Dr Will Unsworth
@unsworthchem.bsky.social
Senior lecturer in Organic Chemistry and research group leader at the University of York
- Macrocycles, spirocycles, ring expansion and biocatalysis.
- Macrocycles, spirocycles, ring expansion and biocatalysis.
Reposted by Dr Will Unsworth
🔓Check out this #OpenAccess research by @unsworthchem.bsky.social ,Gideon Grogan & co @york.ac.uk in our latest issue describing cyclopropanation reactions by a class I unspecific peroxygenase #orgchem
Read it in full below👇
pubs.rsc.org/en/content/a...
Read it in full below👇
pubs.rsc.org/en/content/a...
Cyclopropanation reactions by a class I unspecific peroxygenase
Non-natural biotransformations, such as alkene cyclopropanation through carbene insertion, have been demonstrated for the hemoproteins cytochrome P450 and myoglobin, but have not been investigated…
pubs.rsc.org
May 22, 2025 at 11:40 AM
🔓Check out this #OpenAccess research by @unsworthchem.bsky.social ,Gideon Grogan & co @york.ac.uk in our latest issue describing cyclopropanation reactions by a class I unspecific peroxygenase #orgchem
Read it in full below👇
pubs.rsc.org/en/content/a...
Read it in full below👇
pubs.rsc.org/en/content/a...
Reposted by Dr Will Unsworth
Clearing out my office and came across this much reused folder. You can just make out a scribbled date, 29 Jan 87, for a tutorial with Bruce Gilbert. So it's at least 38 yrs old. Channeling my inner womble, I think I'll keep it a little longer. @professor-dave.bsky.social @unsworthchem.bsky.social
February 26, 2025 at 11:19 AM
Clearing out my office and came across this much reused folder. You can just make out a scribbled date, 29 Jan 87, for a tutorial with Bruce Gilbert. So it's at least 38 yrs old. Channeling my inner womble, I think I'll keep it a little longer. @professor-dave.bsky.social @unsworthchem.bsky.social
Very happy to announce our latest paper - out today in Chemical Science
A very enjoyable collaboration with @roly armRoly Armstrong
on Stereoselective Synthesis of Atropisomeric Amides.
doi.org/10.1039/D4SC05
A very enjoyable collaboration with @roly armRoly Armstrong
on Stereoselective Synthesis of Atropisomeric Amides.
doi.org/10.1039/D4SC05
January 23, 2025 at 4:21 PM
Very happy to announce our latest paper - out today in Chemical Science
A very enjoyable collaboration with @roly armRoly Armstrong
on Stereoselective Synthesis of Atropisomeric Amides.
doi.org/10.1039/D4SC05
A very enjoyable collaboration with @roly armRoly Armstrong
on Stereoselective Synthesis of Atropisomeric Amides.
doi.org/10.1039/D4SC05
🚨Funded PhDs available 🚨
2nd hiring round of the York-Oxford CDT in sustainable synthesis is open.
Seeking a talented organic chemist to work with me, Gideon Grogan and Ed Anderson on a synthesis project using enzymes (#28). Inquiries welcome!
cshp-cdt.chem.ox.ac.uk
2nd hiring round of the York-Oxford CDT in sustainable synthesis is open.
Seeking a talented organic chemist to work with me, Gideon Grogan and Ed Anderson on a synthesis project using enzymes (#28). Inquiries welcome!
cshp-cdt.chem.ox.ac.uk
Home | CSHP CDT
cshp-cdt.chem.ox.ac.uk
January 16, 2025 at 3:09 PM
🚨Funded PhDs available 🚨
2nd hiring round of the York-Oxford CDT in sustainable synthesis is open.
Seeking a talented organic chemist to work with me, Gideon Grogan and Ed Anderson on a synthesis project using enzymes (#28). Inquiries welcome!
cshp-cdt.chem.ox.ac.uk
2nd hiring round of the York-Oxford CDT in sustainable synthesis is open.
Seeking a talented organic chemist to work with me, Gideon Grogan and Ed Anderson on a synthesis project using enzymes (#28). Inquiries welcome!
cshp-cdt.chem.ox.ac.uk
Very happy to announced 2 new papers from the group in the last 24 hours!
The first, Divergent Oxidation Reactions of E- and Z-Allylic Primary Alcohols by an Unspecific Peroxygenases, just out, with my amazing collaborator Prof Gideon Grogan
onlinelibrary.wiley.com/doi/10.1002/...
The first, Divergent Oxidation Reactions of E- and Z-Allylic Primary Alcohols by an Unspecific Peroxygenases, just out, with my amazing collaborator Prof Gideon Grogan
onlinelibrary.wiley.com/doi/10.1002/...
