Rolando Claure
@runningkidneys.bsky.social
#KidneyDoctor #Researcher
Member Executive Committee @kdigo.org Member #SLANH #AKI committee
Views do not represent those of my employer
#KidneyRunner 🏃🏻♂️ #StopAKI
Member Executive Committee @kdigo.org Member #SLANH #AKI committee
Views do not represent those of my employer
#KidneyRunner 🏃🏻♂️ #StopAKI
January 25, 2026 at 10:43 PM
Reposted by Rolando Claure
Supplementing with fish oil reduces the risk of serious cardiovascular events in patients receiving maintenance dialysis per a new randomized clinical trial. Read more in #ASNKidneyNews: kidney.pub/KN1801-26
January 25, 2026 at 4:01 PM
Supplementing with fish oil reduces the risk of serious cardiovascular events in patients receiving maintenance dialysis per a new randomized clinical trial. Read more in #ASNKidneyNews: kidney.pub/KN1801-26
AI is becoming the backbone of kidney care. The #ASN 🤖 Workgroup urges responsible use: patient benefit first, clinician oversight, & innovation where burden is highest. AI should augment, not replace judgment. Transparency, validation + education. www.kidneynews.org/view/journal...
www.kidneynews.org
January 23, 2026 at 5:36 PM
AI is becoming the backbone of kidney care. The #ASN 🤖 Workgroup urges responsible use: patient benefit first, clinician oversight, & innovation where burden is highest. AI should augment, not replace judgment. Transparency, validation + education. www.kidneynews.org/view/journal...
#AKI insights: response to ⚡️
• 17β-estradiol blocks ferroptosis (non-genomic+genomic) → sex diffs
• AKI mtDNA mutations impair resilience; adenosine restores ATP & function
• Hypoxia ↑ tRNA-Asp-GTC-3′tDR traps PUS7 → RNA autophagy → protection
🔗 doi.org/10.1038/s415...
• 17β-estradiol blocks ferroptosis (non-genomic+genomic) → sex diffs
• AKI mtDNA mutations impair resilience; adenosine restores ATP & function
• Hypoxia ↑ tRNA-Asp-GTC-3′tDR traps PUS7 → RNA autophagy → protection
🔗 doi.org/10.1038/s415...
Toward an understanding of the intrinsic kidney response to acute injury - Nature Reviews Nephrology
Kidneys are highly susceptible to acute injury. Several studies in 2025 revealed insights into mechanisms of protection and susceptibility — including sex-specific mechanisms of protection against…
doi.org
January 23, 2026 at 10:42 AM
#AKI insights: response to ⚡️
• 17β-estradiol blocks ferroptosis (non-genomic+genomic) → sex diffs
• AKI mtDNA mutations impair resilience; adenosine restores ATP & function
• Hypoxia ↑ tRNA-Asp-GTC-3′tDR traps PUS7 → RNA autophagy → protection
🔗 doi.org/10.1038/s415...
• 17β-estradiol blocks ferroptosis (non-genomic+genomic) → sex diffs
• AKI mtDNA mutations impair resilience; adenosine restores ATP & function
• Hypoxia ↑ tRNA-Asp-GTC-3′tDR traps PUS7 → RNA autophagy → protection
🔗 doi.org/10.1038/s415...
Climate change is a kidney issue: heat stress, floods/water insecurity, dengue/lepto, pollution & nephrotoxins → more community-acquired #AKI—hitting outdoor workers & underserved communities hardest. “Heat-season” readiness can save lives. Read: rdcu.be/eY1G0
Climate change and AKI: heat, hazards and health-system readiness
Climate change is increasing the risk of acute kidney injury owing to heat stress, infectious and vector-borne diseases, food and water insecurity, pollution and nephrotoxins. Outdoor workers and underserved...
rdcu.be
January 14, 2026 at 11:03 PM
Climate change is a kidney issue: heat stress, floods/water insecurity, dengue/lepto, pollution & nephrotoxins → more community-acquired #AKI—hitting outdoor workers & underserved communities hardest. “Heat-season” readiness can save lives. Read: rdcu.be/eY1G0
Large Danish matched study (2,815 Down syndrome; 1:10 controls) found consistently higher risks of AKI & CKD across adulthood—even among those without congenital heart disease. Kidney monitoring deserves more attention in this population. #DownSyndrome
doi.org/10.1093/ckj/...
doi.org/10.1093/ckj/...
