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schultelab.bsky.social
Leon Schulte
@schultelab.bsky.social
61 followers 98 following 4 posts
Human immunology through the RNA lens. Focused on macrophages, lncRNAs & systems immunology. Professor for RNA- and infection-biology @unimarburg.bsky.social. Web: http://rna-lab.org/
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schultelab.bsky.social
Leon Schulte @schultelab.bsky.social · May 22
How do long noncoding RNAs help macrophages fight bacteria? We built a whole atlas to explore this question — and it’s now published in Nature Communications!
🔗 rdcu.be/em7aM

#lncRNA #macrophage #immunology
A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages
Nature Communications - Long non-coding RNAs (lncRNA) are known immune regulators, yet a systemic understanding of their regulatory crosstalk is still elusive. Here the authors establish a platform...
rdcu.be
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Reposted by Leon Schulte
versteegga.bsky.social
versteegga.bsky.social @versteegga.bsky.social · Jul 1
Our latest study is now out in @narjournal.bsky.social‬: we identify a post-transcriptional bottleneck in interferon gamma signaling that hinges on proper maturation of JAK2 mRNA.
Paper: academic.oup.com/nar/article/...
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schultelab.bsky.social
Leon Schulte @schultelab.bsky.social · May 22
How do long noncoding RNAs help macrophages fight bacteria? We built a whole atlas to explore this question — and it’s now published in Nature Communications!
🔗 rdcu.be/em7aM

#lncRNA #macrophage #immunology
A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages
Nature Communications - Long non-coding RNAs (lncRNA) are known immune regulators, yet a systemic understanding of their regulatory crosstalk is still elusive. Here the authors establish a platform...
rdcu.be
2 4
schultelab.bsky.social
Leon Schulte @schultelab.bsky.social · May 22
We also built SMyLR, a searchable online resource for the immune-lncRNA community:

Explore pathway dependencies, subcellular localization, and protein interactors of hundreds of lncRNAs in macrophages:
🔍 rna-lab.org/smylr/

More info in our paper:
🔗 rdcu.be/em7aM

#lncRNA #openscience #macrophage
schultelab.bsky.social
Leon Schulte @schultelab.bsky.social · May 22
Meet GRADR: our new approach to chart lncRNA–protein interactions transcriptome-wide.

By combining gradient profiling and RNA-binding proteomics, GRADR reveals which lncRNAs engage which protein machineries.

📘 Step-by-step protocol included in:
🔗 www.nature.com/articles/s41...

#lncRNA #methods
schultelab.bsky.social
Leon Schulte @schultelab.bsky.social · May 21
We’re now on Bluesky!
This space will share updates from our lab, covering RNA biology, macrophage immunology, and long noncoding RNAs.
Follow along for papers, resources & insights from the bench.

#lncRNA #macrophage #immunology #RNA #biomed #openscience
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