Lightnews — Scholar-powered news

Reposted by VickySanzMoreno

CRUK Convergence Science Centre @crukconvergence.bsky.social · 19h

Early stages of #metastasis are poorly understood despite causing 90% of cancer deaths. A new project led by Prof Darryl Overby and Prof @vickysanzmoreno.bsky.social is looking to develop tools to study #cancer spread in unprecedented detail while reducing the need for animals in research.🐁👇

CRUK Convergence Science Centre @crukconvergence.bsky.social · 4d

Congratulations to our 2025 Development Fund awardees! 🎉

From new detection tools to targeted nanotech therapies, these seed funded projects explore bold ideas to improve cancer diagnosis & treatment.
👉 bit.ly/4gV38tf

@icr.ac.uk @imperialcollegeldn.bsky.social @imperialsandc.bsky.social

1 1

VickySanzMoreno @vickysanzmoreno.bsky.social · 1d

We are offering a super exciting project to develop new ways of targeting metastatic cancer cells!
Amazing supervisory team:
Primary supervisor: Professor Joanna Loizou
Associate supervisor: Professor Zoran Rankovic
Secondary supervisor: Professor Victoria Sanz-Moreno
@icr.ac.uk

Targeting AMPK as a metabolic vulnerability of metastatic cancer cells

www.icr.ac.uk

3 3

VickySanzMoreno @vickysanzmoreno.bsky.social · 1d

We are so happy to welcome @dorioliveri.bsky.social as a new lab member to the Cytoskeleton and Metastasis Team. Doriana will study how the extracellular matrix in different metastatic sites regulates tumour-immune cell interactions😀
ADAPTMET
@icr.ac.uk
@breastcancernow.bsky.social

1 1 8

Reposted by VickySanzMoreno

CellMech2025 @cellmech2025.bsky.social · 9d

The stage is set! @vickysanzmoreno.bsky.social is kicking off their keynote at #cellmech2025.

1 14

VickySanzMoreno @vickysanzmoreno.bsky.social · 10d

CellMech2025!! Exciting!

2 17

VickySanzMoreno @vickysanzmoreno.bsky.social · Sep 10

Congratulations! Great work👏🏻👏🏻

1

VickySanzMoreno @vickysanzmoreno.bsky.social · Jul 18

Congratulations to Yumiko Teigen who had her PhD viva yesterday! She did such a fantastic job! Thanks to the examiners for their insightful comments
@cancerresearchuk.org @breastcancernow.bsky.social @icr.ac.uk @qmbci.bsky.social 😍

8

Reposted by VickySanzMoreno

Worldwide Cancer Research @worldwidecancer.bsky.social · Jul 16

Really exciting to see these results from our Curestarter researchers - thanks for sharing @vickysanzmoreno.bsky.social!

VickySanzMoreno @vickysanzmoreno.bsky.social · Jul 11

🚨 New publication alert! Excited to share our latest work
SLC7A11 protects amoeboid-disseminating cancer cells from oxidative stress: Cell Reports www.cell.com/cell-reports...

SLC7A11 protects amoeboid-disseminating cancer cells from oxidative stress

Graziani et al. show that SLC7A11 increases during melanoma disease progression. SLC7A11 promotes Myosin II-driven amoeboid invasive behavior while shielding amoeboid cancer cells from oxidative stres...

www.cell.com

1 2

VickySanzMoreno @vickysanzmoreno.bsky.social · Jul 15

Congratulations to Samantha George in the lab for receiving the Best Talk Prize at "The Diversity in Immunology Meeting" by @britsocimm.bsky.social for her beautiful work on tumour-associated macrophages. We are very proud of you Sam! 🤩

6

VickySanzMoreno @vickysanzmoreno.bsky.social · Jul 11

Special thanks to dream team spearheaded by Vittoria Graziani and Eva Crosas-Molist; all co-authors and collaborators. Thanks to all the funders that supported us and @cp-cellreports.bsky.social for such a constructive review process!

2

VickySanzMoreno @vickysanzmoreno.bsky.social · Jul 11

5. Targeting SLC7A11 offers a therapeutic opportunity for patients with SLC7A11-high tumours. SLC7A11 could also serve as a biomarker for invasive phenotypes, aiding patient stratification and precision oncology approaches.

1 2

VickySanzMoreno @vickysanzmoreno.bsky.social · Jul 11

4. Erastin-mediated SLC7A11 inhibition induced ferroptosis in amoeboid cancer cells. Spheroid invasive growth was markedly suppressed by Erastin but restored upon GSH supplementation, highlighting the protective role of GSH against oxidative stress.

1 1

VickySanzMoreno @vickysanzmoreno.bsky.social · Jul 11

3. Glutathione (GSH) supplementation supported amoeboid cancer cell features decreasing Reactive Oxygen Species caused by SLC7A11 loss. SLC7A11 and GSH maintained redox homeostasis. Metastatic amoeboid cancer cells could not cope with oxidative stress when SLC7A11 was inhibited.

