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Steven Tong @steventong.bsky.social · 9d

International funding flows in infectious diseases clinical trials published in selected high-impact journals over a 10-year period

New paper in @cmijournal.bsky.social, led by @seanong.bsky.social.

See thread for details.

@thedohertyinst.bsky.social @unimelb.bsky.social #IDSky

Sean Ong @seanong.bsky.social · 10d

Our new paper in @cmijournal.bsky.social led by the brilliant Hadrien Moffroid, a junior colleague in Melbourne. We examined international funding flows in ID RCTs published in selected high-impact journals over a 10-year period.

doi.org/10.1016/j.cm...
@steventong.bsky.social #IDSky

Heat map of countries funding ID clinical trials and countries where ID clinical trials are conducted.

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Steven Tong @steventong.bsky.social · 21d

Congratulations Amy!! Well deserved. It’s been such a pleasure to see you achieve this body of work

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Steven Tong @steventong.bsky.social · Aug 13

Not as yet. Considering it

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Reposted by Steven Tong

Tom Boyles @tomboylesid.bsky.social · Jul 29

Free access to our article on the inclusion of LMICs in platform trials of bloodstream infections. SNAP in Johannesburg. @steventong.bsky.social @gurujosh.bsky.social

authors.elsevier.com/a/1lVzy,RGPg...

authors.elsevier.com

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Reposted by Steven Tong

Sean Ong @seanong.bsky.social · Jul 18

Glad to have the opportunity to collaborate with Spanish colleagues on this. We conducted a pooled Bayesian post-hoc analysis of the BACSARM and SAFO trials evaluating combination therapy with fosfomycin for SAB. The door may not be closed on adjunctive fosfomycin! Justifies need for more RCTs.

Clinical Infectious Diseases @cidjournal.bsky.social · Jul 17

Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post-hoc Analysis of Individual Participant Data from Two Randomized Trials

✅ Just Accepted
#IDSky

Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post-hoc Analysis of Individual Participant Data from Two Randomized Trials

The role of adjunctive fosfomycin in Staphylococcus aureus bacteremia (SAB) remains uncertain.

doi.org

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Steven Tong @steventong.bsky.social · Jul 8

The Staphylococcus aureus Network Adaptive Platform (SNAP) trial has been nominated for a Patient healthcare communication award!

Public voting is now open 👉 ccrew.accesscr.com.au/cpir-2025/pu...

Find out more about SNAP 🔗 www.snaptrial.com.au

Give us a vote!!

@thedohertyinst.bsky.social

SNAP Trial – Staphylococcus aureus Network Adaptive Platform Trial

SNAP aims to improve treatment outcomes for patients with Staphylococcus aureus bloodstream infections. This website provides information for participants, members of the public, and healthcare profes...

www.snaptrial.com.au

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Reposted by Steven Tong

Genevieve Martin @genevieveemart1.bsky.social · Jul 2

Thrilled to share our new research led by Jane Davies @menziesresearch.bsky.social on First Nations people in the NT living with chronic hepatitis B. An important study that could inform better care:

doi.org/10.1186/s128...

#idsky #MedSky #HepSky #LiverSky

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Reposted by Steven Tong

Sean Ong @seanong.bsky.social · Jun 26

Thankful for another opportunity to write this editorial with @steventong.bsky.social in @jama.com: jamanetwork.com/journals/jam...

We discuss this trial, which evaluated the impact of different recruitment letter formats on RCT enrolment: jamanetwork.com/journals/jam...

Trials Within Trials—Optimizing the Delivery of RCTs

In the latest issue of JAMA, Johansen and colleagues1 report the results of a trial that investigated the impact of digital recruitment letter formats on recruitment to a larger clinical trial, the DA...

jamanetwork.com

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Reposted by Steven Tong

Our World in Data @ourworldindata.org · Jun 19

Tuberculosis (TB), an infectious disease caused by bacteria, was responsible for as many as one-quarter of all deaths in the US and Europe during parts of the 18th and 19th centuries.

However, as we see in the chart for England and Wales, deaths from TB have declined dramatically in rich countries.

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Steven Tong @steventong.bsky.social · Jun 21

I was worried the results were going to be applied to Staph aureus! Got to watch to the end

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Reposted by Steven Tong

Sean Ong @seanong.bsky.social · Jun 16

Our review on hierarchical composite endpoints (HCEs) has just been published in @cidjournal.bsky.social:
doi.org/10.1093/cid/...

We provide a conceptual overview of HCEs, explain the different associated target parameters and analytic methods.

@steventong.bsky.social @gurujosh.bsky.social

Making sense of hierarchical composite endpoints in randomized clinical trials – a primer for infectious disease clinicians and researchers

Hierarchical composite endpoints (HCEs) are increasingly being used in infectious diseases research. In this review aimed at educating the clinical reader,

doi.org

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Steven Tong @steventong.bsky.social · Jun 13

I learnt so much from @seanong.bsky.social in reading / drafting this multiple times! Hope it will be a useful piece for everyone

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Steven Tong @steventong.bsky.social · Jun 7

Thanks for posting all these Stuart!!

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Reposted by Steven Tong

Stuart Campbell @sc345.bsky.social · Jun 5

Dr K Gibney flys the flag for 🦘 clin trials by 🎺

ISAAC 🔎 at Abx prophylaxis of close iGAS contacts (enrolling soon)

STRAP 🔎 backbone Abx, adjunctive Abx, and IVIg (enrolling 2026ish)

Only enrolling in Aus for now but looking for int. collab.

