Rolando Claure
@runningkidneys.bsky.social
#KidneyDoctor #Researcher
Member Executive Committee @kdigo.org Member #SLANH #AKI committee
Views do not represent those of my employer
#KidneyRunner 🏃🏻♂️ #StopAKI
Member Executive Committee @kdigo.org Member #SLANH #AKI committee
Views do not represent those of my employer
#KidneyRunner 🏃🏻♂️ #StopAKI
New in Journal of Biomedical Informatics: EHR data used to map 15 post-AKI clinical states in 20,699 patients; 17% progressed to CKD. Classical (AKI severity, diabetes, HTN, HF, liver disease) & novel risk factors had state-specific impact. #AKI #CKD 👉🏻 www.sciencedirect.com:5037/science/arti...
www.sciencedirect.com
November 26, 2025 at 1:16 PM
New in Journal of Biomedical Informatics: EHR data used to map 15 post-AKI clinical states in 20,699 patients; 17% progressed to CKD. Classical (AKI severity, diabetes, HTN, HF, liver disease) & novel risk factors had state-specific impact. #AKI #CKD 👉🏻 www.sciencedirect.com:5037/science/arti...
New #Kidney360 study in 134 ICU pts: 15% developed severe AKI within 72h. Renal Angina Indices alone had modest performance, but adding urinary biomarkers—especially [TIMP-2]×[IGFBP7]—improved prediction & specificity for severe #AKI #ICU
🔗 journals.lww.com/kidney360/ab...
🔗 journals.lww.com/kidney360/ab...
journals.lww.com
November 25, 2025 at 5:14 PM
New #Kidney360 study in 134 ICU pts: 15% developed severe AKI within 72h. Renal Angina Indices alone had modest performance, but adding urinary biomarkers—especially [TIMP-2]×[IGFBP7]—improved prediction & specificity for severe #AKI #ICU
🔗 journals.lww.com/kidney360/ab...
🔗 journals.lww.com/kidney360/ab...
Just received my complimentary copy of Tropical Nephrology (2nd Ed.) 📘🌿
Recently discussed my chapter on kidney disease from herbal medicine with our fellows—2 days later we saw an AKI case linked to these products.
We must ask about herbal meds/supplements routinely. #AKI #CKD
Recently discussed my chapter on kidney disease from herbal medicine with our fellows—2 days later we saw an AKI case linked to these products.
We must ask about herbal meds/supplements routinely. #AKI #CKD
November 25, 2025 at 4:57 PM
New PLOS ONE paper from the ISARIC ICU cohort: during the Omicron wave, AKI risk in severe COVID-19 🦠 was lower than in earlier waves, but AKI still carried a high risk of death. #AKI #COVID19
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
Omicron surge impact on acute kidney injury in ICU patients: A study using the ISARIC COVID-19 database
Background Acute Kidney Injury (AKI) is common among COVID-19 patients and is associated with a higher risk of death. Compared to earlier COVID-19 variants, Omicron has reduced mortality. To study…
journals.plos.org
November 24, 2025 at 3:31 PM
New PLOS ONE paper from the ISARIC ICU cohort: during the Omicron wave, AKI risk in severe COVID-19 🦠 was lower than in earlier waves, but AKI still carried a high risk of death. #AKI #COVID19
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
Subclinical #AKI in the wards: in 103 at-risk adults, a simple urine microscopy score (UMS≥2) within ARA-F4 identified AKI-1S; 90% developed clinical AKI with higher KRT use & ☠️. UMS (AUC 0.84) is a low-cost trigger for earlier intervention in LMICs. journals.lww.com/kidney360/fu...
November 22, 2025 at 4:43 PM
Subclinical #AKI in the wards: in 103 at-risk adults, a simple urine microscopy score (UMS≥2) within ARA-F4 identified AKI-1S; 90% developed clinical AKI with higher KRT use & ☠️. UMS (AUC 0.84) is a low-cost trigger for earlier intervention in LMICs. journals.lww.com/kidney360/fu...
🗺️ perspective #AKI🇳🇵: a mixed public–private system offers subsidized/free care but faces underfunding, staff shortages & overcrowding, 🔼 quality private care is urban & costly. 📑👉🏻 under-recognized AKI, data gaps & opportunities to improve care. journals.lww.com/kidney360/fu...
https://journals.lww.com/kidney360/fulltext/2025/11000/global_perspective_on_acute_kidney_injury_in_nepal.21.aspx
journals.lww.com
November 22, 2025 at 1:36 PM
🗺️ perspective #AKI🇳🇵: a mixed public–private system offers subsidized/free care but faces underfunding, staff shortages & overcrowding, 🔼 quality private care is urban & costly. 📑👉🏻 under-recognized AKI, data gaps & opportunities to improve care. journals.lww.com/kidney360/fu...
