsky.social studies #genetics and #microglia in #depression & #bipolardisorder. Think #brain #immune cells and #mentalhealth 🧠🧬👨🎓
December 14, 2025 at 7:11 AM
🌟for our last portrait, @fg-pgc.bsky.social is back in Germany @unibonn.bsky.social, where Dr EVA BEINS @evabeins.bsky.social studies #genetics and #microglia in #depression & #bipolardisorder. Think #brain #immune cells and #mentalhealth 🧠🧬👨🎓
🌟... #functionalgenomics @fg-pgc.bsky.social travels from Germany to Toronto, Canada, @utoronto.ca where Dr PAVEL POWLOWSKI recently obtained his PhD👨🎓and studies #genes #endocannabinoids and human cells in a dish #iPSCs in #bipolardisorder. 🧬🧠
December 13, 2025 at 7:41 AM
🌟... #functionalgenomics @fg-pgc.bsky.social travels from Germany to Toronto, Canada, @utoronto.ca where Dr PAVEL POWLOWSKI recently obtained his PhD👨🎓and studies #genes #endocannabinoids and human cells in a dish #iPSCs in #bipolardisorder. 🧬🧠
🧠... our next young #functionalgenomics brain is Dr FATIMA MOHAMEDELMUGADAM from @unibonn.bsky.social in Germany🌟 She is interested in how genetic variants in different populations of the world contribute to #autism and #ADHD in kids👨👩👧👧
December 12, 2025 at 6:55 AM
🧠... our next young #functionalgenomics brain is Dr FATIMA MOHAMEDELMUGADAM from @unibonn.bsky.social in Germany🌟 She is interested in how genetic variants in different populations of the world contribute to #autism and #ADHD in kids👨👩👧👧
🌟Today @fg-pgc.bsky.social and @pgcgenetics.bsky.social are in Bengaluru, India, where we love to highlight Dr KALYANI BINDU's work and the dynamic #functionalgenomics scene 🧬🧠
She shows that many of the same biological mechanisms play a role in different #mentalhealth disorders ! One drug for all?
She shows that many of the same biological mechanisms play a role in different #mentalhealth disorders ! One drug for all?
December 11, 2025 at 10:21 AM
🌟Today @fg-pgc.bsky.social and @pgcgenetics.bsky.social are in Bengaluru, India, where we love to highlight Dr KALYANI BINDU's work and the dynamic #functionalgenomics scene 🧬🧠
She shows that many of the same biological mechanisms play a role in different #mentalhealth disorders ! One drug for all?
She shows that many of the same biological mechanisms play a role in different #mentalhealth disorders ! One drug for all?
🌟...let's meet the next #earlycareerresearcher #ECR #postdoc with a big heart for functional genomics 🧬
🥁 ... Dr RICARDO DE PAOLI-ISEPPI from @unimelb.bsky.social #UniMelb will tell us how he uses #longreadsequencing to understand #RNAsplicing.
🥁 ... Dr RICARDO DE PAOLI-ISEPPI from @unimelb.bsky.social #UniMelb will tell us how he uses #longreadsequencing to understand #RNAsplicing.
December 10, 2025 at 9:38 AM
🌟...let's meet the next #earlycareerresearcher #ECR #postdoc with a big heart for functional genomics 🧬
🥁 ... Dr RICARDO DE PAOLI-ISEPPI from @unimelb.bsky.social #UniMelb will tell us how he uses #longreadsequencing to understand #RNAsplicing.
🥁 ... Dr RICARDO DE PAOLI-ISEPPI from @unimelb.bsky.social #UniMelb will tell us how he uses #longreadsequencing to understand #RNAsplicing.
