Suzie Cro
@suziecro.bsky.social
Associate Professor in Medical Statistics & Clinical Trials @ Imperial Clinical Trials Unit
Reposted by Suzie Cro
A new paper by @suziecro.bsky.social and colleagues will help in this regard. Working with public partners, they developed a practical tool to explain the attributes of an estimand in an accessible manner 7/8
trialsjournal.biomedcentral.com/articles/10....
trialsjournal.biomedcentral.com/articles/10....
November 3, 2025 at 7:44 AM
A new paper by @suziecro.bsky.social and colleagues will help in this regard. Working with public partners, they developed a practical tool to explain the attributes of an estimand in an accessible manner 7/8
trialsjournal.biomedcentral.com/articles/10....
trialsjournal.biomedcentral.com/articles/10....
Reposted by Suzie Cro
📢 New publication in #Trials led by @suziecro.bsky.social with the HEALTHY STATS public involvement group: Supporting public involvement in defining estimands: a practical tool accessibly explaining the five key attributes of an estimand trialsjournal.biomedcentral.com/articles/10....
Supporting public involvement in defining estimands: a practical tool accessibly explaining the five key attributes of an estimand - Trials
Background An estimand is a precise description of the treatment effect a trial is aiming to find out. We previously identified that public partners (defined as patients and/or members of the public w...
trialsjournal.biomedcentral.com
October 28, 2025 at 12:36 PM
📢 New publication in #Trials led by @suziecro.bsky.social with the HEALTHY STATS public involvement group: Supporting public involvement in defining estimands: a practical tool accessibly explaining the five key attributes of an estimand trialsjournal.biomedcentral.com/articles/10....
Reposted by Suzie Cro
New PhD position available at @mrcctu.bsky.social to develop guidance on balancing statistical and clinical considerations when choosing an estimand in RCTs.
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Optimising the choice of estimand in randomised trials: developing guidance on balancing statistical and clinical considerations to ensure results matter to stakeholders at University College London o...
PhD Project - Optimising the choice of estimand in randomised trials: developing guidance on balancing statistical and clinical considerations to ensure results matter to stakeholders at University Co...
www.findaphd.com
October 22, 2025 at 10:46 AM
New PhD position available at @mrcctu.bsky.social to develop guidance on balancing statistical and clinical considerations when choosing an estimand in RCTs.
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Suzie Cro
New publication 📢: A Bayesian framework to evaluate non-inferiority in randomised controlled trials of uncommon conditions - Journal of Clinical Epidemiology led by @vcornelius.bsky.social www.jclinepi.com/article/S089...
A Bayesian framework to evaluate non-inferiority in randomised controlled trials of uncommon conditions
Non-inferiority (NI) trials typically require larger sample sizes than superiority
comparisons. This is problematic for uncommon conditions where recruitment is restricted.
When a power calculation re...
www.jclinepi.com
October 17, 2025 at 2:11 PM
New publication 📢: A Bayesian framework to evaluate non-inferiority in randomised controlled trials of uncommon conditions - Journal of Clinical Epidemiology led by @vcornelius.bsky.social www.jclinepi.com/article/S089...
Reposted by Suzie Cro
💬Got 5 mins?
Help improve clinical trials by sharing your thoughts on health data collection.
@anniestats.bsky.social a PhD researcher at Imperial has designed this survey with the help of her public involvement groups.
🔗 imperial.eu.qualtrics.com/jfe/form/SV_...
#PPI #HealthEquity #ResearchVoices
Help improve clinical trials by sharing your thoughts on health data collection.
@anniestats.bsky.social a PhD researcher at Imperial has designed this survey with the help of her public involvement groups.
🔗 imperial.eu.qualtrics.com/jfe/form/SV_...
#PPI #HealthEquity #ResearchVoices
Public Perspectives on Digital Data Collection in Clinical Trials
The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.
imperial.eu.qualtrics.com
October 2, 2025 at 11:23 AM
💬Got 5 mins?
Help improve clinical trials by sharing your thoughts on health data collection.
@anniestats.bsky.social a PhD researcher at Imperial has designed this survey with the help of her public involvement groups.
🔗 imperial.eu.qualtrics.com/jfe/form/SV_...
#PPI #HealthEquity #ResearchVoices
Help improve clinical trials by sharing your thoughts on health data collection.
@anniestats.bsky.social a PhD researcher at Imperial has designed this survey with the help of her public involvement groups.
🔗 imperial.eu.qualtrics.com/jfe/form/SV_...