Deep learning to predict AKI progression: In 162,079 non-ICU pts from UF Health & UPMC, models predicted progression to ≥stage 2 AKI within 48h (AUC 0.77–0.83). Key predictors: kinetic eGFR, nephrotoxic drug burden, BUN. 👉🏻Kidney360. #AKI journals.lww.com/kidney360/ab...
https://journals.lww.com/kidney360/abstract/9900/predicting_acute_kidney_injury_with_nephrotoxic.762.aspx
journals.lww.com
November 20, 2025 at 2:02 PM
Deep learning to predict AKI progression: In 162,079 non-ICU pts from UF Health & UPMC, models predicted progression to ≥stage 2 AKI within 48h (AUC 0.77–0.83). Key predictors: kinetic eGFR, nephrotoxic drug burden, BUN. 👉🏻Kidney360. #AKI journals.lww.com/kidney360/ab...
CKD care is changing fast. SGLT2i, GLP-1 RAs and targeted IgA nephropathy drugs can slow or even improve kidney function. A “golden era” for kidneys? @NatGeo on the breakthroughs: www.nationalgeographic.com/health/artic... #CKD
Scientists found a way to reverse kidney damage—is a cure next?
Experts say we’re in a golden age for treating chronic kidney disease, with new drugs like Ozempic yielding major results. Will dialysis and organ transplants become a thing of the past?
www.nationalgeographic.com
November 20, 2025 at 1:54 PM
CKD care is changing fast. SGLT2i, GLP-1 RAs and targeted IgA nephropathy drugs can slow or even improve kidney function. A “golden era” for kidneys? @NatGeo on the breakthroughs: www.nationalgeographic.com/health/artic... #CKD
Reposted by Rolando Claure
🎙️ Check out the latest Global Kidney Care Podcast!
In this episode, @acssjr.bsky.social interviews @runningkidneys.bsky.social on how AI is transforming the outlook for patients with AKI and how nephrologists can leverage it to improve patient care.
globalkidneycarepodc...
In this episode, @acssjr.bsky.social interviews @runningkidneys.bsky.social on how AI is transforming the outlook for patients with AKI and how nephrologists can leverage it to improve patient care.
globalkidneycarepodc...
November 19, 2025 at 6:00 AM
🎙️ Check out the latest Global Kidney Care Podcast!
In this episode, @acssjr.bsky.social interviews @runningkidneys.bsky.social on how AI is transforming the outlook for patients with AKI and how nephrologists can leverage it to improve patient care.
globalkidneycarepodc...
In this episode, @acssjr.bsky.social interviews @runningkidneys.bsky.social on how AI is transforming the outlook for patients with AKI and how nephrologists can leverage it to improve patient care.
globalkidneycarepodc...
Reposted by Rolando Claure
Resuman Visual
Revisa el resumen visual realizado por Clemens Weber @salinesolut.bsky.social . Gracias @dramiliflores.bsky.social !
www.nephjc.com/news/2025/11/17/origin-3-el-resumen-visual
Revisa el resumen visual realizado por Clemens Weber @salinesolut.bsky.social . Gracias @dramiliflores.bsky.social !
www.nephjc.com/news/2025/11/17/origin-3-el-resumen-visual
ORIGIN-3: El Resumen Visual — NephJC
ORIGIN-3 ha llegado a NephJC con atacicept en NIgA. Un paso sólido hacia una terapia dirigida anti BAFF/APRIL, que aborda la fisiopatología desde su origen. ¡Las señales tempranas son prometedoras! R...
www.nephjc.com
November 18, 2025 at 12:38 PM
Resuman Visual
Revisa el resumen visual realizado por Clemens Weber @salinesolut.bsky.social . Gracias @dramiliflores.bsky.social !
www.nephjc.com/news/2025/11/17/origin-3-el-resumen-visual
Revisa el resumen visual realizado por Clemens Weber @salinesolut.bsky.social . Gracias @dramiliflores.bsky.social !
www.nephjc.com/news/2025/11/17/origin-3-el-resumen-visual
AI is reshaping kidney care. ASN AI 🤖 Workgroup 📄 in JASN proposes a framework for responsible use: prioritizing patient benefit, keeping physicians in the loop, & addressing data quality, equity, transparency & clinical integration. #nephrology #AI journals.lww.com/jasn/fulltex...
https://journals.lww.com/jasn/fulltext/9900/responsible_use_of_artificial_intelligence_to.826.aspx
journals.lww.com
November 15, 2025 at 3:16 PM
AI is reshaping kidney care. ASN AI 🤖 Workgroup 📄 in JASN proposes a framework for responsible use: prioritizing patient benefit, keeping physicians in the loop, & addressing data quality, equity, transparency & clinical integration. #nephrology #AI journals.lww.com/jasn/fulltex...
