Stephen Senn
@stephensenn.bsky.social
Swiss & British statistician.
Reposted by Stephen Senn
Lots of news in my latest next generation Covid vax update:
- Self-amplifying mRNA vax Kostaive approved in the UK
- New trial for mucosal vax starting in Finland
- Results from AstraZeneca phase 1 trial for mRNA vax ...
absolutelymaybe.plos.org/2026/01/31/a...
1/2
#Vaccines #Covid #Covid19
- Self-amplifying mRNA vax Kostaive approved in the UK
- New trial for mucosal vax starting in Finland
- Results from AstraZeneca phase 1 trial for mRNA vax ...
absolutelymaybe.plos.org/2026/01/31/a...
1/2
#Vaccines #Covid #Covid19
Another Approval and More NextGen Covid Vax News (Update No 37) - Absolutely Maybe
This month, Arcturus’ self-amplifying mRNA vaccine was approved for use in the UK. There were also new clinical trial results for another…
absolutelymaybe.plos.org
January 31, 2026 at 5:24 AM
Lots of news in my latest next generation Covid vax update:
- Self-amplifying mRNA vax Kostaive approved in the UK
- New trial for mucosal vax starting in Finland
- Results from AstraZeneca phase 1 trial for mRNA vax ...
absolutelymaybe.plos.org/2026/01/31/a...
1/2
#Vaccines #Covid #Covid19
- Self-amplifying mRNA vax Kostaive approved in the UK
- New trial for mucosal vax starting in Finland
- Results from AstraZeneca phase 1 trial for mRNA vax ...
absolutelymaybe.plos.org/2026/01/31/a...
1/2
#Vaccines #Covid #Covid19
Today’s hike was from 8 mile burn to Flotterstone via S Black Hill, Scald Law, Carnethy Hill & the martyr’s monument at Rullion Green.
January 29, 2026 at 10:56 PM
Today’s hike was from 8 mile burn to Flotterstone via S Black Hill, Scald Law, Carnethy Hill & the martyr’s monument at Rullion Green.
Interesting postdoc opportunity in biostatistics at the University of Zurich to work on patient recruitment in clinical trials data.snf.ch/grants/grant... with Malgorzata Roos
www.ebpi.uzh.ch/en/research/...
#biostatistics #postdoc #Switzerland
www.ebpi.uzh.ch/en/research/...
#biostatistics #postdoc #Switzerland
Malgorzata Roos
Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Team Biostatistics, Malgorzata Roos
www.ebpi.uzh.ch
January 28, 2026 at 11:00 AM
Interesting postdoc opportunity in biostatistics at the University of Zurich to work on patient recruitment in clinical trials data.snf.ch/grants/grant... with Malgorzata Roos
www.ebpi.uzh.ch/en/research/...
#biostatistics #postdoc #Switzerland
www.ebpi.uzh.ch/en/research/...
#biostatistics #postdoc #Switzerland
Burns Night tonight:
senns.uk/Neep_Tide.htm
senns.uk/Neep_Tide.htm
The Yanks call her a rutabaga
The Sassenachs a swede wad make her
But a’ true Scots fer neep will take her
And ne’er fer sprouts or greens forsake her.
senns.uk
January 25, 2026 at 5:06 PM
Burns Night tonight:
senns.uk/Neep_Tide.htm
senns.uk/Neep_Tide.htm
Have left Stoos by its spectacular funicular. Will be lecturing in Zurich tomorrow on Fisher’s 1926 paper.
January 21, 2026 at 4:04 PM
Have left Stoos by its spectacular funicular. Will be lecturing in Zurich tomorrow on Fisher’s 1926 paper.
Today’s hike was a meander below and above Stoos. #hiking #Switzerland (My identification of many of the peaks is just guesswork.)
January 21, 2026 at 2:18 PM
Today’s hike was a meander below and above Stoos. #hiking #Switzerland (My identification of many of the peaks is just guesswork.)
A century ago RA Fisher proposed randomisation for allocating treatments in designed experiments. Ever since we have been misinterpreting this as a means for producing unbiased estimates but RAF proposed it for validly estimating standard errors.
share.google/Hyfj5Ub07dcN...
share.google/Hyfj5Ub07dcN...
ZüKoSt: Seminar on Applied Statistics
share.google
January 20, 2026 at 8:31 PM
A century ago RA Fisher proposed randomisation for allocating treatments in designed experiments. Ever since we have been misinterpreting this as a means for producing unbiased estimates but RAF proposed it for validly estimating standard errors.
share.google/Hyfj5Ub07dcN...
share.google/Hyfj5Ub07dcN...
Today we hiked up from Stoos to the Fronalpstock.
January 20, 2026 at 3:57 PM
Today we hiked up from Stoos to the Fronalpstock.
I would like to take this opportunity to remind all those in awe of the Neyman-Pearson theory, that Nature pays no attention to your choice of alternative hypothesis. (Although you can occasionally, after careful conversation with Nature make a good choice yourself.)
January 19, 2026 at 7:59 PM
I would like to take this opportunity to remind all those in awe of the Neyman-Pearson theory, that Nature pays no attention to your choice of alternative hypothesis. (Although you can occasionally, after careful conversation with Nature make a good choice yourself.)
I frequently find myself being added to reviewer databases without a by-your-leave. Does anyone know if this is legal?
January 19, 2026 at 7:51 PM
I frequently find myself being added to reviewer databases without a by-your-leave. Does anyone know if this is legal?
It seems to me that a lot of discussion about personalised medicine is like this: “until I know which treatment will be better for my patients I shall continue to recommend the one that has been shown to be worse on average”.
