Paola A. Marignani
@pmarignani.bsky.social
Scientist & Professor.
MarignaniLab.com
Precision Oncology/Model Systems/Signal Transduction/Single Cell Transcriptomics/AI/sometimes athlete.
Creative Destruction Lab (CDL) Scientist/Business Strategist
ORCID: 0000-0001-8070-905X
MarignaniLab.com
Precision Oncology/Model Systems/Signal Transduction/Single Cell Transcriptomics/AI/sometimes athlete.
Creative Destruction Lab (CDL) Scientist/Business Strategist
ORCID: 0000-0001-8070-905X
Reposted by Paola A. Marignani
www.frontiersin.org/journals/cel...
Review: "The Tumor Suppressor Kinase LKB1: Metabolic Nexus"
LKB1 loss is associated with multiple malignancies and causes metabolic reprograming to increase glycolysis and lactate production, elevate hexosamine biosynthesis and glutamine metabolism.
Review: "The Tumor Suppressor Kinase LKB1: Metabolic Nexus"
LKB1 loss is associated with multiple malignancies and causes metabolic reprograming to increase glycolysis and lactate production, elevate hexosamine biosynthesis and glutamine metabolism.
November 25, 2025 at 1:26 AM
www.frontiersin.org/journals/cel...
Review: "The Tumor Suppressor Kinase LKB1: Metabolic Nexus"
LKB1 loss is associated with multiple malignancies and causes metabolic reprograming to increase glycolysis and lactate production, elevate hexosamine biosynthesis and glutamine metabolism.
Review: "The Tumor Suppressor Kinase LKB1: Metabolic Nexus"
LKB1 loss is associated with multiple malignancies and causes metabolic reprograming to increase glycolysis and lactate production, elevate hexosamine biosynthesis and glutamine metabolism.
Emma presenting her Honours project fall report.
👏🏻👏🏻👏🏻👏🏻
👏🏻👏🏻👏🏻👏🏻
November 21, 2025 at 7:37 PM
Emma presenting her Honours project fall report.
👏🏻👏🏻👏🏻👏🏻
👏🏻👏🏻👏🏻👏🏻
In Wolfville with Tapestry Cancer Advocacy group.
Thank you for sharing your cancer journeys with me. And thank you for inviting my lab to share our research discoveries with you.
You all inspire me to do better.
#ScienceSaves #ManageCancer #Recurrence
Thank you for sharing your cancer journeys with me. And thank you for inviting my lab to share our research discoveries with you.
You all inspire me to do better.
#ScienceSaves #ManageCancer #Recurrence
November 18, 2025 at 8:28 PM
In Wolfville with Tapestry Cancer Advocacy group.
Thank you for sharing your cancer journeys with me. And thank you for inviting my lab to share our research discoveries with you.
You all inspire me to do better.
#ScienceSaves #ManageCancer #Recurrence
Thank you for sharing your cancer journeys with me. And thank you for inviting my lab to share our research discoveries with you.
You all inspire me to do better.
#ScienceSaves #ManageCancer #Recurrence
Wonderful 2 have Anisha back in lab conducting Research in Medicine (RIM) project 4 the next 3 yrs. Anisha started in my lab at 9, completed high school then went to #YYZ for undergrad. Now she is in 1styr medicine @dalhousieu.bsky.social
#MachineLearning #DataMining #PrecisionOmics
#ScienceSaves
#MachineLearning #DataMining #PrecisionOmics
#ScienceSaves
November 18, 2025 at 12:21 PM
Wonderful 2 have Anisha back in lab conducting Research in Medicine (RIM) project 4 the next 3 yrs. Anisha started in my lab at 9, completed high school then went to #YYZ for undergrad. Now she is in 1styr medicine @dalhousieu.bsky.social
#MachineLearning #DataMining #PrecisionOmics
#ScienceSaves
#MachineLearning #DataMining #PrecisionOmics
#ScienceSaves
Dr. Sarah Marzi kicking off #CEEHRC2025.
