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Reposted by Ryota IINO 飯野亮太

Dean Astumian, OFS @deanast.bsky.social · 5d

This is a beautiful paper that relates the key idea of kinetic asymmetry, along with the possibility of slip and futile cycling, to understand the performance measures for synthetic molecular machines as well as other non-equilibrium processes coupled to chemical catalysis.

James Gallagher @jamesgallagher.bsky.social · 6d

The physics of molecular machinery can be confusing. We developed a plug-and-play interactive tool based on trajectory thermodynamics. The user can now visualise how/why motors move directionally or respond to a force (see video), without knowledge of the physics or maths.
github.com/JoaquinBaixe...

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Reposted by Ryota IINO 飯野亮太

James Gallagher @jamesgallagher.bsky.social · 6d

The physics of molecular machinery can be confusing. We developed a plug-and-play interactive tool based on trajectory thermodynamics. The user can now visualise how/why motors move directionally or respond to a force (see video), without knowledge of the physics or maths.
github.com/JoaquinBaixe...

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Ryota IINO 飯野亮太 @ryotaiino.bsky.social · 5d

Structure-performance relationships for catalysis-driven molecular machinery: Chem www.cell.com/chem/fulltex...

Structure-performance relationships for catalysis-driven molecular machinery

Molecular machine properties such as speed, efficiency, power, and torque depend upon particular features of structure, mechanism, and chemistry. The graphical abstract shows a Top Trumps-style repres...

www.cell.com

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Ryota IINO 飯野亮太 @ryotaiino.bsky.social · 21d

Interpreting molecular ratchets, directionality, and kinetic asymmetry through the work of Curie, Einstein, and Lewis
www.nature.com/articles/s42...

Interpreting molecular ratchets, directionality, and kinetic asymmetry through the work of Curie, Einstein, and Lewis - Communications Physics

Scalar energy can drive formation of non-equilibrium steady-states or power directional processes such as chemotaxis, ion transport across a membrane, or walking along a polar track. This work focuses...

www.nature.com

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Reposted by Ryota IINO 飯野亮太

Dean Astumian, OFS @deanast.bsky.social · 22d

as an exercise it may be worth considering why the bar-hinge model would work fine when powered by light, but would not work when powered by a chemical reaction unless kinetic asymmetry were incorporated into the design.
www.nature.com/articles/s42...

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Ryota IINO 飯野亮太 @ryotaiino.bsky.social · 22d

A self-assembled nanoscale robotic arm controlled by electric fields | Science www.science.org/doi/10.1126/...

A self-assembled nanoscale robotic arm controlled by electric fields

An electrically driven DNA origami arm can exert piconewton forces and transport fluorophores and nanoparticles.

www.science.org

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Ryota IINO 飯野亮太 @ryotaiino.bsky.social · 22d

The bar-hinge motor: a synthetic protein design exploiting conformational switching to achieve directional motility
doi.org/10.1088/1367...
via @ioppublishing.bsky.social

The bar-hinge motor: a synthetic protein design exploiting conformational switching to achieve directional motility - IOPscience

The bar-hinge motor: a synthetic protein design exploiting conformational switching to achieve directional motility, Small, Lara S R, Zuckermann, Martin J, Sessions, Richard B, Curmi, Paul M G, Linke,...

doi.org

Ryota IINO 飯野亮太 @ryotaiino.bsky.social · 22d

RNase H sequence preferences influence antisense oligonucleotide efficiency url: academic.oup.com/nar/article/...

RNase H sequence preferences influence antisense oligonucleotide efficiency

Abstract. RNase H cleaves RNA in RNA–DNA duplexes. It is present in all domains of life as well as in multiple viruses and is essential for mammalian devel

academic.oup.com

Ryota IINO 飯野亮太 @ryotaiino.bsky.social · 24d

Catalyst: Advancing nonequilibrium chemistry by clarifying misconceptions
www.sciencedirect.com/science/arti...

Catalyst: Advancing nonequilibrium chemistry by clarifying misconceptions

Yoshiyuki Kageyama obtained his PhD in multidisciplinary science from the University of Tokyo in 2006 and is currently an independent assistant profes…

www.sciencedirect.com

Ryota IINO 飯野亮太 @ryotaiino.bsky.social · 24d

Reaction: Unfolding nonequilibrium chemistry through conceptual clarity
www.sciencedirect.com/science/arti...

Reaction: Unfolding nonequilibrium chemistry through conceptual clarity

Guanqi Qiu received her PhD from Princeton University in 2021. Thereafter, she was an Alexander von Humboldt postdoctoral fellow at the Justus-Liebig-…

www.sciencedirect.com

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Ryota IINO 飯野亮太 @ryotaiino.bsky.social · 24d

Reaction: Of myths, misconceptions, and motors—A matter of equilibrium
www.sciencedirect.com/science/arti...

Reaction: Of myths, misconceptions, and motors—A matter of equilibrium

David Leigh earned a PhD in crown ether chemistry from the University of Sheffield in 1987 and has held professorial positions at the Universities of …

www.sciencedirect.com

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Ryota IINO 飯野亮太 @ryotaiino.bsky.social · Sep 5

I gave a poster presentation at the 2nd International Symposium on Molecular Materials for Future (ISMMF–2)! Fully enjoyed excellent invited talks and discussions with Prof. Ben Feringa, Prof. Malcolm Kadodwala, and young researchers! Thanks for the opportunity!
www.tfc.tohoku.ac.jp/junior-resea...