Acute kidney injury and chronic kidney disease in individuals with Down syndrome: A nationwide cohort study
AbstractBackground. It is unclear whether individuals with Down syndrome (DS) are at increased risk of kidney disease. This study aims to examine the risk
doi.org
January 14, 2026 at 4:26 PM
Large Danish matched study (2,815 Down syndrome; 1:10 controls) found consistently higher risks of AKI & CKD across adulthood—even among those without congenital heart disease. Kidney monitoring deserves more attention in this population. #DownSyndrome
doi.org/10.1093/ckj/...
doi.org/10.1093/ckj/...
ABG is the gold standard, but arterial sticks hurt & carry risks. A Kidney360 study (5,419 paired samples) derived formulas to estimate arterial pH, pCO₂ & HCO₃⁻ from VBG—meeting acceptable clinical expectations. #Nephrology #CriticalCare #AcidBase
journals.lww.com/kidney360/ab...
journals.lww.com/kidney360/ab...
https://journals.lww.com/kidney360/abstract/9900/transforming_the_venous_blood_gas_to_the_arterial.847.aspx
journals.lww.com
January 14, 2026 at 4:19 PM
ABG is the gold standard, but arterial sticks hurt & carry risks. A Kidney360 study (5,419 paired samples) derived formulas to estimate arterial pH, pCO₂ & HCO₃⁻ from VBG—meeting acceptable clinical expectations. #Nephrology #CriticalCare #AcidBase
journals.lww.com/kidney360/ab...
journals.lww.com/kidney360/ab...
After preeclampsia, kidney risk persists. 171,693 pregnancies 🤰(FU 7y): preeclampsia → 2.53× severe albuminuria (>300 mg/g) & 2.18× eGFR<60. But in the 1st postpartum year: only 20% Cr and 10% albumin testing. #Preeclampsia #CKD journals.lww.com/jasn/abstrac...
journals.lww.com
January 13, 2026 at 2:21 PM
After preeclampsia, kidney risk persists. 171,693 pregnancies 🤰(FU 7y): preeclampsia → 2.53× severe albuminuria (>300 mg/g) & 2.18× eGFR<60. But in the 1st postpartum year: only 20% Cr and 10% albumin testing. #Preeclampsia #CKD journals.lww.com/jasn/abstrac...
SLANH 🌎 survey (Mar–Dec 2024; n=505; 20 LA countries): EBP for AKI 👉🏻IHD 98%, PD 65%, CRRT 59% (unavailable in 🇭🇹, 🇳🇮, 🇵🇾 & 🇻🇪). Advanced EBP scarce: ECMO 16.7%, ECCO₂R 7%. Top training needs: ECMO, ECCO₂R, CRRT, TPE. @SLANH_ #AKI #EBP
🔗 doi.org/10.1159/0005...
🔗 doi.org/10.1159/0005...
Extracorporeal Blood Purification Therapies in Latin America – Bridging Gaps in Availability and Training
Abstract. Introduction: Socioeconomic and developmental diversity across Latin America (LA) significantly affects the availability of extracorporeal blood purification (EBP) therapies to treat acute k...
doi.org
January 13, 2026 at 12:52 PM
SLANH 🌎 survey (Mar–Dec 2024; n=505; 20 LA countries): EBP for AKI 👉🏻IHD 98%, PD 65%, CRRT 59% (unavailable in 🇭🇹, 🇳🇮, 🇵🇾 & 🇻🇪). Advanced EBP scarce: ECMO 16.7%, ECCO₂R 7%. Top training needs: ECMO, ECCO₂R, CRRT, TPE. @SLANH_ #AKI #EBP
🔗 doi.org/10.1159/0005...
🔗 doi.org/10.1159/0005...
Reposted by Rolando Claure
Hi, I’m Cello Tonelli, President of the ISN.