Epigenetics in neurodegenerative disease like #Alzheimer
#ScienceSaves @ceehrc.bsky.social
Epigenetics in neurodegenerative disease like #Alzheimer
#ScienceSaves @ceehrc.bsky.social
November 13, 2025 at 1:12 AM
Dr. Sarah Marzi kicking off #CEEHRC2025.
Epigenetics in neurodegenerative disease like #Alzheimer
#ScienceSaves @ceehrc.bsky.social
Epigenetics in neurodegenerative disease like #Alzheimer
#ScienceSaves @ceehrc.bsky.social
November 11, 2025 at 7:46 PM
I certainly hope he apologized to Rosalind Franklin for taking her discovery of the structure of DNA. #WomenSTEM #STEMWomen
James Watson, dead at 97, was a scientific legend (because he stole data) and a pariah among his peers www.statnews.com/2025/11/07/j... via @statnews.com
James Watson, dead at 97, was a scientific legend (because he stole data) and a pariah among his peers www.statnews.com/2025/11/07/j... via @statnews.com
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 9, 2025 at 1:25 AM
I certainly hope he apologized to Rosalind Franklin for taking her discovery of the structure of DNA. #WomenSTEM #STEMWomen
James Watson, dead at 97, was a scientific legend (because he stole data) and a pariah among his peers www.statnews.com/2025/11/07/j... via @statnews.com
James Watson, dead at 97, was a scientific legend (because he stole data) and a pariah among his peers www.statnews.com/2025/11/07/j... via @statnews.com
#Windsor taking over Creative Destruction Lab-Cancer
Always nice to meet up with Dr. Jason Cross, Scientist and Windsorsite at MD Anderson.
#ScienceSaves #Entrepreneurship #Innovation #CancerCures
Always nice to meet up with Dr. Jason Cross, Scientist and Windsorsite at MD Anderson.
#ScienceSaves #Entrepreneurship #Innovation #CancerCures
November 6, 2025 at 12:44 PM
#Windsor taking over Creative Destruction Lab-Cancer
Always nice to meet up with Dr. Jason Cross, Scientist and Windsorsite at MD Anderson.
#ScienceSaves #Entrepreneurship #Innovation #CancerCures
Always nice to meet up with Dr. Jason Cross, Scientist and Windsorsite at MD Anderson.
#ScienceSaves #Entrepreneurship #Innovation #CancerCures
So many reasons 2B upset with recent moves by Alberta gov whose current leader benefited from the very #EDI initiatives they intend to dismantle.
As academics, we need 2B vocal- EDI initiatives must remain firmly embedded in academia. @cdnwomenstem.bsky.social
universityaffairs.ca/opinion/the-...
As academics, we need 2B vocal- EDI initiatives must remain firmly embedded in academia. @cdnwomenstem.bsky.social
universityaffairs.ca/opinion/the-...
The Mintz Report is wrong on EDI - University Affairs
Demanding ‘institutional neutrality,’ Alberta’s report on the post-secondary system risks silencing equity.
universityaffairs.ca
November 5, 2025 at 1:50 PM
So many reasons 2B upset with recent moves by Alberta gov whose current leader benefited from the very #EDI initiatives they intend to dismantle.
As academics, we need 2B vocal- EDI initiatives must remain firmly embedded in academia. @cdnwomenstem.bsky.social
universityaffairs.ca/opinion/the-...
As academics, we need 2B vocal- EDI initiatives must remain firmly embedded in academia. @cdnwomenstem.bsky.social
universityaffairs.ca/opinion/the-...
Meetup with Jim @jwoodgett.bsky.social at @ccralliance.bsky.social conference in Calgary #CCRC2025 Always fun when two kinase scientists get together to discuss research. The conversation was definitely active 🧫🔬⚗️
#ScienceIsFun #Kinase #CancerResearch @terryfoxresearch.bsky.social
#ScienceIsFun #Kinase #CancerResearch @terryfoxresearch.bsky.social
November 4, 2025 at 11:24 AM
Meetup with Jim @jwoodgett.bsky.social at @ccralliance.bsky.social conference in Calgary #CCRC2025 Always fun when two kinase scientists get together to discuss research. The conversation was definitely active 🧫🔬⚗️
#ScienceIsFun #Kinase #CancerResearch @terryfoxresearch.bsky.social
#ScienceIsFun #Kinase #CancerResearch @terryfoxresearch.bsky.social
Meet up with colleague Tobias Karakach @dalhousieu.bsky.social @dalhousie.bsky.social at #CCRC2025.
