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RSC Medicinal Chemistry @rscmedchem.rsc.org · 1d

🔓Check out this #OpenAccess Review article by Phanindra Kumar, Poulomi Sengupta and Sudipta Basu discussing small-molecule probes for imaging and impairing the Golgi apparatus in cancer 👏

pubs.rsc.org/en/content/a...

📍IIT Gandhinagar and Indrashil University 🧪

Small-molecule probes for imaging and impairing the Golgi apparatus in cancer

The Golgi apparatus (GA) is one of the most important subcellular organelles controlling protein processing, post-translational modification and secretion. Dysregulation of the GA structure and…

pubs.rsc.org

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 2d

📢Calling all medicinal chemistry researchers from academia and industry 📢

Nominations for the 2026 @rscmedchem.rsc.org Emerging Investigator Lectureship are open, and we’re excited to receive them!

Deadline to nominate is 31 October 2025 ⏰

More info here: www.rsc.org/standards-an...

#chemsky 🧪

Promotional graphic for the RSC Medicinal Chemistry Emerging Investigator Lectureship open to nominations.

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 3d

Take a look at work by Jin-Bu Xu, Feng Gao & co on the synthesis and anti-proliferative activity of 3-aryl-evodiamine derivatives⬇️

pubs.rsc.org/en/content/a...

📍Southwest Jiaotong University 🧪

Design, synthesis and anti-proliferative activity of 3-aryl-evodiamine derivatives

Evodiamine and its analogues have received significant attention owing to their antitumor activity. In this work, Pd-catalyzed Suzuki–Miyaura coupling was employed as a key reaction to diversify the…

pubs.rsc.org

RSC Medicinal Chemistry @rscmedchem.rsc.org · 5d

Don't miss recent work by @ritika7gautam.bsky.social & co on the development of next-generation gold(I)-NHC anticancer agents, particularly for treating apoptosis-resistant lung cancers👏

pubs.rsc.org/en/content/a...

📍IIT Kanpur 🧪

Rational design of gold(I)-NHC complexes as anticancer agents: induction of necroptosis and paraptosis in lung adenocarcinoma

Gold(i)-NHC complexes bearing sterically demanding ligands remain largely underexplored as anticancer agents. In this study, we rationally designed and synthesized a series of gold(i)-NHC complexes…

pubs.rsc.org

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 8d

Be sure to read the latest work by Martin Hemmerling and colleagues where they optimised a series of BET PROTACs towards inhaled route of delivery furnished PROTACs with a picomolar degradation potency and full BRD4 degradation💡

pubs.rsc.org/en/content/a...

📍 @astra-zeneca.bsky.social 🧪

Topical BET PROTACs for locally restricted protein degradation in the lung

Proteolysis targeting chimeras (PROTACs) have been studied extensively to optimize their oral bioavailability. Based on Lipinski's and Veber's rules, molecular weight, log P, log D, the number of…

pubs.rsc.org

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 10d

🔓Explore this #OpenAccess Review article by Ana Jug and Janez Ilaš which focuses on ATP-competitive inhibition in cancer therapy beyond kinases, highlighting recent advances and challenges in the field👇

pubs.rsc.org/en/content/a...

📍University of Ljubljana

ATP-competitive inhibitors for cancer treatment – kinases and the world beyond

Adenosine 5′-(tetrahydrogen triphosphate) (ATP), an essential molecule for cellular energy transfer, plays a crucial role in various biochemical processes, including protein folding, DNA repair and…

pubs.rsc.org

RSC Medicinal Chemistry @rscmedchem.rsc.org · 11d

We are delighted to announce that Professor Christina Chai from National University of Singapore has joined the RSC Medicinal Chemistry Editorial Board as an Associate Editor🎉

Read our blog post to find out more about Christina 👉 rsc.li/4pJ88oR

#chemsky 🧪

RSC Medicinal Chemistry promotional graphic for Professor Christina Chai, our new Associate Editor.

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 12d

Do you know an early career researcher working independently in the field of medicinal chemistry and drug discovery⁉

Why not nominate them for our 2026 Emerging Investigator Lectureship!

Nominations close 31 October 2025🚨

More details here: www.rsc.org/standards-an...

🧪

RSC Medicinal Chemistry @rscmedchem.rsc.org · 15d

Be sure to read the latest work from Kazuya Matsuo, Nobuyuki Tamaoki & co on report a photoswitchable CENP-E inhibitor that is controllable with low-energy blue-green light illumination, seen in our Photoswitches & Photopharmacology collection💡

pubs.rsc.org/en/content/a...