#PPI #HealthEquity #ResearchVoices
Reposted by Suzie Cro
New publication 📣: Are estimands being correctly used? A review of UK research protocols by Timothy P. Clark, Richard H. Wicentowski, Suzie Cro, Matthew R. Sydes & Brennan C. Kahan trialsjournal.biomedcentral.com/articles/10....
Are estimands being correctly used? A review of UK research protocols - Trials
Background The use of estimands in clinical trials was formalised with the adoption of the final International Conference on Harmonisation E9 Addendum on Estimands and Sensitivity Analysis in Clinical...
trialsjournal.biomedcentral.com
September 16, 2025 at 11:42 AM
New publication 📣: Are estimands being correctly used? A review of UK research protocols by Timothy P. Clark, Richard H. Wicentowski, Suzie Cro, Matthew R. Sydes & Brennan C. Kahan trialsjournal.biomedcentral.com/articles/10....
Reposted by Suzie Cro
And that's a wrap on this year's NIHR undergraduate internships. It's been a pleasure hosting three rising stars, they've each achieved so much in just 8 weeks. We can't wait to see what the future holds for them. Congratulations Alex, Mahima & Joe and good luck with the rest of your studies.
September 3, 2025 at 11:30 AM
And that's a wrap on this year's NIHR undergraduate internships. It's been a pleasure hosting three rising stars, they've each achieved so much in just 8 weeks. We can't wait to see what the future holds for them. Congratulations Alex, Mahima & Joe and good luck with the rest of your studies.
Reposted by Suzie Cro
In our latest adverse event webinar Jeffrey Aronson & Igho Onakpoya discuss their review that looked at how data from clinical study reports compare with data in published trial reports. Catch-up on their talk here: www.statsci.co.uk/webinar-series
WEBINARS | StatsCI
www.statsci.co.uk
September 5, 2025 at 8:38 AM
In our latest adverse event webinar Jeffrey Aronson & Igho Onakpoya discuss their review that looked at how data from clinical study reports compare with data in published trial reports. Catch-up on their talk here: www.statsci.co.uk/webinar-series
In the JAKPPPOT 🎰 trial lead by David Gleason, historical placebo data from the APRICOT trial will be used as an external control arm to explore a signal of effect size. The protocol for this mixed-methods feasibility trial is now available #BMJOpen
bmjopen.bmj.com/content/15/8...
bmjopen.bmj.com/content/15/8...
September 3, 2025 at 11:01 AM
In the JAKPPPOT 🎰 trial lead by David Gleason, historical placebo data from the APRICOT trial will be used as an external control arm to explore a signal of effect size. The protocol for this mixed-methods feasibility trial is now available #BMJOpen
bmjopen.bmj.com/content/15/8...
bmjopen.bmj.com/content/15/8...
Are estimands being correctly used?
A new review of protocols led by Timothy Clark shows many incorrectly defined estimand attributes. See the top areas for improvement & full results here:
trialsjournal.biomedcentral.com/articles/10.... #Trials
A new review of protocols led by Timothy Clark shows many incorrectly defined estimand attributes. See the top areas for improvement & full results here:
trialsjournal.biomedcentral.com/articles/10.... #Trials
September 1, 2025 at 7:30 AM
Are estimands being correctly used?
A new review of protocols led by Timothy Clark shows many incorrectly defined estimand attributes. See the top areas for improvement & full results here:
trialsjournal.biomedcentral.com/articles/10.... #Trials
A new review of protocols led by Timothy Clark shows many incorrectly defined estimand attributes. See the top areas for improvement & full results here:
trialsjournal.biomedcentral.com/articles/10.... #Trials
Reposted by Suzie Cro
One week left to apply for this exciting opportunity to join our growing statistics team @statsci.bsky.social. Closing 28th August 2025.
🔊We're hiring!
Imperial Clinical Trials Unit are looking for an ambitious senior statistician with experience in clinical trials & design & analysis of adaptive trials to lead a research programme in antimicrobial resistance & data-enabled trials.
Full details: www.imperial.ac.uk/jobs/search-...
Imperial Clinical Trials Unit are looking for an ambitious senior statistician with experience in clinical trials & design & analysis of adaptive trials to lead a research programme in antimicrobial resistance & data-enabled trials.
Full details: www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
August 20, 2025 at 7:15 AM
One week left to apply for this exciting opportunity to join our growing statistics team @statsci.bsky.social. Closing 28th August 2025.
Reposted by Suzie Cro
Delighted to share registration is open for Professor @vcornelius.bsky.social inaugural lecture -Under pressure: smarter trials for better health outcomes- Thursday, 30 October 2025, 17.30-18.30, Imperial College South Kensington/Online. For details & registration: www.imperial.ac.uk/events/19688...
