SFB1361
@sfb1361.bsky.social
Pinned
SFB1361
@sfb1361.bsky.social
· Oct 15
Registration is open!
Join us at IMB Mainz from 10–13 March 2026 for the 2nd International IMB & SFB 1361 Conference on "The Evil Within: Regulation and Repair of Endogenous DNA Damage".
Don't miss this conference and register now via www.sfb1361.de/dnarepairconf2026
#ISC26DNArepair #IMBMainz
Join us at IMB Mainz from 10–13 March 2026 for the 2nd International IMB & SFB 1361 Conference on "The Evil Within: Regulation and Repair of Endogenous DNA Damage".
Don't miss this conference and register now via www.sfb1361.de/dnarepairconf2026
#ISC26DNArepair #IMBMainz
We are excited to share that our #SFB1361 alumni, Dr Gabriel M. C. Longo, received a Walter Benjamin Fellowship to support his postdoctoral research in the Kleinstiver lab at Harvard Medical School/Massachusetts General Hospital, Boston.
Congratulations! 🎉🎉
Congratulations! 🎉🎉
November 13, 2025 at 3:41 PM
We are excited to share that our #SFB1361 alumni, Dr Gabriel M. C. Longo, received a Walter Benjamin Fellowship to support his postdoctoral research in the Kleinstiver lab at Harvard Medical School/Massachusetts General Hospital, Boston.
Congratulations! 🎉🎉
Congratulations! 🎉🎉
📃Publication alert!!
Congrats to the Krämer lab on their new publication:
"Identification of a Proteolysis-Targeting-Chimera that Addresses Activated Checkpoint Kinase-1 Reveals its Non-Catalytic Functions in Tumor Cells"
🔎Read more about it here: onlinelibrary.wiley.com/doi/10.1002/...
Congrats to the Krämer lab on their new publication:
"Identification of a Proteolysis-Targeting-Chimera that Addresses Activated Checkpoint Kinase-1 Reveals its Non-Catalytic Functions in Tumor Cells"
🔎Read more about it here: onlinelibrary.wiley.com/doi/10.1002/...
Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells
In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and....
onlinelibrary.wiley.com
November 7, 2025 at 9:04 AM
📃Publication alert!!
Congrats to the Krämer lab on their new publication:
"Identification of a Proteolysis-Targeting-Chimera that Addresses Activated Checkpoint Kinase-1 Reveals its Non-Catalytic Functions in Tumor Cells"
🔎Read more about it here: onlinelibrary.wiley.com/doi/10.1002/...
Congrats to the Krämer lab on their new publication:
"Identification of a Proteolysis-Targeting-Chimera that Addresses Activated Checkpoint Kinase-1 Reveals its Non-Catalytic Functions in Tumor Cells"
🔎Read more about it here: onlinelibrary.wiley.com/doi/10.1002/...
We’re excited to have Lorraine Symington and Stephen West as our keynote speakers - covering how cells repair DSBs during replication and how chromosomes are rebuilt via HR.
IMB & SFB 1361 Conference, 10–13 March 2026. Registration is live! #ISC26DNArepair #IMBMainz
IMB & SFB 1361 Conference, 10–13 March 2026. Registration is live! #ISC26DNArepair #IMBMainz
October 28, 2025 at 3:25 PM
We’re excited to have Lorraine Symington and Stephen West as our keynote speakers - covering how cells repair DSBs during replication and how chromosomes are rebuilt via HR.
IMB & SFB 1361 Conference, 10–13 March 2026. Registration is live! #ISC26DNArepair #IMBMainz
IMB & SFB 1361 Conference, 10–13 March 2026. Registration is live! #ISC26DNArepair #IMBMainz
New publication!! 📑
Congrats to the Ulrich and @hopfnerlab.bsky.social labs on their latest work exploring how the INO80 chromatin remodeller facilitates DNA damage bypass via postreplicative gap repair.
🔎Read the paper here:
www.embopress.org/doi/full/10.1038/s44318-025-00580-4
Congrats to the Ulrich and @hopfnerlab.bsky.social labs on their latest work exploring how the INO80 chromatin remodeller facilitates DNA damage bypass via postreplicative gap repair.
🔎Read the paper here:
www.embopress.org/doi/full/10.1038/s44318-025-00580-4
October 16, 2025 at 10:17 AM
New publication!! 📑
Congrats to the Ulrich and @hopfnerlab.bsky.social labs on their latest work exploring how the INO80 chromatin remodeller facilitates DNA damage bypass via postreplicative gap repair.