📍Hokkaido University 🧪

A photoswitchable CENP-E inhibitor with single blue-green light to control chromosome positioning in mitotic cells

Reversibly photoswitchable chemical tools have aided in the development of novel approaches in the biomedical field. The visible region of light should be ideal for the biological application of this…

pubs.rsc.org

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 16d

🔓Read #OpenAccess work by Sergii Afonin, Igor V. Komarov & co on the in vitro evaluation of immunogenic potential of gramicidin S and photocontrolled analogues, in our Photoswitches & Photopharmacology collection💡
pubs.rsc.org/en/content/a...
📍Taras Shevchenko National University of Kyiv, @kit.edu 🧪

In vitro evaluation of the immunogenic potential of gramicidin S and its photocontrolled analogues

Three hallmarks of ICD (immunogenic cell death), release of adenosine triphosphate (ATP), release of high mobility group box 1 protein, and calreticulin exposure on the cell surface, were studied…

pubs.rsc.org

RSC Medicinal Chemistry @rscmedchem.rsc.org · 16d

Work from Subhas Samanta and colleagues on photoswitchable Stat3 inhibitors and their anticancer activity against 2D/3D breast cancer cell cultures is featured in our Photoswitches & Photopharmacology collection, read more here👇

pubs.rsc.org/en/content/a...

📍 University of Calcutta 🧪

Photoswitchable Stat3 inhibitors: design, synthesis and anticancer activity study on 2D and 3D breast cancer cell cultures

Stat3 protein is known to be hyperactive in many human cancer cells, including leukaemia, lymphoma, breast, ovarian, lung, and prostate cancer cells. The treatment of most of these cancer types…

pubs.rsc.org

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 17d

Be sure to read recent work by Maikel Wijtmans, Rob Leurs & co on the synthesis of photoswitchable desloratadine ligands for histamine H1 receptor photopharmacology, as seen in our Photoswitches & Photopharmacology collection💡

pubs.rsc.org/en/content/a...

📍 @vuamsterdam.bsky.social 🧪

Design and synthesis of photoswitchable desloratadine ligands for histamine H1 receptor photopharmacology

Despite the pharmacological relevance of the histamine H1 receptor (H1R), the second most therapeutically targeted G protein-coupled receptor (GPCR), an effective photoswitchable ligand to optically…

pubs.rsc.org

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 17d

🔓Check out this #OpenAccess Review in our Photoswitches & Photopharmacology collection by P. K. Hashim & co discussing recent progress of using photomedicine for approaches in precision medicine and unprecedented treatment methods💡

pubs.rsc.org/en/content/a...

📍Hokkaido University

Conceptual expansion of photomedicine for spatiotemporal treatment methods

Photomedicine has evolved from basic phototherapy to a broad range of light-based technologies to achieve precise and minimally invasive therapeutic outcomes. Recent advances in light sources, photoch...

pubs.rsc.org

Reposted by RSC Medicinal Chemistry

Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 18d

Don't miss the Editorial for the joint collection on Photoswitches & Photopharmacology from the guest editors🔦🔽
pubs.rsc.org/en/content/a...

Introduction to photoswitches and photopharmacology

Martina Cacciarini, G. Andrew Woolley, Wiktor Szymanski and Nadja A. Simeth introduce the Organic & Biomolecular Chemistry and RSC Medicinal Chemistry cross-journal themed collection on ‘Photoswitches...

pubs.rsc.org

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Reposted by RSC Medicinal Chemistry

Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 18d

📢 @orgbiomolchem.rsc.org & @rscmedchem.rsc.org are delighted to share our latest themed issue on Photoswitches & Photopharmacology, guest edited by Martina Cacciarini, @nadjasimeth.bsky.social, Wiktor Szymanski & Andrew Woolley! #chemsky

Explore the collection here🔽
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RSC Medicinal Chemistry @rscmedchem.rsc.org · 19d

Take a look at this Review article by Katrine Qvortrup & co discussing advances in developing small molecules targeting three virulence categories, a promising strategy to combat antibiotic resistant infections👀

pubs.rsc.org/en/content/articlelanding/2025/md/d5md00272a

📍Denmark TU 🧪

Small molecule antipathogenic agents against Staphylococcus aureus infections

Staphylococcus aureus, a Gram-positive bacterium, is a pathogen capable of infecting nearly all host tissues, causing severe morbidity and mortality. Antibiotic resistant S. aureus are abundant, and…

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RSC Medicinal Chemistry @rscmedchem.rsc.org · 22d

🔓The front cover of issue 9 is #OpenAccess work by Khondaker Miraz Rahman, Chris Pepper & co on a PBD-based PROTAC selectively degrading NF-κB subunit for RelA/p65-dependent tumour treatments, read it here👀

pubs.rsc.org/en/content/a...