#ScienceSaves
#ScienceSaves
November 3, 2025 at 10:01 PM
Meet up with colleague Tobias Karakach @dalhousieu.bsky.social @dalhousie.bsky.social at #CCRC2025.
#ScienceSaves
#ScienceSaves
Listening to Parveen Bhatti, BC Cancer, talking about the role artificial light pollution plays in breast cancer. #melatoninsuppression #CCRC2025
November 3, 2025 at 7:53 PM
Listening to Parveen Bhatti, BC Cancer, talking about the role artificial light pollution plays in breast cancer. #melatoninsuppression #CCRC2025
Dalhousie @dalhousie.bsky.social @dalhousieu.bsky.social Who decided to add an additional layer to Sole Source documents for reoccurring consumable purchases? Pls give me an opportunity 2 speak with this person directly about complexity of any research venture, and efficiency. Thx
October 27, 2025 at 4:09 PM
Dalhousie @dalhousie.bsky.social @dalhousieu.bsky.social Who decided to add an additional layer to Sole Source documents for reoccurring consumable purchases? Pls give me an opportunity 2 speak with this person directly about complexity of any research venture, and efficiency. Thx
Definitely feeling like autumn in Halifax.
October 25, 2025 at 3:24 PM
Definitely feeling like autumn in Halifax.
Reposted by Paola A. Marignani
NEW STUDY PUBLISHED IN NATURE: People who got an mRNA COVID vaccine within ~3 months before or after starting immunotherapy for cancer lived longer overall than those who didn’t get the vaccine.
www.washingtonpost.com/science/2025...
www.washingtonpost.com/science/2025...
October 23, 2025 at 11:51 PM
NEW STUDY PUBLISHED IN NATURE: People who got an mRNA COVID vaccine within ~3 months before or after starting immunotherapy for cancer lived longer overall than those who didn’t get the vaccine.
www.washingtonpost.com/science/2025...
www.washingtonpost.com/science/2025...
I don't often post anything from IG however this particular post is a powerful reminder of how women experience the world differently and are judged/criticized differently.
I would rather fail trying than be the critic that "wins" because they never step out.
www.instagram.com/reel/DPzBSUN...
I would rather fail trying than be the critic that "wins" because they never step out.
www.instagram.com/reel/DPzBSUN...
Login • Instagram
Welcome back to Instagram. Sign in to check out what your friends, family & interests have been capturing & sharing around the world.
www.instagram.com
October 22, 2025 at 8:44 AM
I don't often post anything from IG however this particular post is a powerful reminder of how women experience the world differently and are judged/criticized differently.
I would rather fail trying than be the critic that "wins" because they never step out.
www.instagram.com/reel/DPzBSUN...
I would rather fail trying than be the critic that "wins" because they never step out.
www.instagram.com/reel/DPzBSUN...
October 21, 2025 at 10:51 AM
The temp in my lab is out of control (constantly).
Not the best of conditions for trainees or experiments.
@dalhousieu.bsky.social
@dalhousie.bsky.social
Time to fix the fluctuating temperatures in the Tupper building. Maybe less expensive to tear the bldg down and rebuild consulting scientists.
Not the best of conditions for trainees or experiments.
@dalhousieu.bsky.social
@dalhousie.bsky.social
Time to fix the fluctuating temperatures in the Tupper building. Maybe less expensive to tear the bldg down and rebuild consulting scientists.
October 20, 2025 at 12:36 PM
The temp in my lab is out of control (constantly).
Not the best of conditions for trainees or experiments.
@dalhousieu.bsky.social
@dalhousie.bsky.social
Time to fix the fluctuating temperatures in the Tupper building. Maybe less expensive to tear the bldg down and rebuild consulting scientists.
