Sonali J. Bracken, MD, PhD
@sjbracken.bsky.social
640 followers 120 following 7 posts
Rheumatologist, immunologist, and physician-scientist @DukeUniv. B cell and scleroderma enthusiast. Posts reflect my own views.
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Reposted by Sonali J. Bracken, MD, PhD
ryanmarino.bsky.social
One cool thing about the United States is that there are more people whose job is to deny healthcare coverage without having any medical background than there are people to provide healthcare coverage and they’ve somehow convinced people that the doctors are where the monetary waste is happening
cscla.medsky.social
#medsky if an insurer is making a “determination if something is medically necessary”, how is it not a medical decision and therefore practicing medicine?
Reposted by Sonali J. Bracken, MD, PhD
erictopol.bsky.social
Something you don't see every day!
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
The cover image portrays a human composed of proteins who is examining their health status (represented by the ECG monitoring interface) with the assistance of artificial intelligence (represented by the chip and binary codes).
Reposted by Sonali J. Bracken, MD, PhD
scinews.bsky.social
Happy Holidays!💐

Credit to: Dario Brunetti
Reposted by Sonali J. Bracken, MD, PhD
mcuban.bsky.social
If you want to understand why healthcare pricing is horrific, the first thing to know is that our system puts 100% of the credit risk for deductibles, copays and co-insurance on hospitals and doctors. That's insane.

We have turned them into Sub Prime Lenders 🧵
sjbracken.bsky.social
Happy holidays from the Duke Rheum crew ❄️ ⛄️ 🎄 @mithurheum.bsky.social
Reposted by Sonali J. Bracken, MD, PhD
immunofever.bsky.social
There is a human tissue that builds itself up and breaks itself down every 28 days (on average) using non-scarring wound healing and instead of studying that and learning everything we can about it we think it's gross and look for other less relevant models to understand wound healing.
sjbracken.bsky.social
The MITIGATE trial of inebilizumab (aCD19 mAb) for IgG4-RD should get us thinking about which rheumatologic diseases do/don’t warrant deep B cell depletion (i.e. CAR Ts)

⬇️ flares
⬆️ GC-free remission (note rapid steroid taper in placebo group)
⬆️ infections & cytopenias

www.nejm.org/doi/full/10....
Inebilizumab for Treatment of IgG4-Related Disease | NEJM
IgG4-related disease is a multiorgan, relapsing, fibroinflammatory, immune-mediated disorder with no approved therapy. Inebilizumab targets and depletes CD19+ B cells and may be effective for treat...
www.nejm.org
Reposted by Sonali J. Bracken, MD, PhD
mithurheum.bsky.social
🆕 #ACR24 | Updated Guidelines for Lupus Nephritis Treatment & Management 🫘

Highlights 🔶
• Critical role of renal biopsy
• Differences for treatment by LN Class
• Adjunctive Rx w/ HCQ & RAASi
• GC pulse ⇢ *moderate/low* dose PDN

#Lupus #NephSky #RheumSky #Rheumatology #MedSky
sjbracken.bsky.social
It was a wonderful #ACR24 and I am truly honored to have received the Distinguished Fellow Award from the American College of Rheumatology this year
mithurheum.bsky.social
Congratulations to @sjbracken.bsky.social & all the ACR Distinguished Fellow award recipients at #ACR24 🥇

Anyone who knows Sonali knows how dedicated and hardworking she is — from her research to patient care — working to improve the lives of patients with #scleroderma! #DukeRheum
Photograph of Sonali Bracken, MD, PhD Photo of the 2024 ACR Distinguished Fellow award recipients on stage
sjbracken.bsky.social
First-of-its kind evidence in severe dSSc demonstrates that CD19 CAR T may both stabilize/improve:

🔶 Fibrotic organ dysfunction
🔶 Vascular dysfunction (as marked by ⬇️ in RP severity and digital ulcerations)
🔶 Grip strength, contractures, and hand function

www.thelancet.com/journals/lan...
sjbracken.bsky.social
Thank you Mithu! Congrats to all the awardees!
sjbracken.bsky.social
Hi! Would love to be added to this list. Thanks!