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Marija Krasiļņikova

@scotomorph.bsky.social

150 followers 49 following 17 posts

Parasitology @ McCulloch lab at the University of Glasgow

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Marija Krasiļņikova @scotomorph.bsky.social · Jan 17

DNA replication beyond the cores of megabase chromosomes of T. brucei -- some of my PhD work is FINALLY out! doi.org/10.1038/s414... thank you to @rmc9z.bsky.social @marquescata.bsky.social Emma, Dario, Kathryn, Graham and Craig!

Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei - Nature Communications

A full description of trypanosome genome replication has proved elusive. Here, after genome assembly, the authors reveal compartmentalisation of DNA replication activity and stability between transcri...

doi.org

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Reposted by Marija Krasiļņikova

Richard McCulloch @rmc9z.bsky.social · 3d

Our lab has two funded PhDs to start in 2026 via the NorthWestBio programme

Project details here
www.gla.ac.uk/postgraduate...
...and here
www.gla.ac.uk/postgraduate...

Application deadline is Nov 21st 2025; apply here:
www.gla.ac.uk/postgraduate...

University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Understanding Pathogens, from Molecules to Phenotypes - Richard McCulloch

www.gla.ac.uk

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · 5d

Targets of the human antibody response to the variant surface glycoprotein of Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41040341/

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · 5d

The UTRs of Leishmania donovani vary in length and are enriched in potential regulatory structures pubmed.ncbi.nlm.nih.gov/41040140/

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · 5d

Phylogenomics of free-living neobodonids reveals they are a paraphyletic group from which all other metakinetoplastids are descended www.biorxiv.org/content/10.1101/2025.10.03.680260v1

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · 8d

Splice site diversity and abundance of non-canonical introns in diplonemids (Diplonemea, Euglenozoa) pubmed.ncbi.nlm.nih.gov/41027712/

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · 10d

First Genome-Wide Centromere Map of Trypanosoma cruzi Reveals Linear and 3D Compartment Boundaries and Spatial Clustering www.biorxiv.org/content/10.1101/2025.09.26.678825v1

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · 13d

Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin. www.biorxiv.org/content/10.1101/2025.09.24.678203v1

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · 18d

The mitotic spindle kinase MSK co-ordinates segregation of the nucleus and kinetoplast in Leishmania mexicana www.biorxiv.org/content/10.1101/2025.09.19.677349v1

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Marija Krasiļņikova @scotomorph.bsky.social · 21d

New pre-print from Guy @goldrieve.bsky.social on vsgseq2 - a much improved, robust tool to analyse VSG expression in tryps

kinetoplastids papers @kinetoplastpapers.bsky.social · 22d

vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide Trypanosoma brucei VSG expression www.biorxiv.org/content/10.1101/2025.09.12.675796v1

Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · 22d

vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide Trypanosoma brucei VSG expression www.biorxiv.org/content/10.1101/2025.09.12.675796v1

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · 27d

Chemical genetics reveals Leishmania KKT2 and CRK9 kinase activity is required for cell cycle progression www.biorxiv.org/content/10.1101/2025.09.08.674917v1

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Reposted by Marija Krasiļņikova

Dr Joanne Power @hanniepower.bsky.social · 29d

Save the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026!
Keep an eye on the BSP website for registration and abstract submission!
Logo by @shannaraeilean.bsky.social! 🦟

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · 29d

A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania www.biorxiv.org/content/10.1101/2025.09.10.675331v1

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · Sep 10

Transcriptomic and proteomic analysis of quiescent epimastigotes as a resource for investigating Trypanosoma cruzi persistence. www.biorxiv.org/content/10.1101/2025.09.09.675056v1

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · Sep 6

Genome-wide overexpression screen reveals a novel transcription termination factor in Trypanosoma brucei www.biorxiv.org/content/10.1101/2025.09.02.673782v1

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · Sep 2

A Trypanosome Trifecta: an independently tunable triple inducer system for genetic studies in Trypanosoma brucei. www.biorxiv.org/content/10.1101/2025.08.31.673413v1

Reposted by Marija Krasiļņikova

Faria Tryps Lab @fariatrypslab.bsky.social · Aug 11

How do parasites strategically organise their genomes to influence gene expression? If you’re curious, check our latest review in @cp-trendsparasitol.bsky.social !

@biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr

www.sciencedirect.com/science/arti...

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Reposted by Marija Krasiļņikova

bioRxiv Genomics @biorxiv-genomic.bsky.social · Aug 15

Single-molecule landscape of DNA replication pausing https://www.biorxiv.org/content/10.1101/2025.08.14.670160v1

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · Aug 24

The absence of the Leishmania major telomerase TERT component links telomeres and cell homeostasis with infectivity pubmed.ncbi.nlm.nih.gov/40848782/

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Reposted by Marija Krasiļņikova

Richard McCulloch @rmc9z.bsky.social · Aug 15

We’re pleased to share our new study, led by @jezieldamasceno.bsky.social, that used long-read, single molecule sequencing to reveal the full (?) picture of Leishmania DNA replication. Thanks, Mike Boemo and helpful reviewers @uofgsii.bsky.social

www.sciencedirect.com/science/arti...

Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events

DNA replication initiates at genome sites termed origins. Previous origin mapping approaches in the populations of the protozoan parasite Leishmania m…

www.sciencedirect.com

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · Aug 12

Integrating tRNA gene epigenomics and expression with codon usage unravels an intricate connection with translatome dynamics in Trypanosoma cruzi pubmed.ncbi.nlm.nih.gov/40788054/

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · Aug 8

Trypanosoma cruzi surface components: Why so many? Why so polymorphic? pubmed.ncbi.nlm.nih.gov/40774760/

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · Aug 7

Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events pubmed.ncbi.nlm.nih.gov/40768333/

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Reposted by Marija Krasiļņikova

kinetoplastids papers @kinetoplastpapers.bsky.social · Aug 6

Discovery of unique mitotic mechanisms in Paradiplonema papillatum pubmed.ncbi.nlm.nih.gov/40763799/

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Reposted by Marija Krasiļņikova

Jeziel D. Damasceno @jezieldamasceno.bsky.social · Aug 6

Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent.
We show widespread stochastic origin firing and insights into genome variability.

www.cell.com/cell-reports...

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