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Reposted by Thomas B. Poulsen

The Matile Group @matilegroup.bsky.social · Aug 29

Our new paper in Helv. Chim. Acta, the Journal of the Swiss Chemical Society, founded 1917, elaborates on unorthodox reversible Michael addition for cellular uptake; with the groups of @tbpoulsen.bsky.social‬ and @oliverthornseshold.bsky.social‬.

onlinelibrary.wiley.com/doi/10.1002/...

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Reposted by Thomas B. Poulsen

Michael Willis @rhpdcu.bsky.social · Jun 17

Great to see Ivan and Charlie's work on the synthesis and reactivity of vinyl sulfonimidamides out in @chemicalscience.rsc.org Here they show that reactivity either above or below that of the corresponding acrylamide can be achieved. @oxfordchemistry.bsky.social
pubs.rsc.org/en/content/a...

Synthesis and functionalization of vinyl sulfonimidamides and their potential as electrophilic warheads

Covalent inhibitor design is dominated by the use of electrophilic acrylamide warheads. One limitation of acrylamides is that there are limited opportunities to modify their electrophilicity, and henc...

pubs.rsc.org

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Reposted by Thomas B. Poulsen

Gerti Beliu @beliulab.bsky.social · Jun 13

Next up: Thomas Poulsen - diving into precision chemistry from the protein to the proteome! ⚗️ Powerful tools for covalent protein profiling. FANTASTIC work! #ChemBio #Proteomics #CSSB25

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Thomas B. Poulsen @tbpoulsen.bsky.social · May 29

Congrats to all of the authors, in particular to Florian Kromm and Søren Borcher Møller who lead this work together. 👏 We are grateful for the @erc.europa.eu opa.eu for funding.
#totalsynthesis

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Thomas B. Poulsen @tbpoulsen.bsky.social · May 29

Our new route represents a dramatic shortening compared to classic routes to this compound, which was strongly enabled by development of a new transformation to directly couple the challenging attached oxacyclic rings. We are further excited about the generality of this C(sp3)-C(sp3) coupling method

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Thomas B. Poulsen @tbpoulsen.bsky.social · May 29

Delighted to share our newest pre-print. Here, we describe a very short synthesis (11 steps, LLS) of the polyether antibiotic lasalocid acid A.
doi.org/10.26434/che...

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Reposted by Thomas B. Poulsen

Nordic Retrosynthesis Challenge @nordicretrosynt.bsky.social · Apr 17

18 days left until the #NordicRetrosynthesisChallenge begins...
Is your team ready?
Get ready for the #NordicRetrosynthesisChallenge on 5th of May 2025! For more info check nordicretrosynthesischallenge.com
Sponsored by Carbolution Chemicals GmbH and AstraZeneca
Please share! #chemsky #Chembio

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Thomas B. Poulsen @tbpoulsen.bsky.social · Mar 27

Enjoy the meeting Stephan. Unfortunately, I cannot attend this one but hopefully the tradition continues.

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Reposted by Thomas B. Poulsen

Nordic Retrosynthesis Challenge @nordicretrosynt.bsky.social · Mar 21

45 days left until the challenge is revealed... Are you familiar with the rules? Get ready for the #NordicRetrosynthesisChallenge on 5th of May 2025! For more info check nordicretrosynthesischallenge.com! Sponsored by Carbolution Chemicals and AstraZeneca
Please share ! #chemsky #Chembio

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Reposted by Thomas B. Poulsen

Nordic Retrosynthesis Challenge @nordicretrosynt.bsky.social · Feb 28

66 days left until the challenge is revealed... Get ready for the #NordicRetrosynthesisChallenge on 5th of May 2025! For more info check nordicretrosynthesischallenge.com! Sponsored by Carbolution Chemicals and AstraZeneca
Please share and spread the news! #chemsky #Chembio

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Reposted by Thomas B. Poulsen

Nordic Retrosynthesis Challenge @nordicretrosynt.bsky.social · Feb 7

Do you already have a team to participate in the #NordicRetrosynthesisChallenge on 5th of May 2025?
For more info check nordicretrosynthesischallenge.com!
Sponsored by Carbolution Chemicals and AstraZeneca
Please share and spread the news! #chemsky #Chembio

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Thomas B. Poulsen @tbpoulsen.bsky.social · Jan 30

Check out the summary of the newest paper from our lab. Just out in Chemical Science #chembio #chemicalbiology

Anders Kiib @aekiib.bsky.social · Jan 30

I am excited to share that the latest project from the @tbpoulsen.bsky.social group, detailing the syntheses and biological evaluation of the four natural products cyclohelminthol I-IV is now available in Chemical Science!

doi.org/10.1039/D4SC...

A short "Bluetorial" below #ChemSky #ChemBio 1/7

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Reposted by Thomas B. Poulsen

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Jan 26

Ten simple rules for developing good reading habits during graduate school and beyond

To me, the most important are:
Read often, read broadly (incl. older papers and outside your field), and learn to read some papers in detail and others more superficially (and quickly)

Ten simple rules for developing good reading habits during graduate school and beyond by Marcos Méndez
1: Develop the habit of reading on a daily basis
2: Read thoroughly to build a sound background understanding of your topic
3: Do not ignore the pillars of your discipline; read the classics
4: If you have to get familiar with a new topic, consider reading in chronological order
5: Avoid narrow-mindedness by reading beyond your discipline
6: Create a list of relevant journals
7: Not all interesting stuff will appear in articles; read books
8: Use a reference manager to keep track of your literature
9: Keep a long-term review for your own use as a way to remember what you read
10: Build your own library to make yourself independent and inspire others

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Thomas B. Poulsen @tbpoulsen.bsky.social · Jan 9

Big Congrats Luca!

