The Powrie Lab
@powrielab.bsky.social
Powrie Lab news and Mucosal Immunology content! Based at the Kennedy Institute of Rheumatology @kiroxford.bsky.social
Posts are by members of the Powrie Lab, not necessarily representative of the lab as a whole.
Posts are by members of the Powrie Lab, not necessarily representative of the lab as a whole.
Reposted by The Powrie Lab
☕Borsa et al. show that asymmetric #Tcell division after activation requires #autophagy to promote #mitochondria turnover, with T cells inheriting older mitochondria showing decreased degradation, reduced memory potential and altered metabolism.
bit.ly/458ODgL
bit.ly/458ODgL
Client Challenge
bit.ly
January 13, 2026 at 5:59 PM
☕Borsa et al. show that asymmetric #Tcell division after activation requires #autophagy to promote #mitochondria turnover, with T cells inheriting older mitochondria showing decreased degradation, reduced memory potential and altered metabolism.
bit.ly/458ODgL
bit.ly/458ODgL
Reposted by The Powrie Lab
Celebrating #February11 by highlighting Professor Claudia Mauri, the Editor‑in‑Chief of @ceijournal.bsky.social Her leadership and expertise continue to shape the future of immunology.
Read the interview on the BSI website here: https://bit.ly/4abuedR
##WomenInScience
Read the interview on the BSI website here: https://bit.ly/4abuedR
##WomenInScience
February 11, 2026 at 1:48 PM
Celebrating #February11 by highlighting Professor Claudia Mauri, the Editor‑in‑Chief of @ceijournal.bsky.social Her leadership and expertise continue to shape the future of immunology.
Read the interview on the BSI website here: https://bit.ly/4abuedR
##WomenInScience
Read the interview on the BSI website here: https://bit.ly/4abuedR
##WomenInScience
Reposted by The Powrie Lab
This #February11 we are celebrating Prof Jessica Teeling, winner of the BSI Public Engagement Award! Her grant‑supported “Snakes and Letters for a Healthy Brain” project is inspiring conversations on dementia risk + immunity. #WomenInScience
Read here: https://bit.ly/3Ktiito
Read here: https://bit.ly/3Ktiito
February 11, 2026 at 11:15 AM
This #February11 we are celebrating Prof Jessica Teeling, winner of the BSI Public Engagement Award! Her grant‑supported “Snakes and Letters for a Healthy Brain” project is inspiring conversations on dementia risk + immunity. #WomenInScience
Read here: https://bit.ly/3Ktiito
Read here: https://bit.ly/3Ktiito
Reposted by The Powrie Lab
Marking #February11 by celebrating Professor Tracy Hussell, BSI President, and her Nature Mentoring Award for Lifetime Achievement.
A great recognition of her commitment to supporting early career researchers and strengthening the immunology community.
##WomenInScience #Immunology
A great recognition of her commitment to supporting early career researchers and strengthening the immunology community.
##WomenInScience #Immunology
February 11, 2026 at 4:14 PM
Marking #February11 by celebrating Professor Tracy Hussell, BSI President, and her Nature Mentoring Award for Lifetime Achievement.
A great recognition of her commitment to supporting early career researchers and strengthening the immunology community.
##WomenInScience #Immunology
A great recognition of her commitment to supporting early career researchers and strengthening the immunology community.
##WomenInScience #Immunology
Congratulations to the wonderful Natasha for successfully defending her DPhil thesis! We’re excited to see what comes next for Natasha and her MAIT cell story whilst she continues her project as a postdoctoral researcher🥳👩🔬
@kiroxford.bsky.social
@kiroxford.bsky.social
February 11, 2026 at 8:44 PM
Congratulations to the wonderful Natasha for successfully defending her DPhil thesis! We’re excited to see what comes next for Natasha and her MAIT cell story whilst she continues her project as a postdoctoral researcher🥳👩🔬
@kiroxford.bsky.social
@kiroxford.bsky.social
New year, new paper! Thrilled to share that our review “Contextualising TH17 cells in cancer” is out now!