Divergent Oxidation Reactions of E‐ and Z‐Allylic Primary Alcohols by an Unspecific Peroxygenase
Unspecific Peroxygenases (UPOs) catalyze the selective oxygenation of organic substrates using only hydrogen peroxide as the external oxidant. The PaDa-I variant of the UPO from Agrocybe aegerita cat...
onlinelibrary.wiley.com
December 11, 2024 at 3:41 PM
Very happy to announced 2 new papers from the group in the last 24 hours!
The first, Divergent Oxidation Reactions of E- and Z-Allylic Primary Alcohols by an Unspecific Peroxygenases, just out, with my amazing collaborator Prof Gideon Grogan
onlinelibrary.wiley.com/doi/10.1002/...
The first, Divergent Oxidation Reactions of E- and Z-Allylic Primary Alcohols by an Unspecific Peroxygenases, just out, with my amazing collaborator Prof Gideon Grogan
onlinelibrary.wiley.com/doi/10.1002/...
Happy to share our News and Views article on a very cool new ring expansion approached developed by Yifeng Chen and coworkers.
Written with Jack Wootton, and just out in Nature Chemistry
rdcu.be/d0ZAe
Written with Jack Wootton, and just out in Nature Chemistry
rdcu.be/d0ZAe
Cyclic amine ring expansion
Nature Chemistry - Aza-heterocycles with rings of more than 6 members are underrepresented in medicinal chemistry owing to challenges with their synthesis. Now, the conversion of 5- and 6-membered...
rdcu.be
November 22, 2024 at 9:16 AM
Happy to share our News and Views article on a very cool new ring expansion approached developed by Yifeng Chen and coworkers.
Written with Jack Wootton, and just out in Nature Chemistry
rdcu.be/d0ZAe
Written with Jack Wootton, and just out in Nature Chemistry
rdcu.be/d0ZAe
Reposted by Dr Will Unsworth
Second post - major congratulations to Barbara Radzikowska for passing her viva.👩🎓 Thank you to examiners Dr Lianne Willems and Prof Chris Willis. Cosupervised by @unsworthchem.bsky.social . Seriously impressive project on complex alkaloid biosynthesis in Daphniphyllum. 🥳
November 20, 2024 at 12:08 PM
Second post - major congratulations to Barbara Radzikowska for passing her viva.👩🎓 Thank you to examiners Dr Lianne Willems and Prof Chris Willis. Cosupervised by @unsworthchem.bsky.social . Seriously impressive project on complex alkaloid biosynthesis in Daphniphyllum. 🥳
Delighted to announce publication of the 2nd posthumous paper from the lab of our friend and colleague Prof Paul Clarke.
With Saikiran Ravi, Chris Maddocks and Prof Ian Fairlamb
We all miss you Paul – hope we have done the work justice
pubs.rsc.org/en/Content/A...
With Saikiran Ravi, Chris Maddocks and Prof Ian Fairlamb
We all miss you Paul – hope we have done the work justice
pubs.rsc.org/en/Content/A...
November 20, 2024 at 4:50 PM
Delighted to announce publication of the 2nd posthumous paper from the lab of our friend and colleague Prof Paul Clarke.
With Saikiran Ravi, Chris Maddocks and Prof Ian Fairlamb
We all miss you Paul – hope we have done the work justice
pubs.rsc.org/en/Content/A...
With Saikiran Ravi, Chris Maddocks and Prof Ian Fairlamb
We all miss you Paul – hope we have done the work justice
pubs.rsc.org/en/Content/A...
Need something for my first post over here, so gone for a shameless plug of our JACS paper published earlier this year!
Looking forward to interacting with you all again in a better and less angry place.
pubs.acs.org/doi/10.1021/...
Looking forward to interacting with you all again in a better and less angry place.
pubs.acs.org/doi/10.1021/...
A Modular Strategy for the Synthesis of Macrocycles and Medium-Sized Rings via Cyclization/Ring Expansion Cascade Reactions
Macrocycles and medium-sized rings are important in many scientific fields and technologies but are hard to make using current methods, especially on a large scale. Outlined herein is a strategy by wh...
pubs.acs.org
November 20, 2024 at 4:50 PM
Need something for my first post over here, so gone for a shameless plug of our JACS paper published earlier this year!
Looking forward to interacting with you all again in a better and less angry place.
pubs.acs.org/doi/10.1021/...
Looking forward to interacting with you all again in a better and less angry place.
pubs.acs.org/doi/10.1021/...