Reposted by Rolando Claure
𝗜𝗦𝗡 𝗩𝗜𝗗𝗘𝗢 𝗔𝗕𝗦𝗧𝗥𝗔𝗖𝗧 𝗦𝗘𝗥𝗜𝗘𝗦: Combination Cyclophosphamide and Rituximab to Minimise Glucocorticoid use in ANCA-associated Vasculitis. 2025 from @kireports.bsky.social www.kireports.org/ar...
#VideoAbstract by
@gabyneph.bsky.social & @dilushiwijay.bsky.social
#VideoAbstract by
@gabyneph.bsky.social & @dilushiwijay.bsky.social
November 12, 2025 at 12:00 PM
𝗜𝗦𝗡 𝗩𝗜𝗗𝗘𝗢 𝗔𝗕𝗦𝗧𝗥𝗔𝗖𝗧 𝗦𝗘𝗥𝗜𝗘𝗦: Combination Cyclophosphamide and Rituximab to Minimise Glucocorticoid use in ANCA-associated Vasculitis. 2025 from @kireports.bsky.social www.kireports.org/ar...
#VideoAbstract by
@gabyneph.bsky.social & @dilushiwijay.bsky.social
#VideoAbstract by
@gabyneph.bsky.social & @dilushiwijay.bsky.social
Reposted by Rolando Claure
The ISN joined the Silver Economy Forum to champion better kidney care. By promoting early detection and prevention, we can cut global cardiovascular risk and improve healthy aging, answering the WHO’s call for integrated care. Learn more: www.theisn.org/in-action/ad...
#SEF2025 #KidneyHealthMatters
#SEF2025 #KidneyHealthMatters
November 12, 2025 at 2:36 PM
The ISN joined the Silver Economy Forum to champion better kidney care. By promoting early detection and prevention, we can cut global cardiovascular risk and improve healthy aging, answering the WHO’s call for integrated care. Learn more: www.theisn.org/in-action/ad...
#SEF2025 #KidneyHealthMatters
#SEF2025 #KidneyHealthMatters
New study in BMC Nephrology (Iran 🇮🇷) 👉🏻 CKD prevalence 15.1% (Cockcroft–Gault), 14.5% (MDRD), vs 3.5% (CKD-EPI). Similar 5-yr incidence gaps. MASLD ↑ CKD risk with CKD-EPI/MDRD but ↓ with C–G. Equation choice can flip conclusions 👉🏻 use CKD-EPI. doi.org/10.1186/s128...
Inappropriate GFR equations misrepresent CKD epidemiology and risk interpretation in scientific reports - BMC Nephrology
Background The accuracy of chronic kidney disease (CKD) prevalence and its associations with metabolic risk factors depends heavily on the formula used to estimate glomerular filtration rate (eGFR).…
doi.org
November 12, 2025 at 2:50 PM
New study in BMC Nephrology (Iran 🇮🇷) 👉🏻 CKD prevalence 15.1% (Cockcroft–Gault), 14.5% (MDRD), vs 3.5% (CKD-EPI). Similar 5-yr incidence gaps. MASLD ↑ CKD risk with CKD-EPI/MDRD but ↓ with C–G. Equation choice can flip conclusions 👉🏻 use CKD-EPI. doi.org/10.1186/s128...
Great day-by-day recaps of #KidneyWk from the #NephJC team—perfect if you missed a session. Begin here 👉🏻 www.nephjc.com/news/2025/11...
Kidney Week in Houston: Day 3 — NephJC
Day 3 of Kidney Week. Sibeprenlimab and Balcinrenone on NEJM and Lancet, plus a couple of other non-kidneywk studies.
www.nephjc.com
November 11, 2025 at 5:19 PM
Great day-by-day recaps of #KidneyWk from the #NephJC team—perfect if you missed a session. Begin here 👉🏻 www.nephjc.com/news/2025/11...
Great day-by-day recaps of #KidneyWk from the #NephJC team—perfect if you missed a session. Begin here 👉🏻 www.nephjc.com/news/kidneyw...
Kidney Week in Houston: Day 2 — NephJC
in this edition: Fish Oil, GBD, Flozination meta-analysis, CHW intervention in Hispanic/Latino patients, and much more
www.nephjc.com
November 11, 2025 at 5:17 PM
Great day-by-day recaps of #KidneyWk from the #NephJC team—perfect if you missed a session. Begin here 👉🏻 www.nephjc.com/news/kidneyw...
