Tiago Beites
@tiagobeites.bsky.social
Assistant Researcher | #Tuberculosis research | i3S - University of Porto 🇵🇹 | former Ehrt Lab Weill Cornell Medicine 🇺🇸
An excellent summary of what we’re doing in the scope of our @caixaresearch.bsky.social project TRICK-TB funded by Fundación ”la Caixa”, together with some personal notes. Thank you to Observador for highlighting Portuguese science. [interview in Portuguese]
observador.pt/especiais/o-...
observador.pt/especiais/o-...
O cientista que está a reinventar o tratamento da tuberculose
No Instituto de Investigação e Inovação em Saúde, no Porto, Tiago Beites quer forçar o bacilo da tuberculose a provar o seu próprio veneno. O objetivo? Melhorar o tratamento contra a doença.
observador.pt
October 31, 2025 at 9:50 PM
An excellent summary of what we’re doing in the scope of our @caixaresearch.bsky.social project TRICK-TB funded by Fundación ”la Caixa”, together with some personal notes. Thank you to Observador for highlighting Portuguese science. [interview in Portuguese]
observador.pt/especiais/o-...
observador.pt/especiais/o-...
Congratulations @alexandregouzy.bsky.social and @pierresantucci.bsky.social!!
New study shows pyrazinamide kills TB by acidifying bacterial cytosol — not via PanD/CoA depletion. A long-standing debate settled, paving the way for smarter PZA-like drugs. #MicroSky
✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q
✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q
September 29, 2025 at 6:09 AM
Congratulations @alexandregouzy.bsky.social and @pierresantucci.bsky.social!!
Our favorite technician @alexjpinto.bsky.social just got awarded with a PhD fellowship. Here’s to 4 years of exciting research in our team 🥂
August 1, 2025 at 10:24 PM
Our favorite technician @alexjpinto.bsky.social just got awarded with a PhD fellowship. Here’s to 4 years of exciting research in our team 🥂
Reposted by Tiago Beites
📣 Save the date: III ERA Chair #ImmunoHUB Annual Meeting!
📅 December 5
🔗 immunohub.i3s.up.pt/iii-immunohub-…
‼️Stay tuned for more info!
📅 December 5
🔗 immunohub.i3s.up.pt/iii-immunohub-…
‼️Stay tuned for more info!
July 1, 2025 at 11:40 AM
📣 Save the date: III ERA Chair #ImmunoHUB Annual Meeting!
📅 December 5
🔗 immunohub.i3s.up.pt/iii-immunohub-…
‼️Stay tuned for more info!
📅 December 5
🔗 immunohub.i3s.up.pt/iii-immunohub-…
‼️Stay tuned for more info!
Reposted by Tiago Beites
Please consider passing around this very informative interview to everyone you know (especially non-scientists). I believe it does an excellent job explaining why taxpayers benefit from the federal government’s support of scientific research.
www.pbs.org/video/breakt...
www.pbs.org/video/breakt...
Amanpour and Company | Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Season 2025
David Liu joins the show.
www.pbs.org
May 25, 2025 at 1:48 PM
Please consider passing around this very informative interview to everyone you know (especially non-scientists). I believe it does an excellent job explaining why taxpayers benefit from the federal government’s support of scientific research.
www.pbs.org/video/breakt...
www.pbs.org/video/breakt...
Reposted by Tiago Beites
As the U.S. Government endeavors to make tuberculosis great again, please consider preordering a signed copy of my book about our deadliest infection, its long history, and why in the 75 years since TB became curable, we've allowed over 150,000,000 people to die of the disease. everythingistb.com
March 10, 2025 at 12:46 PM
As the U.S. Government endeavors to make tuberculosis great again, please consider preordering a signed copy of my book about our deadliest infection, its long history, and why in the 75 years since TB became curable, we've allowed over 150,000,000 people to die of the disease. everythingistb.com
Authoritarians promising to protect free speech and then acting like authoritarians. Who would expect that?
May 22, 2025 at 8:36 PM
Authoritarians promising to protect free speech and then acting like authoritarians. Who would expect that?
Reposted by Tiago Beites
EtfD links beta oxidation to OxPhos in mycobacteria - recent work suggests that targeting EtfD could shorten #tubeculosis treatment.
But how does EtfD work? And how can you assay its activity?
In his final PhD manuscript @courbongautier.bsky.social provides answers!
www.biorxiv.org/content/10.1...
But how does EtfD work? And how can you assay its activity?
In his final PhD manuscript @courbongautier.bsky.social provides answers!
www.biorxiv.org/content/10.1...
May 16, 2025 at 2:30 PM
EtfD links beta oxidation to OxPhos in mycobacteria - recent work suggests that targeting EtfD could shorten #tubeculosis treatment.
But how does EtfD work? And how can you assay its activity?
In his final PhD manuscript @courbongautier.bsky.social provides answers!
www.biorxiv.org/content/10.1...
But how does EtfD work? And how can you assay its activity?
In his final PhD manuscript @courbongautier.bsky.social provides answers!
www.biorxiv.org/content/10.1...
