FOR5762
@ru5762proteostasis.bsky.social
FOR 5762 - focussed on organismal proteostasis regulation
University Hospital | University of Cologne | University of Konstanz | Max Planck Institute for Metabolism Research
Website: https://www.ru5762proteostasis.com/
University Hospital | University of Cologne | University of Konstanz | Max Planck Institute for Metabolism Research
Website: https://www.ru5762proteostasis.com/
🚨Exciting news: A recent study from our #FOR5762 member @thevilchezlab.bsky.social has been selected for the cover of @febsletters.bsky.social!
Huge congrats to @thevilchezlab.bsky.social, Saygın Bilican and all co-authors for this fantastic highlight on #ALS-linked #Nup107 mislocalization! 🎉
Huge congrats to @thevilchezlab.bsky.social, Saygın Bilican and all co-authors for this fantastic highlight on #ALS-linked #Nup107 mislocalization! 🎉
Saygin’s new ALS paper — showing nucleoporin alterations — just made the journal front cover @febsletters.bsky.social febs.onlinelibrary.wiley.com/doi/10.1002/...
febs.onlinelibrary.wiley.com/doi/10.1002/...
febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
Cover illustration Stress granules in iPSCs treated with arsenite (G3BP1 (green) / NUP107 (red) / Hoechst (nucleus)). Image credit: Saygin Bilican. The image refers to Bilican et al., “C9orf72 ALS-ca....
febs.onlinelibrary.wiley.com
November 11, 2025 at 8:00 AM
🚨Exciting news: A recent study from our #FOR5762 member @thevilchezlab.bsky.social has been selected for the cover of @febsletters.bsky.social!
Huge congrats to @thevilchezlab.bsky.social, Saygın Bilican and all co-authors for this fantastic highlight on #ALS-linked #Nup107 mislocalization! 🎉
Huge congrats to @thevilchezlab.bsky.social, Saygın Bilican and all co-authors for this fantastic highlight on #ALS-linked #Nup107 mislocalization! 🎉
🚨 Thrilled to share this exciting new paper by our #FOR5762 member Prof. Thorsten Hoppe. This study reveals how leucine boosts mitochondrial function by protecting key proteins. Congratulations! 🎉
@cecad.bsky.social @unicologne.bsky.social @natcellbio.nature.com
@cecad.bsky.social @unicologne.bsky.social @natcellbio.nature.com
From food to fuel: How leucine enhances mitochondrial energy production
Researchers from the University of Cologne discovered how a specific dietary amino acid increases cellular energy, opening new possibilities for treating metabolic diseases / publication in “Nature Ce...
www.cecad.uni-koeln.de
November 3, 2025 at 7:59 AM
🚨 Thrilled to share this exciting new paper by our #FOR5762 member Prof. Thorsten Hoppe. This study reveals how leucine boosts mitochondrial function by protecting key proteins. Congratulations! 🎉
@cecad.bsky.social @unicologne.bsky.social @natcellbio.nature.com
@cecad.bsky.social @unicologne.bsky.social @natcellbio.nature.com
Reposted by FOR5762
🚨 Speaker Alert! 🚨
We’re thrilled to host @uweohler.bsky.social for the next #CRC1678 Seminar!
🧬 He’ll present:
"Dissecting Regulatory Networks from Single-Cell Multi-Omics Data"
📅 November 6
📍 CECAD Lecture Hall
⏰ 3:00 PM
Explore the frontier of computational biology and cellular complexity!
We’re thrilled to host @uweohler.bsky.social for the next #CRC1678 Seminar!
🧬 He’ll present:
"Dissecting Regulatory Networks from Single-Cell Multi-Omics Data"
📅 November 6
📍 CECAD Lecture Hall
⏰ 3:00 PM
Explore the frontier of computational biology and cellular complexity!
October 27, 2025 at 3:54 PM
🚨 Speaker Alert! 🚨
We’re thrilled to host @uweohler.bsky.social for the next #CRC1678 Seminar!
🧬 He’ll present:
"Dissecting Regulatory Networks from Single-Cell Multi-Omics Data"
📅 November 6
📍 CECAD Lecture Hall
⏰ 3:00 PM
Explore the frontier of computational biology and cellular complexity!
We’re thrilled to host @uweohler.bsky.social for the next #CRC1678 Seminar!
🧬 He’ll present:
"Dissecting Regulatory Networks from Single-Cell Multi-Omics Data"
📅 November 6
📍 CECAD Lecture Hall
⏰ 3:00 PM
Explore the frontier of computational biology and cellular complexity!
