The Lancet Infectious Diseases
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The Lancet Infectious Diseases
@thelancetinfdis.bsky.social
The Lancet Infectious Diseases is the leading clinical infectious diseases journal for peer-reviewed research and review, comment, and news.

🌐 https://www.thelancet.com/journals/laninf/home
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Read our December issue!

Featuring testing obeldesivir for COVID-19 therapy, measles transmission patterns in Italy, and single dose of HPV vaccine in Costa Rica.

www.thelancet.com/issue/S1473-...
New comment:

Strengthening global preparedness and response to arboviral disease threats: a call to action

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Strengthening global preparedness and response to arboviral disease threats: a call to action
Arthropod-borne viruses (arboviruses), particularly those transmitted by Aedes aegypti and Aedes albopictus, are a growing global health threat. Approximately 70% of the world's population is at risk ...
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November 25, 2025 at 8:36 AM
New Research:

Comparison of the performance and costs of testing algorithms using rapid diagnostic tests for detection and treatment of syphilis among pregnant individuals and men who have sex with men: a modelling study

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Comparison of the performance and costs of testing algorithms using rapid diagnostic tests for detection and treatment of syphilis among pregnant individuals and men who have sex with men: a modelling...
No single algorithm was optimal across all settings. T-RDTs remain suitable for antenatal screening, but the standard or modified T/NT-RDT might be preferable for populations at high risk for syphilis...
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November 24, 2025 at 8:38 AM
New comment:

The genomic surveillance gap: averting the antimicrobial resistance pandemic requires global equity and action

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The genomic surveillance gap: averting the antimicrobial resistance pandemic requires global equity and action
The COVID-19 pandemic provided a stark, real-time demonstration of genomic surveillance's power. By sequencing SARS-CoV-2, the global health community tracked viral evolution, identified variants of c...
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November 24, 2025 at 8:37 AM
Read our December issue!

Featuring testing obeldesivir for COVID-19 therapy, measles transmission patterns in Italy, and single dose of HPV vaccine in Costa Rica.

www.thelancet.com/issue/S1473-...
November 20, 2025 at 5:51 AM
New Research

Post-COVID-19 resurgence of Mycoplasma pneumoniae infections in French children (ORIGAMI): a retrospective and prospective multicentre cohort study

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Post-COVID-19 resurgence of Mycoplasma pneumoniae infections in French children (ORIGAMI): a retrospective and prospective multicentre cohort study
The 2023–2024 M pneumoniae epidemic in France resulted in a substantial paediatric hospitalisation burden. Although severe cases were uncommon, children older than 11 years, those with asthma, other c...
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November 20, 2025 at 5:45 AM
New Research:

National burden of and optimal vaccine policy for Japanese encephalitis virus in Bangladesh: a seroprevalence and modelling study

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National burden of and optimal vaccine policy for Japanese encephalitis virus in Bangladesh: a seroprevalence and modelling study
A spatially targeted vaccine campaign would be most effective in reducing JEV burden; however, it would still not meet standard cost-effectiveness targets.
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November 19, 2025 at 4:07 PM
Reposted by The Lancet Infectious Diseases
The role of AI in infectious diseases is emerging—offering new opportunities for infection prevention, detection & control.

Explore developments & practical applications ⤵️
spkl.io/63323Ad83c @thelancetinfdis.bsky.social #WorldAMRAwarenessWeek
November 19, 2025 at 12:03 PM
New Research

Complications and mortality of typhoid fever: an updated global systematic review and meta-analysis

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Complications and mortality of typhoid fever: an updated global systematic review and meta-analysis
We identified substantial ongoing morbidity and mortality due to typhoid fever in Africa and Asia, in facility-based sites, and across age groups. This updated evidence can be used to support decision...
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November 13, 2025 at 10:43 AM
New Research

Field evaluation of a rapid antigen test for mpox in the Democratic Republic of the Congo and Uganda: a multicentre, prospective, diagnostic accuracy study

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Field evaluation of a rapid antigen test for mpox in the Democratic Republic of the Congo and Uganda: a multicentre, prospective, diagnostic accuracy study
Although performance of the NG-Test Monkeypox antigen RDT did not fully meet WHO Target Product Profile benchmarks, driven mainly by lower sensitivity in DR Congo, results in Uganda were more encourag...
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November 13, 2025 at 10:41 AM
New Research

Safety, tolerability, and immunogenicity of the ChAdOx1 RVF vaccine against Rift Valley fever among healthy adults in Uganda: a single-centre, single-blind, randomised, placebo-controlled, dose-escalation, phase 1 trial

www.thelancet.com/journals/lan...
Safety, tolerability, and immunogenicity of the ChAdOx1 RVF vaccine against Rift Valley fever among healthy adults in Uganda: a single-centre, single-blind, randomised, placebo-controlled, dose-escala...
A single dose of ChAdOx1 RVF vaccine seemed to be safe, tolerable, and immunogenic in healthy adults in an RVF-endemic setting, eliciting humoral and cellular immunity. Further evaluation of the 5·0 ×...
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November 12, 2025 at 9:01 AM
Reposted by The Lancet Infectious Diseases
@seanong.bsky.social takes to the next level analysis of the BALANCE trial (7 vs 14 days of antibiotics) and impact of protocol non-adherence (there was about 20% non-adherence to protocol durations).

Read his thread and read his paper!

@thelancetinfdis.bsky.social @thedohertyinst.bsky.social
Hot off the press at @thelancetinfdis.bsky.social: our paper diving into non-adherence in the BALANCE trial. We identify factors associated with protocol non-adherence, and evaluate the impact of potential bias on trial results.

authors.elsevier.com/a/1m5He5E-Uo...