🔎Read the paper here:
www.embopress.org/doi/full/10.1038/s44318-025-00580-4
Congrats to the Ulrich and @hopfnerlab.bsky.social labs on their latest work exploring how the INO80 chromatin remodeller facilitates DNA damage bypass via postreplicative gap repair.
🔎Read the paper here:
www.embopress.org/doi/full/10.1038/s44318-025-00580-4
Registration is open!
Join us at IMB Mainz from 10–13 March 2026 for the 2nd International IMB & SFB 1361 Conference on "The Evil Within: Regulation and Repair of Endogenous DNA Damage".
Don't miss this conference and register now via www.sfb1361.de/dnarepairconf2026
#ISC26DNArepair #IMBMainz
Join us at IMB Mainz from 10–13 March 2026 for the 2nd International IMB & SFB 1361 Conference on "The Evil Within: Regulation and Repair of Endogenous DNA Damage".
Don't miss this conference and register now via www.sfb1361.de/dnarepairconf2026
#ISC26DNArepair #IMBMainz
October 15, 2025 at 8:00 AM
Registration is open!
Join us at IMB Mainz from 10–13 March 2026 for the 2nd International IMB & SFB 1361 Conference on "The Evil Within: Regulation and Repair of Endogenous DNA Damage".
Don't miss this conference and register now via www.sfb1361.de/dnarepairconf2026
#ISC26DNArepair #IMBMainz
Join us at IMB Mainz from 10–13 March 2026 for the 2nd International IMB & SFB 1361 Conference on "The Evil Within: Regulation and Repair of Endogenous DNA Damage".
Don't miss this conference and register now via www.sfb1361.de/dnarepairconf2026
#ISC26DNArepair #IMBMainz
It is with deep sadness that we share the news of the unexpected passing of our dear colleague and associated member Dr Nard Kubben last week.
We extend our heartfelt condolences to his family, friends, and all those who had the privilege of knowing him.
We extend our heartfelt condolences to his family, friends, and all those who had the privilege of knowing him.
We are deeply saddened to announce the unexpected passing of our colleague Dr Nard Kubben. He joined IMB as a Group Leader in 2021, bringing a passion for understanding ageing & improving human health. Our heartfelt condolences go to his family, friends & all who knew him.
www.imb.de/about-imb/ne...
www.imb.de/about-imb/ne...
October 7, 2025 at 11:37 AM
It is with deep sadness that we share the news of the unexpected passing of our dear colleague and associated member Dr Nard Kubben last week.
We extend our heartfelt condolences to his family, friends, and all those who had the privilege of knowing him.
We extend our heartfelt condolences to his family, friends, and all those who had the privilege of knowing him.
Publication alert!!📑
Congratulations to the @hopfnerlab.bsky.social, @yilanfan.bsky.social and @filizkuybu.bsky.social on the great work!
Read about it here: www.nature.com/articles/s41...
Congratulations to the @hopfnerlab.bsky.social, @yilanfan.bsky.social and @filizkuybu.bsky.social on the great work!
Read about it here: www.nature.com/articles/s41...
Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
October 7, 2025 at 11:35 AM
Publication alert!!📑
Congratulations to the @hopfnerlab.bsky.social, @yilanfan.bsky.social and @filizkuybu.bsky.social on the great work!
Read about it here: www.nature.com/articles/s41...
Congratulations to the @hopfnerlab.bsky.social, @yilanfan.bsky.social and @filizkuybu.bsky.social on the great work!
Read about it here: www.nature.com/articles/s41...
Yesterday’s full-day workshop co-organised with @imbmainz.bsky.social focused on building a strategic approach to research funding for postdocs.
We’re proud to stand behind our postdocs as they shape the future of research!
#PAWde #PostdocAppreciationWeek2025 #IMBMainz
We’re proud to stand behind our postdocs as they shape the future of research!
#PAWde #PostdocAppreciationWeek2025 #IMBMainz
September 19, 2025 at 1:22 PM
Yesterday’s full-day workshop co-organised with @imbmainz.bsky.social focused on building a strategic approach to research funding for postdocs.
We’re proud to stand behind our postdocs as they shape the future of research!
#PAWde #PostdocAppreciationWeek2025 #IMBMainz
We’re proud to stand behind our postdocs as they shape the future of research!
#PAWde #PostdocAppreciationWeek2025 #IMBMainz
📃Just published: new #SFB1361 publication by the Krämer and Christmann labs!
The article focuses on how the deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2.
Find out more here:
🔎 www.nature.com/articles/s41...
