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Reposted by Suzie Cro

Imperial Clinical Trials Unit @imperialctu.bsky.social · 6d

💬Got 5 mins?
Help improve clinical trials by sharing your thoughts on health data collection.
@anniestats.bsky.social a PhD researcher at Imperial has designed this survey with the help of her public involvement groups.
🔗 imperial.eu.qualtrics.com/jfe/form/SV_...
#PPI #HealthEquity #ResearchVoices

Public Perspectives on Digital Data Collection in Clinical Trials

The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.

imperial.eu.qualtrics.com

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Reposted by Suzie Cro

StatsCI @statsci.bsky.social · 22d

New publication 📣: Are estimands being correctly used? A review of UK research protocols by Timothy P. Clark, Richard H. Wicentowski, Suzie Cro, Matthew R. Sydes & Brennan C. Kahan trialsjournal.biomedcentral.com/articles/10....

Are estimands being correctly used? A review of UK research protocols - Trials

Background The use of estimands in clinical trials was formalised with the adoption of the final International Conference on Harmonisation E9 Addendum on Estimands and Sensitivity Analysis in Clinical...

trialsjournal.biomedcentral.com

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Reposted by Suzie Cro

Imperial Clinical Trials Unit @imperialctu.bsky.social · Sep 3

And that's a wrap on this year's NIHR undergraduate internships. It's been a pleasure hosting three rising stars, they've each achieved so much in just 8 weeks. We can't wait to see what the future holds for them. Congratulations Alex, Mahima & Joe and good luck with the rest of your studies.

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Reposted by Suzie Cro

Rachel Phillips @rachpips.bsky.social · Sep 5

In our latest adverse event webinar Jeffrey Aronson & Igho Onakpoya discuss their review that looked at how data from clinical study reports compare with data in published trial reports. Catch-up on their talk here: www.statsci.co.uk/webinar-series

WEBINARS | StatsCI

www.statsci.co.uk

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Suzie Cro @suziecro.bsky.social · Sep 3

In the JAKPPPOT 🎰 trial lead by David Gleason, historical placebo data from the APRICOT trial will be used as an external control arm to explore a signal of effect size. The protocol for this mixed-methods feasibility trial is now available #BMJOpen
bmjopen.bmj.com/content/15/8...

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Suzie Cro @suziecro.bsky.social · Sep 1

Are estimands being correctly used?
A new review of protocols led by Timothy Clark shows many incorrectly defined estimand attributes. See the top areas for improvement & full results here:
trialsjournal.biomedcentral.com/articles/10.... #Trials

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Reposted by Suzie Cro

Imperial Clinical Trials Unit @imperialctu.bsky.social · Aug 20

One week left to apply for this exciting opportunity to join our growing statistics team @statsci.bsky.social. Closing 28th August 2025.

StatsCI @statsci.bsky.social · Aug 15

🔊We're hiring!
Imperial Clinical Trials Unit are looking for an ambitious senior statistician with experience in clinical trials & design & analysis of adaptive trials to lead a research programme in antimicrobial resistance & data-enabled trials.
Full details: www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

www.imperial.ac.uk

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Reposted by Suzie Cro

StatsCI @statsci.bsky.social · Aug 13

Delighted to share registration is open for Professor @vcornelius.bsky.social inaugural lecture -Under pressure: smarter trials for better health outcomes- Thursday, 30 October 2025, 17.30-18.30, Imperial College South Kensington/Online. For details & registration: www.imperial.ac.uk/events/19688...

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Reposted by Suzie Cro

StatsCI @statsci.bsky.social · Jul 15

New publication📣: Incorporation of Patient and Public Involvement in Statistical Methodology Research: Summary of Workshop Proceedings - aimed at addressing barriers to meaningful PPI in statistical methodology research. Open access in Statistics in Medicine onlinelibrary.wiley.com/doi/10.1002/...

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Reposted by Suzie Cro

Brennan Kahan @brennankahan.bsky.social · Jul 1

New paper posted on Arxiv: "When do composite estimands answer non-causal questions?"

This can happen more often than you think, and can have a dramatic impact on trial results (e.g. a false-positive rate of almost 90%)

arxiv.org/abs/2506.22610 @timpmorris.bsky.social

When do composite estimands answer non-causal questions?

Under a composite estimand strategy, the occurrence of the intercurrent event is incorporated into the endpoint definition, for instance by assigning a poor outcome value to patients who experience th...

arxiv.org

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Suzie Cro @suziecro.bsky.social · Jun 10

Looking forward to this in todays Estimands and Missing data session @ #PSI2025 & being the estimands and missing data bridge between James Bells talk on composite estimand strategies with a continuous outcome & @timpmorris.bsky.social talk on how many multiple imputations you need!

