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Reposted by tmoeckli

PastelBio @pastelbio.bsky.social · 2d

msBayesImpute: A Versatile Framework for Addressing Missing Values in Biomedical Mass Spectrometry Proteomics Data www.biorxiv.org/cont...

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#proteomics #prot-preprint

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John Lees @bacpop.org · Aug 15

My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology:
www.ebi.ac.uk/training/onl...

Including both molecular and epidemiological examples

Mathematical modelling for biologists - Modelling concepts in biological research

www.ebi.ac.uk

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DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · Jul 30

1/New paper on peroxisome assembly, reporting the detailed mechanism of PEX39, a new peroxin involved in PTS2 protein transport. Fantastic work by ‪@walterwchen.bsky.social‬ and a dream team of collaborators, as explained below. www.nature.com/articles/s41...

PEX39 facilitates the peroxisomal import of PTS2-containing proteins - Nature Cell Biology

Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the im...

www.nature.com

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PastelBio @pastelbio.bsky.social · Jul 31

SynchroSep-MS: Parallel LC Separations for Multiplexed Proteomics pubs.acs.org/doi/10....

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#proteomics #prot-paper

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Walter W. Chen, MD, PhD @walterwchen.bsky.social · Jul 30

Our work on new paradigm in peroxisome biogenesis and PEX39 (1st human peroxisomal biogenesis protein (peroxin/PEX) found in > 20 yr) is out in @natcellbio.nature.com! Equal collab w/Tony Rodrigues (Jorge Azevedo lab), @dwendscheck.bsky.social (Bettina Warscheid lab)

www.nature.com/articles/s41...

PEX39 facilitates the peroxisomal import of PTS2-containing proteins - Nature Cell Biology

Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the im...

www.nature.com

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tmoeckli @tmoeckli.bsky.social · Jul 30

🥳🥳🥳 Congratulations to everyone involved and in particular to @dwendscheck.bsky.social!
I am soooo happy to see that this story is online now and that I could contribute to it ❤️

Daniel Wendscheck @dwendscheck.bsky.social · Jul 30

Major part of my PhD thesis is finally online! Thanks to everyone involved 🙏 @walterwchen.bsky.social @rjdlab.bsky.social @tmoeckli.bsky.social @hirakdas.bsky.social and the entire @warscheidlab.bsky.social #peroxisomes #Massspec #proteomics

Julius-Maximilians-Universität Würzburg @uni-wuerzburg.de · Jul 30

#Biochemistry: #PEX39, a newly discovered #peroxin protein, transports enzymes into #peroxisomes like a relay racer. New paper @natcellbio.nature.com – congratulations to @dwendscheck.bsky.social @warscheidlab.bsky.social et al!
➡️ www.uni-wuerzburg.de/en/news-and-...

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tmoeckli @tmoeckli.bsky.social · Jul 13

One aspect to highlight: Despite #signaling through the same #receptor, different #IFN subtypes induce distinct and in part contrary effects. Regulatory mechanisms seem to be deeply conserved.
Many thanks to the organizers @thebinderlab.bsky.social and Marieke Essers 3/3

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tmoeckli @tmoeckli.bsky.social · Jul 13

It was great to see how ubiquitously interferons are involved in biology. From #stem #cell homeostasis, over cellular morphology and #antiviral defense mechanisms to anti-tumoral effects!
Big shoutout to all people presenting their in many parts unpublished work ❤️ 2/3

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tmoeckli @tmoeckli.bsky.social · Jul 13

📈 Last week I had the chance to present my project on the influence of #interferon on antigen processing by the proteasome at the 2nd #Heidelberg Interferon Symposium! 🦠🧬🧫 1/3

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PRIDE Database @pride-ebi.bsky.social · Jul 12

PXD051501 🚨

Pex39 facilitates peroxisomal import of PTS2 proteins – ScPex18 AP-MS data

🚨 New dataset alert! 🚨

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The Binder Lab (DKFZ Heidelberg) @thebinderlab.bsky.social · Jul 11

Great first day at the #IFNSymposiumHD, with BBQ dinner, drinks and especially: great people and discussions 😊

Now looking forward to the second day, which will be kicked off by @meganstanifer.bsky.social shortly!