The article focuses on how the deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2.
Find out more here:
🔎 www.nature.com/articles/s41...
The deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2 - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - The deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2
www.nature.com
September 3, 2025 at 1:35 PM
📃Just published: new #SFB1361 publication by the Krämer and Christmann labs!
The article focuses on how the deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2.
Find out more here:
🔎 www.nature.com/articles/s41...
The article focuses on how the deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2.
Find out more here:
🔎 www.nature.com/articles/s41...
We’re excited to welcome Susanne Gerber from the University Medical Center Mainz as an associated member of the #SFB1361! 🎉
Her expertise in bioinformatics and cutting-edge nanopore sequencing protocols will advance genomic and epigenomic research within our network.
Her expertise in bioinformatics and cutting-edge nanopore sequencing protocols will advance genomic and epigenomic research within our network.
August 15, 2025 at 12:22 PM
We’re excited to welcome Susanne Gerber from the University Medical Center Mainz as an associated member of the #SFB1361! 🎉
Her expertise in bioinformatics and cutting-edge nanopore sequencing protocols will advance genomic and epigenomic research within our network.
Her expertise in bioinformatics and cutting-edge nanopore sequencing protocols will advance genomic and epigenomic research within our network.
We‘re proud to share that our #SFB1361 PhD student, Yilan Fan from the @hopfnerlab.bsky.social, has been awarded a poster prize at the CNIO-CaixaResearch Frontiers Meeting “Machines on DNA and RNA: A Molecular Mechanistic Perspective“ held on 28-30 May 2025 in Madrid, Spain.
Congrats! 🎉
Congrats! 🎉
August 7, 2025 at 2:29 PM
We‘re proud to share that our #SFB1361 PhD student, Yilan Fan from the @hopfnerlab.bsky.social, has been awarded a poster prize at the CNIO-CaixaResearch Frontiers Meeting “Machines on DNA and RNA: A Molecular Mechanistic Perspective“ held on 28-30 May 2025 in Madrid, Spain.
Congrats! 🎉
Congrats! 🎉
Last week our #SFB1361 members gathered in Würzburg to discuss and plan for the 3rd funding period.
This 3-day retreat led to many fruitful discussions and fresh ideas! Now its time to put these ideas to work! 🔬⚗️🧬
#scientificretreat #planning #DNArepair
This 3-day retreat led to many fruitful discussions and fresh ideas! Now its time to put these ideas to work! 🔬⚗️🧬
#scientificretreat #planning #DNArepair
June 24, 2025 at 7:37 AM
Last week our #SFB1361 members gathered in Würzburg to discuss and plan for the 3rd funding period.
This 3-day retreat led to many fruitful discussions and fresh ideas! Now its time to put these ideas to work! 🔬⚗️🧬
#scientificretreat #planning #DNArepair
This 3-day retreat led to many fruitful discussions and fresh ideas! Now its time to put these ideas to work! 🔬⚗️🧬
#scientificretreat #planning #DNArepair
The 2nd Life Sciences Postdoc Symposium in Mainz is happening this week! Registration is still open!
www.imb.de/seminars-mee...
#postdoc #postdoclife
www.imb.de/seminars-mee...
#postdoc #postdoclife
2nd Life Sciences Postdoc Symposium Mainz - Connect, learn & grow with fellow postdocs & staff scientists from Mainz, Frankfurt, Darmstadt & the region! 🔬
26 June 2025
➡️ www.imb.de/postdoc-symposium25
Join us to strengthen your scientific network & exchange ideas with your peers.
#postdoclife
26 June 2025
➡️ www.imb.de/postdoc-symposium25
Join us to strengthen your scientific network & exchange ideas with your peers.
#postdoclife
June 23, 2025 at 1:21 PM
The 2nd Life Sciences Postdoc Symposium in Mainz is happening this week! Registration is still open!
www.imb.de/seminars-mee...
#postdoc #postdoclife
www.imb.de/seminars-mee...
#postdoc #postdoclife
Our members came from Mainz, Frankfurt, Darmstadt, and Munich to Würzburg for this retreat to discuss, network, and plan for the next years.
We also took the opportunity to visit the Würzburg Residence and immerse ourselves in the art, culture, and history!
#würzburg #SFB1361 #retreat
We also took the opportunity to visit the Würzburg Residence and immerse ourselves in the art, culture, and history!
#würzburg #SFB1361 #retreat
June 19, 2025 at 9:20 AM
Poster presentations, discussions, and networking.
