Alexandra Nicaise
@telencephale.bsky.social
Incoming assistant professor @UAMS
Neural stem cells & the choroid plexus in neuroinflammation using patient-based 2D and 3D models
Senior Research Associate, Dept of Clinical Neurosciences, University of Cambridge
Neural stem cells & the choroid plexus in neuroinflammation using patient-based 2D and 3D models
Senior Research Associate, Dept of Clinical Neurosciences, University of Cambridge
Pinned
Excited to see our work published in @cp-neuron.bsky.social !
Reposted by Alexandra Nicaise
Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis
Bigotte et al. show that motile cilia on ependymal cells—epithelial cells lining the brain ventricles—are disrupted in multiple sclerosis. Using patient ti
academic.oup.com
November 28, 2025 at 6:43 PM
Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Reposted by Alexandra Nicaise
Endothelial gateways for brain lipid uptake and metabolism: www.jci.org/articles/vie...
A. Dushani Ranasinghe & Timothy Hla Comment on Wenxin Song et al: www.jci.org/articles/vie...
A. Dushani Ranasinghe & Timothy Hla Comment on Wenxin Song et al: www.jci.org/articles/vie...
October 10, 2025 at 4:16 PM
Endothelial gateways for brain lipid uptake and metabolism: www.jci.org/articles/vie...
A. Dushani Ranasinghe & Timothy Hla Comment on Wenxin Song et al: www.jci.org/articles/vie...
A. Dushani Ranasinghe & Timothy Hla Comment on Wenxin Song et al: www.jci.org/articles/vie...
Reposted by Alexandra Nicaise
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 10, 2025 at 8:45 AM
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Excited to see our work published in @cp-neuron.bsky.social !
October 12, 2025 at 9:45 AM
Excited to see our work published in @cp-neuron.bsky.social !