Join us for the #ISNWCN in March. Register today ➡️ lite.spr.ly/6007Ol8D
Join us for the #ISNWCN in March. Register today ➡️ lite.spr.ly/6007Ol8D
January 7, 2026 at 9:39 PM
Hi, I’m Cello Tonelli, President of the ISN.
Join us for the #ISNWCN in March. Register today ➡️ lite.spr.ly/6007Ol8D
Join us for the #ISNWCN in March. Register today ➡️ lite.spr.ly/6007Ol8D
PPIs have been linked to AKI/CKD risk. A 📑 in 🇰🇷 found P-CAB users had fewer kidney events than PPI users: creatinine doubling and eGFR ≥50% decline were lower; adjusted risk reductions 48% and 37%. Observational—needs confirmation.
🔗 doi.org/10.1093/ckj/...
🔗 doi.org/10.1093/ckj/...
January 8, 2026 at 3:26 PM
PPIs have been linked to AKI/CKD risk. A 📑 in 🇰🇷 found P-CAB users had fewer kidney events than PPI users: creatinine doubling and eGFR ≥50% decline were lower; adjusted risk reductions 48% and 37%. Observational—needs confirmation.
🔗 doi.org/10.1093/ckj/...
🔗 doi.org/10.1093/ckj/...
AKI is rising 🗺️ hit hardest in LMICs. The 5R framework (Risk, Recognition, Response, Renal Support, Rehab) guides action: advocacy + access, better detection, patient-centered care, closing gaps, equity & climate action, & tools like POC tests, EMRs, digital health & AI. #AKI
January 8, 2026 at 12:50 PM
AKI is rising 🗺️ hit hardest in LMICs. The 5R framework (Risk, Recognition, Response, Renal Support, Rehab) guides action: advocacy + access, better detection, patient-centered care, closing gaps, equity & climate action, & tools like POC tests, EMRs, digital health & AI. #AKI
Reposted by Rolando Claure
Grow professionally with the ISN. Access high-impact scientific and clinical research through our journals. Join/renew your ISN Membership ➡️ http://lite.spr.ly/6...
#ThisIsISN - Advancing kidney health worldwide. Together.
#ThisIsISN - Advancing kidney health worldwide. Together.
ISN Membership: Advance Global Kidney Care | Join or Renew Today
Access cutting-edge research content, connect with a global community, grow professionally, and make a difference in kidney health with the International Society of Nephrology.
lite.spr.ly
January 2, 2026 at 2:01 PM
Grow professionally with the ISN. Access high-impact scientific and clinical research through our journals. Join/renew your ISN Membership ➡️ http://lite.spr.ly/6...
#ThisIsISN - Advancing kidney health worldwide. Together.
#ThisIsISN - Advancing kidney health worldwide. Together.
Non-tunneled vs tunneled HD catheters: a 301-patient study found no significant difference in CRBSI rates with pre-curved non-tunneled catheters vs tunneled. Suggests longer use may be reasonable while awaiting AVF/PD cath/transplant. doi.org/10.1093/ckj/...
Comparable rates of catheter-related bloodstream infections between non-tunneled and tunneled hemodialysis catheters: a retrospective single-center study
AbstractBackground. A hemodialysis catheter may serve as a short- or medium-term vascular access solution. Current guidelines suggest restricting non-tunne
doi.org
January 2, 2026 at 2:30 PM
Non-tunneled vs tunneled HD catheters: a 301-patient study found no significant difference in CRBSI rates with pre-curved non-tunneled catheters vs tunneled. Suggests longer use may be reasonable while awaiting AVF/PD cath/transplant. doi.org/10.1093/ckj/...
Reposted by Rolando Claure
As the year draws to a close, we invite you to look back at 25 KDIGO resources from 2025, organized alphabetically by topic. KDIGO wishes you a happy and healthy 2026!
KDIGO 25 from 2025: kdigo.co/25-from-2025
KDIGO 25 from 2025: kdigo.co/25-from-2025
December 31, 2025 at 6:14 PM
As the year draws to a close, we invite you to look back at 25 KDIGO resources from 2025, organized alphabetically by topic. KDIGO wishes you a happy and healthy 2026!