Of course, our PhDs and Postdocs are also very much involved in this retreat.
#SFB1361 #DNArepair #scientificretreat
Of course, our PhDs and Postdocs are also very much involved in this retreat.
#SFB1361 #DNArepair #scientificretreat
June 17, 2025 at 9:38 AM
Poster presentations, discussions, and networking.
Of course, our PhDs and Postdocs are also very much involved in this retreat.
#SFB1361 #DNArepair #scientificretreat
Of course, our PhDs and Postdocs are also very much involved in this retreat.
#SFB1361 #DNArepair #scientificretreat
Our #SFB1361 is away on #retreat from today until Wednesday!
Starting off the day with most of us travelling by train to Würzburg and plenty of project updates in the afternoon!
Excited to plan for the next years and the next funding period!
#ecofriendly #worktravel
#dnarepair
Starting off the day with most of us travelling by train to Würzburg and plenty of project updates in the afternoon!
Excited to plan for the next years and the next funding period!
#ecofriendly #worktravel
#dnarepair
June 16, 2025 at 2:34 PM
Our #SFB1361 is away on #retreat from today until Wednesday!
Starting off the day with most of us travelling by train to Würzburg and plenty of project updates in the afternoon!
Excited to plan for the next years and the next funding period!
#ecofriendly #worktravel
#dnarepair
Starting off the day with most of us travelling by train to Würzburg and plenty of project updates in the afternoon!
Excited to plan for the next years and the next funding period!
#ecofriendly #worktravel
#dnarepair
Cheers to a successful #PintofScience in Mainz! 🎉🎉
We're proud to have supported this effort and that our associated member presented her science in an interesting way to the public! Also a round of applause to all other presenters 👏👏
#pint25de #sciencecommunication
We're proud to have supported this effort and that our associated member presented her science in an interesting way to the public! Also a round of applause to all other presenters 👏👏
#pint25de #sciencecommunication
May 23, 2025 at 6:33 AM
Cheers to a successful #PintofScience in Mainz! 🎉🎉
We're proud to have supported this effort and that our associated member presented her science in an interesting way to the public! Also a round of applause to all other presenters 👏👏
#pint25de #sciencecommunication
We're proud to have supported this effort and that our associated member presented her science in an interesting way to the public! Also a round of applause to all other presenters 👏👏
#pint25de #sciencecommunication
On next Wednesday (21 May), our associated member, Siyao Wang will talk on how the damage on the #DNA of fathers affects the children as part of the Pint of Science 2025 events!
Buy your tickets now! www.pintofscience.de/events/mainz
#pint25de 🥳
Buy your tickets now! www.pintofscience.de/events/mainz
#pint25de 🥳
On Wednesday we'll also hear from Siyao how the damage on the #DNA of fathers affects the children.
Siyao is a junior group leader at @imbmainz.bsky.social and is looking forward to meeting you at the #pint25de 🥳
Buy your tickets now! www.pintofscience.de/events/mainz
#DNAdamage #MainzErleben
Siyao is a junior group leader at @imbmainz.bsky.social and is looking forward to meeting you at the #pint25de 🥳
Buy your tickets now! www.pintofscience.de/events/mainz
#DNAdamage #MainzErleben
May 14, 2025 at 8:04 AM
On next Wednesday (21 May), our associated member, Siyao Wang will talk on how the damage on the #DNA of fathers affects the children as part of the Pint of Science 2025 events!
Buy your tickets now! www.pintofscience.de/events/mainz
#pint25de 🥳
Buy your tickets now! www.pintofscience.de/events/mainz
#pint25de 🥳
Are you interested in what goes on in the minds of scientists in Mainz? Here's your chance to listen to exciting talks on physics, stress, genetics and more in a relaxed atmosphere and chat with the scientists.
Get your tickets now! www.pintofscience.de/events/mainz
#pint25de #Mainz #scicomm
Get your tickets now! www.pintofscience.de/events/mainz
#pint25de #Mainz #scicomm
May 13, 2025 at 10:02 AM
Are you interested in what goes on in the minds of scientists in Mainz? Here's your chance to listen to exciting talks on physics, stress, genetics and more in a relaxed atmosphere and chat with the scientists.
Get your tickets now! www.pintofscience.de/events/mainz
#pint25de #Mainz #scicomm
Get your tickets now! www.pintofscience.de/events/mainz
#pint25de #Mainz #scicomm
(1/2) Have you thought about using AI Assistants? How and where can these tools help us? Our researchers were surely excited to explore!