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Thomas B. Poulsen @tbpoulsen.bsky.social · Jan 9

#ChemBio

Thomas B. Poulsen @tbpoulsen.bsky.social · Jan 9

Here is a very interesting new paper from the Baker and Chudasama groups at University College London. A clever example of leveraging reversible disulfide rebridging chemistry to achieve selective lysine modification (via proximity) of antibody-fragments.
pubs.rsc.org/en/content/a...

Formation of mono- and dual-labelled antibody fragment conjugates via reversible site-selective disulfide modification and proximity induced lysine reactivity

Many protein bioconjugation strategies focus on the modification of lysine residues owing to the nucleophilicity of their amine side-chain, the generally high abundance of lysine residues on a protein...

pubs.rsc.org

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Reposted by Thomas B. Poulsen

Stephan Hacker @stephanhacker2.bsky.social · Nov 26

It is great to have @aekiib.bsky.social from the group of @tbpoulsen.bsky.social as visiting PhD student in the lab. His stay in our lab allows us to exchange a lot of thoughts and technologies between the labs and learn so much from each other. #ChemBio onlinelibrary.wiley....

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Thomas B. Poulsen @tbpoulsen.bsky.social · Nov 26

Cool picture! Very happy about this exchange - Thanks for hosting. So many interesting experiments and data already.

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Reposted by Thomas B. Poulsen

Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · Nov 20

Now that’s a good #ChemSky thread!

Can’t wait to read the final version of this preprint in some top notch journal. Congrats to all involved. Beautiful work 👌🏻

Esben Svenningsen @esbensv.bsky.social · Nov 20

In my first #bsky post, I am very happy and proud to share the new(ish) preprint of my post doc project on N-terminal cysteine (NCys) chemoprotomics using the oxSTEF probes!

Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549

Skeeturial (??) below ⬇️ #ChemSky #ChemBio

Graphical abstract of scientific paper. Chemical structures of oxSTEF probes and N-terminal cysteine, showing their reaction followed by a schematic of a proteomics experiment

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Reposted by Thomas B. Poulsen

Verhelst Lab @verhelstlab.bsky.social · Nov 20

This looks like an interesting application of the oxSTEF probes developed in the Poulsen lab before. Good example of developing interesting chemistry/chemical biology and then asking the right biological questions.

Esben Svenningsen @esbensv.bsky.social · Nov 20

In my first #bsky post, I am very happy and proud to share the new(ish) preprint of my post doc project on N-terminal cysteine (NCys) chemoprotomics using the oxSTEF probes!

Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549

Skeeturial (??) below ⬇️ #ChemSky #ChemBio

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Reposted by Thomas B. Poulsen

Stephan Hacker @stephanhacker2.bsky.social · Nov 21

Interesting ChemRxiv preprint by the group of @tbpoulsen.bsky.social with first author @esbensv.bsky.social. They used OxSTEF probes to study proteins with N-terminal cysteines in the proteome and used the method to specifically investigate difference in normoxia and hypoxia. doi.org/10.26434/che...

Chemoproteomic mapping of the N-terminal cysteinome

The oxidation status of N-terminal cysteines directly dictates protein stability via arginylation and proteasomal degradation. However, only a handful of proteins have been shown to be regulated via t...

doi.org

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Reposted by Thomas B. Poulsen

Stephan Hacker @stephanhacker2.bsky.social · Nov 21

Great to see them apply the proteome-wide profiling method for electrophile reactivity and selectivity that we developed together with @nesvilab.bsky.social in Fragpipe in this exciting system. chemrxiv.org/engage/chemr...

Profiling the proteome-wide selectivity of diverse electrophiles

Targeted covalent inhibitors are powerful entities in drug discovery, but their application has so far mainly been limited to addressing cysteine residues. The development of cysteine-directed covalen...

chemrxiv.org

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Thomas B. Poulsen @tbpoulsen.bsky.social · Nov 20

Thanks a lot!

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Thomas B. Poulsen @tbpoulsen.bsky.social · Nov 20

Interested in covalent probes? Check out our most recent pre-print on chemoproteomic profiling of N-terminal cysteines. Nice overview/summary from lead author @esbensv.bsky.social

Esben Svenningsen @esbensv.bsky.social · Nov 20

In my first #bsky post, I am very happy and proud to share the new(ish) preprint of my post doc project on N-terminal cysteine (NCys) chemoprotomics using the oxSTEF probes!

Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549

Skeeturial (??) below ⬇️ #ChemSky #ChemBio

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Reposted by Thomas B. Poulsen

Thorn-Seshold Lab @thornsesholdlab.bsky.social · Nov 17

📯📯 Chemical Biology starter pack 📯📯
140 PIs & groups posting primary research in chemical biology.

Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj

Let's make ChemBioSky even greater again!

#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

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