RSC Chemical Biology
@rscchembio.rsc.org
A gold open-access journal focused on innovative chemical biology tools and their application in exploring and manipulating molecular biological processes.
🌐 Website: rsc.li/rscchembio Published by @rsc.org
🌐 Website: rsc.li/rscchembio Published by @rsc.org
#RSCChemBio Issue 12 is now online and #openaccess!
In this issue: photoresponsive molecular tweezers, probing the role of LytG in cell wall metabolism, peroxidase-based proximal protein labelling, and much more!
📰Read the full issue here: pubs.rsc.org/en/journals/...
In this issue: photoresponsive molecular tweezers, probing the role of LytG in cell wall metabolism, peroxidase-based proximal protein labelling, and much more!
📰Read the full issue here: pubs.rsc.org/en/journals/...
November 27, 2025 at 11:16 AM
#RSCChemBio Issue 12 is now online and #openaccess!
In this issue: photoresponsive molecular tweezers, probing the role of LytG in cell wall metabolism, peroxidase-based proximal protein labelling, and much more!
📰Read the full issue here: pubs.rsc.org/en/journals/...
In this issue: photoresponsive molecular tweezers, probing the role of LytG in cell wall metabolism, peroxidase-based proximal protein labelling, and much more!
📰Read the full issue here: pubs.rsc.org/en/journals/...
🧬New article out now!
K Onizuka, F Nagatsugi et al introduce novel RNA-binding molecular probes by conjugating thiazole orange derivatives to G-clamp for applications in Fluorescent Indicator Displacement (FID) assays.
➡️Read the full paper:
K Onizuka, F Nagatsugi et al introduce novel RNA-binding molecular probes by conjugating thiazole orange derivatives to G-clamp for applications in Fluorescent Indicator Displacement (FID) assays.
➡️Read the full paper:
RNA-binding fluorogenic probes: G-clamp conjugated with a thiazole orange derivative for screening RNA-binding small molecules
RNA has emerged as an attractive target for drug discovery, increasing the importance of methods for identifying RNA-binding small molecules. Fluorescent indicator displacement (FID) assays are commonly used for screening such molecules. However, because fluorescent indicators detect hit compounds through competiti
doi.org
November 25, 2025 at 2:45 PM
🧬New article out now!
K Onizuka, F Nagatsugi et al introduce novel RNA-binding molecular probes by conjugating thiazole orange derivatives to G-clamp for applications in Fluorescent Indicator Displacement (FID) assays.
➡️Read the full paper:
K Onizuka, F Nagatsugi et al introduce novel RNA-binding molecular probes by conjugating thiazole orange derivatives to G-clamp for applications in Fluorescent Indicator Displacement (FID) assays.
➡️Read the full paper:
📣Present your research at the 29th Enzyme Mechanisms Conference (4 – 8 Jan 2026)
🧪RSC Chem. Biol. is proud to sponsor a poster prize!
📅Poster abstracts due by 29th November 2025 – submit now!
➡️www.enzymemechanisms...
#enzyme #ChemicalBiology
🧪RSC Chem. Biol. is proud to sponsor a poster prize!
📅Poster abstracts due by 29th November 2025 – submit now!
➡️www.enzymemechanisms...
#enzyme #ChemicalBiology
EMC2026 29th Enzyme Mechanisms Conference
Since their inception in 1969, Enzyme Mechanisms Conferences have brought together academic and industrial scientists to discuss new ideas at the forefront of mechanistic enzymology. EMC2024 will take place from the 3rd-7th of January 2024 in Naples FL.
www.enzymemechanismsconference.org
November 21, 2025 at 6:59 PM
📣Present your research at the 29th Enzyme Mechanisms Conference (4 – 8 Jan 2026)
🧪RSC Chem. Biol. is proud to sponsor a poster prize!
📅Poster abstracts due by 29th November 2025 – submit now!
➡️www.enzymemechanisms...
#enzyme #ChemicalBiology
🧪RSC Chem. Biol. is proud to sponsor a poster prize!
📅Poster abstracts due by 29th November 2025 – submit now!
➡️www.enzymemechanisms...
