RSC Medicinal Chemistry
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rscmedchem.rsc.org
RSC Medicinal Chemistry
@rscmedchem.rsc.org
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The journal for research and review articles in medicinal chemistry and related drug discovery science.

Published by @rsc.org 🌐 Website: rsc.li/rscmedchem
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rscmedchem.rsc.org
🔓Be sure to read this #OpenAccess article from Philip Reigan et al. @cuanschutz.bsky.social investigating the structural requirements of 3,5-substituted oxindoles that determine selective AMPK or GSK3β inhibition #medchem 🧪

Find their full report👇
The structural requirements of 3,5-substituted oxindoles that determine selective AMPK or GSK3β inhibition
AMP-activated protein kinase (AMPK) acts as a central cellular sensor at the interface of metabolic and signaling networks, that supports cell survival in energetically unfavorable environments. Due…
pubs.rsc.org
February 11, 2026 at 3:05 PM
rscmedchem.rsc.org
Don't miss research by Yu Zhang, Jun Luo & co. at Nanjing University of Science & Technology in our latest issue using peripheral tailoring of pentacene to develop next-generation organic sonosensitizers for cancer sonodynamic therapy #medchem 🧪

Check it out here🔽
Peripheral tailoring of pentacene: developing next-generation organic sonosensitizers for cancer sonodynamic therapy
Sonodynamic therapy (SDT) is an innovative, non-invasive, and effective method for cancer treatment. However, exploring sonosensitizers with high sonosensitivity and biosafety remains a significant…
pubs.rsc.org
February 9, 2026 at 9:30 AM
rscmedchem.rsc.org
Check out research by Trevor J. Kilpatrick, Jonathan B. Baell et al. from @monashuniversity.bsky.social reporting fluorinated pyrimidine 5-carboxamides as potential tools for MERTK targeted fluorine-18-PET-radioligand development #medchem 🧪

Read in full below👇
Fluorinated pyrimidine 5-carboxamides as potential tools for MERTK targeted fluorine-18-PET-radioligand development
MER tyrosine kinase (MERTK) is highly expressed on the protective and reparative phenotype of microglia, which is in response to neuroregeneration following the neuronal damage induced by multiple…
pubs.rsc.org
February 6, 2026 at 10:02 AM
rscmedchem.rsc.org
🔓Take a look in our latest issue at this #OpenAccess review by Franck Amblard, Raymond Schinazi & co. providing an overview of prodrug strategies in developing antiviral nucleoside analogs #medchem 🧪

📍Emory University
Prodrug strategies in developing antiviral nucleoside analogs
Prodrug strategies are used to enhance the physicochemical and pharmaceutical properties of drug candidates that may not be suitable for specific delivery or are limited by formulation options. A…
pubs.rsc.org
February 3, 2026 at 3:29 PM
rscmedchem.rsc.org
🔓Be sure to read #OpenAccess research, part of our 5th Anniversary collection, from Jean-Louis Reymond et al. @reymondgroup.bsky.social at @unibe.ch in our latest issue diversifying the triquinazine scaffold of a Janus kinase inhibitor #medchem 🧪

Find the full report👇
Diversifying the triquinazine scaffold of a Janus kinase inhibitor
The exploration of novel three-dimensional scaffolds remains essential for expanding chemical space and discovering new bioactive molecules. Here, we describe a robust synthetic strategy that enables…
pubs.rsc.org
February 2, 2026 at 12:02 PM
rscmedchem.rsc.org
Don't miss this review in our latest issue by Natalie Holmberg-Douglas & co. @bristolmyerssquibb.bsky.social looking at the recent advances in glutarimide chemistry for cereblon-mediated targeted protein degradation #medchem 🧪

Check it out in full here🔽
Recent advances in glutarimide chemistry for cereblon-mediated targeted protein degradation: developments in synthesis and diversification
The field of targeted protein degradation has garnered significant attention over the past two decades, highlighted by the FDA approval of several therapeutics and the entry of numerous drug…
pubs.rsc.org
January 30, 2026 at 2:34 PM
rscmedchem.rsc.org
📢Our first issue of 2026 is now online!

🔓Check out the #OpenAccess article behind the cover by Naoko Yoshizawa-Sugata, Hisao Masai, Yoko Yamakoshi & co. @ethz.ch reporting new water-soluble cationic porphyrins with enhanced phototoxicity to cancer cell lines #medchem