@steventong.bsky.social #IDSky
authors.elsevier.com
November 12, 2025 at 1:30 AM
New Research

Accounting for non-adherence to assigned antibiotic treatment duration for bloodstream infection (BALANCE): a post-hoc analysis of a randomised clinical trial

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Accounting for non-adherence to assigned antibiotic treatment duration for bloodstream infection (BALANCE): a post-hoc analysis of a randomised clinical trial
Non-adherence in BALANCE was significantly associated with a range of important prognostic factors, which might have introduced bias. Causal inference methods addressing this bias showed a consistent ...
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November 12, 2025 at 8:58 AM
New Personal View

Post-tuberculosis lung disease: a case definition for use in research studies

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Post-tuberculosis lung disease: a case definition for use in research studies
Despite growing awareness of the substantial burden of long-term pulmonary impairment among tuberculosis survivors, marked variability in how post-tuberculosis lung disease is defined across research ...
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November 11, 2025 at 8:13 AM
New Review

British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases: 2025 update

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British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases: 2025 update
The fungal diagnostic landscape is evolving; whereas previously, traditional culture-based methods dominated, most invasive fungal disease is now diagnosed with non-culture-based tests, including dire...
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November 11, 2025 at 8:12 AM
Reposted by The Lancet Infectious Diseases
Our November issue is now online:

www.thelancet.com/journals/lan...

Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #HTLV-1 #AMR #Lassa #Neisseria #gonorrhoea #tuberculosis #TB #influenza

#IDSky #ClinMicro #OA
November 8, 2025 at 9:38 PM
New Comment

Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease

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Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease
Long COVID is an umbrella term for the heterogeneous long-term consequences of SARS-CoV-2 infection. It encompasses a wide spectrum of phenotypes (sometimes overlapping), and its underlying mechanisms...
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November 9, 2025 at 7:52 PM
New Research

Long-term consequences of monkeypox virus infection or modified vaccinia virus Ankara vaccination in Belgium (MPX-COHORT and POQS-FU-PLUS): a 24-month prospective and retrospective cohort study

www.thelancet.com/journals/lan...
Long-term consequences of monkeypox virus infection or modified vaccinia virus Ankara vaccination in Belgium (MPX-COHORT and POQS-FU-PLUS): a 24-month prospective and retrospective cohort study
Individuals previously infected with MPXV show strong and durable immunological memory lasting up to 2 years after infection, in contrast to the less robust and shorter-lived response observed after M...
www.thelancet.com
November 9, 2025 at 7:48 PM
New Research

Immunogenicity and safety of an 18-month booster dose
of the VLA15 Lyme borreliosis vaccine candidate after primary
immunisation in children, adolescents, and adults in the USA:
a randomised, observer-blind, placebo-controlled, phase 2 trial

www.thelancet.com/journals/lan...
Immunogenicity and safety of an 18-month booster dose of the VLA15 Lyme borreliosis vaccine candidate after primary immunisation in children, adolescents, and adults in the USA: a randomised, observer...
The safety and robust anamnestic immune responses associated with VLA15 boosting support its use as a strategy to increase anti-OspA antibody levels before tick season among children, adolescents, and...
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November 9, 2025 at 7:46 PM
New Research

Global, regional, and national burden of Chagas disease, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

www.thelancet.com/journals/lan...
Global, regional, and national burden of Chagas disease, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
The GBD 2023 Chagas disease estimates are notably higher than previous GBD estimates, reflecting additional data and methodological improvements, and those published by the Pan American Health Organiz...
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November 5, 2025 at 8:35 AM
New Comment

G20 2025: advancing equity and affordability in future tuberculosis vaccines for adolescents and adults

www.thelancet.com/journals/lan...
G20 2025: advancing equity and affordability in future tuberculosis vaccines for adolescents and adults
Ending tuberculosis is more than just a global health necessity; it is fundamental to sustainable development and global health security. With at least 10 million new cases and more than 1 million dea...
www.thelancet.com
November 5, 2025 at 8:32 AM
Reposted by The Lancet Infectious Diseases
The November issue is now live! www.thelancet.com/journals/lan...
Post-partum haemorrhage
www.thelancet.com/journals/lan...
Impact of breastfeeding on the global burden of NCDs in mothers and children www.thelancet.com/journals/lan...
Vaccine ecosystem in Africa www.thelancet.com/journals/lan...
November 3, 2025 at 1:03 PM
📅 Marco De Ambrogi will be attending ASTMH 2025, #TropMed25, November 9-13, 2025 in Toronto, Ontario, Canada on behalf of The Lancet Infectious Diseases!

📧Feel free to reach out with enquiries. Explore our scope, reach & impact, commitment to publishing excellence, & more: hubs.li/Q03BL6Th0
November 4, 2025 at 3:50 PM
Reposted by The Lancet Infectious Diseases
Derivation and external validation of community-acquired #pneumonia subphenotypes in Southeast Asia: a secondary analysis of prospective cohort studies

These subphenotypes may represent unique targets for future #CAP interventional trials

www.thelancet.com/journals/ecl...
#MedSky
October 29, 2025 at 12:08 PM
New Research

Oral itraconazole versus oral voriconazole for treatment-naive patients with chronic pulmonary aspergillosis in India (VICTOR-CPA trial): a single-centre, open-label, randomised, controlled, superiority trial

www.thelancet.com/journals/lan...
Oral itraconazole versus oral voriconazole for treatment-naive patients with chronic pulmonary aspergillosis in India (VICTOR-CPA trial): a single-centre, open-label, randomised, controlled, superiori...
Voriconazole was not superior to itraconazole for treating chronic pulmonary aspergillosis and was associated with a significantly higher incidence of adverse events. Our findings support the continue...
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October 30, 2025 at 9:53 AM