Lightnews — Scholar-powered news

Sakari Vanharanta @svanharanta.bsky.social · Apr 14

New issue of Annual Reviews of Cancer Biology is out!
www.annualreviews.org/content/jour...

Annual Review of Cancer Biology | Annual Reviews

AIMS AND SCOPE OF JOURNAL: The Annual Review of Cancer Biology reviews a range of subjects in cancer research that represent important and emerging areas in the field. With recent advances in our unde...

www.annualreviews.org

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Sakari Vanharanta @svanharanta.bsky.social · Mar 21

www.cnbc.com/2025/03/19/w...

Finland is the happiest country in the world for the eighth year in a row

For the eighth year in a row, Finland ranked in the top spot on the World's Happiness Report's annual ranking of the happiest countries in the world.

www.cnbc.com

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Sakari Vanharanta @svanharanta.bsky.social · Jan 16

Very interesting work on the role of germline genetics in somatic tumor evolution.

Sarah Aitken @s-j-aitken.bsky.social · Jan 15

🌟NEW PREPRINT ALERT!🌟

We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution”

www.biorxiv.org/content/10.1...

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Genetic background sets the trajectory of cancer evolution

Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...

www.biorxiv.org

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Sakari Vanharanta @svanharanta.bsky.social · Jan 7

Last few days to apply👇! In addition to hot science, our campus offers refreshing dips within walking distance 💪🏖️ #BalticSea #Helsinki

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Reposted by Sakari Vanharanta

Adaptmet @adaptmet.bsky.social · Dec 20

Looking for a PhD? Follow this🧵 to know how Adaptmet's innovative training will combine continuous training in cutting-edge metastasis research with custom-made network-wide events to enhance, accelerate & elevate the skills, capacities & network of our doctoral candidates (DCs)

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Reposted by Sakari Vanharanta

AndreaVenturaLab @andreaventura.bsky.social · Dec 18

🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...

Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature

Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...

www.nature.com

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Sakari Vanharanta @svanharanta.bsky.social · Dec 18

Super cool work, congrats Andrea and the team!

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Reposted by Sakari Vanharanta

Ulrich Elling @ulielling.bsky.social · Dec 16

Today we published a new paradigm to do CRISPR screens in complex model systems such as in vivo but also e.g. in organoids. The publication came out in Nature Biotechnology.
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www.nature.com/articles/s41...

CRISPR-StAR enables high-resolution genetic screening in complex in vivo models - Nature Biotechnology

Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls.

www.nature.com

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Sakari Vanharanta @svanharanta.bsky.social · Dec 16

aacrjournals.org/cdnews/news/...

Inherited Gene Variant Tied to Breast Cancer Spread

A common germline variant of PCSK9 significantly increases the risk of breast cancer metastasis, a new study has revealed. The finding—a first example of inherited genes driving metastatic progression...

aacrjournals.org

Sakari Vanharanta @svanharanta.bsky.social · Dec 10

Come join us!

Adaptmet @adaptmet.bsky.social · Dec 10

📢 Calling all future cancer researchers! Adaptmet is offering 16 MSCA PhD positions in cutting-edge metastasis research. Follow this thread & get to know the exciting projects on offer among Europe’s best teams from top host institutions! More details 👉https://adaptmet.eu/recruitment/

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Sakari Vanharanta @svanharanta.bsky.social · Dec 10

Very interesting insight into tumor-immune interaction under chemotherapy in ovarian cancer. Congrats Anniina, Anna and the teams!

Färkkilä Laboratory @farkkilab.bsky.social · Dec 10

1/n New paper alert 🚨 We're thrilled to share our just published paper in #CancerCell
Do you ever wonder how the #TME in #HGSC changes during chemotherapy? Check it here: www.sciencedirect.com/science/arti... and let’s dive into the highlights together #spatialbiology #ovariancancer #cancerresarch

Chemotherapy induces myeloid-driven spatially confined T cell exhaustion in ovarian cancer

Anti-tumor immunity is crucial for high-grade serous ovarian cancer (HGSC) prognosis, yet its adaptation upon standard chemotherapy remains poorly und…

www.sciencedirect.com

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Sakari Vanharanta @svanharanta.bsky.social · Dec 10

Congrats Direna, fantastic news!

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Reposted by Sakari Vanharanta

Memorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · Dec 4

New in @natureportfolio.bsky.social from the Tuomas Tammela Lab: how aging suppresses tumorigenesis and stemness in the lung by promoting functional iron insufficiency in the alveolar epithelium. Interestingly, this renders aged cells resistant to ferroptosis. #OncSky www.nature.com/articles/s41...

Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis - Nature

Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2.

www.nature.com

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Reposted by Sakari Vanharanta

Kristian Pietras lab @kpietraslab.bsky.social · Dec 4

Come join us and @svanharanta.bsky.social @cedric-blanpain.bsky.social Roger Gomis @irbbarcelona.bsky.social @obenaufa.bsky.social Karin de Visser @nkinl.bsky.social @grauperalab.bsky.social @prat-aleix-md.bsky.social @vickysanzmoreno.bsky.social @johannajoyce.bsky.social @momobentires.bsky.social

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Sakari Vanharanta @svanharanta.bsky.social · Nov 28

Congrats Anais and @guillemxtivill.bsky.social, you've done such a fantastic job with this!

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Sakari Vanharanta @svanharanta.bsky.social · Nov 27

Inflammatory monocytes can restimulate T cells in tumors, and cancer cell-induced disruption of this process can lead to tumor immune evasion. Details 👇 in the wonderful 🧵 by @obenaufa.bsky.social and the paper published today @Nature. What a privilege it has been to be part of this amazing team!

Anna Obenauf @obenaufa.bsky.social · Nov 27

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

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Sakari Vanharanta @svanharanta.bsky.social · Nov 27

Maybe me too? Thanks so much!

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Sakari Vanharanta @svanharanta.bsky.social · Nov 25

Hello Bluesky, we are recruiting PhD students in cancer and metastasis biology! This is a fantastic program that brings together several leading European research institutes. Details here: adaptmet.eu/recruitment/

Recruitment

Recruitment is now open! Apply for one of the 16 positions availablein the Adaptmet network and build your futureas a researcher in metastasis! Adaptmet is offering generous three-year fellowship...

adaptmet.eu

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