pubs.rsc.org/en/content/a...
January 28, 2026 at 3:10 PM
Reposted by RSC Medicinal Chemistry
shepherdlabkent.bsky.social
Here is our exciting new work on madecassic acid inhibiting bacterial respiration @kent.ac.uk @cjserpell.bsky.social @rscmedchem.rsc.org
doi.org/10.1039/D5MD...
Investigating the role of cytochrome bd oxidases in the antibacterial activity of madecassic acid and derivatives thereof
Natural products are valuable starting points for drug discovery, although individual modes of action are often difficult to pin down. Ursanes such as madecassic acid have been shown to have antibacte...
doi.org
January 22, 2026 at 5:41 PM
Reposted by RSC Medicinal Chemistry
docklahn.bsky.social
Fantastic line up at the “34th GP2A 2026 Conference on Medicinal Chemistry 2026” #GP2A2026 in Gothenburg, Sweden from 26th- 28th of August 2026. Registration will open soon at the end of January 2026. #MedChem #ChemBio #youngresearcher @naturvetenskap.bsky.social
January 16, 2026 at 10:00 PM
rscmedchem.rsc.org
Take a look at recent work by Jhuma Bhadra, Santanu Bhattacharya and colleagues where they present a promising therapeutic strategy for treating persistent infections caused by both Gram-positive and Gram-negative pathogens, including co-infective scenarios👏

pubs.rsc.org/en/content/a...

📍IACS 🧪
An innovative strategy to treat pathogenic biofilm-associated infections in vitro and in vivo using guanidinium-linked neomycin lipidation
To overcome neomycin's limited efficacy against complex Gram-positive and Gram-negative co-infections, we have developed a novel guanidinium-linked neomycin–lipid conjugate (guanidino Neo-lipid).…
pubs.rsc.org
December 24, 2025 at 9:45 AM
rscmedchem.rsc.org
🔓Don't miss this #OpenAccess work by Moustafa T. Gabr & co on the discovery of a first-in-class SLIT2 binder disrupting the SLIT2/ROBO1 axis via DNA-encoded library screening⬇️

pubs.rsc.org/en/content/a...

📍 @weillcornell.bsky.social 🧪
Discovery of a first-in-class SLIT2 binder disrupting the SLIT2/ROBO1 axis via DNA-encoded library (DEL) screening
The SLIT2/ROBO1 signaling axis plays a critical role in neural development, immune regulation, and tumor progression, including glioblastoma. However, small molecule inhibitors targeting this…
pubs.rsc.org
December 22, 2025 at 2:03 PM
rscmedchem.rsc.org
🔓Don't miss this #OpenAccess article by @gerhardecker.bsky.social and colleagues, using KNIME and ChEMBL data to show how common bioisosteric swaps predictably shift off‑target potencies 👇

pubs.rsc.org/en/content/a...

📍 @univie.ac.at 🧪
Data-driven assessment of bioisosteric replacements and their influence on off-target activity profiles
Bioisosterism, a fundamental concept in medicinal chemistry, involves the substitution of chemical groups with structural analogs that preserve similar physicochemical properties while potentially…
pubs.rsc.org
December 19, 2025 at 10:15 AM
rscmedchem.rsc.org
Explore this Review by Jialin Guo, Chun Hu, Junhai Xiao & co discussing the recent progress in finding inhibitors targeting clathrin-mediated endocytosis👏

pubs.rsc.org/en/content/a...

📍State Key Laboratory of National Security Specially Needed Medicines & Shenyang Pharmaceutical University 🧪
Targeting clathrin-mediated endocytosis: recent advances in inhibitor development, mechanistic insights, and therapeutic prospects
Clathrin-mediated endocytosis (CME) is a critical pathway for cellular uptake of metabolites, hormones, and pathogens, including viruses. Recent advances in understanding CME mechanisms and…
pubs.rsc.org
December 17, 2025 at 9:01 AM
rscmedchem.rsc.org
🔓Read this #OpenAccess Opinion article by Prabir Kumar Gharai & co on how the use of peptoid-based hydrogels could progress neuroregenerative therapies💡

pubs.rsc.org/en/content/a...

📍 @okstate.edu 🧪
Sequence-controlled peptoid hydrogels for neuronal trans-differentiation: a synthetic biomaterials approach in future neuroregenerative research
Peptide-based hydrogels stimulate stem cell differentiation into neurons, improve neuroprotection, and aid in spinal cord/brain injury repair by moderating inflammatory responses and activating…
pubs.rsc.org
December 15, 2025 at 10:00 AM
rscmedchem.rsc.org
Our inside front cover is work by Renato J. S. Oliveira, Dennis Russowsky & co on synthesising fluorescent dihydropyridine–dihydropyrimidinone hybrids and their inhibition of protein kinases for anticancer applications, take a look⬇️

pubs.rsc.org/en/content/a...

📍UFRGS and Barretos Cancer Hospital🧪
RSC Medicinal Chemistry inside front cover for vol 16, issue 12.
December 12, 2025 at 2:01 PM
rscmedchem.rsc.org
This month's front cover showcases a Review article by Paul Groundwater & co discussing structural qualities of β-lactamase enzymes and the efficacy of emerging β-lactamase inhibitors against clinically significant carbapenemases, read it here👀

pubs.rsc.org/en/content/a...