StatsCI @statsci.bsky.social · Jun 9

Attending #PSI2025 at Wembley stadium ⚽ this week? Don’t miss new research on a novel multiple imputation procedure for handling missing data in clinical trials targeting a treatment policy estimand by @suziecro.bsky.social James Roger & James Carpenter

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Reposted by Suzie Cro

StatsCI @statsci.bsky.social · May 27

🔈Job alert! We are looking for an ambitious senior trial statistician to join an exciting new partnership between Imperial College London & Imperial College Healthcare NHS Trust, the Fleming Initiative, which aims to tackle antimicrobial resistance (AMR). www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

www.imperial.ac.uk

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Reposted by Suzie Cro

Rachel Phillips @rachpips.bsky.social · May 23

Catch up on all the talks from our Adverse Event special series so far: www.statsci.co.uk/webinar-series

WEBINARS | StatsCI

www.statsci.co.uk

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Suzie Cro @suziecro.bsky.social · May 20

Hope your jet lag soon passes Annie & your presentation goes well - you are a great presenter! 🤗

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Suzie Cro @suziecro.bsky.social · May 19

Interested in a new way to impute missing data in clinical trials targeting treatment policy estimands?

New blog post introducing **Retrieved Dropout Reference-Based Centred Multiple Imputation**

A New Way to Impute Missing Data in Clinical Trials Targeting Treatment Policy Estimands

When patients stop taking their assigned treatment in a clinical trial - whether due to side effects, lack of effectiveness, or personal choice - researchers often still want to understand how that treatment...

www.statsci.co.uk

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Reposted by Suzie Cro

StatsCI @statsci.bsky.social · May 14

New Publication 🔊: Investigating the trustworthiness of randomized controlled trials in osteopathic research: a systematic review with meta-analysis by @davidhosch.bsky.social et al in
@jclinepi.bsky.social
www.jclinepi.com/article/S089...

Investigating the trustworthiness of randomized controlled trials in osteopathic research: a systematic review with meta-analysis

To systematically investigate trustworthiness (methodological rigor, transparency, good governance, research integrity, and absence of misconduct) in randomized controlled trials (RCTs) of osteopathic...

www.jclinepi.com

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Reposted by Suzie Cro

Rachel Phillips @rachpips.bsky.social · May 13

In 2023 Trials invited submissions that related to the collection, analysis & reporting of adverse events in clinical trials. In this editorial @vcornelius.bsky.social & I summarise the submissions & discuss the implications on applied clinical trials & future methodological research rdcu.be/elLFa

Trials special series - the collection, analysis and reporting of adverse events in randomised controlled trials

rdcu.be

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Reposted by Suzie Cro

Annie Wright @anniestats.bsky.social · Apr 8

A quick round up of #cctmm25 organised by @imperialctu.bsky.social and NIHR RSS!

Day 1 had a range of brilliant speakers and overall was a very inspiring day of clinical trials! Can’t wait for the next one

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Reposted by Suzie Cro

Rachel Phillips @rachpips.bsky.social · Apr 4

📢 New job alert. We're recruiting a Lecturer in Digital Health & Clinical Trials @ Imperial Clinical Trials Unit. We're seeking an experienced methodologist looking for a new leadership & research role to help us grow our portfolio of digitally enabled trials.
shorturl.at/IioXW
Closing 5th May

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

shorturl.at

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Reposted by Suzie Cro

Louise Marston @proflouisemarston.bsky.social · Mar 29

Meaning the outcome may not be measuring what we thought it was measuring. We used "A four-step strategy for handling missing outcome data in randomised trials affected by a pandemic bmcmedresmethodol.biomedcentral.com/articles/10.... to account for this @suziecro.bsky.social 3/n

A four-step strategy for handling missing outcome data in randomised trials affected by a pandemic - BMC Medical Research Methodology

Background The coronavirus pandemic (Covid-19) presents a variety of challenges for ongoing clinical trials, including an inevitably higher rate of missing outcome data, with new and non-standard reas...

bmcmedresmethodol.biomedcentral.com

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Reposted by Suzie Cro

Louise Marston @proflouisemarston.bsky.social · Mar 29

Exploring the effect of COVID-19 restrictions on the social functioning scale in a clinical trial of antipsychotic reduction: using multiple imputation to target a hypothetical estimand is out in @jclinepi.bsky.social www.sciencedirect.com/science/arti... 1/n

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Suzie Cro @suziecro.bsky.social · Mar 31

Looking forward to #CCTMM25 this week! an exciting programme is in store bit.ly/CCTMM25

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Reposted by Suzie Cro

HRB-TMRN @hrb-tmrn.bsky.social · Mar 20

Our expressions of interest form is now open for anyone who wishes to apply to attend the 'Roadmap Workshop: A road trip for PPI with Trials Methodology Research'. Please click the following link to access it: forms.office.com/e/kx5w4MgHad

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Suzie Cro @suziecro.bsky.social · Mar 18

New publication led by @proflouisemarston.bsky.social using multiple imputation to target a hypothetical estimand in a pandemic restriction-free world for a trial in
schizophrenia - demonstrating the potential impact of the pandemic on the trial results

Journal of Clinical Epidemiology @jclinepi.bsky.social · Mar 13

Exploring the effect of COVID-19 restrictions on the Social Functioning Scale in a clinical trial of Antipsychotic Reduction: using multiple imputation to target a hypothetical estimand - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Exploring the effect of COVID-19 restrictions on the Social Functioning Scale in a clinical trial of Antipsychotic Reduction: using multiple imputation to target a hypothetical estimand

Many trials are affected by unforeseen events after recruitment has commenced. The aim of this study is to explore a hypothetical strategy for dealing with an intercurrent event that occurred during t...

www.jclinepi.com

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