📍 @kingscollegelondon.bsky.social, @bsmsmedschool.bsky.social🧪

RSC Medicinal Chemistry outside front cover for vol 16, issue 9.

RSC Medicinal Chemistry @rscmedchem.rsc.org · 23d

In case you missed it: Nominations for the 2026 @rscmedchem.rsc.org Emerging Investigator Lectureship are now open👀

⌛Deadline for nominations is 31 October 2025!

Details about how to nominate are here: www.rsc.org/standards-an...

🧪

Promotional graphic for the RSC Medicinal Chemistry Emerging Investigator Lectureship open for nominations.

RSC Medicinal Chemistry @rscmedchem.rsc.org · Sep 11

Hi Andrea, please find the correct link, here: www.rsc.org/standards-an...

RSC Medicinal Chemistry Emerging Investigator Lectureship

Recognising early career researchers in academia or industry, who have made significant contributions to medicinal chemistry and drug discovery.

www.rsc.org

RSC Medicinal Chemistry @rscmedchem.rsc.org · Sep 4

We’re excited to announce that nominations for our 2026 Emerging Investigator Lectureship are now open📢

Details about how to nominate: www.rsc.org/standards-an...

We’re looking for up-and-coming researchers in drug discovery within 12 yrs of their PhD.

Nominate before 31 October 2025!
#chemsky 🧪

Promotional graphic for the 2026 RSC Medicinal Chemistry Emerging Investigator Lectureship nominations.

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RSC Medicinal Chemistry @rscmedchem.rsc.org · Sep 3

🔓Check out recent #OpenAccess work by Nils Metzler-Nolte and colleagues on a facile synthetic route, using click-able azido linkers, for di-pyridyl-thiosemicarbazone antibody–drug conjugates💡

pubs.rsc.org/en/content/a...

📍 @ruhr-uni-bochum.de 🧪

Synthesis and biological evaluation of thiosemicarbazone-based antibody–drug conjugates

Metal chelators belonging to the di-pyridyl-thiosemicarbazone (DpTs) class have shown great promise as adjuvant therapeutics for treating cancer, with DpC and Dp44mT emerging as the lead candidates.…

pubs.rsc.org

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Reposted by RSC Medicinal Chemistry

Emily Cuffin-Munday @emilyc-m.bsky.social · Sep 1

This week I am attending the EFMC-ASMC in Porto, representing @rscmedchem.rsc.org

If you see me, come and say hello 👋 and keep a look out for our flyers for more information on the journal!

#efmcasmc

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RSC Medicinal Chemistry @rscmedchem.rsc.org · Sep 1

🔓Read recent #OpenAccess work by Daohong Zhou, Guangrong Zheng & co on the potential of CRBN-recruiting Bcl-xL degraders as promising anticancer agents with improved efficacy and manageable platelet toxicity🔥

pubs.rsc.org/en/content/a...

📍 @ufresearch.bsky.social 🧪

Discovery of PZ671, a highly potent and in vivo active CRBN-recruiting Bcl-xL degrader

The conversion of conventional inhibitors of Bcl-xL, a key anti-apoptotic protein, to PROTAC degraders has shown significant promise, particularly in mitigating the on-target thrombocytopenia…

pubs.rsc.org

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RSC Medicinal Chemistry @rscmedchem.rsc.org · Aug 29

🔓Be sure to read this recent #OpenAccess work by Nils Metzler-Nolte & co: "Glycosidase-activated prodrugs of a cytotoxic iron chelator for targeted cancer therapy"👀

pubs.rsc.org/en/content/a...

📍@ruhr-uni-bochum.de 🧪

Glycosidase-activated prodrugs of a cytotoxic iron chelator for targeted cancer therapy

New glycoside-prodrugs based on the iron chelator deferasirox were designed. Selective enzymatic activation by glycosidases was observed within 24 hours, accompanied by cancer cell-selective…

pubs.rsc.org

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RSC Medicinal Chemistry @rscmedchem.rsc.org · Aug 27

📢Highlight your work on the cover of RSC Medicinal Chemistry!

We are looking for vibrant, eye-catching artwork to feature on our upcoming covers. Check out some of our previous covers and the benefits you receive for them👇

Interested in amplifying your research with a cover? Please let us know!

Promotional graphic for RSC Medicinal Chemistry covers.

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