📍 @sydney.edu.au 🧪
RSC Medicinal Chemistry outside front cover for vol 16, issue 12.
December 12, 2025 at 10:00 AM
rscmedchem.rsc.org
📢Our last issue of 2025 is now online! Read it here👇

pubs.rsc.org/en/journals/...
RSC Medicinal Chemistry outside front cover for vol 16, issue 12. RSC Medicinal Chemistry inside front cover for vol 16, issue 12.
December 11, 2025 at 1:32 PM
rscmedchem.rsc.org
Recently added to the RSC Medicinal Chemistry Editor's Choice collection are Hayley Binch's chosen articles!

Be sure to read our blog to see what she chose and why 👉 blogs.rsc.org/md/2025/11/25/editors-choice-collection-hayley-binch

And scan the QR code to see our collection as it grows👀 🧪
Promotional graphic for the RSC Medicinal Chemistry Editor's Choice collection.
December 9, 2025 at 12:17 PM
Reposted by RSC Medicinal Chemistry
rscchembio.rsc.org
We are pleased to sponsor Poster Prizes at the 34th GP2A Medicinal Chemistry Conference with @rscmedchem.rsc.org & @rscpharmaceutics.rsc.org

📅26-28 Aug 2026
📍Department of Chemistry and Molecular Biology, University of Gothenburg
👉Visit gp2a.org/index.php/gp...

#GP2A #MedChem @omc-gu.bsky.social
December 5, 2025 at 11:53 AM
Reposted by RSC Medicinal Chemistry
lucalaraia.bsky.social
Happy to share our latest paper in @rscmedchem.rsc.org as part of their 5-year anniversary collection! We carried out comprehensive SAR analysis of natural and synthetic analogues of the #Schweinfurthins, highly potent and selective inhibitors of #OSBP! (1/n) pubs.rsc.org/en/content/a...
Schweinfurthins and their analogues are highly selective cellular probes for oxysterol-binding protein (OSBP)
Schweinfurthins (SWs) are natural products isolated from the plant genus Macaranga which display a unique cytotoxicity profile in human cancer cell lines with low nanomolar potency. Their known target...
pubs.rsc.org
December 2, 2025 at 1:17 PM
rscmedchem.rsc.org
2025 marks our journal's 5th Anniversary🎉

To celebrate, we have launched a collection aimed to highlight key advances in medicinal chemistry and drug discovery research in the last 5 years, as well as current breakthroughs and future prospects.

Read it here👉 pubs.rsc.org/en/journals/...
#chemsky🧪
RSC Medicinal Chemistry promotional graphic for the 5th Anniversary collection.
December 2, 2025 at 11:05 AM
rscmedchem.rsc.org
🔓Read #OpenAccess work by Vipul Navinchandra Panchal, @ruthbrenk.bsky.social & co where they demonstrate the effective use of biolayer interferometry to investigate RNA–small molecule interactions using three different riboswitches💡

pubs.rsc.org/en/content/a...

📍 @unibergen.bsky.social 🧪
Discovery of RNA-binding fragments using biolayer interferometry
Structured RNAs are increasingly explored as novel pharmacological targets for a range of diseases. Therefore, evaluating methods for RNA-focused hit discovery is crucial. Biolayer Interferometry…
pubs.rsc.org
November 26, 2025 at 9:45 AM
rscmedchem.rsc.org
Don't miss recent work by Yeong-Jiunn Jang, Yang-Chang Wu & co on the synthesis and anti-cancer biological evaluation of a novel protoapigenone analogue, WYC-241⬇️

pubs.rsc.org/en/content/a...

📍China Medical University 🧪
Synthesis and anti-cancer biological evaluation of a novel protoapigenone analogue, WYC-241
Natural products are an important source for developing anti-cancer agents. Previously, we identified the anti-cancer flavonoid protoapigenone from Thelypteris torresiana (Gaud.) and synthesized its…
pubs.rsc.org
November 24, 2025 at 10:01 AM
rscmedchem.rsc.org
Be sure to read the latest Review by Zahoor Ahmad & co discussing ultrashort cationic β-peptides as promising antimicrobial therapeutics👏

pubs.rsc.org/en/content/a...

📍CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM) 🧪
The rise of ultrashort cationic β-peptides as promising antimicrobial therapeutics
Antimicrobial resistance (AMR) is a mounting global health crisis demanding novel, sustainable therapeutic strategies beyond traditional antibiotics. Ultra-short cationic β-peptides have emerged as a…
pubs.rsc.org
November 21, 2025 at 10:00 AM
rscmedchem.rsc.org
🔓Read this #OpenAccess Opinion article by Louise Sternicki and our Associate Editor, Sally-Ann Poulsen, where they discuss the role of native mass spectrometry (nMS) to gain important insights to guide drug discovery and development👇

pubs.rsc.org/en/content/a...

📍 @griffith.edu.au 🧪
Toward routine utilisation of native mass spectrometry as an enabler of contemporary drug development
As therapeutic modalities increasingly diversify, the need for biophysical tools for routine characterisation of the underlying biomolecular targets and their noncovalent interactions is growing. In…
pubs.rsc.org
November 19, 2025 at 9:30 AM