#enzyme #ChemicalBiology
Reposted by RSC Chemical Biology
📢Nominations for the @rsc.org 2026 Prizes are now open and close on 14 January 2026 - consider making a nomination to our Horizon Prizes, Inclusion and Diversity Prize, Research & Innovation Prizes and Volunteer Recognition Prizes 💫
🔗https://www.rsc.org/standards-and-recognition/prizes/
🔗https://www.rsc.org/standards-and-recognition/prizes/
November 19, 2025 at 9:49 AM
📢Nominations for the @rsc.org 2026 Prizes are now open and close on 14 January 2026 - consider making a nomination to our Horizon Prizes, Inclusion and Diversity Prize, Research & Innovation Prizes and Volunteer Recognition Prizes 💫
🔗https://www.rsc.org/standards-and-recognition/prizes/
🔗https://www.rsc.org/standards-and-recognition/prizes/
📰 New article from Jani Bolla, Carol Robinson et al. from @ox.ac.uk
Evaluating the feasibility of peptidiscs for native mass-spectrometry analysis and structural characterisation of membrane proteins and their assemblies.
👉 Read more at: doi.org/10.1039/D5CB...
Evaluating the feasibility of peptidiscs for native mass-spectrometry analysis and structural characterisation of membrane proteins and their assemblies.
👉 Read more at: doi.org/10.1039/D5CB...
Native mass spectrometry of membrane proteins reconstituted in peptidiscs
Membrane proteins and lipids are essential for a wide range of cellular processes, making their structural characterisation essential for understanding biological function. However, the amphipathic na...
doi.org
November 19, 2025 at 9:55 AM
📰 New article from Jani Bolla, Carol Robinson et al. from @ox.ac.uk
Evaluating the feasibility of peptidiscs for native mass-spectrometry analysis and structural characterisation of membrane proteins and their assemblies.
👉 Read more at: doi.org/10.1039/D5CB...
Evaluating the feasibility of peptidiscs for native mass-spectrometry analysis and structural characterisation of membrane proteins and their assemblies.
👉 Read more at: doi.org/10.1039/D5CB...
Fresh from Tom Wennekes et al., from @utrechtuniversity.bsky.social
New ortho-quinone methide probes selectively label viral and bacterial neuraminidases, enabling imaging of these key virulence enzymes in their native environment.
👉 Read the full paper here: doi.org/10.1039/D5CB...
New ortho-quinone methide probes selectively label viral and bacterial neuraminidases, enabling imaging of these key virulence enzymes in their native environment.
👉 Read the full paper here: doi.org/10.1039/D5CB...
November 14, 2025 at 10:45 AM
Fresh from Tom Wennekes et al., from @utrechtuniversity.bsky.social
New ortho-quinone methide probes selectively label viral and bacterial neuraminidases, enabling imaging of these key virulence enzymes in their native environment.
👉 Read the full paper here: doi.org/10.1039/D5CB...
New ortho-quinone methide probes selectively label viral and bacterial neuraminidases, enabling imaging of these key virulence enzymes in their native environment.
👉 Read the full paper here: doi.org/10.1039/D5CB...
Fresh from Yogo Sakakibara et al.!
"Comparative aptamer profiling reveals cell surface remodeling under oncogenic signaling — including the unexpected surface appearance of a mitochondrial protein."
👉Read the full article here: doi.org/10.1039/D5CB...
"Comparative aptamer profiling reveals cell surface remodeling under oncogenic signaling — including the unexpected surface appearance of a mitochondrial protein."
👉Read the full article here: doi.org/10.1039/D5CB...
November 12, 2025 at 12:10 PM
Fresh from Yogo Sakakibara et al.!
"Comparative aptamer profiling reveals cell surface remodeling under oncogenic signaling — including the unexpected surface appearance of a mitochondrial protein."
👉Read the full article here: doi.org/10.1039/D5CB...
"Comparative aptamer profiling reveals cell surface remodeling under oncogenic signaling — including the unexpected surface appearance of a mitochondrial protein."
👉Read the full article here: doi.org/10.1039/D5CB...
New in RSC Chemical Biology:
Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations by Martin Fascione et al., from @york.ac.uk
Read the full paper here👉 doi.org/10.1039/D5CB...
Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations by Martin Fascione et al., from @york.ac.uk
Read the full paper here👉 doi.org/10.1039/D5CB...
November 5, 2025 at 8:04 AM
New in RSC Chemical Biology:
Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations by Martin Fascione et al., from @york.ac.uk
Read the full paper here👉 doi.org/10.1039/D5CB...
Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations by Martin Fascione et al., from @york.ac.uk
Read the full paper here👉 doi.org/10.1039/D5CB...
New research by Weijun Shen, Muyu Xu et al. at Shenzhen Bay Laboratory:
"Cell-based high-throughput screening using a target–NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein"
Read the full paper here👉 doi.org/10.1039/D5CB...
"Cell-based high-throughput screening using a target–NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein"
Read the full paper here👉 doi.org/10.1039/D5CB...
October 29, 2025 at 12:32 PM
New research by Weijun Shen, Muyu Xu et al. at Shenzhen Bay Laboratory:
"Cell-based high-throughput screening using a target–NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein"
Read the full paper here👉 doi.org/10.1039/D5CB...
"Cell-based high-throughput screening using a target–NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein"
Read the full paper here👉 doi.org/10.1039/D5CB...
Reposted by RSC Chemical Biology
Looking forward to today's #EMBOEpitrans by @events.embl.org! Get in touch or meet me in tomorrow's "Meet the Editors" session if you'd like to find out about @rscchembio.rsc.org and @molecularomics.rsc.org
October 28, 2025 at 7:07 AM
Looking forward to today's #EMBOEpitrans by @events.embl.org! Get in touch or meet me in tomorrow's "Meet the Editors" session if you'd like to find out about @rscchembio.rsc.org and @molecularomics.rsc.org
Reposted by RSC Chemical Biology
Looking forward to attending the @embo.org | @embl.org "The Epitranscriptome" meeting next week, on behalf of @rscchembio.rsc.org! I'll be taking part in the "Meet the Editor" session during Tuesday's lunch break. Feel free to message me to set up a meeting, or find me any time during the event.
October 21, 2025 at 3:45 PM
Looking forward to attending the @embo.org | @embl.org "The Epitranscriptome" meeting next week, on behalf of @rscchembio.rsc.org! I'll be taking part in the "Meet the Editor" session during Tuesday's lunch break. Feel free to message me to set up a meeting, or find me any time during the event.
New from @llparker100.bsky.social et al. from @uminnpress.bsky.social
Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays
Read the full paper👉 doi.org/10.1039/D5CB...
Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays
Read the full paper👉 doi.org/10.1039/D5CB...
October 21, 2025 at 2:30 PM
New from @llparker100.bsky.social et al. from @uminnpress.bsky.social
Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays
Read the full paper👉 doi.org/10.1039/D5CB...
Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays
Read the full paper👉 doi.org/10.1039/D5CB...
Reposted by RSC Chemical Biology
One more week until registration closes for this year's Chemical Science symposium on the chemistry of imaging, biosensing and diagnostics on 18-19 November in London!
Join us in person or online to hear from our expert speakers and the 2025 Lectureship winner next month: www.rsc.org/events/d...
Join us in person or online to hear from our expert speakers and the 2025 Lectureship winner next month: www.rsc.org/events/d...
October 13, 2025 at 11:34 AM
One more week until registration closes for this year's Chemical Science symposium on the chemistry of imaging, biosensing and diagnostics on 18-19 November in London!
Join us in person or online to hear from our expert speakers and the 2025 Lectureship winner next month: www.rsc.org/events/d...
Join us in person or online to hear from our expert speakers and the 2025 Lectureship winner next month: www.rsc.org/events/d...
Fresh from RSC Chemical Biology: Hao et al. from the Chinese Academy of Sciences:
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
October 15, 2025 at 1:48 PM
Fresh from RSC Chemical Biology: Hao et al. from the Chinese Academy of Sciences:
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
Reposted by RSC Chemical Biology
In honour of the 2025 #NobelPrize in Chemistry, we’ve curated a collection of impactful articles from across RSC journals on metal–organic frameworks (MOFs) 🏆 Free to read until the end of November 👉 pubs.rsc.org/en/jour...
