Raju Kumar
@tumorscholar.bsky.social
Postdoctoral researcher🔬
@blizardinstitute.bsky.social
Investigating role of T cells in early-stage liver and adipose tissue fibrosis using single cell multiomics #MASLD #MASH mywebsite: https://tumorscholar.github.io/
@blizardinstitute.bsky.social
Investigating role of T cells in early-stage liver and adipose tissue fibrosis using single cell multiomics #MASLD #MASH mywebsite: https://tumorscholar.github.io/
T-cell ageing is not a fixed process — it is something that is modifiable www.nature.com/articles/d41...
Restoring youth to old immune cells: mRNA therapy turns back the clock
Testing in mice suggests that rejuvenating T cells could make vaccines and some cancer therapies more effective.
www.nature.com
December 18, 2025 at 12:38 PM
T-cell ageing is not a fixed process — it is something that is modifiable www.nature.com/articles/d41...
Dietary restriction enhances CD8+ T cell metabolic fitness via ketone body metabolism
rdcu.be/eVbQN
rdcu.be/eVbQN
Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses
Nature Metabolism - Dietary restriction promotes the expansion of effector T cells via ketone bodies, which enhances anti-tumour immunity and synergizes with immunotherapy in mice.
rdcu.be
December 17, 2025 at 11:04 PM
Dietary restriction enhances CD8+ T cell metabolic fitness via ketone body metabolism
rdcu.be/eVbQN
rdcu.be/eVbQN
Glycolytic macrophages are associated with proinflammatory functions in proximity with activated fibroblasts| Science Advances www.science.org/doi/10.1126/...
Persistent glycolysis defines pathological foreign body–associated inflammation to polymeric implants
Persistent glycolytic dependence underlies chronic inflammation and deleterious fibrosis associated with implant complications.
www.science.org
December 17, 2025 at 10:52 PM
Glycolytic macrophages are associated with proinflammatory functions in proximity with activated fibroblasts| Science Advances www.science.org/doi/10.1126/...
Reposted by Raju Kumar
🚀 New preprint!
The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab!
🔗 www.biorxiv.org/content/10.6...
The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab!
🔗 www.biorxiv.org/content/10.6...
December 15, 2025 at 10:42 PM
🚀 New preprint!
The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab!
🔗 www.biorxiv.org/content/10.6...
The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab!
🔗 www.biorxiv.org/content/10.6...
Reposted by Raju Kumar
Real-World Evidence (#RWE) is crucial for understanding the full spectrum of #MASLD.
Our new review in @thelancet.com Reg. Heal. Eur. explores how RWE complements RCTs, aids in drug repurposing, and how #AI is improving patient phenotyping.
👇 Read the full paper: www.thelancet.com/journals/lan...
Our new review in @thelancet.com Reg. Heal. Eur. explores how RWE complements RCTs, aids in drug repurposing, and how #AI is improving patient phenotyping.
👇 Read the full paper: www.thelancet.com/journals/lan...
December 14, 2025 at 11:45 AM
Real-World Evidence (#RWE) is crucial for understanding the full spectrum of #MASLD.
Our new review in @thelancet.com Reg. Heal. Eur. explores how RWE complements RCTs, aids in drug repurposing, and how #AI is improving patient phenotyping.
👇 Read the full paper: www.thelancet.com/journals/lan...
Our new review in @thelancet.com Reg. Heal. Eur. explores how RWE complements RCTs, aids in drug repurposing, and how #AI is improving patient phenotyping.
👇 Read the full paper: www.thelancet.com/journals/lan...
Had a great time at the Cambridge Immunology Forum! www.immunology.cam.ac.uk/events/cambr... Loved the talks on T cells and was really happy to share my work. Big thanks to my supervisor, collaborators, lab members & the organisers - honoured to get the Best Poster Prize!