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Nikolai Slavov @slavov-n.bsky.social · Jun 30

Let's leave behind simplistic & naive notions.

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tmoeckli @tmoeckli.bsky.social · Jun 25

📣Attention please!

🦠🧫🧬Interferon researcher in and around Heidelberg are kindly welcome to register for the 2nd Interferon at DKFZ symposium in July!

📜Submit your abstract until tomorrow here: indico.dkfz.de/event/1320/

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PastelBio @pastelbio.bsky.social · Jun 18

A unified pan-cancer proteome atlas www.cell.com/cancer-...

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#proteomics #prot-paper

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tmoeckli @tmoeckli.bsky.social · Jun 18

I am sad I miss it this year! Enjoy EuPA ❤️

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tmoeckli @tmoeckli.bsky.social · Jun 18

Salami Tactics?

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Andy Tseng @andytseng.bsky.social · Jun 8

@miquai.bsky.social and Robert Hazen explore a bold new law of nature: complexity steadily rises - not just in biology, but in everything from rocks to life. A fascinating weekend read. Thoughts welcome. #Science #Biology #Evolution #LawsOfNature #FunctionalInformation #ResearchSky #WeekendReads

A New Law of Nature Attempts to Explain the Complexity of the Universe

A novel suggestion that complexity increases over time, not just in living organisms but in the nonliving world, promises to rewrite notions of time and evolution.

www.wired.com

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tmoeckli @tmoeckli.bsky.social · Jun 6

Start your day right with 1,184,046 error messages 😂

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tmoeckli @tmoeckli.bsky.social · Jun 6

I am just sadsad

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Andrew Leduc @andrewleduc.bsky.social · May 30

More evidence for the role of protein degradation in significantly shaping the proteome of brain tissue!

Nikolai Slavov @slavov-n.bsky.social · May 30

Alzheimer's disease (AD) is associated with numerous proteome changes.

We find large & consistent decrease in the abundance and stoichiometry of 20S proteasome subunits.
⬛️ It leads to abnormal accumulation of 20S substrate proteins.

🧵
biorxiv.org/content/10.1...

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Peter Gleick @petergleick.bsky.social · May 31

There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd.
It's not just budgets but research, institutions, expertise, and training the next generation.

Graphs showing 25 years of budgets for the National Institute of Health, NASA, and the NSF. In all cases, the proposed budget for next year is far, far below any year of the previous quarter century.

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Andrew Burgess @drandrewburgess.bsky.social · May 27

Love today’s #xkcd comic on
#MassSpec
🤣

BEFORE THE BATHROOM SCALE WAS INVENTED, THE ONLY
WAY TO WEIGH PEOPLE WAS MASS SPECTROMETRY.

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PLOS Biology @plosbiology.org · May 8

The antiviral cytokine interferon is thought to act through the induction of hundreds of genes. In this #PLOSBiology Perspective, @jschoggins.bsky.social highlights recent findings that instead suggest distinct viruses are targeted by small subsets of the induced gene repertoire. 🧪

plos.io/4m7hOYi

Old cytokine, new tricks: A refined model of interferon’s antiviral activity

Interferon is a central component of the vertebrate antiviral immune response, thought to act through induction of hundreds of interferon-stimulated genes, with some redundancy. This Perspective highl...

plos.io

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The Binder Lab (DKFZ Heidelberg) @thebinderlab.bsky.social · May 9

Second Heidelberg Interferons Symposium coming up!! If you are based in HD or Mannheim (@dkfz.bsky.social, @uniheidelberg.bsky.social, @hlsalliance.bsky.social, @embl.org,...) and interested in any facet of these incredible #cytokines, join us on

🗓️ July 10/11
🏫 Marsilius Kolleg
✍🏻 bit.ly/IFN2025

Advertising flyer for the symposium, keynote lectures by Nadine Laguette from Montepellier (Crosstalk between DNA damage response and DNA sensing), Megan Stanifer from Florida (Lambda interferon in the gut epithelium) and Alessandra Mortellaro from Milano (type I interferons in hematopoiesis), plus local keynotes by Ana Martín-Villalba, Marieke Essers and Stefan Jordan.

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tmoeckli @tmoeckli.bsky.social · May 18

Very interesting!