We jointly organised a 2-day workshop on "Using AI Assistants to Increase Productivity" to provide the initial stepping stones to use these tools.
#training #AI
We jointly organised a 2-day workshop on "Using AI Assistants to Increase Productivity" to provide the initial stepping stones to use these tools.
#training #AI
May 9, 2025 at 11:25 AM
Our RMU Master Module on DNA Repair & Genome Stability starts today with the first lecture from Prof Brian Luke!
#SFB1361 #DNArepair #RMU
#SFB1361 #DNArepair #RMU
April 28, 2025 at 11:08 AM
Our RMU Master Module on DNA Repair & Genome Stability starts today with the first lecture from Prof Brian Luke!
#SFB1361 #DNArepair #RMU
#SFB1361 #DNArepair #RMU
Pre-print alert from @hopfnerlab.bsky.social!
Great job! Read more about it here: www.biorxiv.org/content/10.1...
#DNArepair #SFB1361
Great job! Read more about it here: www.biorxiv.org/content/10.1...
#DNArepair #SFB1361
Happy to share our latest pre-print!
We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨
www.biorxiv.org/content/10.1...
We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨
www.biorxiv.org/content/10.1...
Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex
The MRE11-RAD50-NBS1 (MRN) complex is a central, multifunctional factor in the detection, signaling and nucleolytic processing of DNA double-strand breaks (DSBs). To clarify how human MRN binds generi...
www.biorxiv.org
March 17, 2025 at 10:44 AM
Pre-print alert from @hopfnerlab.bsky.social!
Great job! Read more about it here: www.biorxiv.org/content/10.1...
#DNArepair #SFB1361
Great job! Read more about it here: www.biorxiv.org/content/10.1...
#DNArepair #SFB1361
(1/3) In conjunction with International Women’s Day, we organised a day of training and experience sharing tailored for our fantastic female PhDs and Postdocs.
It was a pleasure to co-organise this event with @4r-rtg.bsky.social, GenEvo, and @sfb1551.bsky.social.
#IWD2025 #Workshop #CareerPanel
It was a pleasure to co-organise this event with @4r-rtg.bsky.social, GenEvo, and @sfb1551.bsky.social.
#IWD2025 #Workshop #CareerPanel
March 12, 2025 at 2:38 PM
(1/3) In conjunction with International Women’s Day, we organised a day of training and experience sharing tailored for our fantastic female PhDs and Postdocs.
It was a pleasure to co-organise this event with @4r-rtg.bsky.social, GenEvo, and @sfb1551.bsky.social.
#IWD2025 #Workshop #CareerPanel
It was a pleasure to co-organise this event with @4r-rtg.bsky.social, GenEvo, and @sfb1551.bsky.social.
#IWD2025 #Workshop #CareerPanel
Publication alert! An interesting review on RNA damage coming from the lab of @jstingele.bsky.social!
Read the review here: www.cell.com/cell/fulltex...
Read an interview on the article from @lmumuenchen.bsky.social (LMU Munich) here: www.lmu.de/en/newsroom/...
Read the review here: www.cell.com/cell/fulltex...
Read an interview on the article from @lmumuenchen.bsky.social (LMU Munich) here: www.lmu.de/en/newsroom/...
March 10, 2025 at 7:55 AM
Publication alert! An interesting review on RNA damage coming from the lab of @jstingele.bsky.social!
Read the review here: www.cell.com/cell/fulltex...
Read an interview on the article from @lmumuenchen.bsky.social (LMU Munich) here: www.lmu.de/en/newsroom/...
Read the review here: www.cell.com/cell/fulltex...
Read an interview on the article from @lmumuenchen.bsky.social (LMU Munich) here: www.lmu.de/en/newsroom/...
Happy International Women's Day!
Today we celebrate the achievement of women everywhere and the progress made towards equality! Let's stay committed on this path and #AccelerateAction towards #genderequality!
#IWD2025 #InternationalWomensDay
Today we celebrate the achievement of women everywhere and the progress made towards equality! Let's stay committed on this path and #AccelerateAction towards #genderequality!
#IWD2025 #InternationalWomensDay
March 8, 2025 at 9:59 AM
Happy International Women's Day!
Today we celebrate the achievement of women everywhere and the progress made towards equality! Let's stay committed on this path and #AccelerateAction towards #genderequality!
#IWD2025 #InternationalWomensDay
Today we celebrate the achievement of women everywhere and the progress made towards equality! Let's stay committed on this path and #AccelerateAction towards #genderequality!
#IWD2025 #InternationalWomensDay