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rcbagot.bsky.social
Rose Bagot
@rcbagot.bsky.social
530 followers 640 following 16 posts
Neuroscientist in Montréal
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Aug 20
Had a great time visiting USyd! Thanks for hosting me @nataliematosin.bsky.social
nataliematosin.bsky.social
Natalie Matosin @nataliematosin.bsky.social · Aug 17
Wonderful visits, highlighted the need for face-to-face interactions. Cant wait for all our upcoming collabs 🙌 thanks for carving time out to come see us @drcricru.bsky.social @nikosdaskalakis.bsky.social @rcbagot.bsky.social
mindslab.bsky.social
MINDS Lab USYD @mindslab.bsky.social · Aug 17
Grateful to host @drcricru.bsky.social, @nikosdaskalakis.bsky.social & @rcbagot.bsky.social at USYD over the last few months. Your talks highlighted the importance of our field and understanding stress in mental illness. Lots of new ideas for future collaborations. Thanks for coming!
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Reposted by Rose Bagot
carmensandi10.bsky.social
Carmen Sandi @carmensandi10.bsky.social · Aug 20
Happy to announce our new paper in Nature Communications: rdcu.be/eBpGY
We show how CRH in the thalamic reticular nucleus modulates NREM sleep, helping to understand how stress impacts sleep

Congrats to Loredana Cumpana and team, in work led by Simone Astori!
@epfl-brainmind.bsky.social‬
Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus
Nature Communications - Corticotropin-releasing hormone (CRH), known for activating the HPA axis during stress, also acts centrally in the brain. Here, the authors show that CRH modulates thalamic...
rdcu.be
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Reposted by Rose Bagot
martinowk.bsky.social
Keri Martinowich @martinowk.bsky.social · Jun 5
Important 'Matters Arising' from @neurome.bsky.social and Zhaoxia Yu discussing false positives due to multiple comparisons in large-scale gene expression data. I applaud Eran and others who consistently raise these issues for discussion in the community.

www.nature.com/articles/s41...
False positives in study of memory-related gene expression - Nature
Nature - False positives in study of memory-related gene expression
www.nature.com
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · May 23
Sam Weiss speaking #unfiltered at the CAN-ACN EDI session. Make more jobs for Canadians! @canacn.bsky.social
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Reposted by Rose Bagot
cannabrain.bsky.social
Matt Hill @cannabrain.bsky.social · May 20
To all those descending onto Toronto for the @canacn.bsky.social annual meeting, as program chair I hope you have an exciting meeting and enjoy our featured speakers @franklandlab.bsky.social
@yulonglilab.bsky.social @neurovoice.bsky.social @turrigiano.bsky.social and Kerry Ressler #CAN2025
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Reposted by Rose Bagot
kalischlab.bsky.social
KalischLab @kalischlab.bsky.social · May 14
#resilience2025 fantastic speaker line-up: Andrew Holmes, Moh Milad, Dominique de Quervain @dequervain.bsky.social, Birgit Kleim, Rose Bagot @rcbagot.bsky.social, Floris Klumpers, Patricia Molina @pmolinamolina.bsky.social, Marianne Müller, Penny Lewis, Niels Niethard @nniethard.bsky.social, ...
Symposium 2025 | LIR Mainz - Leibniz-Institut für Resilienzforschung
lir-mainz.de
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Reposted by Rose Bagot
franklandlab.bsky.social
Paul Frankland @franklandlab.bsky.social · May 14
Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.

rdcu.be/el18q

A short thread follows for those interested.

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Systems consolidation reorganizes hippocampal engram circuitry
Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...
rdcu.be
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Reposted by Rose Bagot
ivazovkic.bsky.social
Iva Zovkic @ivazovkic.bsky.social · May 14
If you are in Toronto on Tuesday next week, please consider coming to see a FREE public lecture on memory, delivered by the amazing @sjo09.bsky.social and @barense.bsky.social . Tix at this link can-acn.org/meeting-2025... Please repost and hope to see you there!
CAN 2025 Public Lectures: Neuroscience of memory and tools for making our memories stronger – Canadian Association for Neuroscience
can-acn.org
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Reposted by Rose Bagot
mallarchak.bsky.social
Mallar Chakravarty @mallarchak.bsky.social · May 12
Really excited to share this new preprint led by senior PhD student Liz Herrera Portillo who is co-supervised by
@rcbagot.bsky.social
!!

