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Reposted by UNSW Single Molecule Science

Izzy Jayasinghe @ijayas.bsky.social · 17d

Privileged to join the ranks of EMBL Australia’s partner laboratories steering committee, representing @singmolsci.bsky.social, the EMBL Aus node in Single Molecule Science. Lots of new developments around the corner for this wonderful Medical & Life Sciences community in Australia.

EMBL Australia @emblaustralia.org · 18d

We’re expanding our Partner Laboratory Network Steering Committee! 🎉

Thrilled to welcome Lisa Butler, Edwina McGlinn, @ijayas.bsky.social, Amee George, @ryanlister.bsky.social & Denise Doolan to our #leadership team - strengthening national & international collab'n in life sciences.

bit.ly/4gFxzDE

EMBL Australia expands Steering Committee to strengthen national collaboration | EMBL Australia

EMBL Australia is pleased to announce the expansion of its Partner Laboratory Network Steering Committee, welcoming new senior representatives from leading research institutions across the country. Th...

bit.ly

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UNSW Single Molecule Science @singmolsci.bsky.social · Aug 18

Well done to the team from Single Molecule Science who participated in the Science in the Swamp celebration of 2025 National Science Week at Centennial Park, Sydney. 'Microscopic Safari' was a fun journey over everything in the nano and micron scale on a sunny winter Sunday. ✨😎 🧪

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Reposted by UNSW Single Molecule Science

John Lock @locusj.bsky.social · May 20

Our #AI #research @natcomms.nature.com uses #multiomics data integration concepts to fuse 4-channel imaging data into unlimitedly multiplexed image datasets via generative deep learning to interrogate complex cell biology, like #EMT. Multiplexing made easy! rdcu.be/emtBc @singmolsci.bsky.social

Extensible Immunofluorescence (ExIF) accessibly generates high-plexity datasets by integrating standard 4-plex imaging data

Nature Communications - Gunawan et al. propose an Extensible Immunofluorescence (ExIF) strategy that integrates distinct 4-plex image panels from routine fluorescence microscopy into multiplexed...

rdcu.be

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UNSW Single Molecule Science @singmolsci.bsky.social · May 17

Fantastic to see this short film about A/Prof Lawrence Lee who is a Group Leader in UNSW Single Molecule Science and the founding CEO of the exciting startup, SWAN Genomics 🧬🔬

ARC Centre of Excellence in Synthetic Biology @arccoesb.bsky.social · May 15

🚀 Meet Our Centre Startups: SWAN Genomics with Associate Professor Lawrence Lee

SWAN Genomics is changing the way we sequence #DNA with a new approach that goes beyond today’s short-read and long-read methods. #Startup #SyntheticBiology #Biotechnology

youtu.be/WCT3sA2-jtY?...

Swan Genomics

YouTube video by ARC Centre of Excellence in Synthetic Biology

youtu.be

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Reposted by UNSW Single Molecule Science

Izzy Jayasinghe @ijayas.bsky.social · May 1

Hello #AcademicBsky hivemind! Is there anyone out here (preferably from Australia / nearby) who uses FIB or BE lithography at submicron resolution on materials like quartz, and might be interested in collaborating with us on a cool new project?

Happy to take recommendations. 🧪 🔬

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Reposted by UNSW Single Molecule Science

kate poole @katepoole.bsky.social · Apr 9

A beautifully elegant study from Vaish and Leeba and team looking at mitochondrial volume regulation using cleverly designed and fabricated chambers to track fission yeast divisions over time

Vaishnavi Ananthanarayanan (She/Her) @vaishananth.bsky.social · Apr 9

How is mitochondrial volume maintained across successive generations of dividing cells? In our new preprint, we show how fission yeast cells use mitochondrial activity to control division timing and maintain mitochondrial homeostasis! (1/n)

📖 www.biorxiv.org/content/10.1...

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Reposted by UNSW Single Molecule Science

Vaishnavi Ananthanarayanan (She/Her) @vaishananth.bsky.social · Apr 9

How is mitochondrial volume maintained across successive generations of dividing cells? In our new preprint, we show how fission yeast cells use mitochondrial activity to control division timing and maintain mitochondrial homeostasis! (1/n)

📖 www.biorxiv.org/content/10.1...