September 26, 2025 at 9:29 AM
Had a great time at the Cambridge Immunology Forum! www.immunology.cam.ac.uk/events/cambr... Loved the talks on T cells and was really happy to share my work. Big thanks to my supervisor, collaborators, lab members & the organisers - honoured to get the Best Poster Prize!
How TCR clonality profiles, distribution in T cell subsets, and bioinformatic screening against continuously improving TCR databases can guide the selection of TCRs for therapeutic application
doi.org/10.3390/cell...
doi.org/10.3390/cell...
doi.org
August 19, 2025 at 8:08 PM
How TCR clonality profiles, distribution in T cell subsets, and bioinformatic screening against continuously improving TCR databases can guide the selection of TCRs for therapeutic application
doi.org/10.3390/cell...
doi.org/10.3390/cell...
Human memory CD8+ T cell cytotoxicity is intricately regulated by environmental cues reflecting tissue location and antigen specificity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity
Memory CD8+ T cells have differential cytotoxic capacities across human tissues.
www.science.org
July 18, 2025 at 7:36 PM
Human memory CD8+ T cell cytotoxicity is intricately regulated by environmental cues reflecting tissue location and antigen specificity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Insulin exerts distinct regulatory effects on glucose metabolism in periportal and pericentral hepatocytes: Cell Metabolism www.cell.com/cell-metabol...
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling
How hepatocyte lobular organization affects insulin signaling is a question with potential
therapeutic significance. He et al. generate mouse models with impairment of insulin
signaling specifically i...
www.cell.com
July 18, 2025 at 8:29 AM
Insulin exerts distinct regulatory effects on glucose metabolism in periportal and pericentral hepatocytes: Cell Metabolism www.cell.com/cell-metabol...
Environmental, dietary, and lifestyle factors may hold the key to understand #Inflammaging
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Ageing is linked to inflammation — but only in the industrialized world
Inflammation, thought to be a driver of age-related disease, does not worsen with age in some Indigenous communities.
www.nature.com
July 16, 2025 at 8:50 PM
Environmental, dietary, and lifestyle factors may hold the key to understand #Inflammaging
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors | Science Immunology www.science.org/doi/10.1126/...
Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors
Cd69 mRNA levels distinguish potent and dysfunctional activation among CD69+ CD8 T cells in tumors.
www.science.org
July 16, 2025 at 8:37 PM
Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors | Science Immunology www.science.org/doi/10.1126/...
Reposted by Raju Kumar
Mitochondrial respiration is necessary for CD8+ T cell proliferation and cell fate @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 16, 2025 at 6:10 PM
Mitochondrial respiration is necessary for CD8+ T cell proliferation and cell fate @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Hello everyone! I am excited to share my blog post on a topic close to my research and history: the liver.
🧬 From Prometheus to P450: Why the Liver Deserves Our Attention 🧪
Read the full post: tumorscholar.github.io/blog/liver.h...
If you have ever underestimated the liver, this post is for you.
🧬 From Prometheus to P450: Why the Liver Deserves Our Attention 🧪
Read the full post: tumorscholar.github.io/blog/liver.h...
If you have ever underestimated the liver, this post is for you.
tumorscholar.github.io
May 10, 2025 at 1:58 PM
Hello everyone! I am excited to share my blog post on a topic close to my research and history: the liver.
🧬 From Prometheus to P450: Why the Liver Deserves Our Attention 🧪
Read the full post: tumorscholar.github.io/blog/liver.h...
If you have ever underestimated the liver, this post is for you.
🧬 From Prometheus to P450: Why the Liver Deserves Our Attention 🧪
Read the full post: tumorscholar.github.io/blog/liver.h...
If you have ever underestimated the liver, this post is for you.
Protein Synthesis and Metabolism in T Cells | Annual Reviews - www.annualreviews.org/content/jour...
