Leon Schulte
@schultelab.bsky.social
Human immunology through the RNA lens. Focused on macrophages, lncRNAs & systems immunology. Professor for RNA- and infection-biology @unimarburg.bsky.social. Web: http://rna-lab.org/
Pinned
Leon Schulte
@schultelab.bsky.social
· May 22
A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages
Nature Communications - Long non-coding RNAs (lncRNA) are known immune regulators, yet a systemic understanding of their regulatory crosstalk is still elusive. Here the authors establish a platform...
rdcu.be
How do long noncoding RNAs help macrophages fight bacteria? We built a whole atlas to explore this question — and it’s now published in Nature Communications!
🔗 rdcu.be/em7aM
#lncRNA #macrophage #immunology
🔗 rdcu.be/em7aM
#lncRNA #macrophage #immunology
Reposted by Leon Schulte
Tuesday 25.11 13:00 CET we are happy to host Prof. Leon Schulte (rna-lab.org) @schultelab.bsky.social join us for an exciting talk "Multi-omic Dissection of Regulatory lncRNA-Protein Networks in Innate Immunity" thanks @rnasociety.bsky.social @imbb-forth.bsky.social us02web.zoom.us/meeting/regi...
November 21, 2025 at 2:24 PM
Tuesday 25.11 13:00 CET we are happy to host Prof. Leon Schulte (rna-lab.org) @schultelab.bsky.social join us for an exciting talk "Multi-omic Dissection of Regulatory lncRNA-Protein Networks in Innate Immunity" thanks @rnasociety.bsky.social @imbb-forth.bsky.social us02web.zoom.us/meeting/regi...
Reposted by Leon Schulte
Our latest study is now out in @narjournal.bsky.social: we identify a post-transcriptional bottleneck in interferon gamma signaling that hinges on proper maturation of JAK2 mRNA.
Paper: academic.oup.com/nar/article/...
Paper: academic.oup.com/nar/article/...
July 1, 2025 at 8:22 AM
Our latest study is now out in @narjournal.bsky.social: we identify a post-transcriptional bottleneck in interferon gamma signaling that hinges on proper maturation of JAK2 mRNA.
Paper: academic.oup.com/nar/article/...
Paper: academic.oup.com/nar/article/...
How do long noncoding RNAs help macrophages fight bacteria? We built a whole atlas to explore this question — and it’s now published in Nature Communications!
🔗 rdcu.be/em7aM
#lncRNA #macrophage #immunology
🔗 rdcu.be/em7aM
#lncRNA #macrophage #immunology
A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages
Nature Communications - Long non-coding RNAs (lncRNA) are known immune regulators, yet a systemic understanding of their regulatory crosstalk is still elusive. Here the authors establish a platform...
rdcu.be
May 22, 2025 at 3:54 PM
How do long noncoding RNAs help macrophages fight bacteria? We built a whole atlas to explore this question — and it’s now published in Nature Communications!
🔗 rdcu.be/em7aM
#lncRNA #macrophage #immunology
🔗 rdcu.be/em7aM
#lncRNA #macrophage #immunology
We also built SMyLR, a searchable online resource for the immune-lncRNA community:
Explore pathway dependencies, subcellular localization, and protein interactors of hundreds of lncRNAs in macrophages:
🔍 rna-lab.org/smylr/
More info in our paper:
🔗 rdcu.be/em7aM
#lncRNA #openscience #macrophage
Explore pathway dependencies, subcellular localization, and protein interactors of hundreds of lncRNAs in macrophages:
🔍 rna-lab.org/smylr/
More info in our paper:
🔗 rdcu.be/em7aM
#lncRNA #openscience #macrophage
May 22, 2025 at 11:57 AM
We also built SMyLR, a searchable online resource for the immune-lncRNA community:
Explore pathway dependencies, subcellular localization, and protein interactors of hundreds of lncRNAs in macrophages:
🔍 rna-lab.org/smylr/
More info in our paper:
🔗 rdcu.be/em7aM
#lncRNA #openscience #macrophage
Explore pathway dependencies, subcellular localization, and protein interactors of hundreds of lncRNAs in macrophages:
🔍 rna-lab.org/smylr/
More info in our paper:
🔗 rdcu.be/em7aM
#lncRNA #openscience #macrophage
Meet GRADR: our new approach to chart lncRNA–protein interactions transcriptome-wide.
By combining gradient profiling and RNA-binding proteomics, GRADR reveals which lncRNAs engage which protein machineries.
📘 Step-by-step protocol included in:
🔗 www.nature.com/articles/s41...
#lncRNA #methods
By combining gradient profiling and RNA-binding proteomics, GRADR reveals which lncRNAs engage which protein machineries.
📘 Step-by-step protocol included in:
🔗 www.nature.com/articles/s41...
#lncRNA #methods
May 22, 2025 at 11:53 AM
Meet GRADR: our new approach to chart lncRNA–protein interactions transcriptome-wide.
By combining gradient profiling and RNA-binding proteomics, GRADR reveals which lncRNAs engage which protein machineries.
📘 Step-by-step protocol included in:
🔗 www.nature.com/articles/s41...
#lncRNA #methods
By combining gradient profiling and RNA-binding proteomics, GRADR reveals which lncRNAs engage which protein machineries.
📘 Step-by-step protocol included in:
🔗 www.nature.com/articles/s41...
#lncRNA #methods
We’re now on Bluesky!
This space will share updates from our lab, covering RNA biology, macrophage immunology, and long noncoding RNAs.
Follow along for papers, resources & insights from the bench.
#lncRNA #macrophage #immunology #RNA #biomed #openscience
This space will share updates from our lab, covering RNA biology, macrophage immunology, and long noncoding RNAs.
Follow along for papers, resources & insights from the bench.
#lncRNA #macrophage #immunology #RNA #biomed #openscience
May 21, 2025 at 8:21 PM
We’re now on Bluesky!
This space will share updates from our lab, covering RNA biology, macrophage immunology, and long noncoding RNAs.
Follow along for papers, resources & insights from the bench.
#lncRNA #macrophage #immunology #RNA #biomed #openscience
This space will share updates from our lab, covering RNA biology, macrophage immunology, and long noncoding RNAs.
Follow along for papers, resources & insights from the bench.
#lncRNA #macrophage #immunology #RNA #biomed #openscience