We use longitudinal MRI to show that mice exposed stress undergo sex-specific neuroanatomical reorganization.

www.biorxiv.org/content/10.1...
Whole brain dimensional approach identifies shared and sex-specific networks of stress susceptibility in male and female mice.
Background: Stress is a significant risk factor for depression and anxiety, two highly comorbid disorders with sex differences in symptom presentation and prevalence. The Chronic Variable Stress (CVS)...
www.biorxiv.org
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Apr 18
Looking forward to exploring exciting new directions together!
veronicachelu.bsky.social
Veronica Chelu @veronicachelu.bsky.social · Apr 17
Excited to share that I’ll be starting as a postdoc in @rcbagot.bsky.social’s lab at @mcgilluniversity.bsky.social, studying the neural mechanisms of psychedelics ✨🐁🌀 Grateful for this new adventure into the unknown.
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Reposted by Rose Bagot
eshaaniyer.bsky.social
Eshaan Iyer @eshaaniyer.bsky.social · Apr 15
Thrilled to see this part of my PhD work with @rcbagot.bsky.social now out in @natcomms.nature.com!
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www.nature.com/articles/s41...
Reward integration in prefrontal-cortical and ventral-hippocampal nucleus accumbens inputs cooperatively modulates engagement - Nature Communications
Neural circuit mechanisms underlying integrating information about reward across time are not fully understood. Here, the authors show that common outcome-integration signals from the medial...
www.nature.com
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Reposted by Rose Bagot
alexkwan.bsky.social
Alex Kwan @alexkwan.bsky.social · Jan 6
Our latest work led by @claraliao.bsky.social is a collaboration with the other Kwan lab @kwanlab.bsky.social

We used single-nucleus RNA sequencing to measure transcriptional responses in the mouse medial frontal cortex following a single dose of psilocybin. 🍄 🧠 🧬

www.biorxiv.org/content/10.1...
Schematic of the experiment
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Jan 9
This work was co-led by post-doc Delong Zhou and grad student Heike Schuler- both yet to land in Bsky. Big thank you to some of the funders that supported this work @ludmercentre.bsky.social and @hbhlmcgill.bsky.social
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Jan 9
Taken together, this work points to L5/6NP neurons as a key mediator of psilocybin’s neuroplastic effects. Our findings suggest that integrated 5-HTR signaling mediates acute cell-type specific responses to psilocybin that lead to sustained remodeling of mPFC neuronal network activity.
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Jan 9
Finally, we examined differential gene expression. We find that psilocybin induces cell-type specific transcriptional programs associated with synaptic plasticity, upregulating synaptic genes in L5/6 NP and GABAergic neurons while increasing activity associated genes in L2-6 IT and L6 CT neurons.
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Jan 9
We then examined cell-cell communication and find that psilocybin predominantly alters communication between neurons, suppressing GABAergic neuron signaling to all excitatory neurons.
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Jan 9
This predicts that, psilocybin will primarily activate L5/6 NP neurons while suppressing all other excitatory neurons. We also saw interesting patterns in GABAergic sub-types that predict overall reduction of GABAergic suppression of excitatory neurons.
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Jan 9
We find that L5/6 NP neurons are unique among excitatory neurons in that a large number of these neurons only express genes for excitatory 5-HT receptors, predominantly 5-HT2C. In contrast, all other excitatory neuron types predominantly express uniquely inhibitory 5-HT receptor genes.
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Jan 9
Single-cell sequencing methods are prone to ‘technical drop-outs’ so not optimal for definitively mapping co-expression identity of at the single-cell level. We used spatial transcriptomics data sets to rigorously map cell-type specific expression and co-expression of a wide range of 5-HT receptors.
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Jan 9
Neurons express many 5-HT receptors and psilocin binds these too. We hypothesized that the integrated expression patterns of excitatory and inhibitory 5-HT receptor genes might explain the specific sensitivity of L5/6 NP neurons.
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Jan 9
Using an algorithm for cell-type prioritization, we show that a type of deep layer near projecting neuron – L5/6 NP - is most robustly regulated 24h after psilocybin. Interestingly, these neurons are not enriched for the gene encoding 5-HT2A. So why are they especially sensitive to psilocybin?
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Jan 9
We used single-cell RNA sequencing to discover which mPFC cell types psilocybin impacts in female mice. We chose single cell over single nucleus RNAseq, which although more technically demanding in brain, can more accurately detect cellular state changes and differential transcriptional regulation.
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Jan 9
This differential impact of sex on acute and delayed behavior supports findings suggesting distinct mechanisms mediate the hallucinogenic and neuroplastic effects of psilocybin.
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Jan 9
First, we show that, while acutely, psilocybin similarly induced head twitch response in male and female mice, 24h later, psilocybin only reduced anxiety-like behavior in female mice.
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rcbagot.bsky.social
Rose Bagot @rcbagot.bsky.social · Jan 9
New lab preprint ! There is a lot of excitement about the therapeutic potential of psilocybin but what is the mechanism? A beautiful body of work from @alexkwan.bsky.social shows that PFC plasticity is important. But how does this unfold and in which cell types?

www.biorxiv.org/content/10.1...
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