Congratulations to Declan & team for a fantastic, in depth overview🥳
Go give it a read here:
doi.org/10.1038/s415...
@natrevimmunol.nature.com
@kiroxford.bsky.social
Congratulations to Declan & team for a fantastic, in depth overview🥳
Go give it a read here:
doi.org/10.1038/s415...
@natrevimmunol.nature.com
@kiroxford.bsky.social
Contextualizing TH17 cells in cancer - Nature Reviews Immunology
T helper 17 (TH17) cells can have both pro-tumour and antitumour effects. Understanding how they are regulated by environmental and regulatory cues according to context will inform strategies to harne...
doi.org
January 7, 2026 at 10:53 AM
New year, new paper! Thrilled to share that our review “Contextualising TH17 cells in cancer” is out now!
Congratulations to Declan & team for a fantastic, in depth overview🥳
Go give it a read here:
doi.org/10.1038/s415...
@natrevimmunol.nature.com
@kiroxford.bsky.social
Congratulations to Declan & team for a fantastic, in depth overview🥳
Go give it a read here:
doi.org/10.1038/s415...
@natrevimmunol.nature.com
@kiroxford.bsky.social
Last night was our Lab Christmas party! Special thanks to Claire and Nick for organising some excellent party games for us (guessing the flavour of Skittles whilst blindfolded is much harder than you’d think!) and to Branca for hosting us🎅🎄🌟
@kiroxford.bsky.social
@nickilott.bsky.social
@kiroxford.bsky.social
@nickilott.bsky.social
December 12, 2025 at 9:10 PM
Last night was our Lab Christmas party! Special thanks to Claire and Nick for organising some excellent party games for us (guessing the flavour of Skittles whilst blindfolded is much harder than you’d think!) and to Branca for hosting us🎅🎄🌟
@kiroxford.bsky.social
@nickilott.bsky.social
@kiroxford.bsky.social
@nickilott.bsky.social
An excellent opportunity, please have a look at the position below!🧫👩🔬
Hiring: Group Leader in Microbiome Studies! ✨
The successful candidate would establish & lead a new research group in human microbiome science, advancing understanding of microbe-microbe and microbe-host interactions in health & disease.
Apply by 22 Dec.
www.ndorms.ox.ac.uk/jobs/kennedy...
The successful candidate would establish & lead a new research group in human microbiome science, advancing understanding of microbe-microbe and microbe-host interactions in health & disease.
Apply by 22 Dec.
www.ndorms.ox.ac.uk/jobs/kennedy...
Kennedy Trust for Rheumatology Research (KTRR) Group Leader in Microbiome Studies (183704)
We are seeking applications from an outstanding scientist to establish and lead a new research group in human microbiome science, advancing understanding of microbe–microbe and microbe–host interactio...
