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Simon Waddington @profsimonwad.bsky.social · 2d

I was in Jerusalem on 1st September 2024. There were protests every week against Netanyahu's attempt to muzzle the legal system and we in the UK, were being warned it might be a travel danger. These are two things I saw, that I found interesting at the time @odedrechavi.bsky.social

Simon Waddington @profsimonwad.bsky.social · 7d

Sorry all, been a bit away from social media - but very happy to show our latest, slightly massive review on neuro gene therapy. Some quite amazing co-authors who dwarf me in their amazingness. Here, as a pre-proof. Still some (quite a bit) of finessing pharmrev.aspetjournals.org/article/S003... 🧪

Genetic therapies for neurological diseases

Often, gene therapy reviews concentrate upon specific therapeutic modalities – particularly either viral vector-mediated or a non-viral approach. Here, we draw together a comprehensive array of knowle...

pharmrev.aspetjournals.org

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Simon Waddington @profsimonwad.bsky.social · Aug 27

fascinating article - the link to the research article is broken though - here is the working one (I hope) www.nature.com/articles/s41...

Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water - Nature

Aminoacyl-thiols reacting selectively with RNA diols over amine nucleophiles and demonstration of chemically controlled formation of peptidyl-RNA in water at neutral pH suggest an important role for t...

www.nature.com

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Simon Waddington @profsimonwad.bsky.social · Jul 28

I saw this about baby spiders eating their mother www.theguardian.com/tv-and-radio.... It validated something I saw as a child in the north of England. I was always poking arthropods; poked this spider and the body dissolved into fleeing tiny spiders. Mum never budged again. I thought I imagined it.

Mother-eating spiders ‘will chill parents to the bone’ in new David Attenborough series

African social spiders’ sinister game of ‘grandmother’s footsteps’ could be breakout moment in BBC’s Parenthood

www.theguardian.com

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Simon Waddington @profsimonwad.bsky.social · Jul 1

And beautiful places on the way. Oh and it took ages (17ish hrs) and was really hard

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Simon Waddington @profsimonwad.bsky.social · Jul 1

And sunset in Ayr

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Simon Waddington @profsimonwad.bsky.social · Jul 1

This is sunrise in Whitley Bay

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Simon Waddington @profsimonwad.bsky.social · Jul 1

I cycled this a couple of weeks ago. 200 miles across the UK in one day. Thank you very much for your lovely sponsorship. It was massively inspirational to me to make it before sunset 🙏🏻

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Simon Waddington @profsimonwad.bsky.social · Jun 13

Yay!

Simon Waddington @profsimonwad.bsky.social · May 29

Sorry I haven't posted much science/history/gene therapy recently - will get back on this soon. Am doing some preparation for a big cycle ride next month. And did this practice ride a week ago (ride initially mapped by Chris Ward road.cc/content/blog...). Saw so many nice places.

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Simon Waddington @profsimonwad.bsky.social · May 21

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Simon Waddington @profsimonwad.bsky.social · May 21

I had the pleasure of being at the @asgct.bsky.social in New Orleans last week - fantastic conference, as always, and a welcoming city. I won't post anything about the conference, just three photos I took of a monument facing the Mississippi River. The "Monument to the Immigrant":

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Simon Waddington @profsimonwad.bsky.social · May 15

Well done to Juan Diaz, Sonam Gurung for their awards @asgct.bsky.social 🧬 🥳🍾

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Simon Waddington @profsimonwad.bsky.social · May 3

While on a cycle yesterday I parked up and took this photo. Bluebells and fern. Calming

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Simon Waddington @profsimonwad.bsky.social · Apr 25

As a kid I always thought dandelion clocks were beautiful. They still are.

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Simon Waddington @profsimonwad.bsky.social · Apr 20

I think I've seen this colour after drinking it...

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Simon Waddington @profsimonwad.bsky.social · Apr 14

A new paper hitting the press: Gene therapy for AIPL-1 retinal dystrophy. Almost all kids with this can only perceive light, at best. Getting early will help with vision also neurodevelopment and psychosocial aspects. 🧬 ⭐ 👁

www.thelancet.com/journals/lan...

Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study

Our findings indicate that young children with AIPL1-related retinal dystrophy benefited substantially from subretinal administration of rAAV8.hRKp.AIPL1, with improved visual acuity and functional vi...

www.thelancet.com

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Simon Waddington @profsimonwad.bsky.social · Apr 10

Fascinating and comprehensive review just out, exploring the concept of fetal gene therapy for spinal muscular atrophy academic.oup.com/brain/advanc...

In utero therapy for spinal muscular atrophy: closer to clinical translation

In type 1 spinal muscular atrophy, pathological changes begin during prenatal development, which means that a complete cure is unlikely even with early pos

academic.oup.com

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Simon Waddington @profsimonwad.bsky.social · Apr 10

Brilliant conference and well done to all the @ucltro.bsky.social who did a magnificent job!

UCL Translational Research Office @ucltro.bsky.social · Apr 9

🧬The first @ucl.ac.uk Advanced Therapies Symposium is now underway, #UCL2025AdvTx, bringing together UCL scientists and external partners. @profsimonwad.bsky.social kicks off the event and in the photo we have Prof. Stephanie Schorge for her talk. UCL’s #ATMP Pipelines
bit.ly/42dlq1F

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Reposted by Simon Waddington

UCL Translational Research Office @ucltro.bsky.social · Apr 9

🧬The first @ucl.ac.uk Advanced Therapies Symposium is now underway, #UCL2025AdvTx, bringing together UCL scientists and external partners. @profsimonwad.bsky.social kicks off the event and in the photo we have Prof. Stephanie Schorge for her talk. UCL’s #ATMP Pipelines
bit.ly/42dlq1F

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Simon Waddington @profsimonwad.bsky.social · Mar 27

There are magnets beneath and on top of the bags so the pairs just hold the plastic together to limit their range of motion

Reposted by Simon Waddington

Rob Watts (RobWords) @robwords.bsky.social · Mar 26

Just been laughing my head off at this alternative phonetic alphabet (Alpha, Bravo, Charlie etc.).

You can play around with it here: web.cs.dal.ca/~jamie/Words...

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Simon Waddington @profsimonwad.bsky.social · Mar 26

😂 so good. Gosh I'm so glad you're in my world (with your content, and your directions to other content)

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Simon Waddington @profsimonwad.bsky.social · Mar 26

The magnets were there to limit the amount of kicking. The fetal sheep were kicking the bags, and Alan and team surmised that this was fictive running training. So they had to put the magnets in place to make sure they didn't breach the bags.

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Simon Waddington @profsimonwad.bsky.social · Mar 26

Seems harsh to have Alan Flake's sheep-in-a-bag as a bodyoid. Those were real brainful sheeplings!

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