Protein Synthesis and Metabolism in T Cells | Annual Reviews
T lymphocytes are essential for immune responses to pathogens and tumors. Their ability to rapidly clonally expand and differentiate to effector cells following infection, and then to curb effector fu...
www.annualreviews.org
May 5, 2025 at 12:34 PM
Protein Synthesis and Metabolism in T Cells | Annual Reviews - www.annualreviews.org/content/jour...
Reposted by Raju Kumar
Tissue-resident memory T cells have high levels of mRNA of proinflammatory cytokines but produce the proteins only upon stimulation. 🧪⑂
The integrated stress response inhibits mRNA translation in these cells, having these cells poised for rapid responses in 🐭 and 🧓. 1/2
The integrated stress response inhibits mRNA translation in these cells, having these cells poised for rapid responses in 🐭 and 🧓. 1/2
April 24, 2025 at 2:06 PM
Tissue-resident memory T cells have high levels of mRNA of proinflammatory cytokines but produce the proteins only upon stimulation. 🧪⑂
The integrated stress response inhibits mRNA translation in these cells, having these cells poised for rapid responses in 🐭 and 🧓. 1/2
The integrated stress response inhibits mRNA translation in these cells, having these cells poised for rapid responses in 🐭 and 🧓. 1/2
Hey folks! 👋🏽
I’ve just launched my blog, where I'll be sharing thoughts from the bench and the bioinformatics terminal -
Starting with my first post:
𝐏𝐨𝐬𝐭𝐝𝐨𝐜, 𝐏𝐢𝐩𝐞𝐭𝐭𝐞𝐬, 𝐚𝐧𝐝 𝐏𝐚𝐠𝐞𝐬: 𝐀 𝐍𝐞𝐰 𝐂𝐡𝐚𝐩𝐭𝐞𝐫 𝐁𝐞𝐠𝐢𝐧𝐬
I’d love for you to explore it and share your impressions!
#Immunology #SingleCell
I’ve just launched my blog, where I'll be sharing thoughts from the bench and the bioinformatics terminal -
Starting with my first post:
𝐏𝐨𝐬𝐭𝐝𝐨𝐜, 𝐏𝐢𝐩𝐞𝐭𝐭𝐞𝐬, 𝐚𝐧𝐝 𝐏𝐚𝐠𝐞𝐬: 𝐀 𝐍𝐞𝐰 𝐂𝐡𝐚𝐩𝐭𝐞𝐫 𝐁𝐞𝐠𝐢𝐧𝐬
I’d love for you to explore it and share your impressions!
#Immunology #SingleCell
Postdoc, Pipettes, and Pages: A New Chapter Begins
tumorscholar.github.io
April 24, 2025 at 2:40 PM
Hey folks! 👋🏽
I’ve just launched my blog, where I'll be sharing thoughts from the bench and the bioinformatics terminal -
Starting with my first post:
𝐏𝐨𝐬𝐭𝐝𝐨𝐜, 𝐏𝐢𝐩𝐞𝐭𝐭𝐞𝐬, 𝐚𝐧𝐝 𝐏𝐚𝐠𝐞𝐬: 𝐀 𝐍𝐞𝐰 𝐂𝐡𝐚𝐩𝐭𝐞𝐫 𝐁𝐞𝐠𝐢𝐧𝐬
I’d love for you to explore it and share your impressions!
#Immunology #SingleCell
I’ve just launched my blog, where I'll be sharing thoughts from the bench and the bioinformatics terminal -
Starting with my first post:
𝐏𝐨𝐬𝐭𝐝𝐨𝐜, 𝐏𝐢𝐩𝐞𝐭𝐭𝐞𝐬, 𝐚𝐧𝐝 𝐏𝐚𝐠𝐞𝐬: 𝐀 𝐍𝐞𝐰 𝐂𝐡𝐚𝐩𝐭𝐞𝐫 𝐁𝐞𝐠𝐢𝐧𝐬
I’d love for you to explore it and share your impressions!
#Immunology #SingleCell