🥁🎇✨ ... first up is KIRA HÖFFLER @kirahoeffler.bsky.social from the #UniversityofBergen in Norway and #McLeanHospital in Boston ! So tell us, Kira, what do you do in #functionalgenomics and @pgc_fg ?🤔 Any #funfacts #genetics 🐝❓
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December 9, 2025 at 11:45 AM
🥁🎇✨ ... first up is KIRA HÖFFLER @kirahoeffler.bsky.social from the #UniversityofBergen in Norway and #McLeanHospital in Boston ! So tell us, Kira, what do you do in #functionalgenomics and @pgc_fg ?🤔 Any #funfacts #genetics 🐝❓
🧵3/3
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@pgc_fg and @PGCgenetics our work is global 🌎🌍🌏 so no surprise that our #brains #earlycareerresearchers #phd_students #postdocs hail from all corners of the world ! So get ready ✨🤓
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December 9, 2025 at 11:44 AM
@pgc_fg and @PGCgenetics our work is global 🌎🌍🌏 so no surprise that our #brains #earlycareerresearchers #phd_students #postdocs hail from all corners of the world ! So get ready ✨🤓
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Genes🧬are expressed differently in different cell types
This is really important for brain function🧠, which is one of the most complex organs in the human body🧍🏾
Single cell sequencing is a super cool way of exploring this!
🧵2/2
This is really important for brain function🧠, which is one of the most complex organs in the human body🧍🏾
Single cell sequencing is a super cool way of exploring this!
🧵2/2
December 8, 2025 at 3:24 PM
Genes🧬are expressed differently in different cell types
This is really important for brain function🧠, which is one of the most complex organs in the human body🧍🏾
Single cell sequencing is a super cool way of exploring this!
🧵2/2
This is really important for brain function🧠, which is one of the most complex organs in the human body🧍🏾
Single cell sequencing is a super cool way of exploring this!
🧵2/2
Our fourth group is the ✨Multi-level Quantitative Trait Loci✨group!
🧬AKA themQTL group🧬
🔎QTL analysis is a way to understand how genetic sequences🧬affect gene expression...
🧐Think RNA transcripts and proteins!
All these methods to understand genetics🤩
🧬AKA themQTL group🧬
🔎QTL analysis is a way to understand how genetic sequences🧬affect gene expression...
🧐Think RNA transcripts and proteins!
All these methods to understand genetics🤩
December 7, 2025 at 3:41 PM
Our fourth group is the ✨Multi-level Quantitative Trait Loci✨group!
🧬AKA themQTL group🧬
🔎QTL analysis is a way to understand how genetic sequences🧬affect gene expression...
🧐Think RNA transcripts and proteins!
All these methods to understand genetics🤩
🧬AKA themQTL group🧬
🔎QTL analysis is a way to understand how genetic sequences🧬affect gene expression...
🧐Think RNA transcripts and proteins!
All these methods to understand genetics🤩
Next up is the awesome✨Methylation-wide association studies✨group!
AKA the MWAS group😉
#Epigenetics are changes that happen to DNA expression🧬without actually changing the sequence!
Instead, these changes happen to molecules that are attached to the DNA - how cool 🤯!
AKA the MWAS group😉
#Epigenetics are changes that happen to DNA expression🧬without actually changing the sequence!
Instead, these changes happen to molecules that are attached to the DNA - how cool 🤯!
December 6, 2025 at 5:11 PM
Next up is the awesome✨Methylation-wide association studies✨group!
AKA the MWAS group😉
#Epigenetics are changes that happen to DNA expression🧬without actually changing the sequence!
Instead, these changes happen to molecules that are attached to the DNA - how cool 🤯!
AKA the MWAS group😉
#Epigenetics are changes that happen to DNA expression🧬without actually changing the sequence!
Instead, these changes happen to molecules that are attached to the DNA - how cool 🤯!
The second of our 5 project groups we are thrilled to introduce is the✨Isoforms✨group!
Isoforms are different versions of RNA transcripts or proteins🧬
They are a result of splicing✂️during gene expression and are an important part of how one gene can act in different ways!
Isoforms are different versions of RNA transcripts or proteins🧬
They are a result of splicing✂️during gene expression and are an important part of how one gene can act in different ways!
December 5, 2025 at 3:33 PM
The second of our 5 project groups we are thrilled to introduce is the✨Isoforms✨group!
Isoforms are different versions of RNA transcripts or proteins🧬
They are a result of splicing✂️during gene expression and are an important part of how one gene can act in different ways!
Isoforms are different versions of RNA transcripts or proteins🧬
They are a result of splicing✂️during gene expression and are an important part of how one gene can act in different ways!
The @fg-pgc.bsky.social is all about understanding how our genetic findings🔬translate into psychiatric conditions 🧠
We have 5 project groups, and we are excited to introduce the✨Functional Validation✨group first!
We asked them for a status update and a highlight of the year...