Reposted by FOR5762
🧬🧬🧬Targeting Genome Stability to Mitigate Human Aging and Disease - read now our comprehensive review article written with Debbie Toiber how we can target the most fundamental mechanisms of aging and cancer. @annualreviews.bsky.social 🔗 go.shr.lc/3JohYMp
a computer generated image of a dna molecule with a dark background
ALT: a computer generated image of a dna molecule with a dark background
media.tenor.com
October 24, 2025 at 3:18 PM
🧬🧬🧬Targeting Genome Stability to Mitigate Human Aging and Disease - read now our comprehensive review article written with Debbie Toiber how we can target the most fundamental mechanisms of aging and cancer. @annualreviews.bsky.social 🔗 go.shr.lc/3JohYMp
📢 We are thrilled that our Research Unit #FOR5762 is hosting this joint seminar with #CRC1678!
Don't miss Prof. Bernd Bukau's talk about 'Mechanisms of Co-Translational Folding and Assembly of Proteins' !
Don't miss Prof. Bernd Bukau's talk about 'Mechanisms of Co-Translational Folding and Assembly of Proteins' !
🚨 Speaker Alert! 🚨
We’re excited to welcome Prof. Bernd Bukau (ZMBH Heidelberg) for the next #CRC1678 Seminar!
🧬 Talking About Mechanisms of Co-Translational Folding and Assembly of Proteins
📅 October 23
📍 Auditorium, MPI for Biology of Ageing
⏰ 2:00 PM
Join us!
We’re excited to welcome Prof. Bernd Bukau (ZMBH Heidelberg) for the next #CRC1678 Seminar!
🧬 Talking About Mechanisms of Co-Translational Folding and Assembly of Proteins
📅 October 23
📍 Auditorium, MPI for Biology of Ageing
⏰ 2:00 PM
Join us!
October 20, 2025 at 8:51 AM
🚨Check out this new study from our Research Unit member @bjornschumacher.bsky.social on gene expression patterns linked to age deceleration and rejuvenation during Dauer Diapause. Congratulations! 🎉
🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Age Deceleration and Reversal Gene Patterns in Dauer Diapause
The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...
onlinelibrary.wiley.com
October 20, 2025 at 8:28 AM
🚨Check out this new study from our Research Unit member @bjornschumacher.bsky.social on gene expression patterns linked to age deceleration and rejuvenation during Dauer Diapause. Congratulations! 🎉
Reposted by FOR5762
🎉What a wonderful way to wrap up the CGA Welcome Days! Today's party was a lot of fun! There was delicious "homemade" food, an exciting pub quiz, and just the nicest group of people.
A big thank you to our PhD reps, Moritz and Anna, for putting everything together! We all really enjoyed ourselves.
A big thank you to our PhD reps, Moritz and Anna, for putting everything together! We all really enjoyed ourselves.
October 10, 2025 at 8:46 PM
🎉What a wonderful way to wrap up the CGA Welcome Days! Today's party was a lot of fun! There was delicious "homemade" food, an exciting pub quiz, and just the nicest group of people.
A big thank you to our PhD reps, Moritz and Anna, for putting everything together! We all really enjoyed ourselves.
A big thank you to our PhD reps, Moritz and Anna, for putting everything together! We all really enjoyed ourselves.
Reposted by FOR5762
🚨 Just 3 weeks left to apply for our 12 PhD positions in ageing research! 🚨
🏃♀️ Don't wait- hurry up and submit your application now! ✉️
🏃♀️ Don't wait- hurry up and submit your application now! ✉️
Apply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny.
🗓️ Deadline: November 3, 2025.
ℹ️ More info: www.ageing-grad-school.de
📣 Spread the news!
🗓️ Deadline: November 3, 2025.
ℹ️ More info: www.ageing-grad-school.de
📣 Spread the news!
October 10, 2025 at 12:19 PM
🚨 Just 3 weeks left to apply for our 12 PhD positions in ageing research! 🚨
🏃♀️ Don't wait- hurry up and submit your application now! ✉️
🏃♀️ Don't wait- hurry up and submit your application now! ✉️
Reposted by FOR5762
It was great fun speaking with Debbie Toiber and @barakrotblat.bsky.social on my path to science and why studying aging is so important to me. open.spotify.com/episode/2brg...
September 30, 2025 at 5:33 AM
It was great fun speaking with Debbie Toiber and @barakrotblat.bsky.social on my path to science and why studying aging is so important to me. open.spotify.com/episode/2brg...
Reposted by FOR5762
🧓How aging drives neurodegenerative diseases🧠
@thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.
@thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.
September 3, 2025 at 3:24 PM
🧓How aging drives neurodegenerative diseases🧠
@thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.
@thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.
Reposted by FOR5762
⏰🔬⏳What if we could prevent age-related diseases before they even start? At #CECAD Cologne, that’s exactly our #mission! In this new video, Prof. Dr. Carien Niessen shares our vision uncovering the biology of #aging to improve #health.