www.ndorms.ox.ac.uk
December 11, 2025 at 11:27 AM
An excellent opportunity, please have a look at the position below!🧫👩🔬
We’re hiring! Two postdoctoral research positions are available in our lab - one in mucosal immunology, and one in exposome immunology (MRC CoRE)! Apply by December 22nd!🎄
Position 1: tinyurl.com/2mh44tn4
Position 2: tinyurl.com/5ffzxsfb
@kiroxford.bsky.social @exposomeimmunology.bsky.social
Position 1: tinyurl.com/2mh44tn4
Position 2: tinyurl.com/5ffzxsfb
@kiroxford.bsky.social @exposomeimmunology.bsky.social
Job Details
tinyurl.com
December 9, 2025 at 5:13 PM
We’re hiring! Two postdoctoral research positions are available in our lab - one in mucosal immunology, and one in exposome immunology (MRC CoRE)! Apply by December 22nd!🎄
Position 1: tinyurl.com/2mh44tn4
Position 2: tinyurl.com/5ffzxsfb
@kiroxford.bsky.social @exposomeimmunology.bsky.social
Position 1: tinyurl.com/2mh44tn4
Position 2: tinyurl.com/5ffzxsfb
@kiroxford.bsky.social @exposomeimmunology.bsky.social
Congratulations to our fantastic DPhil student, Henry, for defending his PhD thesis today!! It’s been a pleasure to have Henry in the lab & we miss him already! Go check out the review (linked below) if you’d like to see some of his work🥳🧑🔬
@kiroxford.bsky.social
pubmed.ncbi.nlm.nih.gov/40252635/
@kiroxford.bsky.social
pubmed.ncbi.nlm.nih.gov/40252635/
December 8, 2025 at 4:54 PM
Congratulations to our fantastic DPhil student, Henry, for defending his PhD thesis today!! It’s been a pleasure to have Henry in the lab & we miss him already! Go check out the review (linked below) if you’d like to see some of his work🥳🧑🔬
@kiroxford.bsky.social
pubmed.ncbi.nlm.nih.gov/40252635/
@kiroxford.bsky.social
pubmed.ncbi.nlm.nih.gov/40252635/
We’re very proud of our very own Dr Alice Bertocchi for winning a Kennedy Trust Transition Fellowship! Keep up the amazing work as always, Ali!🥳❤️
Dr Lakshanie Wickramasinghe, Dr Alice Bertocchi and Dr Adrien Hallou have been awarded highly competitive funding from the Kennedy Trust for Rheumatology Research!
Read about their exciting research projects 👇
www.kennedy.ox.ac.uk/news/researc...
Read about their exciting research projects 👇
www.kennedy.ox.ac.uk/news/researc...
Researchers win prestigious Kennedy Trust grant awards
Two Kennedy researchers have been awarded highly competitive Kennedy Trust Transition Fellowships, supporting their journey towards independent research leadership, and another receiving a Research Ig...
www.kennedy.ox.ac.uk
December 6, 2025 at 6:34 PM
We’re very proud of our very own Dr Alice Bertocchi for winning a Kennedy Trust Transition Fellowship! Keep up the amazing work as always, Ali!🥳❤️
Reposted by The Powrie Lab
We are hiring a Postdoctoral Research Assistant to study how microbiomes influence barrier biology and shape responses to viral infection!
This post is part of the exciting new MRC CoRE in Exposome Immunology.
Apply by December 18 👇
www.kennedy.ox.ac.uk/jobs/postdoc...
This post is part of the exciting new MRC CoRE in Exposome Immunology.
Apply by December 18 👇
www.kennedy.ox.ac.uk/jobs/postdoc...
Postdoctoral Research Assistant - MRC CoRE in Exposome Immunology (183191)
You will lead delivery of a CoRE research project, managing your own research and coordinating project activities to meet deadlines. The role includes developing and adapting scientific techniques, an...
www.kennedy.ox.ac.uk
December 3, 2025 at 4:43 PM
We are hiring a Postdoctoral Research Assistant to study how microbiomes influence barrier biology and shape responses to viral infection!
This post is part of the exciting new MRC CoRE in Exposome Immunology.
Apply by December 18 👇
www.kennedy.ox.ac.uk/jobs/postdoc...
This post is part of the exciting new MRC CoRE in Exposome Immunology.
Apply by December 18 👇
www.kennedy.ox.ac.uk/jobs/postdoc...
