Nature Reviews Immunology, Published online: 12 February 2026; doi:10.1038/s41577-026-01279-1Intracellular bacteria in cancer cells promote the recruitment of neutrophils and their polarization towards an immunosuppressive phenotype via a cGAS-STING-dependent pathway.

Nature Reviews Immunology, Published online: 12 February 2026; doi:10.1038/s41577-026-01268-4Fibrosis disrupts organ function through excessive extracellular matrix deposition, particularly in pulmonary cases. Insights from single-cell sequencing reveal fibroblast heterogeneity and regulation by immunological, mechanical and metabolic factors, highlighting pathways leading to progressive fibrosis versus effective tissue repair.

Nature Reviews Immunology, Published online: 13 February 2026; doi:10.1038/s41577-026-01269-3Ageing of the immune system is now realized to drive systemic ageing, and there is interest in targeting immune ageing in order to promote healthy ageing. Here, the authors detail how ageing affects different immune cell populations and discuss strategies to rejuvenate the immune system in order to extend healthspan.

Nature Reviews Immunology, Published online: 12 February 2026; doi:10.1038/s41577-026-01279-1Intracellular bacteria in cancer cells promote the recruitment of neutrophils and their polarization towards an immunosuppressive phenotype via a cGAS-STING-dependent pathway.

Nature Reviews Immunology, Published online: 12 February 2026; doi:10.1038/s41577-026-01268-4Fibrosis disrupts organ function through excessive extracellular matrix deposition, particularly in pulmonary cases. Insights from single-cell sequencing reveal fibroblast heterogeneity and regulation by immunological, mechanical and metabolic factors, highlighting pathways leading to progressive fibrosis versus effective tissue repair.

Nature Reviews Immunology, Published online: 11 February 2026; doi:10.1038/s41577-026-01281-7Intestinal macrophages that support the enteric nervous system may be involved in the spread of α-synuclein pathology from the gut to the brain.

Nature Reviews Immunology, Published online: 10 February 2026; doi:10.1038/s41577-026-01278-2A preprint by Heieis et al. shows that O-GlcNAcylation regulates the alternative activation of macrophages and their tissue residency through effects on cell cycle and metabolism.

Nature Reviews Immunology - A preprint by Heieis et al. shows that O-GlcNAcylation regulates the alternative activation of macrophages and their tissue residency through effects on cell cycle and...

Nature Reviews Immunology, Published online: 10 February 2026; doi:10.1038/s41577-026-01278-2A preprint by Heieis et al. shows that O-GlcNAcylation regulates the alternative activation of macrophages and their tissue residency through effects on cell cycle and metabolism.

In this Review, Luri-Rey et al. present evidence for the crucial role of conventional type 1 dendritic cells in cross-presenting antigens from other cells via the major histocompatibility complex class I antigen-presenting machinery, which in turn is necessary to prime CD8+ T cells, which then mount efficient immune responses against cancer. The authors also discuss how we can exploit these processes in cancer immunotherapy by increasing the number and/or maturation or activation status of this specialist subtype of antigen-presenting cell.

Nature Reviews Immunology - A preprint by Yan et al. reports that local antibody production in germinal centres contributes to negative feedback on low-affinity B cells that target the same epitope.

Nature Reviews Immunology, Published online: 06 February 2026; doi:10.1038/s41577-026-01277-3A preprint by Yan et al. reports that local antibody production in germinal centres contributes to negative feedback on low-affinity B cells that target the same epitope.

Nature Reviews Immunology, Published online: 06 February 2026; doi:10.1038/s41577-026-01277-3A preprint by Yan et al. reports that local antibody production in germinal centres contributes to negative feedback on low-affinity B cells that target the same epitope.

Nature Reviews Immunology, Published online: 05 February 2026; doi:10.1038/s41577-026-01276-4Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

Nature Reviews Microbiology, Published online: 05 February 2026; doi:10.1038/s41579-026-01284-0The widespread prokaryotic immune systems, in particular restriction–modification, CRISPR–Cas and defensive toxin–antitoxin systems, are absent in eukaryotes, whereas relatively rare ones, such as Argonautes and antiviral STAND NTPases, became central to eukaryotic innate immunity. In this Comment, we hypothesize that the cause of this paradox is the drastic reduction of horizontal gene transfer rate in eukaryotes.

Nature Reviews Immunology - Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern...

Nature Reviews Immunology, Published online: 05 February 2026; doi:10.1038/s41577-026-01276-4Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

Nature Reviews Immunology, Published online: 28 January 2026; doi:10.1038/s41577-026-01275-5A preprint by El-Daher et al. describes an interferonopathy-associated mutation in the chromatin remodeller ATRX, which identifies an unexpected role for nuclear cGAS in transcriptional regulation.