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Ryota IINO 飯野亮太 @ryotaiino.bsky.social · Sep 4

Control and synchronization of rapid nanoscale DNA heat engine by local heating | Science Advances www.science.org/doi/10.1126/...

Control and synchronization of rapid nanoscale DNA heat engine by local heating

A microheater synchronizes the binding/unbinding of DNA sticky ends, increasing the strength and speed of DNA hinge machine.

www.science.org

Ryota IINO 飯野亮太 @ryotaiino.bsky.social · Sep 3

The official YouTube channel of the Biophysical Society of Japan (BSJ). Please take a look at the movies briefly introducing papers published in Biophysics and Physicobiology (BPPB), the official journal of the BSJ.
youtube.com/@TheBiophysi...
The BSJ website
www.biophys.jp/index-e.html

The Biophysical Society of Japan

The official YouTube channel of the Biophysical Society of Japan. https://www.biophys.jp/index-e.html

youtube.com

Ryota IINO 飯野亮太 @ryotaiino.bsky.social · Aug 24

落合さんに素晴らしいセミナーをして頂きました！分子研の若手の皆様の研究紹介とラボツアーも行いました。ありがとうございました！
Ochiai-san gave us a wonderful seminar! We also introduced research of young researchers at IMS and had lab tours. Thank you all!
www.ims.ac.jp/en/research/...

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Ryota IINO 飯野亮太 @ryotaiino.bsky.social · Aug 24

From Molecules to Machines: A Multiscale Roadmap to Intelligent, Multifunctional Soft Robotics | Chemical Reviews pubs.acs.org/doi/full/10....

From Molecules to Machines: A Multiscale Roadmap to Intelligent, Multifunctional Soft Robotics

Soft robots, with their exceptional compliance, adaptability, and ability to safely interact with delicate objects, are redefining human–machine interfaces and expanding robotic capabilities into envi...

pubs.acs.org

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Ryota IINO 飯野亮太 @ryotaiino.bsky.social · Aug 22

本日15時より開催です！落合さんの原著論文は下記です。
SUPREM: an engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency
academic.oup.com/nar/article/...

Ryota IINO 飯野亮太 @ryotaiino.bsky.social · Jul 17

落合佳樹さん（OIST）にセミナーをして頂きます。

日時：2025年8月22日(金) 15:00-16:00
場所：山手3号館2階共通セミナー室
講演者：落合佳樹 (Yoshiki Ochiai)
所属：沖縄科学技術大学院大学(OIST)
題目：DNA/RNA標識ツールの開発を目指した非配列特異的DNA/RNAメチルトランスフェラーゼの探索と改変
Exploring and Engineering non-site-specific DNA/RNA Methyltransferases for Development of DNA/RNA Labeling Tools

Ryota IINO 飯野亮太 @ryotaiino.bsky.social · Aug 21

佐野さん（東京科学大）が短期インターン生として4日間、ラボで実験を行いました！新しいテーマを試し面白い結果が得られました！お疲れさまでした！写真の掲載をご了承頂きありがとうございます。
Sano-san (Science Tokyo) tried new experiments as a short intern at IMS!
sites.google.com/ims.ac.jp/ta...

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Ryota IINO 飯野亮太 @ryotaiino.bsky.social · Aug 21

We had a farewell lunch for Tom, an internship student from Chimie ParisTech. Thank you so much for your tremendous contribution to the lab for 5 months! He also traveled all over Japan during his stay. I'm sure he had a great time!
groups.ims.ac.jp/organization...
www.chimieparistech.psl.eu/en/

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Reposted by Ryota IINO 飯野亮太

Guillaume De Bo @guillaumedebo.bsky.social · Jul 14

Dual release with a bit of logic!

We show the release of a double cargo payload with 2 stimuli, force and water, with an AND gate mechanism.

Great work from Lei Chen, now available in #openaccess as a #HotPaper in @angewandtechemie.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

#chemsky

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Reposted by Ryota IINO 飯野亮太

Nature @nature.com · Aug 6

A nanoscopic machine transforms a molecular chain into interlocking loops

go.nature.com/4omi3zO

Tiny motor uses heat to perform molecular magic

A nanoscopic machine transforms a molecular chain into interlocking loops.

go.nature.com

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Ryota IINO 飯野亮太 @ryotaiino.bsky.social · Aug 19

Molecule of the Month: Plastic-eating Enzymes
pdb101.rcsb.org/motm/277

PDB101: Molecule of the Month: Plastic-eating Enzymes

Researchers are looking to Nature to find ways to dispose of discarded plastic.

pdb101.rcsb.org

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Ryota IINO 飯野亮太 @ryotaiino.bsky.social · Aug 19

I will give a talk at the East Asia Single-Molecule Biophysics Symposium 2025 (EASMB 2025). Thanks for the opportunity! The EASMB is a very important event for me to reconnect with old friends and make new ones!

Abstract submission deadline: 12 Sep 2025
physics.nus.edu.sg/easmb2025/

Ryota IINO 飯野亮太 @ryotaiino.bsky.social · Aug 19

Multistate and functional protein design using RoseTTAFold sequence space diffusion
www.nature.com/articles/s41...

Multistate and functional protein design using RoseTTAFold sequence space diffusion - Nature Biotechnology

ProteinGenerator simultaneously generates protein sequences and structures using sequence space diffusion.

www.nature.com

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Ryota IINO 飯野亮太 @ryotaiino.bsky.social · Aug 19

Sparks of function by de novo protein design
www.nature.com/articles/s41...

Sparks of function by de novo protein design - Nature Biotechnology

Chu and colleagues discuss recent developments in de novo protein design.

www.nature.com

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