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UNSW Single Molecule Science @singmolsci.bsky.social · Feb 7

Aaaand that’s a wrap at Asia Pacific Microscopy Congress 2025 in sunny Brisbane, attended by a big team from Single Molecule Science. Lots of exciting new 🔬 tools and translation in biomedical investigations. @ijayas.bsky.social @arindam92.bsky.social

Group photo of eight colleagues representing the dept, standing in front of the conference mural

Some colleagues sitting around a dinner table

A conference speaker standing at a lectern podium

Arindam Ghosh being introduced to the symposium by Liz Hinde.

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UNSW Single Molecule Science @singmolsci.bsky.social · Aug 16

More photos of the activities put on show by the Molecular Medicine team.

The light sensing robots, each with a different type of cellular motility and carrying a different coloured flag, lined up at the start line in a dark room. In front of them is a small LED light in the distance that they are looking to move towards. Above the light, is a projector screen with the text, “Immune Cell Robots on Patrol”.

Dr Daryan, Guiyuan, and Matteo explaining and demonstrating the robots to a group of high school students.

Dr Jesse standing next to the simulation of Killer T Cell sensing infected epithelial cells (on an art board next to him).

Upasana explaining to a group of kids and their families the difference between four models of 👌🏾 hands 3D printed at different resolutions in order to explain the importance of resolution in microscopy.

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UNSW Single Molecule Science @singmolsci.bsky.social · Aug 16

We’ve had a single molecule festival here today at the @UNSW SciFest yesterday. Our corner of the exhibition featuring light sensing robots 🤖, reef cleaning super hero bacteria 🦸🏾‍♂️ , miniature microscopes, when killer T cells. A wonderful team effort and a busy evening for Team Molecular Medicine.

A group photo of the Molecular Medicine (Single Molecule Sciences) team. In front, a table with some objects, including a miniature microscope. In the background, a large tv screen with vibrant images of cells and molecules.

A conversation between Upasana from Molecular Medicine and a little girl and her mum. Upasana is leaning over a table with a miniature microscope.

Some team members of Molecular Medicine standing in front of a colourful big tv screen and talking to some of the SciFest visitors

A father and daughter speaking with Dr Jon and pinning the superhero capes on the art board game of bacteria deployed to save the Great Barrier Reef.

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Reposted by UNSW Single Molecule Science

Izzy Jayasinghe @ijayas.bsky.social · Feb 6

Final week for applications for up to 2 postdoc posts in advanced biomedical (super-resolution) microscopy with my team in Sydney, based at @singmolsci.bsky.social. The post is especially suited for ECRs interested in single molecule imaging, &/or image analysis. International applicants welcome 🧪

Post-Doctoral Fellow in Advanced Biomedical Microscopy

UNSW Department of Molecular Medicine seeks an enthusiastic researcher in super-resolution microscopy to develop novel super resolution methods and leverage these techniques to study cellular architec...

external-careers.jobs.unsw.edu.au

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Reposted by UNSW Single Molecule Science

Molecular Machines & Structural Virology Group @molecmachines.bsky.social · Jan 25

The #HIV capsid mimics host chaperones to gain access into the nucleus, solving a long-standing mystery – David Jacques' team published in Nature.
@singmolsci.bsky.social #UNSWSBMS
🔗 nature.com/articles/s41...
🎨: Jon Berengut

Artistic depiction of the HIV capsid disguised as a host chaperone protein

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Reposted by UNSW Single Molecule Science

Molecular Machines & Structural Virology Group @molecmachines.bsky.social · Nov 28

🚨preprint @biorxivpreprint.bsky.social
We use #SingleMolecule🔬to see how a capsid-targeting antiviral (lenacapavir) hacks assembly of the HIV capsid, which normally protects the #HIV genome. Now also with real-time visualization of the drug breaking open the capsid. www.biorxiv.org/content/10.1...

Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

www.biorxiv.org

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Reposted by UNSW Single Molecule Science

Molecular Machines & Structural Virology Group @molecmachines.bsky.social · Nov 28

We've still taking applications to join our team @singmolsci.bsky.social. Now closing 10Dec2023
🔗 external-careers.jobs.unsw.edu.au/cw/en/job/52...

