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Ryosuke Kojima @ryosukekojima.bsky.social · Aug 28

Related post in Japanese
web-cdn.bsky.app/profile/ryos...

Ryosuke Kojima (@ryosukekojima.bsky.social)

抗原に結合するだけで光る蛍光プローブの新規設計法に関する論文がJACSで公開になりました! 日本語プレスリリースはこちらです。@jacs.acspublications.org https://www.u-tokyo.ac.jp/content/400268162.pdf [contains quote post or other embedded content]

web-cdn.bsky.app

Ryosuke Kojima @ryosukekojima.bsky.social · Aug 28

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Ryosuke Kojima @ryosukekojima.bsky.social · Aug 28

Our paper on the antigen fluorogenic sensor is featured as a supplementary cover in this week’s @jacs.acspublications.org
! Beautiful artwork by our co-author, Ryo Tachibana! Read it here: pubs.acs.org/doi/full/10....
#MyACSCover

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Reposted by Ryosuke Kojima

Bryan Dickinson @chembiobryan.bsky.social · Aug 6

Thrilled our PANCS-binder tech is finally out in print!
www.nature.com/articles/s41...

This technology, 11-years in the making, has transformed how we do research in my lab, and was led by an amazing postdoc, Matt Styles, who is currently entering the academic job market - so look out for him! 1/n

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Reposted by Ryosuke Kojima

Yasu Okamoto @yasuokamoto.bsky.social · Aug 1

Our latest paper is finally published in @natcomms.nature.com (doi.org/10.1038/s414...) !! We successfully constructed synthetic multinuclear metal complexes using only proteins.

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Ryosuke Kojima @ryosukekojima.bsky.social · Jul 24

抗原に結合するだけで光る蛍光プローブの新規設計法に関する論文がJACSで公開になりました! 日本語プレスリリースはこちらです。@jacs.acspublications.org www.u-tokyo.ac.jp/content/4002...

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Ryosuke Kojima @ryosukekojima.bsky.social · Jul 24

From the preprint version, we updated validation/demonstration of our probes, including the possilibty of lighting up antigen positive cells even in mixed cell population. Congrats to Nakadate-san, Seike-kun, and co-workers!
bsky.app/profile/ryos...
chemrxiv.org/engage/chemr...

Ryosuke Kojima @ryosukekojima.bsky.social · Jul 24

Excited to share that our new paper is out in
@jacs.acspublications.org !
We introduce a new design principle for fluorogenic antigen probes, using an intramolecular reaction between a thiol-reactive fluorophore and a cysteine engineered into a DARPin.
pubs.acs.org/doi/10.1021/...

Design of Antigen-Targeting Fluorogenic Probes Utilizing Intramolecular Addition Reaction of Protein-Dye Hybrids

Fluorogenic probes for antigens are useful for various purposes, including medical diagnostics and imaging, but achieving a rapid, large fluorescence increase is difficult. Here, we report a new class...

pubs.acs.org

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Ryosuke Kojima @ryosukekojima.bsky.social · Apr 23

リンクがきちんと貼れていなかったので再掲
jes1950.jp/J_MEETING/75...

第73回日本電気泳動学会シンポジウム

jes1950.jp

Ryosuke Kojima @ryosukekojima.bsky.social · Apr 23

5/12(月)に第75回日本電気泳動シンポジウム@ Shimadzu Tokyo Innovation Plaza (川崎殿町)を企画しております。非常に魅力的なスピーカー陣＆会場ですので、ご興味のある方はぜひご参加ください (参加者把握のため、事前登録をお願いします)。参加費無料です！https://jes1950.jp/J_MEETING/75th_sympo/75th_sympo.html

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Ryosuke Kojima @ryosukekojima.bsky.social · Mar 14

New preprint! 当ラボ卒業生の王さんを中心として、生体直交性の高い蛍光プローブ・改変レポーター酵素ペアを開発し、低バックグラウンドのがんイメージングを実現しました。新しいレポーターシステムとして, ELISA, ADEPT他、多用途に使えると考えています！

Ryosuke Kojima @ryosukekojima.bsky.social · Mar 14

New preprint! In a study led by Wang-san, we developed a novel biorthogonal fluorescence probe and an engineered reporter enzyme, enabling low-background cancer imaging. This powerful pair could also be valuable for applications such as ELISA and ADEPT.
www.biorxiv.org/content/10.1...

Low-Background Cancer Imaging With a Bioorthogonal Fluorescence Probe and Engineered Reporter Enzyme Bearing a Targeting Moiety

Combinatorial use of an antibody-reporter enzyme conjugate and a fluorescence probe activated by the enzyme is a powerful strategy for fluorescence-guided cancer surgery. However, conventional probes ...

www.biorxiv.org

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Ryosuke Kojima @ryosukekojima.bsky.social · Mar 14

New preprint! In a study led by Wang-san, we developed a novel biorthogonal fluorescence probe and an engineered reporter enzyme, enabling low-background cancer imaging. This powerful pair could also be valuable for applications such as ELISA and ADEPT.
www.biorxiv.org/content/10.1...

