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Angry Redhead @sidherian.bsky.social · 1d

Source:
Yokohama City University
Journal reference:
Fujimoto, Y., et al. (2025). Systemic increase of AMPA receptors associated with cognitive impairment of long COVID. Brain Communications. doi.org/10.1093/braincomms/fcaf337

www.news-medical.net/news/2025093...

Systemic increase of AMPA receptors associated with cognitive impairment of long COVID

Fujimoto et al. report that the patients with cognitive impairments after SARS-CoV-2 infection showed significant AMPA receptors upregulation across their

doi.org

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Angry Redhead @sidherian.bsky.social · 1d

In summary, the team's findings resolve key uncertainties about the biological basis of Long COVID brain fog and may pave the way for novel diagnostic tools and effective therapies for patients suffering from this condition.”

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Angry Redhead @sidherian.bsky.social · 1d

This could encourage the healthcare industry to accelerate the development of diagnostic and therapeutic approaches for this disorder," concludes Prof. Takahashi.

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Angry Redhead @sidherian.bsky.social · 1d

While further efforts will be needed to find a definitive solution for Long COVID, this work is a promising step in the right direction. "Our findings clearly demonstrate that Long COVID brain fog should be recognized as a legitimate clinical condition.

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Angry Redhead @sidherian.bsky.social · 1d

"By applying our newly developed AMPA receptor PET imaging technology, we aim to provide a novel perspective and innovative solutions to the pressing medical challenge that is Long COVID," remarks Prof. Takahashi.

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Angry Redhead @sidherian.bsky.social · 1d

For example, drugs that suppress AMPAR activity could be a viable approach to mitigate brain fog. Interestingly, the team's analysis also demonstrated that imaging data can be used to distinguish patients from healthy controls with 100% sensitivity and 91% specificity.

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Angry Redhead @sidherian.bsky.social · 1d

Taken together, the study's findings represent a crucial step forward in addressing many unresolved issues regarding Long COVID. The systemic increase in AMPARs provides a direct biological explanation for the cognitive symptoms, highlighting a target for potential treatments.

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Angry Redhead @sidherian.bsky.social · 1d

By comparing imaging data from 30 patients with Long COVID to 80 healthy individuals, the researchers found a notable and widespread increase in the density of AMPARs across the brains of patients.

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Angry Redhead @sidherian.bsky.social · 1d

and learning-based on prior research into psychiatric and neurological disorders such as depression, bipolar disorder, schizophrenia, and dementia. Thus, they used a novel method called [11C]K-2 AMPAR PET imaging to directly visualize and quantify the density of AMPARs in the living human brain.

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Angry Redhead @sidherian.bsky.social · 1d

As explained in their paper, published in Brain Communications on October 01, 2025, the team hypothesized that patients with brain fog might exhibit disrupted expression of AMPA receptors (AMPARs)-key molecules for memory

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Angry Redhead @sidherian.bsky.social · 1d

To address this challenge, a research team led by Professor Takuya Takahashi from the Graduate School of Medicine at Yokohama City University, Japan, has made a significant breakthrough in understanding the cause of Long COVID brain fog.

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Angry Redhead @sidherian.bsky.social · 1d

Since it's difficult to observe the molecules that govern communication between brain cells directly, researchers are left without objective biomarkers to confirm a Long COVID diagnosis or develop therapies.

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Angry Redhead @sidherian.bsky.social · 1d

Unfortunately, despite its prevalence, the underlying causes of Long COVID and brain fog remain poorly understood. Previous imaging studies have shown some structural changes in the brain, but they could not pinpoint the molecular dysfunctions responsible for the cognitive symptoms.

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Angry Redhead @sidherian.bsky.social · 1d

Given the hundreds of millions of global cases, Long COVID represents a massive public health and socioeconomic challenge, as it severely impacts people's ability to work and perform daily activities.

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Angry Redhead @sidherian.bsky.social · 1d

Among the most common and debilitating of these is cognitive impairment, often referred to as "brain fog," which affects over 80% of people with Long COVID.

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Angry Redhead @sidherian.bsky.social · 1d

This is especially true for Long COVID, a chronic condition that can develop after COVID-19 that causes a variety of lasting symptoms.
This is especially true for Long COVID, a chronic condition that can develop after COVID-19 that causes a variety of lasting symptoms.

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Angry Redhead @sidherian.bsky.social · 1d

#covidisnotover #maskforyourlife #cleantheair
“Even though many years have passed since the start of the COVID-19 pandemic, the effects of infection with SARS-CoV-2 are not completely understood.

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Angry Redhead @sidherian.bsky.social · 1d

These reservoirs keep the immune system overstimulated, leading to fatigue, brain fog, and organ damage.

Reservoirs of virus noted back in 2022.

www.niaid.nih.gov/news-events/...

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Angry Redhead @sidherian.bsky.social · 1d

#covidisnotover #maskforyourlife #cleantheair

Via @atranscendedman.bsky.social
UC Irvine scientists report that Long COVID may be driven by hidden reservoirs of SARS-CoV-2 lingering in organs for months or years.

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Angry Redhead @sidherian.bsky.social · 4d

• Early detection, high level of vigilance and appropriate neurosurgical care are the key stone of treatment paradigm for such a rare medical event.

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Angry Redhead @sidherian.bsky.social · 4d

• Anterior spinal, posterior spinal and central watershed areas are the most common sites of spinal ischemia following COVID-10 infection.
• Epidural, subdural and intramedullary hematoma are the most encountered types of hemorrhagic spinal stroke following COVID-19 infection.

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Angry Redhead @sidherian.bsky.social · 4d

#covidisnotover #maskforyourlife #cleantheair

Highlights
• COVID-19 is associated with spinal ischemia and hemorrhage.
A systematic review on COVID-19 and spinal strokes.

www.sciencedirect.com/science/arti...

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Reposted by Angry Redhead

Anonymous @youranoncentral.bsky.social · 8d

Trump is a con artist & he’s representing a legion of oligarchs & criminals. They’ll maintain power long after he’s gone. It’s a sleight of hand strategy; Trump rambles or passes some EO that is going to be shut down by the courts. In the background massive embezzlement & fleecing is taking place.

87 760 2.4K

Angry Redhead @sidherian.bsky.social · 8d

Fin

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Angry Redhead @sidherian.bsky.social · 8d

Why does this matter?
Reprogramming translation isn’t just a clever trick - it’s dangerous.
It blocks the cell from making key defense proteins and creates stress that can spill over into long-term damage, from immune exhaustion to neurological effects.”

www.biorxiv.org/content/10.1...

SARS-CoV-2 Exploits Host Translation and Immune Evasion Pathways via Viral RNA–Host Protein Interactions

RNA viruses, including SARS-CoV-2, Influenza A Virus (IAV), Zika Virus, and Dengue Virus (DENV) pose serious global health challenges by manipulating host cellular mechanisms. SARS-COV-2, in particula...

www.biorxiv.org

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