August 13, 2025 at 7:22 AM
Delighted to share registration is open for Professor @vcornelius.bsky.social inaugural lecture -Under pressure: smarter trials for better health outcomes- Thursday, 30 October 2025, 17.30-18.30, Imperial College South Kensington/Online. For details & registration: www.imperial.ac.uk/events/19688...
Reposted by Suzie Cro
New publication📣: Incorporation of Patient and Public Involvement in Statistical Methodology Research: Summary of Workshop Proceedings - aimed at addressing barriers to meaningful PPI in statistical methodology research. Open access in Statistics in Medicine onlinelibrary.wiley.com/doi/10.1002/...
July 15, 2025 at 12:51 PM
New publication📣: Incorporation of Patient and Public Involvement in Statistical Methodology Research: Summary of Workshop Proceedings - aimed at addressing barriers to meaningful PPI in statistical methodology research. Open access in Statistics in Medicine onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Suzie Cro
New paper posted on Arxiv: "When do composite estimands answer non-causal questions?"
This can happen more often than you think, and can have a dramatic impact on trial results (e.g. a false-positive rate of almost 90%)
arxiv.org/abs/2506.22610 @timpmorris.bsky.social
This can happen more often than you think, and can have a dramatic impact on trial results (e.g. a false-positive rate of almost 90%)
arxiv.org/abs/2506.22610 @timpmorris.bsky.social
When do composite estimands answer non-causal questions?
Under a composite estimand strategy, the occurrence of the intercurrent event is incorporated into the endpoint definition, for instance by assigning a poor outcome value to patients who experience th...
arxiv.org
July 1, 2025 at 9:31 AM
New paper posted on Arxiv: "When do composite estimands answer non-causal questions?"
This can happen more often than you think, and can have a dramatic impact on trial results (e.g. a false-positive rate of almost 90%)
arxiv.org/abs/2506.22610 @timpmorris.bsky.social
This can happen more often than you think, and can have a dramatic impact on trial results (e.g. a false-positive rate of almost 90%)
arxiv.org/abs/2506.22610 @timpmorris.bsky.social
Looking forward to this in todays Estimands and Missing data session @ #PSI2025 & being the estimands and missing data bridge between James Bells talk on composite estimand strategies with a continuous outcome & @timpmorris.bsky.social talk on how many multiple imputations you need!
Attending #PSI2025 at Wembley stadium ⚽ this week? Don’t miss new research on a novel multiple imputation procedure for handling missing data in clinical trials targeting a treatment policy estimand by @suziecro.bsky.social James Roger & James Carpenter
June 10, 2025 at 7:25 AM
Looking forward to this in todays Estimands and Missing data session @ #PSI2025 & being the estimands and missing data bridge between James Bells talk on composite estimand strategies with a continuous outcome & @timpmorris.bsky.social talk on how many multiple imputations you need!
Reposted by Suzie Cro
🔈Job alert! We are looking for an ambitious senior trial statistician to join an exciting new partnership between Imperial College London & Imperial College Healthcare NHS Trust, the Fleming Initiative, which aims to tackle antimicrobial resistance (AMR). www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
May 27, 2025 at 12:47 PM
🔈Job alert! We are looking for an ambitious senior trial statistician to join an exciting new partnership between Imperial College London & Imperial College Healthcare NHS Trust, the Fleming Initiative, which aims to tackle antimicrobial resistance (AMR). www.imperial.ac.uk/jobs/search-...
Reposted by Suzie Cro
Catch up on all the talks from our Adverse Event special series so far: www.statsci.co.uk/webinar-series
WEBINARS | StatsCI
www.statsci.co.uk
May 23, 2025 at 8:14 AM
Catch up on all the talks from our Adverse Event special series so far: www.statsci.co.uk/webinar-series
Interested in a new way to impute missing data in clinical trials targeting treatment policy estimands?
New blog post introducing **Retrieved Dropout Reference-Based Centred Multiple Imputation**
New blog post introducing **Retrieved Dropout Reference-Based Centred Multiple Imputation**
A New Way to Impute Missing Data in Clinical Trials Targeting Treatment Policy Estimands
When patients stop taking their assigned treatment in a clinical trial - whether due to side effects, lack of effectiveness, or personal choice - researchers often still want to understand how that treatment...
www.statsci.co.uk
May 19, 2025 at 8:30 AM
Interested in a new way to impute missing data in clinical trials targeting treatment policy estimands?