Low-Background Cancer Imaging With a Bioorthogonal Fluorescence Probe and Engineered Reporter Enzyme Bearing a Targeting Moiety

Combinatorial use of an antibody-reporter enzyme conjugate and a fluorescence probe activated by the enzyme is a powerful strategy for fluorescence-guided cancer surgery. However, conventional probes ...

www.biorxiv.org

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Ryosuke Kojima @ryosukekojima.bsky.social · Jan 21

ハイパーリンクがうまくいっていなかったので、再掲。
www.m.u-tokyo.ac.jp/news/jobs/20...

www.m.u-tokyo.ac.jp

Ryosuke Kojima @ryosukekojima.bsky.social · Jan 21

キャリアステージ/バックグラウンドがやや違っても検討できる可能性ももちろんあるので、ご興味があればまずはご連絡下さい！

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Ryosuke Kojima @ryosukekojima.bsky.social · Jan 21

当グループ(@東大医)で博士研究員を募集しています。細胞外小胞/細胞間コミュニケーションの理解や操作を可能とする合成生物学研究に興味のある方はぜひご検討ください。もちろん学振PDの応募などの相談にものれます。ご興味があればお気軽にDMください！https://www.m.u-tokyo.ac.jp/news/jobs/20250121.pdf

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Reposted by Ryosuke Kojima

Dr. Christian Scharun @christianscharun.de · Dec 30

2025

= 45²

= (20 + 25)²

= (1 + 2 + 3 +4 + 5 + 6 + 7 + 8 + 9)²

= 1³ + 2³ + 3³ +4³ + 5³ + 6³ + 7³ + 8³ + 9³

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Reposted by Ryosuke Kojima

Takashi Fukaya @fukayalab.bsky.social · Dec 19

Are you interested in studying enhancer biology/3D genome organization in my lab at the University of Tokyo? This Biohub Network program would be a great opportunity for you! Feel free to reach out if you're interested!!
www.czbiohub.org/program-ssfc...

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Reposted by Ryosuke Kojima

Yasu Okamoto @yasuokamoto.bsky.social · Dec 13

📣 Our website got a fresh makeover! 🔍 Check out our updated lab website!
sites.google.com/view/y-okamo...

Designer Biomolecular Chemistry - English

Member Staff Assoc. Prof. (PI) : Yasunori Okamoto Assist. Prof. : – Administrative assistant : Ayaka Noda Research assistant : Tomoko Etoh Student It's you. Apply now！

sites.google.com

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Ryosuke Kojima @ryosukekojima.bsky.social · Dec 12

新作preprint @chemrxiv.bsky.social を公開しました。チオール反応性蛍光団と抗原認識タンパク質をうまく組み合わせて、抗原に結合して初めて光る蛍光センサーを開発しました。洗浄なしでのがんイメージングなどに応用可能です。卒業生の中館さんが中心となって研究を進めてくれました! bsky.app/profile/ryos...

Ryosuke Kojima @ryosukekojima.bsky.social · Dec 12

New preprint @chemrxiv.bsky.social ! In this work led by Nakadate-san, we have developed a new type of fluorogenic sensor for an antigen that enables wash-free cancer imaging. Check out our unique probe design using a thiol-reactive fluorophore and DARPin! chemrxiv.org/engage/chemr...

New class of fluorogenic probes for antigens based on DARPin-silicon pyronine conjugates

Fluorogenic probes for antigens are useful for various purposes, including medical diagnostics and imaging, but achieving a rapid, large fluorescence increase is difficult. Here, we report a new class...

chemrxiv.org

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Ryosuke Kojima @ryosukekojima.bsky.social · Dec 12

New preprint @chemrxiv.bsky.social ! In this work led by Nakadate-san, we have developed a new type of fluorogenic sensor for an antigen that enables wash-free cancer imaging. Check out our unique probe design using a thiol-reactive fluorophore and DARPin! chemrxiv.org/engage/chemr...

New class of fluorogenic probes for antigens based on DARPin-silicon pyronine conjugates

Fluorogenic probes for antigens are useful for various purposes, including medical diagnostics and imaging, but achieving a rapid, large fluorescence increase is difficult. Here, we report a new class...

chemrxiv.org

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Ryosuke Kojima @ryosukekojima.bsky.social · Dec 12

日本語プレスリリース: www.u-tokyo.ac.jp/content/4002...

www.u-tokyo.ac.jp

Ryosuke Kojima @ryosukekojima.bsky.social · Dec 12

English press release: www.eurekalert.org/news-release...

Labeling cell particles with barcodes

Cell-to-cell communication through nanosized particles, working as messengers and carriers, can now be analyzed in a whole new way, thanks to a new method involving CRISPR gene-editing technology. The...

www.eurekalert.org

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Ryosuke Kojima @ryosukekojima.bsky.social · Dec 12

Behind the paper story:https://communities.springernature.com/posts/unveiling-the-release-mechanism-of-small-extracellular-vesicles-with-an-unprecedented-throughput

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Ryosuke Kojima @ryosukekojima.bsky.social · Dec 12

Introducing our recent “CIBER screening” paper describing the use of CRISPR-gRNA-barcoded extracellular vesicles (EVs) for high-throughput identification of EV release regulators @naturecomms.bsky.social
www.nature.com/articles/s41...

Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis and release regulators - Nature Communications

The release processes of small extracellular vesicles (sEVs) remain poorly understood despite their importance. Here, Kunitake et al. present a screening platform called CIBER screening that enables e...

www.nature.com

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