Day 4 and the final day of the BSI saw a fantastic talk from @labliston.bsky.social about Tregs in the brain and an excellent session devoted to “Barriers, bugs, and breakdowns” - right up our street! Thank you to all organisers and presenters @britsocimm.bsky.social for a great week in Liverpool🫶
December 6, 2025 at 6:30 PM
Day 4 and the final day of the BSI saw a fantastic talk from @labliston.bsky.social about Tregs in the brain and an excellent session devoted to “Barriers, bugs, and breakdowns” - right up our street! Thank you to all organisers and presenters @britsocimm.bsky.social for a great week in Liverpool🫶
Day 3 of the BSI was a busy one, with Yuqing & Dehui presenting posters, and Ffion giving an excellent talk all about AMR Klebsiella dynamics in the gut! It was also great to see Dave Withers give a fantastic plenary talk!🧫🧬
@dehuic.bsky.social @yuqinglong.bsky.social
@witherslab.bsky.social
@dehuic.bsky.social @yuqinglong.bsky.social
@witherslab.bsky.social
December 4, 2025 at 11:02 AM
Day 3 of the BSI was a busy one, with Yuqing & Dehui presenting posters, and Ffion giving an excellent talk all about AMR Klebsiella dynamics in the gut! It was also great to see Dave Withers give a fantastic plenary talk!🧫🧬
@dehuic.bsky.social @yuqinglong.bsky.social
@witherslab.bsky.social
@dehuic.bsky.social @yuqinglong.bsky.social
@witherslab.bsky.social
Day 2 of the BSI saw Gemma & Rachel from the lab presenting posters, as well as the lovely Anna Ahlback from the Maloy lab delivering a great talk on Hh infection and its impact on DSS colitis (go check out their new preprint!)👩🔬
@gemmala.bsky.social @rachelanscombe.bsky.social @aahlback.bsky.social
@gemmala.bsky.social @rachelanscombe.bsky.social @aahlback.bsky.social
December 4, 2025 at 10:17 AM
Day 2 of the BSI saw Gemma & Rachel from the lab presenting posters, as well as the lovely Anna Ahlback from the Maloy lab delivering a great talk on Hh infection and its impact on DSS colitis (go check out their new preprint!)👩🔬
@gemmala.bsky.social @rachelanscombe.bsky.social @aahlback.bsky.social
@gemmala.bsky.social @rachelanscombe.bsky.social @aahlback.bsky.social
Day 1 of the BSI 2025 on Monday saw the wonderful Judi Allen deliver a fabulous keynote talk! We were also very excited to see Judi share the news of our new MRC Exposome Immunology Manchester/Oxford collaboration👩🔬
@profjudiallen.bsky.social
@exposomeimmunology.bsky.social
@britsocimm.bsky.social
@profjudiallen.bsky.social
@exposomeimmunology.bsky.social
@britsocimm.bsky.social
December 3, 2025 at 12:20 PM
Day 1 of the BSI 2025 on Monday saw the wonderful Judi Allen deliver a fabulous keynote talk! We were also very excited to see Judi share the news of our new MRC Exposome Immunology Manchester/Oxford collaboration👩🔬
@profjudiallen.bsky.social
@exposomeimmunology.bsky.social
@britsocimm.bsky.social
@profjudiallen.bsky.social
@exposomeimmunology.bsky.social
@britsocimm.bsky.social
Delighted to share that Fiona was awarded the FSI EFIS-IL Lecture Award last week as a keynote speaker at the 56th Annual Meeting of the French Society for Immunology! We’d like to warmly thank the SFI for the award, it was a pleasure to attend!🇫🇷👩🔬
@sfi-immunologie.bsky.social @kiroxford.bsky.social
@sfi-immunologie.bsky.social @kiroxford.bsky.social
November 21, 2025 at 10:58 AM
Delighted to share that Fiona was awarded the FSI EFIS-IL Lecture Award last week as a keynote speaker at the 56th Annual Meeting of the French Society for Immunology! We’d like to warmly thank the SFI for the award, it was a pleasure to attend!🇫🇷👩🔬
@sfi-immunologie.bsky.social @kiroxford.bsky.social
@sfi-immunologie.bsky.social @kiroxford.bsky.social
We’re thrilled to share that we’re part of the Experimental Medicine Collaboration (EMC) with GSK! The EMC will put translational science at the forefront of developing treatments for immune mediated inflammatory diseases👩🔬🧬🧫
www.ox.ac.uk/news/2025-11...