January 19, 2026 at 5:37 PM
It seems to me that a lot of discussion about personalised medicine is like this: “until I know which treatment will be better for my patients I shall continue to recommend the one that has been shown to be worse on average”.
We have arrived in Stoos, Schwyz via the world’s steepest funicular and are looking forward to some winter walking. #hiking #Switzerland
January 19, 2026 at 4:25 PM
We have arrived in Stoos, Schwyz via the world’s steepest funicular and are looking forward to some winter walking. #hiking #Switzerland
www.strathspey-herald.co.uk/news/badenoc...
My daughter Helen’s account of her journey to China by bicycle with her husband Ed is now officially out.
My daughter Helen’s account of her journey to China by bicycle with her husband Ed is now officially out.
Badenoch couple’s journey of discovery along the Silk Road is revealed
Travelogue 16 years in the making sheds light on hidden worlds
www.strathspey-herald.co.uk
January 17, 2026 at 9:32 AM
www.strathspey-herald.co.uk/news/badenoc...
My daughter Helen’s account of her journey to China by bicycle with her husband Ed is now officially out.
My daughter Helen’s account of her journey to China by bicycle with her husband Ed is now officially out.
100 years ago RA Fisher set out his views on randomisation. This blog of mine errorstatistics.com/2020/04/20/s... from five years ago tries to explain them.
S. Senn: Randomisation is not about balance, nor about homogeneity but about randomness (Guest Post)
Stephen Senn Consultant Statistician Edinburgh The intellectual illness of clinical drug evaluation that I have discussed here can be cured, and it will be cured when we restore intellectual primac…
errorstatistics.com
January 16, 2026 at 7:45 AM
100 years ago RA Fisher set out his views on randomisation. This blog of mine errorstatistics.com/2020/04/20/s... from five years ago tries to explain them.
1) A covariate that is predictive of outcome should be in the model even if unpredictive of assignment (eg matched pairs design).
2) A covariate that is not predictive of outcome should not be in the model, even if predictive of assignment.
3) The propensity score is stupid.
2) A covariate that is not predictive of outcome should not be in the model, even if predictive of assignment.
3) The propensity score is stupid.
January 14, 2026 at 11:48 PM
1) A covariate that is predictive of outcome should be in the model even if unpredictive of assignment (eg matched pairs design).
2) A covariate that is not predictive of outcome should not be in the model, even if predictive of assignment.
3) The propensity score is stupid.
2) A covariate that is not predictive of outcome should not be in the model, even if predictive of assignment.
3) The propensity score is stupid.
Any statistician who hates propensity scores and target populations can’t be all bad.
January 14, 2026 at 11:34 PM
Any statistician who hates propensity scores and target populations can’t be all bad.
I sometimes think we had a clearer idea of what we should do for design and analysis of experiments in 1940 than in 2026. Our forbears studied spreading manure; we just do it.
January 14, 2026 at 11:31 PM
I sometimes think we had a clearer idea of what we should do for design and analysis of experiments in 1940 than in 2026. Our forbears studied spreading manure; we just do it.
Having started in Euston and gone out almost as far as Wembley we have now backed towards Kings Cross. It’s taken the train 50 minutes to do what I could in
less than 20 on foot. Why didn’t the train just start at Kings Cross?
less than 20 on foot. Why didn’t the train just start at Kings Cross?
January 14, 2026 at 11:24 PM
Having started in Euston and gone out almost as far as Wembley we have now backed towards Kings Cross. It’s taken the train 50 minutes to do what I could in
less than 20 on foot. Why didn’t the train just start at Kings Cross?
less than 20 on foot. Why didn’t the train just start at Kings Cross?
There is a baffling train “system” in this country. The Euston to Edinburgh train is currently backing in the direction of London because of something something Wembley.
January 14, 2026 at 11:04 PM
There is a baffling train “system” in this country. The Euston to Edinburgh train is currently backing in the direction of London because of something something Wembley.
@caledoniansleeper.bsky.social
Less than 10 minutes to go before your train leaves to Edinburgh from Euston. You must know which platform it will leave from but can’t share the information. Disgraceful
Less than 10 minutes to go before your train leaves to Edinburgh from Euston. You must know which platform it will leave from but can’t share the information. Disgraceful
January 14, 2026 at 9:20 PM
@caledoniansleeper.bsky.social
Less than 10 minutes to go before your train leaves to Edinburgh from Euston. You must know which platform it will leave from but can’t share the information. Disgraceful
Less than 10 minutes to go before your train leaves to Edinburgh from Euston. You must know which platform it will leave from but can’t share the information. Disgraceful
“They who stick everything they have measured in the model will create a colliderscope of patterns.” Sayings of Confuseus
January 13, 2026 at 6:12 PM
“They who stick everything they have measured in the model will create a colliderscope of patterns.” Sayings of Confuseus
Today I did a short walk around Queensferry.
January 12, 2026 at 6:09 PM
Today I did a short walk around Queensferry.
“You will find that many alternative medicine enthusiasts are into proidiotics.” Sayings of Confuseus
January 12, 2026 at 7:25 AM
“You will find that many alternative medicine enthusiasts are into proidiotics.” Sayings of Confuseus
I continue to be annoying about ANOVA www.linkedin.com/pulse/poolin...
Pooling the Interaction
..
www.linkedin.com
January 10, 2026 at 4:33 PM
I continue to be annoying about ANOVA www.linkedin.com/pulse/poolin...
January 10, 2026 at 2:35 PM