Long-chain fatty acids can be carbon sources for pathogens but are also potent antimicrobials. In our latest work, we explored the question of how Mycobacterium tuberculosis avoids getting killed by a preferred carbon source.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The Mycobacterium tuberculosis long-chain fatty acid resistome reveals the universal stress protein TB15.3 as essential for infection
The human pathogen Mycobacterium tuberculosis (Mtb) thrives in lipid-rich microenvironments. Long-chain fatty acids (LCFA) are some of the most abundant lipids encountered by Mtb during infection. Mtb...
www.biorxiv.org
April 15, 2025 at 6:30 AM
Long-chain fatty acids can be carbon sources for pathogens but are also potent antimicrobials. In our latest work, we explored the question of how Mycobacterium tuberculosis avoids getting killed by a preferred carbon source.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Tiago Beites
Today is the 24th of March and it's World TB Day. We typically have many activities to educate and raise awareness about TB and how important it is for us all to commit to doing more to end TB! This year feels different though.
March 24, 2025 at 2:34 PM
Today is the 24th of March and it's World TB Day. We typically have many activities to educate and raise awareness about TB and how important it is for us all to commit to doing more to end TB! This year feels different though.
Reposted by Tiago Beites
For World TB Day, PIH is hosting a webinar at 12pm EST to discuss the repercussions of recently slashed US foreign aid and the hope that remains. #worldTBday @partnersinhealth.bsky.social
Register here:
act.pih.org/worldtbday2025
Register here:
act.pih.org/worldtbday2025
Register | Turmoil, TB Care, & Taking Action
Join experts on World TB Day to discuss the history, innovations, and social justice impact of TB, the world’s deadliest infectious disease.
act.pih.org
March 24, 2025 at 3:09 PM
For World TB Day, PIH is hosting a webinar at 12pm EST to discuss the repercussions of recently slashed US foreign aid and the hope that remains. #worldTBday @partnersinhealth.bsky.social
Register here:
act.pih.org/worldtbday2025
Register here:
act.pih.org/worldtbday2025
In this current political environment it is more important than ever to highlight the #WorldTBday. Let’s keep bending the arc.
March 24, 2025 at 3:06 PM
In this current political environment it is more important than ever to highlight the #WorldTBday. Let’s keep bending the arc.
I’ve been thinking quite a bit on what will be our job as scientists in the AI era. I’m starting to think it will be all about finding new and meaningful questions.
AI cracks superbug problem in two days that took scientists years - BBC News
The lead researcher has told the BBC he was so astounded he assumed his computer had been hacked.
www-bbc-co-uk.cdn.ampproject.org
February 24, 2025 at 3:04 PM
I’ve been thinking quite a bit on what will be our job as scientists in the AI era. I’m starting to think it will be all about finding new and meaningful questions.
Reposted by Tiago Beites
Today is Dr Paul Farmer's 3rd death anniversary
A good day to remember the lessons he taught us, even as we face the chaos caused by the US administration's attacks on science, and global health
www.forbes.com/sites/madhuk...
A good day to remember the lessons he taught us, even as we face the chaos caused by the US administration's attacks on science, and global health
www.forbes.com/sites/madhuk...
Paul Farmer’s Moral Clarity Offers Hope, Amidst Chaos And Darkness
On the 3rd anniversary of Dr Paul Farmer's death, several leaders reflect on his lessons for dealing with the ongoing crisis in global health and development
www.forbes.com
February 21, 2025 at 5:03 PM
Today is Dr Paul Farmer's 3rd death anniversary
A good day to remember the lessons he taught us, even as we face the chaos caused by the US administration's attacks on science, and global health
www.forbes.com/sites/madhuk...
A good day to remember the lessons he taught us, even as we face the chaos caused by the US administration's attacks on science, and global health
www.forbes.com/sites/madhuk...
Reposted by Tiago Beites
Excited to have contributed to this fascinating study led by Rafael Prados Rosales! Uncovers how M. tuberculosis regulates extracellular vesicle production via VirR, shedding light on cell envelope remodeling & potential therapeutic targets! #MicroSky
@elife.bsky.social
doi.org/10.7554/eLif...
@elife.bsky.social
doi.org/10.7554/eLif...
February 18, 2025 at 5:02 AM
Excited to have contributed to this fascinating study led by Rafael Prados Rosales! Uncovers how M. tuberculosis regulates extracellular vesicle production via VirR, shedding light on cell envelope remodeling & potential therapeutic targets! #MicroSky
@elife.bsky.social
doi.org/10.7554/eLif...
@elife.bsky.social
doi.org/10.7554/eLif...