Not the best of conditions for trainees or experiments.
@dalhousieu.bsky.social
@dalhousie.bsky.social
Time to fix the fluctuating temperatures in the Tupper building. Maybe less expensive to tear the bldg down and rebuild consulting scientists.
October 20, 2025 at 12:37 AM
Reposted by Paola A. Marignani
For something different, check out this new blog by @aminnoorani.bsky.social!
Explore a biologist’s roadmap to epigenomic data analysis, from understanding raw data to gaining deep biological insights.
thisisepigenetics.ca...
#ThisIsEpigenetics #epigenetics #epigenomics #bioinformatics
Explore a biologist’s roadmap to epigenomic data analysis, from understanding raw data to gaining deep biological insights.
thisisepigenetics.ca...
#ThisIsEpigenetics #epigenetics #epigenomics #bioinformatics
Beyond the Sequence: A Biologist's Roadmap to Epigenomic Analysis | This is Epigenetics
Unlock the complexities of epigenomic data analysis with this comprehensive guide, from quality control to visualization.
thisisepigenetics.ca
August 14, 2025 at 5:00 PM
For something different, check out this new blog by @aminnoorani.bsky.social!
Explore a biologist’s roadmap to epigenomic data analysis, from understanding raw data to gaining deep biological insights.
thisisepigenetics.ca...
#ThisIsEpigenetics #epigenetics #epigenomics #bioinformatics
Explore a biologist’s roadmap to epigenomic data analysis, from understanding raw data to gaining deep biological insights.
thisisepigenetics.ca...
#ThisIsEpigenetics #epigenetics #epigenomics #bioinformatics
Joy to see a Marignani Lab trainees innovating, creating and changing the healthcare narrative for women, makes me 🙂.
Dr. Heidi Bentley MD, Assistant Professor, former undergraduate & honours student, now an Ob/Gy expert in menopause leading the Complex Menopause Clinic at the IWK Health Centre.
Dr. Heidi Bentley MD, Assistant Professor, former undergraduate & honours student, now an Ob/Gy expert in menopause leading the Complex Menopause Clinic at the IWK Health Centre.
October 17, 2025 at 4:26 PM
Joy to see a Marignani Lab trainees innovating, creating and changing the healthcare narrative for women, makes me 🙂.
Dr. Heidi Bentley MD, Assistant Professor, former undergraduate & honours student, now an Ob/Gy expert in menopause leading the Complex Menopause Clinic at the IWK Health Centre.
Dr. Heidi Bentley MD, Assistant Professor, former undergraduate & honours student, now an Ob/Gy expert in menopause leading the Complex Menopause Clinic at the IWK Health Centre.
☀️☕👩🏻💻
Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells | The EMBO Journal www.embopress.org/doi/full/10....
Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells | The EMBO Journal www.embopress.org/doi/full/10....
Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells | The EMBO Journal
imageimageCDKs control cell cycle progression and transcription, pathways commonly dysregulated
in cancer. This study identifies a resistance mechanism of prostate cancer cells towards
the CDK7 inhibi...
www.embopress.org
October 16, 2025 at 8:12 AM
☀️☕👩🏻💻
Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells | The EMBO Journal www.embopress.org/doi/full/10....
Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells | The EMBO Journal www.embopress.org/doi/full/10....
Thanksgiving is always a time 4 me 2 reflect what it is 2 be Canadian, and 2 be grateful that my family chose 🇨🇦. The freedoms & liberties we share are part of the Canadian dream, a dream built on a foundation of multiculturalism, opportunity and mutual respect. 🍁🍂🇨🇦
Happy Thanksgiving. Be thankful
Happy Thanksgiving. Be thankful
October 12, 2025 at 11:40 PM
Thanksgiving is always a time 4 me 2 reflect what it is 2 be Canadian, and 2 be grateful that my family chose 🇨🇦. The freedoms & liberties we share are part of the Canadian dream, a dream built on a foundation of multiculturalism, opportunity and mutual respect. 🍁🍂🇨🇦
Happy Thanksgiving. Be thankful
Happy Thanksgiving. Be thankful