Scott Berry
@scottbscience.bsky.social
Group leader at Single Molecule Science and UNSW RNA Institute at the University of New South Wales, Sydney. Interested in quantitative regulation of gene expression in single cells. Views my own. @scottbscience https://berrygroup.github.io
What happens when you suddenly remove half of an essential enzyme from cells? 🤔
We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance.
Our lab's new preprint 👇
bit.ly/4pyPgax
We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance.
Our lab's new preprint 👇
bit.ly/4pyPgax
Hierarchical buffering of cellular RNA polymerase II pools maintains transcriptional homeostasis
RNA polymerase II (Pol II) abundance and transcriptional output are coordinated across diverse conditions to maintain mRNA homeostasis. To determine whether Pol II acts as a limiting factor for transc...
bit.ly
January 15, 2026 at 5:25 AM
What happens when you suddenly remove half of an essential enzyme from cells? 🤔
We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance.
Our lab's new preprint 👇
bit.ly/4pyPgax
We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance.
Our lab's new preprint 👇
bit.ly/4pyPgax
Reposted by Scott Berry
Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Stalling of elongating Pol II triggers Ser7 phosphorylation in trans to drive transcription recovery
DNA is scattered with obstacles that stall RNA polymerase II (Pol II) and block the production of full-length transcripts. Two mechanisms are known to resolve stalled Pol II: transcription-coupled nuc...
www.biorxiv.org
December 9, 2025 at 10:13 PM
Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Scott Berry
🎉 𝙒𝙝𝙖𝙩 𝙖 𝙙𝙖𝙮! 🎉
On Thursday we held our inaugural EMCR Mini Symposium, bringing together six in-person nodes plus online attendees from across Australasia. It was fantastic to see our community come together to share science, build connections, and finish 2025 strong.
#EMCR #AEpiA #epigenetics
On Thursday we held our inaugural EMCR Mini Symposium, bringing together six in-person nodes plus online attendees from across Australasia. It was fantastic to see our community come together to share science, build connections, and finish 2025 strong.
#EMCR #AEpiA #epigenetics
December 5, 2025 at 10:49 PM
🎉 𝙒𝙝𝙖𝙩 𝙖 𝙙𝙖𝙮! 🎉
On Thursday we held our inaugural EMCR Mini Symposium, bringing together six in-person nodes plus online attendees from across Australasia. It was fantastic to see our community come together to share science, build connections, and finish 2025 strong.
#EMCR #AEpiA #epigenetics
On Thursday we held our inaugural EMCR Mini Symposium, bringing together six in-person nodes plus online attendees from across Australasia. It was fantastic to see our community come together to share science, build connections, and finish 2025 strong.
#EMCR #AEpiA #epigenetics
Reposted by Scott Berry
Optimised nanobody-based quenchbodies are developed through rational design and in vitro evolution, enabling improved protein detection with up to 2.4-fold fluorescence increase @haiboyu.bsky.social
@lisannes.bsky.social @molecularhorizons.bsky.social
www.nature.com/articles/s42...
@lisannes.bsky.social @molecularhorizons.bsky.social
www.nature.com/articles/s42...
Optimised nanobody-based quenchbodies for enhanced protein detection - Communications Biology
Optimised nanobody-based quenchbodies are developed through rational design and in vitro evolution, enabling improved protein detection with up to 2.4-fold fluorescence increase and 2 nM sensitivity f...
www.nature.com
June 19, 2025 at 1:21 PM
Optimised nanobody-based quenchbodies are developed through rational design and in vitro evolution, enabling improved protein detection with up to 2.4-fold fluorescence increase @haiboyu.bsky.social
@lisannes.bsky.social @molecularhorizons.bsky.social
www.nature.com/articles/s42...
@lisannes.bsky.social @molecularhorizons.bsky.social
www.nature.com/articles/s42...
Reposted by Scott Berry
🌟 𝐈𝐧𝐭𝐫𝐨𝐝𝐮𝐜𝐢𝐧𝐠 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦 𝐂𝐚𝐫𝐞𝐞𝐫 𝐏𝐚𝐧𝐞𝐥𝐥𝐢𝐬𝐭 – 𝐃𝐫 𝐋𝐮𝐤𝐞 𝐈𝐬𝐛𝐞𝐥 🌟
We’re excited to spotlight Dr Luke Isbel, one of our inspiring career development panellists for the upcoming Australasian Epigenetics Alliance 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦!
aepia.org.au/emcr-symposium
We’re excited to spotlight Dr Luke Isbel, one of our inspiring career development panellists for the upcoming Australasian Epigenetics Alliance 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦!