1 2

VickySanzMoreno @vickysanzmoreno.bsky.social · Jul 11

2. Inspecting melanoma biopsies, we found that SLC7A11 protein levels are higher in metastatic lesions vs. primary tumours but also increased at the invasive front. This supports SLC7A11 upregulation as an adaptive feature of aggressive melanoma cells.

1 1

VickySanzMoreno @vickysanzmoreno.bsky.social · Jul 11

🔬 Key findings from our work:

1. SLC7A11 levels are higher in cancer cells with higher Myosin II activity and located at the invasive front of melanomas. SLC7A11 depletion in these cells reduced Myosin II activity and 3D invasion, highlighting its potential role in melanoma dissemination.

1 1

VickySanzMoreno @vickysanzmoreno.bsky.social · Jul 11

🚨 New publication alert! Excited to share our latest work
SLC7A11 protects amoeboid-disseminating cancer cells from oxidative stress: Cell Reports www.cell.com/cell-reports...

SLC7A11 protects amoeboid-disseminating cancer cells from oxidative stress

Graziani et al. show that SLC7A11 increases during melanoma disease progression. SLC7A11 promotes Myosin II-driven amoeboid invasive behavior while shielding amoeboid cancer cells from oxidative stres...

www.cell.com

1 1 13

Reposted by VickySanzMoreno

The Institute of Cancer Research @icr.ac.uk · Jul 11

The results, published in @cp-cellreports.bsky.social could lead to new tests to spot the most aggressive cancers, and treatments to stop them spreading.

“If we take away the melanoma cells’ shield and armour, we could stop cancer in its tracks.’
- Lead researcher Prof @vickysanzmoreno.bsky.social

1 1 1

Reposted by VickySanzMoreno

The Institute of Cancer Research @icr.ac.uk · Jul 11

BREAKING 📰

A ‘suit of armour’ protein could be targeted to stop aggressive #Melanoma from spreading.

ICR scientists have discovered that SLC7A11 protects the most aggressive melanoma cancer cells from damage as they pass through stressful environments.

More here ⤵️
www.icr.ac.uk/about-us/icr...

1 2 3

VickySanzMoreno @vickysanzmoreno.bsky.social · Jun 30

I am happy to be shortlisted in the Life Sciences category of the #GlobalCall25. This recognition brings
me a step closer to the Science Breakthroughs of the Year, to be celebrated at the #FallingWalls
#ScienceSummit25 from 6-9 November.
More info: falling-walls.com/science-summ... @FallingWalls

6

Reposted by VickySanzMoreno

Biochemical Society @biochemsoc.bsky.social · Jun 27

A huge thank you to all the amazing delegates who joined us for Small G Proteins in Cellular Signalling and Disease 2025 this week! We hope you enjoyed the conference and look forward to seeing you at the next one. #BiochemEvent #SGP25 🧪

2 10

Reposted by VickySanzMoreno

Imogen Ramsden @imogen-ramsden.bsky.social · Jun 27

Last day of the #SmallGproteins meeting, great evening last night meeting researchers in the field hearing about people’s journeys, and gave advice on expressing a phosphorylated GTPase.

Looking forward to Session 6 kicked off by @vickysanzmoreno.bsky.social!

@biochemsoc.bsky.social #BiochemEvent

3 3

Reposted by VickySanzMoreno

Imogen Ramsden @imogen-ramsden.bsky.social · Jun 18

Excited to be selected as one of the Social Media Contributors at the #BiochemEvent Small G Proteins Meeting next week, thanks to @biochemsoc.bsky.social.
I look forward to hearing about and discussing the latest research in the area as well as presenting my own PhD work about Arf proteins!

2 7

Reposted by VickySanzMoreno

The Company of Biologists @biologists.bsky.social · Jun 26

The Company of Biologists Workshop - Mechanometabolism Unleashed: The Interface of Cell Mechanics and Metabolism

Thank you to Workshop organisers Marco Foiani, Ana-Maria Lennon-Duménil, Victoria Sanz-Moreno and Giorgio Scita.

#Workshop #Biology #CellBiology #Community #Collaboration #Research

Group photo from the Mechanometabolism Unleashed: The Interface of Cell Mechanics and Metabolism Workshop

Held at Buxted Park, East Sussex, UK
22-25 June 2025

6 17

Reposted by VickySanzMoreno

mcb-sheffield.bsky.social @mcb-sheffield.bsky.social · Jun 4

We are delighted to host @vickysanzmoreno.bsky.social today from the @icr.ac.uk!

"Biomechanical hallmarks and vulnerabilities of metastatic cancer cells"

📍 Alfred Denny Conference Room
📅 4th June - 1pm

@insigneoinstitute.bsky.social
@sheffielduni.bsky.social
@sheffielduni.bsky.social

3 12

VickySanzMoreno @vickysanzmoreno.bsky.social · Jun 3

Very proud of former PhD student Yaiza Jung who has received the #BACR Chris Marshall Prize for Cell Signalling 😍!
it was such a pleasure to co-supervise her PhD with @jezcarlton.bsky.social 😀

1 5