Analysis of AKI-related mortality (43 countries, 1996–2021): ⬆️ in high-income nations (esp. older adults & women) and ⬇️ in LMICs. Drivers: HIC aging/comorbidity; LMIC younger pops + better infection control/access. Projection: gradual global rise to 2050. #KidneyWk25 #AKI
November 11, 2025 at 1:21 PM
Analysis of AKI-related mortality (43 countries, 1996–2021): ⬆️ in high-income nations (esp. older adults & women) and ⬇️ in LMICs. Drivers: HIC aging/comorbidity; LMIC younger pops + better infection control/access. Projection: gradual global rise to 2050. #KidneyWk25 #AKI
Great day-by-day recaps of #KidneyWk from the #NephJC team—perfect if you missed a session. Begin here 👉🏻 www.nephjc.com/news/kidneyw...
Kidney Week in Houston: Day 1 — NephJC
in this edition: Atacicept in IgAN; Albuminuria as a surrogate outcome, Renal Remission and additional CONFIDENCE analysis
www.nephjc.com
November 10, 2025 at 11:30 PM
Great day-by-day recaps of #KidneyWk from the #NephJC team—perfect if you missed a session. Begin here 👉🏻 www.nephjc.com/news/kidneyw...
Reposted by Rolando Claure
If you read only one obit of James Watson, read this one
www.statnews.com/2025/11/07/j...
(From the late Sharon Begley, for @statnews.com )
www.statnews.com/2025/11/07/j...
(From the late Sharon Begley, for @statnews.com )
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 9, 2025 at 11:56 AM
If you read only one obit of James Watson, read this one
www.statnews.com/2025/11/07/j...
(From the late Sharon Begley, for @statnews.com )
www.statnews.com/2025/11/07/j...
(From the late Sharon Begley, for @statnews.com )
Reposted by Rolando Claure
AI in Healthcare
@asakhuja.bsky.social gave an excellent overview of what this entails, the opportunities and its limitations
youtu.be/0qOaoGncKHw?...
#NephGR #NephSky
@asakhuja.bsky.social gave an excellent overview of what this entails, the opportunities and its limitations
youtu.be/0qOaoGncKHw?...
#NephGR #NephSky
AI in Healthcare with Dr Ankit Sakhuja
YouTube video by Ottawa Nephrology
youtu.be
November 10, 2025 at 12:03 PM
AI in Healthcare
@asakhuja.bsky.social gave an excellent overview of what this entails, the opportunities and its limitations
youtu.be/0qOaoGncKHw?...
#NephGR #NephSky
@asakhuja.bsky.social gave an excellent overview of what this entails, the opportunities and its limitations
youtu.be/0qOaoGncKHw?...
#NephGR #NephSky
Why add thymus to a xenokidney (thymokidney)? → Induce central tolerance (new T cells see donor as self), cut T-cell rejection/DSA, enable lower IS (→ fewer infections/tox), and reduce chronic injury → longer graft life (early data). #KidneyWk #Xenotransplantation
November 9, 2025 at 2:47 PM
Why add thymus to a xenokidney (thymokidney)? → Induce central tolerance (new T cells see donor as self), cut T-cell rejection/DSA, enable lower IS (→ fewer infections/tox), and reduce chronic injury → longer graft life (early data). #KidneyWk #Xenotransplantation
Xenotransplant kidneys 👉🏻 ethics at #KidneyWk: Human 👩🏻 : autonomy/informed consent, unknown long-term risks, fair access, privacy. Animal 🐖 : robust welfare & 3Rs, limits on edits/breeding, humane endpoints, independent oversight. #Bioethics #Xenotransplantation
November 9, 2025 at 2:40 PM
Xenotransplant kidneys 👉🏻 ethics at #KidneyWk: Human 👩🏻 : autonomy/informed consent, unknown long-term risks, fair access, privacy. Animal 🐖 : robust welfare & 3Rs, limits on edits/breeding, humane endpoints, independent oversight. #Bioethics #Xenotransplantation
Xenokidneys at #KidneyWk: Trials are starting, but key hurdles remain—Rejection (AMR/TMA; anti-CD40 + C5 help, not cure). Technical (thrombosis; ureter/size). Infection (tight PCMV/PERV surveillance). Scale-up: DPF herds, standardized crossmatch, multicenter EXPAND trial.
November 9, 2025 at 2:36 PM
Xenokidneys at #KidneyWk: Trials are starting, but key hurdles remain—Rejection (AMR/TMA; anti-CD40 + C5 help, not cure). Technical (thrombosis; ureter/size). Infection (tight PCMV/PERV surveillance). Scale-up: DPF herds, standardized crossmatch, multicenter EXPAND trial.
November 9, 2025 at 2:09 PM