October 8, 2025 at 2:14 PM
In honour of the 2025 #NobelPrize in Chemistry, we’ve curated a collection of impactful articles from across RSC journals on metal–organic frameworks (MOFs) 🏆 Free to read until the end of November 👉 pubs.rsc.org/en/jour...
New from Christopher Coxon et al., from @edinburgh-uni.bsky.social
"19F NMR-tags for peptidyl prolyl conformation analysis"
Fluorinated tags + 19F NMR = fresh insights into proline cis/trans isomerism, a key player in protein folding + interactions.
Read the paper 👉 doi.org/10.1039/D5CB...
"19F NMR-tags for peptidyl prolyl conformation analysis"
Fluorinated tags + 19F NMR = fresh insights into proline cis/trans isomerism, a key player in protein folding + interactions.
Read the paper 👉 doi.org/10.1039/D5CB...
October 7, 2025 at 1:21 PM
New from Christopher Coxon et al., from @edinburgh-uni.bsky.social
"19F NMR-tags for peptidyl prolyl conformation analysis"
Fluorinated tags + 19F NMR = fresh insights into proline cis/trans isomerism, a key player in protein folding + interactions.
Read the paper 👉 doi.org/10.1039/D5CB...
"19F NMR-tags for peptidyl prolyl conformation analysis"
Fluorinated tags + 19F NMR = fresh insights into proline cis/trans isomerism, a key player in protein folding + interactions.
Read the paper 👉 doi.org/10.1039/D5CB...
Excited to support #ChemBioParis2025 this October 6 in Paris!
Our Executive Editor, Anna Rulka + Associate Editors Claudia Höbartner and Zaneta Nikolovska-Coleska are attending—come say hi!
Let’s connect and talk science and publishing!
🔗 chembioparis2025.com
#ChemicalBiology #ICBS #ECBS
Our Executive Editor, Anna Rulka + Associate Editors Claudia Höbartner and Zaneta Nikolovska-Coleska are attending—come say hi!
Let’s connect and talk science and publishing!
🔗 chembioparis2025.com
#ChemicalBiology #ICBS #ECBS
October 2, 2025 at 3:06 PM
Excited to support #ChemBioParis2025 this October 6 in Paris!
Our Executive Editor, Anna Rulka + Associate Editors Claudia Höbartner and Zaneta Nikolovska-Coleska are attending—come say hi!
Let’s connect and talk science and publishing!
🔗 chembioparis2025.com
#ChemicalBiology #ICBS #ECBS
Our Executive Editor, Anna Rulka + Associate Editors Claudia Höbartner and Zaneta Nikolovska-Coleska are attending—come say hi!
Let’s connect and talk science and publishing!
🔗 chembioparis2025.com
#ChemicalBiology #ICBS #ECBS
🧬 New study reveals how biosensors + crystallography can detect ligand-induced shape changes in ACh binding proteins—models for ion channels. A powerful toolkit for studying weak or fast interactions!
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #StructuralBiology #Biosensors
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #StructuralBiology #Biosensors
October 1, 2025 at 2:36 PM
🧬 New study reveals how biosensors + crystallography can detect ligand-induced shape changes in ACh binding proteins—models for ion channels. A powerful toolkit for studying weak or fast interactions!
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #StructuralBiology #Biosensors
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #StructuralBiology #Biosensors
🦠 Can resistant bacteria protect their neighbours? A new paper reveals how β-lactamase activity, membrane permeability & antibiotic type shape antibiotic sheltering in microbial communities.
Read it here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #AntibioticResistance #BetaLactamase
Read it here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #AntibioticResistance #BetaLactamase
September 23, 2025 at 12:49 PM
🦠 Can resistant bacteria protect their neighbours? A new paper reveals how β-lactamase activity, membrane permeability & antibiotic type shape antibiotic sheltering in microbial communities.
Read it here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #AntibioticResistance #BetaLactamase
Read it here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #AntibioticResistance #BetaLactamase
RSC Chemical Biology was proud to support the next generation of researchers at the 21st Annual Tri-Institutional Chemical Biology Symposium!
Congratulations to all the winners!
Congratulations to all the winners!