Molecular Machines & Structural Virology Group @molecmachines.bsky.social · Nov 8

🚨Join us at UNSW Sydney!
We're searching for a postdoc to join our team to investigate dynamics of host-pathogen interactions🦠.
#SingleMolecule #microscopy🔬
Apply by 26Nov2023. Please share 🔗https://external-careers.jobs.unsw.edu.au/cw/en/job/520570/post-doctoral-fellow-hostpathogen-biophysics

Ariel photo of UNSW's main campus located near close to beaches

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UNSW Single Molecule Science @singmolsci.bsky.social · Nov 21

Being able to work with a research & cultural leader like Izzy @ijayas.bsky.social is an opportunity you won’t want to miss.

Izzy Jayasinghe @ijayas.bsky.social · Nov 21

If there is anybody on Bluesky with an interest in working towards a PhD with a vibrant and inclusive group of people, we have a funded project available through @singmolsci.bsky.social in UNSW, Sydney, to do some advanced single molecule & electron 🔬. Please pass on to any students you may know. 🧪

Molecular scale mapping of intracellular signalling nanodomains and giant channels in the heart

www.unsw.edu.au

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Reposted by UNSW Single Molecule Science

Vaishnavi Ananthanarayanan (She/Her) @vaishananth.bsky.social · Nov 16

Thanks for highlighting our (@polybiotique.bsky.social) report and its coverage by @dyanilewis.bsky.social, Izzy. As we mention in our report, fixing this will require clearly earmarked resources, and importantly, the will and strong commitment to equity from the leadership in Indian academia.

Izzy Jayasinghe @ijayas.bsky.social · Nov 15

A shocking description 👇🏾 of how women are being let down by scientific research communities in India. This is of course only mirroring many of the trends that we know exist everywhere else too. The 📊 showing conferences where women are outnumbered or excluded entirely leaves one absolutely appalled.

Plots showing the % of conferences with no female speakers (top panel) or an under-representation of women (bottom panel) were common in India across science, technology, engineering and mathematics disciplines during phase 1 (June 2020 - August 2021) and phase 2 (August 2021 - March 2023) of data collection. Many of the comparisons at the two phases reflecting only little to no improvements made over time.

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Reposted by UNSW Single Molecule Science

Izzy Jayasinghe @ijayas.bsky.social · Nov 13

Latest paper from our team on variations in cellular staining with 14 different fluorescent dye esters when combined with expansion microscopy. Strategic deployment of these dyes with expansion 🔬 can not only provide EM-like images, but also highlight different sets of cellular organelles. 🧪

Differential labelling of human sub-cellular compartments with fluorescent dye esters and expansion ...

Amine-reactive esters of aromatic fluorescent dyes are emerging as imaging probes for nondescript staining of cellular and tissue architectures. We characterised the staining patterns of 14 fluorescen...

pubs.rsc.org

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Reposted by UNSW Single Molecule Science

Izzy Jayasinghe @ijayas.bsky.social · Nov 3

A few things that I've needed to get off my chest for some time now. 🧪 🌋

Remembering the role of luck and privilege in academic achievement

This week I woke up to the announcement by my alma mater — The University of Auckland — of its 2023 cohort of ’40 under 40’ that listed me…

medium.com

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UNSW Single Molecule Science @singmolsci.bsky.social · Nov 10

Towards inclusive and sustainable scientific meetings

Felicity Davis @davislab.bsky.social · Nov 10

Our thoughts on how to make conferences more inclusive and sustainable - with @vaishananth.bsky.social and a great international team. Check it out here: rdcu.be/dqHEM

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Reposted by UNSW Single Molecule Science

Molecular Machines & Structural Virology Group @molecmachines.bsky.social · Nov 8

🚨Join us at UNSW Sydney!
We're searching for a postdoc to join our team to investigate dynamics of host-pathogen interactions🦠.
#SingleMolecule #microscopy🔬
Apply by 26Nov2023. Please share 🔗https://external-careers.jobs.unsw.edu.au/cw/en/job/520570/post-doctoral-fellow-hostpathogen-biophysics

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