New blog post introducing **Retrieved Dropout Reference-Based Centred Multiple Imputation**
New blog post introducing **Retrieved Dropout Reference-Based Centred Multiple Imputation**
Reposted by Suzie Cro
New Publication 🔊: Investigating the trustworthiness of randomized controlled trials in osteopathic research: a systematic review with meta-analysis by @davidhosch.bsky.social et al in
@jclinepi.bsky.social
www.jclinepi.com/article/S089...
@jclinepi.bsky.social
www.jclinepi.com/article/S089...
Investigating the trustworthiness of randomized controlled trials in osteopathic research: a systematic review with meta-analysis
To systematically investigate trustworthiness (methodological rigor, transparency,
good governance, research integrity, and absence of misconduct) in randomized controlled
trials (RCTs) of osteopathic...
www.jclinepi.com
May 14, 2025 at 8:06 AM
New Publication 🔊: Investigating the trustworthiness of randomized controlled trials in osteopathic research: a systematic review with meta-analysis by @davidhosch.bsky.social et al in
@jclinepi.bsky.social
www.jclinepi.com/article/S089...
@jclinepi.bsky.social
www.jclinepi.com/article/S089...
Reposted by Suzie Cro
In 2023 Trials invited submissions that related to the collection, analysis & reporting of adverse events in clinical trials. In this editorial @vcornelius.bsky.social & I summarise the submissions & discuss the implications on applied clinical trials & future methodological research rdcu.be/elLFa
Trials special series - the collection, analysis and reporting of adverse events in randomised controlled trials
rdcu.be
May 13, 2025 at 8:21 AM
In 2023 Trials invited submissions that related to the collection, analysis & reporting of adverse events in clinical trials. In this editorial @vcornelius.bsky.social & I summarise the submissions & discuss the implications on applied clinical trials & future methodological research rdcu.be/elLFa
Reposted by Suzie Cro
A quick round up of #cctmm25 organised by @imperialctu.bsky.social and NIHR RSS!
Day 1 had a range of brilliant speakers and overall was a very inspiring day of clinical trials! Can’t wait for the next one
Day 1 had a range of brilliant speakers and overall was a very inspiring day of clinical trials! Can’t wait for the next one
April 8, 2025 at 8:13 AM
A quick round up of #cctmm25 organised by @imperialctu.bsky.social and NIHR RSS!
Day 1 had a range of brilliant speakers and overall was a very inspiring day of clinical trials! Can’t wait for the next one
Day 1 had a range of brilliant speakers and overall was a very inspiring day of clinical trials! Can’t wait for the next one
Reposted by Suzie Cro
📢 New job alert. We're recruiting a Lecturer in Digital Health & Clinical Trials @ Imperial Clinical Trials Unit. We're seeking an experienced methodologist looking for a new leadership & research role to help us grow our portfolio of digitally enabled trials.
shorturl.at/IioXW
Closing 5th May
shorturl.at/IioXW
Closing 5th May
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
shorturl.at
April 4, 2025 at 7:32 AM
📢 New job alert. We're recruiting a Lecturer in Digital Health & Clinical Trials @ Imperial Clinical Trials Unit. We're seeking an experienced methodologist looking for a new leadership & research role to help us grow our portfolio of digitally enabled trials.
shorturl.at/IioXW
Closing 5th May
shorturl.at/IioXW
Closing 5th May
Reposted by Suzie Cro
Meaning the outcome may not be measuring what we thought it was measuring. We used "A four-step strategy for handling missing outcome data in randomised trials affected by a pandemic bmcmedresmethodol.biomedcentral.com/articles/10.... to account for this @suziecro.bsky.social 3/n
A four-step strategy for handling missing outcome data in randomised trials affected by a pandemic - BMC Medical Research Methodology
Background The coronavirus pandemic (Covid-19) presents a variety of challenges for ongoing clinical trials, including an inevitably higher rate of missing outcome data, with new and non-standard reas...
bmcmedresmethodol.biomedcentral.com
March 29, 2025 at 11:24 AM
Meaning the outcome may not be measuring what we thought it was measuring. We used "A four-step strategy for handling missing outcome data in randomised trials affected by a pandemic bmcmedresmethodol.biomedcentral.com/articles/10.... to account for this @suziecro.bsky.social 3/n
Reposted by Suzie Cro
Exploring the effect of COVID-19 restrictions on the social functioning scale in a clinical trial of antipsychotic reduction: using multiple imputation to target a hypothetical estimand is out in @jclinepi.bsky.social www.sciencedirect.com/science/arti... 1/n
March 29, 2025 at 11:24 AM
Exploring the effect of COVID-19 restrictions on the social functioning scale in a clinical trial of antipsychotic reduction: using multiple imputation to target a hypothetical estimand is out in @jclinepi.bsky.social www.sciencedirect.com/science/arti... 1/n