News - Tri-Institutional PhD Program in Chemical Biology
Latest news and events in the TPCB chemical biology graduate program.
chembio.triiprograms.org
September 19, 2025 at 2:20 PM
RSC Chemical Biology was proud to support the next generation of researchers at the 21st Annual Tri-Institutional Chemical Biology Symposium!
Congratulations to all the winners!
Congratulations to all the winners!
Congratulations to Johannes Broichhagen (@broichhagenj.bsky.social) & team—winners of RSC Chemical Biology’s Outstanding Early Career Researcher Award for cleavable dyes to track GPCR trafficking & signalling!
📖 Read the paper here: doi.org/10.1039/D4CB...
📖 Read the paper here: doi.org/10.1039/D4CB...
September 18, 2025 at 11:00 AM
Congratulations to Johannes Broichhagen (@broichhagenj.bsky.social) & team—winners of RSC Chemical Biology’s Outstanding Early Career Researcher Award for cleavable dyes to track GPCR trafficking & signalling!
📖 Read the paper here: doi.org/10.1039/D4CB...
📖 Read the paper here: doi.org/10.1039/D4CB...
🧬 Boosting mRNA stability through smart poly(A) tail design! New study explores chemical modifications that protect against degradation while preserving translation.
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
September 17, 2025 at 11:16 AM
🧬 Boosting mRNA stability through smart poly(A) tail design! New study explores chemical modifications that protect against degradation while preserving translation.
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
RSC Chem. Biol. & Molecular Omics are sponsoring the EMBL’s The Epitranscriptome (28–30 Oct)!
🗓️ Today (16 Sept) is the last day to register for on-site attendance – be part of it in person!
(Virtual registration open until 13 Oct.)
👉 www.embl.org/about/i...
#Epitranscriptome
🗓️ Today (16 Sept) is the last day to register for on-site attendance – be part of it in person!
(Virtual registration open until 13 Oct.)
👉 www.embl.org/about/i...
#Epitranscriptome
September 16, 2025 at 10:47 AM
RSC Chem. Biol. & Molecular Omics are sponsoring the EMBL’s The Epitranscriptome (28–30 Oct)!
🗓️ Today (16 Sept) is the last day to register for on-site attendance – be part of it in person!
(Virtual registration open until 13 Oct.)
👉 www.embl.org/about/i...
#Epitranscriptome
🗓️ Today (16 Sept) is the last day to register for on-site attendance – be part of it in person!
(Virtual registration open until 13 Oct.)
👉 www.embl.org/about/i...
#Epitranscriptome
🧪 New in #RSCChemicalBiology: Breakthrough in phage display! By combining unnatural amino acids with CuAAC click chemistry, this study expands molecular diversity for next-gen ligand discovery.
doi.org/10.1039/D5CB...
#PhageDisplay #ChemicalBiology #ClickChemistry
doi.org/10.1039/D5CB...
#PhageDisplay #ChemicalBiology #ClickChemistry
September 9, 2025 at 12:41 PM
🧪 New in #RSCChemicalBiology: Breakthrough in phage display! By combining unnatural amino acids with CuAAC click chemistry, this study expands molecular diversity for next-gen ligand discovery.
doi.org/10.1039/D5CB...
#PhageDisplay #ChemicalBiology #ClickChemistry
doi.org/10.1039/D5CB...
#PhageDisplay #ChemicalBiology #ClickChemistry
🚨 New paper on enhancing NIR-PIT for cancer treatment! SiPc-1, a silicon phthalocyanine analogue, targets HTLV-1-infected cells with selective toxicity. Find out how this breakthrough could shape the future of ATL treatment 👉doi.org/10.1039/D5CB...
#RSCChemicalBiology #NIRPIT #CancerResearch
#RSCChemicalBiology #NIRPIT #CancerResearch
September 3, 2025 at 3:05 PM
🚨 New paper on enhancing NIR-PIT for cancer treatment! SiPc-1, a silicon phthalocyanine analogue, targets HTLV-1-infected cells with selective toxicity. Find out how this breakthrough could shape the future of ATL treatment 👉doi.org/10.1039/D5CB...
#RSCChemicalBiology #NIRPIT #CancerResearch
#RSCChemicalBiology #NIRPIT #CancerResearch