@gsk.bsky.social @kiroxford.bsky.social
www.ox.ac.uk/news/2025-11...
@gsk.bsky.social @kiroxford.bsky.social
Oxford and GSK launch Experimental Medicine Collaboration |
GSK invests £10 million over five years to establish the Experimental Medicine Collaboration with the University of Oxford.
www.ox.ac.uk
November 20, 2025 at 9:57 AM
We’re thrilled to share that we’re part of the Experimental Medicine Collaboration (EMC) with GSK! The EMC will put translational science at the forefront of developing treatments for immune mediated inflammatory diseases👩🔬🧬🧫
www.ox.ac.uk/news/2025-11...
@gsk.bsky.social @kiroxford.bsky.social
www.ox.ac.uk/news/2025-11...
@gsk.bsky.social @kiroxford.bsky.social
Some pics from our annual lab autumn walk! We went to the lovely Blenheim palace to get some steps in & enjoy the autumn leaves🍁🚶♀️🌳
November 4, 2025 at 10:11 PM
Some pics from our annual lab autumn walk! We went to the lovely Blenheim palace to get some steps in & enjoy the autumn leaves🍁🚶♀️🌳
Reposted by The Powrie Lab
A great afternoon celebrating the award of our MRC CoRE in person. We heard about projects spanning our discovery pipeline, from ExWAS and mechanistic barrier immunology, to potential therapeutic angles for IBD and machine learning for diagnostics.
#exposome #immunology
#exposome #immunology
October 20, 2025 at 10:25 AM
A great afternoon celebrating the award of our MRC CoRE in person. We heard about projects spanning our discovery pipeline, from ExWAS and mechanistic barrier immunology, to potential therapeutic angles for IBD and machine learning for diagnostics.
#exposome #immunology
#exposome #immunology
Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
bulletin.ndorms.ox.ac.uk
October 29, 2025 at 8:55 PM
Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
Throwing it back a few weeks to the final meeting of the CRUK grand challenges optimisticc study! We had a great time in Boston discussing progress in the colorectal cancer & microbiome field - it’s been a real pleasure being part of this group!🧫🫶
@elayton13.bsky.social
@elayton13.bsky.social
October 27, 2025 at 10:05 AM
Throwing it back a few weeks to the final meeting of the CRUK grand challenges optimisticc study! We had a great time in Boston discussing progress in the colorectal cancer & microbiome field - it’s been a real pleasure being part of this group!🧫🫶
@elayton13.bsky.social
@elayton13.bsky.social
We’re delighted to hear that our favourite cell type (Regulatory T cells!) have been recognised in the Nobel Prize this year! Huge congratulations to Mary, Fred, and Shimon for their pivotal work in the field & here’s to many exciting Treg advances to come!🥳👏🎉
October 7, 2025 at 10:37 AM
We’re delighted to hear that our favourite cell type (Regulatory T cells!) have been recognised in the Nobel Prize this year! Huge congratulations to Mary, Fred, and Shimon for their pivotal work in the field & here’s to many exciting Treg advances to come!🥳👏🎉
Reposted by The Powrie Lab
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
October 6, 2025 at 11:21 AM
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
Reposted by The Powrie Lab
Happy #treg day everyone - congratulations to Mary Brunkow, Fred Ramsdell, Shimon Sakaguchi and to all the immunologists who have contributed to this incredible field. See our collection: www.nature.com/collections/...
Nobel Prize in Physiology or Medicine 2025
The 2025 Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries ...
www.nature.com
October 6, 2025 at 5:02 PM
Happy #treg day everyone - congratulations to Mary Brunkow, Fred Ramsdell, Shimon Sakaguchi and to all the immunologists who have contributed to this incredible field. See our collection: www.nature.com/collections/...