KDIGO 25 from 2025: kdigo.co/25-from-2025
KDIGO 25 from 2025: kdigo.co/25-from-2025
🌍🏃♂️ We’re ending the year running around the world: 3 continents (Americas, Europe, Asia), 7 countries (🇧🇴🇪🇨🇺🇸🇮🇳🇩🇪🇵🇦🇲🇽) & 10 cities—1,450 km total. Proud to complete the #850Challenge again, raising kidney disease awareness worldwide. 💚🩺🌎 #Run4Kidneys 🫘
December 31, 2025 at 9:43 PM
🌍🏃♂️ We’re ending the year running around the world: 3 continents (Americas, Europe, Asia), 7 countries (🇧🇴🇪🇨🇺🇸🇮🇳🇩🇪🇵🇦🇲🇽) & 10 cities—1,450 km total. Proud to complete the #850Challenge again, raising kidney disease awareness worldwide. 💚🩺🌎 #Run4Kidneys 🫘
December 25, 2025 at 1:51 PM
Key updates on IgAN & complement-mediated kidney disease from KI/KIR: felzartamab, vWF–platelet targeting, and advances in C3G & IC-MPGN. Plus endotyping, biomarkers, and trial updates refining risk stratification & therapy.
ISN eDigest team 👏🏻
🔗 www.theisn.org/edigest-isn-...
ISN eDigest team 👏🏻
🔗 www.theisn.org/edigest-isn-...
December 17, 2025 at 4:43 PM
Key updates on IgAN & complement-mediated kidney disease from KI/KIR: felzartamab, vWF–platelet targeting, and advances in C3G & IC-MPGN. Plus endotyping, biomarkers, and trial updates refining risk stratification & therapy.
ISN eDigest team 👏🏻
🔗 www.theisn.org/edigest-isn-...
ISN eDigest team 👏🏻
🔗 www.theisn.org/edigest-isn-...
VTL-308 post-hoc 📑 (n=151) in severe alcohol-associated hepatitis, AKI → higher 90-day mortality. Higher bilirubin ↑ AKI risk; corticosteroids were linked to ↓ AKI incidence. After AKI, steroids didn’t improve recovery; high bilirubin ↓ reversal.
🔗 doi.org/10.1038/s415...
🔗 doi.org/10.1038/s415...
Steroid therapy is linked to lower incidence of acute kidney injury in patients with severe alcohol-associated hepatitis - Scientific Reports
Scientific Reports - Steroid therapy is linked to lower incidence of acute kidney injury in patients with severe alcohol-associated hepatitis
doi.org
December 17, 2025 at 3:22 PM
VTL-308 post-hoc 📑 (n=151) in severe alcohol-associated hepatitis, AKI → higher 90-day mortality. Higher bilirubin ↑ AKI risk; corticosteroids were linked to ↓ AKI incidence. After AKI, steroids didn’t improve recovery; high bilirubin ↓ reversal.
🔗 doi.org/10.1038/s415...
🔗 doi.org/10.1038/s415...
POCUS is changing nephrology at the 🛌 answering focused questions fast and sharpening decisions. But untrained use can cause diagnostic errors and harm. As adoption grows, we need standardized training + certification to keep #POCUS safe and effective. doi.org/10.62716/kn....
doi.org
December 16, 2025 at 3:34 PM
POCUS is changing nephrology at the 🛌 answering focused questions fast and sharpening decisions. But untrained use can cause diagnostic errors and harm. As adoption grows, we need standardized training + certification to keep #POCUS safe and effective. doi.org/10.62716/kn....
Inactive lupus nephritis & SGLT2i data: NDT cross-over trial (n=30). Dapagliflozin + standard care vs usual therapy for 6 mo; 9 excluded (flare/LTFU). Proteinuria ↓ –36.1% vs –3.5%. More hypotension symptoms; no sig BP/weight changes. #LupusNephritis
🔗 doi.org/10.1093/ndt/...
🔗 doi.org/10.1093/ndt/...