#LISSSD25 #idsky #clinicaltrials #strep

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Reposted by Steven Tong

🎃nisillos @onisillos.bsky.social · Jun 4

Kick off the new season with our latest issue. 😄

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Steven Tong @steventong.bsky.social · Jun 3

Have joined a Push-Up challenge to raise awareness and funds for mental health. 3,214 push-ups in 23 days.
www.thepushupchallenge.com.au/fundraiser/s...

Donate to level-up mental health in Australia

Help raise funds for much-needed mental health services and initiatives by donating to my page. I’m completing The Push-Up Challenge to support this great cause and would love your help to reach my fu...

www.thepushupchallenge.com.au

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Steven Tong @steventong.bsky.social · May 21

PROMOAT: What is the optimal antibiotic regimen for women with premature, prelabour rupture of membranes (PPROM)?

BabyCINO: Comparing the different doses and regimens of caffeine given to very preterm infants with apnoea of prematurity (breathing problems)

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Steven Tong @steventong.bsky.social · May 21

Exciting to see this new adaptive platform trial!

For pregnant women and people who are at risk of preterm birth, and babies born preterm.

PLATIPUS (Platform for Adaptive Trial in Perinatal UnitS)

@platipus.bsky.social @drbretty.bsky.social

First domains will be: PROMOAT and BabyCINO

The PLATIPUS trial @platipus.bsky.social · May 7

We're pleased to share our first animation, that aims to grow potential participant awareness of PLATIPUS and how it works.
Special thanks to Stephanie Hebbard, Kelly Fredell, Tara Lofhelm, PLATIPUS Lived Experience Committee and others who helped create this.
www.platipustrial.org/participants...

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Steven Tong @steventong.bsky.social · May 20

Always a privilege to write with @seanong.bsky.social!

Sean Ong @seanong.bsky.social · May 20

Honoured to be invited to write this commentary with @steventong.bsky.social, on an excellent target trial emulation study which showed that antibiotic use was not associated with improved outcomes in non-severe COVID-19.

jamanetwork.com/journals/jam...

#IDSky

Target Trial Emulation for Antibiotic Use in Acute COVID-19

This study by Pulia and colleagues1 reports results from a large population-based cohort using target trial emulation to examine the associations of antibiotic treatment with clinical outcomes in pati...

jamanetwork.com

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Steven Tong @steventong.bsky.social · May 13

We will see in SNAP. We randomise to PET or not and then leave it up to treating clinicians as to what they do with the result

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Reposted by Steven Tong

Ilan Schwartz @germhuntermd.bsky.social · May 9

Cefazolin vs Antistaphylococcal Penicillins for Treatment of Methicillin-Susceptible Staphylococcus aureus Bacteremia: A Systematic Review & Meta-Analysis

@connorprosty.bsky.social @seanong.bsky.social &c

Cefaz more effective, safer #idsky
www.clinicalmicrobiologyandinfection.com/article/S119... 🔓

Forest plot of 30 day all cause mortality which favors cefazolin (OR=0.73, 95%CI=0.62-0.85)

Forest plot of discontinuation due to adverse effects which favors cefazolin (OR=0.13, 95%CI=0.06-0.27)

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Reposted by Steven Tong

Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · May 9

🆕💫 Systematic Review and Meta-Analysis
30 observational studies( SNAP & CloCeBa not included)
N: 3869
Cefazolin versus Antistaphylococcal Penicillins for the Treatment of MSSA Bacteremia #idsky
www.clinicalmicrobiologyandinfection.com/article/S119...

Cefazolin versus Antistaphylococcal Penicillins for the Treatment of Methicillin-Susceptible Staphylococcus aureus Bacteremia: A Systematic Review and Meta-Analysis

There is debate on whether cefazolin or antistaphylococcal penicillins should be the first-line treatment for methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. Ongoing trials are invest...

www.clinicalmicrobiologyandinfection.com

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Reposted by Steven Tong

Sean Ong @seanong.bsky.social · May 7

Our new paper in @cmijournal.bsky.social, a systematic review where we evaluated reporting of baseline sociodemographic characteristics across 1343 ID clinical trials over a 10-year period. A 🧵:

@steventong.bsky.social #IDSky

doi.org/10.1016/j.cm...

Redirecting

doi.org

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Reposted by Steven Tong

Erin McCreary, PharmD @erinmccreary.bsky.social · May 5

such a joy to discuss PSSA/MSSA domains of SNAP. incredible work led by @gurujosh.bsky.social @steventong.bsky.social conversation w/ the fabulous @angelahuttner.bsky.social

joint effort @escmid.bsky.social Communicable & @sidpharm.bsky.social Breakpoints podcast

podcasts.apple.com/us/podcast/s...

SNAP Out of It: Rethinking Antistaphylococcal Penicillins for S. Aureus Bacteremia – The SNAP Trial PSSA/MSSA Results

Podcast Episode · Breakpoints · 05/04/2025 · 1h 11m

podcasts.apple.com

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Reposted by Steven Tong

Society of Infectious Diseases Pharmacists - SIDP @sidpharm.bsky.social · May 4

🆕 Episode of #Breakpoints/Communicable:
Breakpoints joins forces w @cmicomms.bsky.social podcast to discuss the highly anticipated SNAP trial updates presented at ESCMID Global 2025.

Listen to Breakpoints: sidp.pinecast.co | breakpoints-sidp.org
Listen to Communicable: communicable.transistor.fm

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