aepia.org.au/emcr-symposium
October 9, 2025 at 10:25 PM
🌟 𝐈𝐧𝐭𝐫𝐨𝐝𝐮𝐜𝐢𝐧𝐠 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦 𝐂𝐚𝐫𝐞𝐞𝐫 𝐏𝐚𝐧𝐞𝐥𝐥𝐢𝐬𝐭 – 𝐃𝐫 𝐋𝐮𝐤𝐞 𝐈𝐬𝐛𝐞𝐥 🌟
We’re excited to spotlight Dr Luke Isbel, one of our inspiring career development panellists for the upcoming Australasian Epigenetics Alliance 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦!
aepia.org.au/emcr-symposium
We’re excited to spotlight Dr Luke Isbel, one of our inspiring career development panellists for the upcoming Australasian Epigenetics Alliance 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦!
aepia.org.au/emcr-symposium
Reposted by Scott Berry
A purpose built solution to Australia’s biomedical funding crisis….. release the #MRFF = invest in our future scientists & their discoveries. #DiscoveriesNeedDollars www.smh.com.au/politics/fed...
September 29, 2025 at 1:52 AM
A purpose built solution to Australia’s biomedical funding crisis….. release the #MRFF = invest in our future scientists & their discoveries. #DiscoveriesNeedDollars www.smh.com.au/politics/fed...
Reposted by Scott Berry
The Asia RNA Club Symposium will be happening in Seoul in Nov 3-5, bringing together RNA scientists from the Asia-Pacific region. Excellent speakers and a great opportunity to connect! Abstract submission by Sept 5 asiarnaclub.org
August 21, 2025 at 8:04 AM
The Asia RNA Club Symposium will be happening in Seoul in Nov 3-5, bringing together RNA scientists from the Asia-Pacific region. Excellent speakers and a great opportunity to connect! Abstract submission by Sept 5 asiarnaclub.org
Reposted by Scott Berry
We have some news to share: The Kueh lab is moving to Yale this fall! We will be joining the Yale Center for Systems and Engineering Immunology @yalecsei.bsky.social and the Department of Immunobiology.
medicine.yale.edu/systems-engi...
medicine.yale.edu/systems-engi...
Research
The immune system is a spatially distributed, whole-body sensory-reactive system that monitors, reacts, and adapts to various stress signals (e.g., tissue
medicine.yale.edu
August 19, 2025 at 2:53 AM
We have some news to share: The Kueh lab is moving to Yale this fall! We will be joining the Yale Center for Systems and Engineering Immunology @yalecsei.bsky.social and the Department of Immunobiology.
medicine.yale.edu/systems-engi...
medicine.yale.edu/systems-engi...
Reposted by Scott Berry
Our #AI #research @natcomms.nature.com uses #multiomics data integration concepts to fuse 4-channel imaging data into unlimitedly multiplexed image datasets via generative deep learning to interrogate complex cell biology, like #EMT. Multiplexing made easy! rdcu.be/emtBc @singmolsci.bsky.social
Extensible Immunofluorescence (ExIF) accessibly generates high-plexity datasets by integrating standard 4-plex imaging data
Nature Communications - Gunawan et al. propose an Extensible Immunofluorescence (ExIF) strategy that integrates distinct 4-plex image panels from routine fluorescence microscopy into multiplexed...
rdcu.be
May 20, 2025 at 8:44 AM
Our #AI #research @natcomms.nature.com uses #multiomics data integration concepts to fuse 4-channel imaging data into unlimitedly multiplexed image datasets via generative deep learning to interrogate complex cell biology, like #EMT. Multiplexing made easy! rdcu.be/emtBc @singmolsci.bsky.social
Reposted by Scott Berry
Fantastic to see this short film about A/Prof Lawrence Lee who is a Group Leader in UNSW Single Molecule Science and the founding CEO of the exciting startup, SWAN Genomics 🧬🔬
🚀 Meet Our Centre Startups: SWAN Genomics with Associate Professor Lawrence Lee
SWAN Genomics is changing the way we sequence #DNA with a new approach that goes beyond today’s short-read and long-read methods. #Startup #SyntheticBiology #Biotechnology
youtu.be/WCT3sA2-jtY?...
SWAN Genomics is changing the way we sequence #DNA with a new approach that goes beyond today’s short-read and long-read methods. #Startup #SyntheticBiology #Biotechnology
youtu.be/WCT3sA2-jtY?...
