Steve Cappell
@stevecappell.bsky.social
Tenure-track investigator @NIH. My lab is interested in the single-cell dynamics of cell cycle regulation. Views and comments are my own.
https://ccr.cancer.gov/staff-directory/steven-d-cappellhttps://ccr.cancer.gov/staff-directory/steven-d-cappell
https://ccr.cancer.gov/staff-directory/steven-d-cappellhttps://ccr.cancer.gov/staff-directory/steven-d-cappell
Reposted by Steve Cappell
I’m excited to highlight our latest paper, just published in Cell 🎉
We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.
1/n 🧪
www.cell.com/cell/fulltex...
We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.
1/n 🧪
www.cell.com/cell/fulltex...
RNA Pol II inhibition activates cell death independently from the loss of transcription
When RNA polymerase II (RNA Pol II) is inhibited, the inhibition is sensed and signaled
to mitochondria, leading to programmed cell death independently of the loss of RNA
Pol II transcription activity...
www.cell.com
August 15, 2025 at 6:35 PM
I’m excited to highlight our latest paper, just published in Cell 🎉
We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.
1/n 🧪
www.cell.com/cell/fulltex...
We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.
1/n 🧪
www.cell.com/cell/fulltex...
Check out our new paper by postdoc Debasish Paul, out now in @Nature.com. Cells need a boost of energy to jumpstart the cell cycle, but how can this happen while the APC/C is inhibiting glycolysis? We found cells solve this paradox through a highly dynamic mechanism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry - Nature
APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.
www.nature.com
July 30, 2025 at 6:46 PM
Check out our new paper by postdoc Debasish Paul, out now in @Nature.com. Cells need a boost of energy to jumpstart the cell cycle, but how can this happen while the APC/C is inhibiting glycolysis? We found cells solve this paradox through a highly dynamic mechanism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...