#HealthyAging @unicologne.bsky.social
youtu.be/9ALNLpG3oYc
#HealthyAging @unicologne.bsky.social
youtu.be/9ALNLpG3oYc
CECAD: Our Scientific Mission
YouTube video by CECAD Cologne
youtu.be
September 16, 2025 at 9:54 AM
⏰🔬⏳What if we could prevent age-related diseases before they even start? At #CECAD Cologne, that’s exactly our #mission! In this new video, Prof. Dr. Carien Niessen shares our vision uncovering the biology of #aging to improve #health.
#HealthyAging @unicologne.bsky.social
youtu.be/9ALNLpG3oYc
#HealthyAging @unicologne.bsky.social
youtu.be/9ALNLpG3oYc
Reposted by FOR5762
🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
www.nature.com
September 20, 2025 at 4:31 AM
🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by FOR5762
🌍👩🔬🤝 At #CECAD, excellence starts with #people!
This new short film takes you inside our vibrant, international research #community, where #collaboration, #diversity, and #support drive discovery.
✨ Meet our researchers, hear their stories, and get a glimpse of life at CECAD! 🎥
This new short film takes you inside our vibrant, international research #community, where #collaboration, #diversity, and #support drive discovery.
✨ Meet our researchers, hear their stories, and get a glimpse of life at CECAD! 🎥
CECAD: Our Community
YouTube video by CECAD Cologne
www.youtube.com
September 24, 2025 at 12:02 PM
🌍👩🔬🤝 At #CECAD, excellence starts with #people!
This new short film takes you inside our vibrant, international research #community, where #collaboration, #diversity, and #support drive discovery.
✨ Meet our researchers, hear their stories, and get a glimpse of life at CECAD! 🎥
This new short film takes you inside our vibrant, international research #community, where #collaboration, #diversity, and #support drive discovery.
✨ Meet our researchers, hear their stories, and get a glimpse of life at CECAD! 🎥
A new study from our Research Unit identifies age-related hyperactivation of EPS8/RAC signaling as a driver of protein aggregation in neurodegenerative diseases, highlighting EPS8 and its regulators as potential therapeutic targets @cecad.bsky.social @unicologne.bsky.social @nataging.nature.com
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging
Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...
www.nature.com
September 3, 2025 at 9:24 AM
A new study from our Research Unit identifies age-related hyperactivation of EPS8/RAC signaling as a driver of protein aggregation in neurodegenerative diseases, highlighting EPS8 and its regulators as potential therapeutic targets @cecad.bsky.social @unicologne.bsky.social @nataging.nature.com
Check out this new study from our Research Unit member @thevilchezlab.bsky.social on how C9orf72 ALS‐causing mutations lead to aggregation of nucleoporin Nup107 into stress granules
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...
febs.onlinelibrary.wiley.com
September 2, 2025 at 7:15 AM
Check out this new study from our Research Unit member @thevilchezlab.bsky.social on how C9orf72 ALS‐causing mutations lead to aggregation of nucleoporin Nup107 into stress granules
We have a 4-year postdoc position open in our Research Unit on proteostasis!
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
Postdoc Position (f/m/x)
We are looking to support our rapidly growing team as soon as possible:
jobs-uk-koeln.onlyfy.jobs
May 15, 2025 at 10:03 AM
We have a 4-year postdoc position open in our Research Unit on proteostasis!
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
Reposted by FOR5762
New Preprint out !
The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...
Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more
Short thread below 🧵1/4
The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...
Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more
Short thread below 🧵1/4
April 28, 2025 at 3:08 PM
New Preprint out !
The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...
Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more
Short thread below 🧵1/4
The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...
Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more
Short thread below 🧵1/4
Reposted by FOR5762
Happy to share our new preprint, where we find that anle138b reduces Huntingtin inclusions and improves disease phenotypes in #Huntington’sDisease models, showing its potential as an HD treatment.
Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social
Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social
March 14, 2025 at 8:08 AM
Happy to share our new preprint, where we find that anle138b reduces Huntingtin inclusions and improves disease phenotypes in #Huntington’sDisease models, showing its potential as an HD treatment.
Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social
Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social
Reposted by FOR5762
C9orf72 ALS-causing mutations lead to nucleoporin Nup107 aggregation and subsequent pathological changes https://www.biorxiv.org/content/10.1101/2025.04.16.649118v1
April 17, 2025 at 8:30 PM
C9orf72 ALS-causing mutations lead to nucleoporin Nup107 aggregation and subsequent pathological changes https://www.biorxiv.org/content/10.1101/2025.04.16.649118v1
Reposted by FOR5762
Thrilled to announce that our DFG Research Unit on cell-autonomous regulation of proteostasis has been approved for funding!
March 31, 2025 at 1:39 PM
Thrilled to announce that our DFG Research Unit on cell-autonomous regulation of proteostasis has been approved for funding!