December 10, 2025 at 4:06 PM
Inactive lupus nephritis & SGLT2i data: NDT cross-over trial (n=30). Dapagliflozin + standard care vs usual therapy for 6 mo; 9 excluded (flare/LTFU). Proteinuria ↓ –36.1% vs –3.5%. More hypotension symptoms; no sig BP/weight changes. #LupusNephritis
🔗 doi.org/10.1093/ndt/...
🔗 doi.org/10.1093/ndt/...
In 102 PICU children 🇮🇷 Ultrasound ❤️ Output Monitoring showed CI as the only useful USCOM predictor for early AKI. AUC: CI 0.66 vs RAI 0.70. +RAI ↑ AKI risk 6.23x; abnormal CI 3.92x. PPV 60% (RAI) vs 57.1% (CI). USCOM may complement RAI. #AKI
🔗 doi.org/10.1007/s004...
🔗 doi.org/10.1007/s004...
Ultrasound cardiac output monitoring compared to the renal angina index for early prediction of pediatric acute kidney injury - Pediatric Nephrology
Background Acute kidney injury (AKI) is a significant concern within pediatric intensive care units (PICUs), leading to increased morbidity, longer hospitalization, and increased healthcare costs.…
doi.org
December 10, 2025 at 3:59 PM
In 102 PICU children 🇮🇷 Ultrasound ❤️ Output Monitoring showed CI as the only useful USCOM predictor for early AKI. AUC: CI 0.66 vs RAI 0.70. +RAI ↑ AKI risk 6.23x; abnormal CI 3.92x. PPV 60% (RAI) vs 57.1% (CI). USCOM may complement RAI. #AKI
🔗 doi.org/10.1007/s004...
🔗 doi.org/10.1007/s004...
Our 🆕 review out in Nature Reviews Nephrology! We discuss the global epidemiology of #AKI why major gaps and inequities persist 🗺️ , & practical opportunities to improve outcomes through the 5R framework, stronger surveillance, & digital/innovation-enabled care.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 6, 2025 at 4:26 PM
Our 🆕 review out in Nature Reviews Nephrology! We discuss the global epidemiology of #AKI why major gaps and inequities persist 🗺️ , & practical opportunities to improve outcomes through the 5R framework, stronger surveillance, & digital/innovation-enabled care.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
After 🏥#AKI, albuminuria at 3 months is recommended—but often missed. In 554 CRIC pts, uPCR measured within 1 year still strongly predicted risk. Each doubling of proteinuria → ~3x higher kidney disease progression risk. #AKI to #CKD
🔗 journals.lww.com/kidney360/ab...
🔗 journals.lww.com/kidney360/ab...
journals.lww.com
December 5, 2025 at 4:22 PM
After 🏥#AKI, albuminuria at 3 months is recommended—but often missed. In 554 CRIC pts, uPCR measured within 1 year still strongly predicted risk. Each doubling of proteinuria → ~3x higher kidney disease progression risk. #AKI to #CKD
🔗 journals.lww.com/kidney360/ab...
🔗 journals.lww.com/kidney360/ab...
🚨 Abstracts close Dec 12 for the International AKI & CRRT Conference.
Showcase your research, boost visibility, and connect with the AKI & CRRT and critical care community.
Submit today!
#AKI #CRRT #MedicalResearch #AKICRRT
🔗 crrtonline.com/crrtconferen...
Showcase your research, boost visibility, and connect with the AKI & CRRT and critical care community.
Submit today!
#AKI #CRRT #MedicalResearch #AKICRRT
🔗 crrtonline.com/crrtconferen...
December 5, 2025 at 12:11 PM
🚨 Abstracts close Dec 12 for the International AKI & CRRT Conference.
Showcase your research, boost visibility, and connect with the AKI & CRRT and critical care community.
Submit today!
#AKI #CRRT #MedicalResearch #AKICRRT
🔗 crrtonline.com/crrtconferen...
Showcase your research, boost visibility, and connect with the AKI & CRRT and critical care community.
Submit today!
#AKI #CRRT #MedicalResearch #AKICRRT
🔗 crrtonline.com/crrtconferen...