Reposted by Tiago Beites
Huge thanks to @marcopsilva.bsky.social, Thales Costa and all the students for the kind invite to speak at the @i3suporto.bsky.social Student symposium! 🌟
Top-notch organization, amazing vibes, and a truly warm welcome, an unforgettable experience! 🙏
#i3Ssymposium
Top-notch organization, amazing vibes, and a truly warm welcome, an unforgettable experience! 🙏
#i3Ssymposium
February 21, 2025 at 3:02 PM
Huge thanks to @marcopsilva.bsky.social, Thales Costa and all the students for the kind invite to speak at the @i3suporto.bsky.social Student symposium! 🌟
Top-notch organization, amazing vibes, and a truly warm welcome, an unforgettable experience! 🙏
#i3Ssymposium
Top-notch organization, amazing vibes, and a truly warm welcome, an unforgettable experience! 🙏
#i3Ssymposium
Reposted by Tiago Beites
First time at #EMBOtuberculosis presenting a part of my PhD work through a flash talk and poster presentation. Great to finally meet the TB community! Incredible experience in India, with amazing science, wonderful people, and delicious food! 🇮🇳
February 12, 2025 at 7:17 PM
First time at #EMBOtuberculosis presenting a part of my PhD work through a flash talk and poster presentation. Great to finally meet the TB community! Incredible experience in India, with amazing science, wonderful people, and delicious food! 🇮🇳
What a great conference #EMBOtuberculosis has been! Amazing science, amazing food and a very friendly community! And it was a pleasure to share the work we’re developing at i3S U. Porto.
February 12, 2025 at 10:24 AM
What a great conference #EMBOtuberculosis has been! Amazing science, amazing food and a very friendly community! And it was a pleasure to share the work we’re developing at i3S U. Porto.
Esperar pelos resultados da FCT parece a emoção da Eurovisão. A quem vai dar a Estónia os 12 pontos?
January 31, 2025 at 6:36 PM
Esperar pelos resultados da FCT parece a emoção da Eurovisão. A quem vai dar a Estónia os 12 pontos?
Hi5 for everyone that submitted The grant today! What a journey!
January 14, 2025 at 9:31 PM
Hi5 for everyone that submitted The grant today! What a journey!
Reposted by Tiago Beites
🎉 Thrilled to share the first paper by @saurabhchugh09.bsky.social, a talented Marie Skłodowska-Curie fellow in our lab!
Discover how the exometabolome acts as a hidden driver of bacterial virulence and pathogenesis
#MicroSky
@cp-trendsmicrobiol.bsky.social www.sciencedirect.com/science/arti...
Discover how the exometabolome acts as a hidden driver of bacterial virulence and pathogenesis
#MicroSky
@cp-trendsmicrobiol.bsky.social www.sciencedirect.com/science/arti...
The exometabolome as a hidden driver of bacterial virulence and pathogenesis
The traditional view of metabolism as merely supplying energy and biosynthetic precursors is undergoing a paradigm shift. Metabolic dynamics not only …
www.sciencedirect.com
December 19, 2024 at 9:43 AM
🎉 Thrilled to share the first paper by @saurabhchugh09.bsky.social, a talented Marie Skłodowska-Curie fellow in our lab!
Discover how the exometabolome acts as a hidden driver of bacterial virulence and pathogenesis
#MicroSky
@cp-trendsmicrobiol.bsky.social www.sciencedirect.com/science/arti...
Discover how the exometabolome acts as a hidden driver of bacterial virulence and pathogenesis
#MicroSky
@cp-trendsmicrobiol.bsky.social www.sciencedirect.com/science/arti...
A very special one. My dear friends @healycl.bsky.social and @alexandregouzy.bsky.social published a paper with our common mentor @saehrt.bsky.social. On top of that, this is Alex’ first corresponding authorship!! And, of course, excellent bacterial physiology science.
Happy to share my first ever (co)last author paper 🥳 reporting on how Mtb adapts its carbon diet under acid stress. A big thank you to my partners in crime @saehrt.bsky.social and @healycl.bsky.social without who this would not have been possible 😘
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
An exacerbated phosphate starvation response triggers Mycobacterium tuberculosis glycerol utilization at acidic pH | mBio
Despite the availability of antibiotic treatment, M. tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a major infectious disease
killer worldwide. A better understanding of the en...
journals.asm.org
December 8, 2024 at 10:06 AM
A very special one. My dear friends @healycl.bsky.social and @alexandregouzy.bsky.social published a paper with our common mentor @saehrt.bsky.social. On top of that, this is Alex’ first corresponding authorship!! And, of course, excellent bacterial physiology science.
Ignorant drug development question. What’s missing on target-based drug development to make it truly useful? As opposed to the unbiased compound library screens that seem to be the gold standard. I may or may not be thinking on organizing a symposium to address this question.
November 24, 2024 at 3:22 PM
Ignorant drug development question. What’s missing on target-based drug development to make it truly useful? As opposed to the unbiased compound library screens that seem to be the gold standard. I may or may not be thinking on organizing a symposium to address this question.
Introducing my wonderful team at i3S - University of Porto. PhD student @marcopsilva.bsky.social and research fellow @alexjpinto.bsky.social
November 17, 2024 at 1:46 PM
Introducing my wonderful team at i3S - University of Porto. PhD student @marcopsilva.bsky.social and research fellow @alexjpinto.bsky.social
TRICK-TB is up and running! Collaboration with Robert Jansen with the support of CaixaResearch, laCaixaFoundation.
November 12, 2024 at 8:41 PM
TRICK-TB is up and running! Collaboration with Robert Jansen with the support of CaixaResearch, laCaixaFoundation.