Swan Genomics
YouTube video by ARC Centre of Excellence in Synthetic Biology
youtu.be
May 17, 2025 at 11:09 PM
Fantastic to see this short film about A/Prof Lawrence Lee who is a Group Leader in UNSW Single Molecule Science and the founding CEO of the exciting startup, SWAN Genomics 🧬🔬
Reposted by Scott Berry
Join our group (www.luginbuehllab.com) at @camplantsci.bsky.social! Are you excited about mycorrhiza, (single-cell) transcriptomics, carbon physiology, and the model crop rice? We have a 2-year postdoc position available, starting ASAP. Closing date 23rd May 2025!
www.jobs.cam.ac.uk/job/51214/
www.jobs.cam.ac.uk/job/51214/
Research Assistant / Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant / Research Associate (Fixed Term) in the Department of Plant Sciences at the University of Cambridge.
www.jobs.cam.ac.uk
May 4, 2025 at 11:13 AM
Join our group (www.luginbuehllab.com) at @camplantsci.bsky.social! Are you excited about mycorrhiza, (single-cell) transcriptomics, carbon physiology, and the model crop rice? We have a 2-year postdoc position available, starting ASAP. Closing date 23rd May 2025!
www.jobs.cam.ac.uk/job/51214/
www.jobs.cam.ac.uk/job/51214/
Reposted by Scott Berry
We have had multiple discussions about why people have not previously observed the very dramatic reduction in transcription upon PNUTS depletion. So I looked at our own TT-seq data and analysed it without including the spike-in. The numbers speak for themselves! Spike-in calibration is important!
December 12, 2024 at 10:50 AM
We have had multiple discussions about why people have not previously observed the very dramatic reduction in transcription upon PNUTS depletion. So I looked at our own TT-seq data and analysed it without including the spike-in. The numbers speak for themselves! Spike-in calibration is important!
Reposted by Scott Berry
Mechanism of quality control of gene expression revealed by @anatv.bsky.social & @scottbscience.bsky.social’s groups in study of Pol II molecules.
Read more about the work, led by Roberta Cacioppo, Alexander Gillis, Iván Shlamovitz & Andrew Zeller: www2.mrc-lmb.cam.ac.uk/newly-identi...
#LMBResearch
Read more about the work, led by Roberta Cacioppo, Alexander Gillis, Iván Shlamovitz & Andrew Zeller: www2.mrc-lmb.cam.ac.uk/newly-identi...
#LMBResearch
December 11, 2024 at 4:05 PM
Mechanism of quality control of gene expression revealed by @anatv.bsky.social & @scottbscience.bsky.social’s groups in study of Pol II molecules.
Read more about the work, led by Roberta Cacioppo, Alexander Gillis, Iván Shlamovitz & Andrew Zeller: www2.mrc-lmb.cam.ac.uk/newly-identi...
#LMBResearch
Read more about the work, led by Roberta Cacioppo, Alexander Gillis, Iván Shlamovitz & Andrew Zeller: www2.mrc-lmb.cam.ac.uk/newly-identi...
#LMBResearch
Was a pleasure working with @anatv.bsky.social on this!
The first paper from our lab is online! A wonderful collaboration with @scottbscience.bsky.social lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle!
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription
Cacioppo, Gillis, Shlamovitz, Zeller, et al. show that CRL3ARMC5 ubiquitylates RNA Pol II at early stages of transcription as part of a major homeostatic RNA Pol II turnover mechanism. CRL3ARMC5 and the Integrator phosphatase act as complementary pathways, monitoring the quantity and quality of RNA Pol II complexes before they are licensed into elongation.
www.cell.com
December 12, 2024 at 5:40 AM
Was a pleasure working with @anatv.bsky.social on this!
📣 New paper from the lab!
In a fantastic new collaboration with @anatv.bsky.social lab, we characterise a major Pol II homeostasis pathway in human cells. Congratulations Roberta, Alex, Ivan, and Andrew.
www.cell.com/molecular-ce...
In a fantastic new collaboration with @anatv.bsky.social lab, we characterise a major Pol II homeostasis pathway in human cells. Congratulations Roberta, Alex, Ivan, and Andrew.
www.cell.com/molecular-ce...
CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription
Cacioppo, Gillis, Shlamovitz, Zeller, et al. show that CRL3ARMC5 ubiquitylates RNA Pol II at early stages of transcription as part of a major homeostatic RNA Pol II turnover mechanism. CRL3ARMC5 and the Integrator phosphatase act as complementary pathways, monitoring the quantity and quality of RNA Pol II complexes before they are licensed into elongation.
www.cell.com
December 12, 2024 at 5:38 AM
📣 New paper from the lab!
In a fantastic new collaboration with @anatv.bsky.social lab, we characterise a major Pol II homeostasis pathway in human cells. Congratulations Roberta, Alex, Ivan, and Andrew.
www.cell.com/molecular-ce...
In a fantastic new collaboration with @anatv.bsky.social lab, we characterise a major Pol II homeostasis pathway in human cells. Congratulations Roberta, Alex, Ivan, and Andrew.
www.cell.com/molecular-ce...
Reposted by Scott Berry
Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
The PNUTS phosphatase complex controls transcription pause release
Kelley et al. discover that the PNUTS phosphatase complex plays an essential role
in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves
this through its TND, which recog...
www.cell.com
November 26, 2024 at 4:18 PM
Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)