We have 5 project groups, and we are excited to introduce the✨Functional Validation✨group first!
We asked them for a status update and a highlight of the year...
December 4, 2025 at 4:43 PM
The @fg-pgc.bsky.social is all about understanding how our genetic findings🔬translate into psychiatric conditions 🧠
We have 5 project groups, and we are excited to introduce the✨Functional Validation✨group first!
We asked them for a status update and a highlight of the year...
We have 5 project groups, and we are excited to introduce the✨Functional Validation✨group first!
We asked them for a status update and a highlight of the year...
So, who are the the Functional Genomics Working Group?
🎯Our goal is to understand how genes🧬, cells🦠and molecules💠contribute to psychiatric disorders🧠
We work with other PGC groups and different 'omics data (methylation, cytometry, single cell etc.) to do this🧪
🧵1/3
🎯Our goal is to understand how genes🧬, cells🦠and molecules💠contribute to psychiatric disorders🧠
We work with other PGC groups and different 'omics data (methylation, cytometry, single cell etc.) to do this🧪
🧵1/3
December 3, 2025 at 5:37 PM
So, who are the the Functional Genomics Working Group?
🎯Our goal is to understand how genes🧬, cells🦠and molecules💠contribute to psychiatric disorders🧠
We work with other PGC groups and different 'omics data (methylation, cytometry, single cell etc.) to do this🧪
🧵1/3
🎯Our goal is to understand how genes🧬, cells🦠and molecules💠contribute to psychiatric disorders🧠
We work with other PGC groups and different 'omics data (methylation, cytometry, single cell etc.) to do this🧪
🧵1/3
Before we get started, let’s introduce our two Social Media Reps - @natashaberthold.bsky.social and @evacschulte.bsky.social!
We're here for the #functionalgenomics🧬, and #Science #Communication📡is a🔑key part!
💫Check out their profiles💫
We're here for the #functionalgenomics🧬, and #Science #Communication📡is a🔑key part!
💫Check out their profiles💫
December 2, 2025 at 2:35 PM
Before we get started, let’s introduce our two Social Media Reps - @natashaberthold.bsky.social and @evacschulte.bsky.social!
We're here for the #functionalgenomics🧬, and #Science #Communication📡is a🔑key part!
💫Check out their profiles💫
We're here for the #functionalgenomics🧬, and #Science #Communication📡is a🔑key part!
💫Check out their profiles💫
✨Welcome to the Functional Genomics Takeover of the PGC main account!✨
For the next 2 weeks @natashaberthold.bsky.social and @evacschulte.bsky.social will be taking you through the achievements and highlights of year 2 in the @fg-pgc.bsky.social.
So sit forward, get excited, and celebrate with us!
For the next 2 weeks @natashaberthold.bsky.social and @evacschulte.bsky.social will be taking you through the achievements and highlights of year 2 in the @fg-pgc.bsky.social.
So sit forward, get excited, and celebrate with us!
December 2, 2025 at 2:22 PM
✨Welcome to the Functional Genomics Takeover of the PGC main account!✨
For the next 2 weeks @natashaberthold.bsky.social and @evacschulte.bsky.social will be taking you through the achievements and highlights of year 2 in the @fg-pgc.bsky.social.
So sit forward, get excited, and celebrate with us!
For the next 2 weeks @natashaberthold.bsky.social and @evacschulte.bsky.social will be taking you through the achievements and highlights of year 2 in the @fg-pgc.bsky.social.
So sit forward, get excited, and celebrate with us!
Congratulations to Dr. Wouter Peyrot, recipient of the 2025 Pamela Sklar Award at #WCPG2025! His innovative work continues to advance the field of psychiatric genomics. 🧬👏
October 29, 2025 at 3:04 PM
Congratulations to Dr. Wouter Peyrot, recipient of the 2025 Pamela Sklar Award at #WCPG2025! His innovative work continues to advance the field of psychiatric genomics. 🧬👏
Attending the 2025 @behaviorgenetic.bsky.social Meeting in Atlanta? Be sure to check out some exciting work from members of the PGC-SUD working group:
June 21, 2025 at 4:47 PM
Attending the 2025 @behaviorgenetic.bsky.social Meeting in Atlanta? Be sure to check out some exciting work from members of the PGC-SUD working group:
