@vinceconticello.bsky.social
Reposted
Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses! www.nature.com/articles/s41...
Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology
Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.
www.nature.com
November 28, 2025 at 4:43 PM
Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses! www.nature.com/articles/s41...
Reposted
A Bundled Antiparallel Cytochrome Nanowire Structure Suggests Roles in Cell-Cell Electron Transfer and Biofilm Formation pubmed.ncbi.nlm.nih.gov/41279714/ #cryoem
November 25, 2025 at 6:58 PM
A Bundled Antiparallel Cytochrome Nanowire Structure Suggests Roles in Cell-Cell Electron Transfer and Biofilm Formation pubmed.ncbi.nlm.nih.gov/41279714/ #cryoem
Reposted
The Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge pubmed.ncbi.nlm.nih.gov/41280101/ #cryoem
November 25, 2025 at 2:16 PM
The Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge pubmed.ncbi.nlm.nih.gov/41280101/ #cryoem
Reposted
Latest work from the group looking at using our functionalised dipeptides for energy storage via a micellar analogue to MOST...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Functionalized azobenzenes for micellar solar thermal energy storage as a next-generation MOST system - Communications Chemistry
Molecular solar thermal energy storage (MOST) systems employ photoswitchable molecules that absorb sunlight and store energy through reversible isomerization, cyclization or other intramolecular rearr...
www.nature.com
November 25, 2025 at 9:04 AM
Latest work from the group looking at using our functionalised dipeptides for energy storage via a micellar analogue to MOST...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted
How Sup35 monomer conformation and amyloid fibril polymorphism determine yeast strain phenotypes pubmed.ncbi.nlm.nih.gov/41282265/ #cryoem
November 25, 2025 at 10:31 AM
How Sup35 monomer conformation and amyloid fibril polymorphism determine yeast strain phenotypes pubmed.ncbi.nlm.nih.gov/41282265/ #cryoem
Assembly, architecture and functional roles of microbial surface layers
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
www.nature.com
November 14, 2025 at 5:53 PM
Reposted
Structural insights into the atypical filament assembly of pyrin domain-containing IFI16 pubmed.ncbi.nlm.nih.gov/41193640/ #cryoem
November 6, 2025 at 8:43 PM
Structural insights into the atypical filament assembly of pyrin domain-containing IFI16 pubmed.ncbi.nlm.nih.gov/41193640/ #cryoem
Reposted
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted
Structures of the sheathed flagellum reveal mechanisms of assembly and rotation in Vibrio cholerae pubmed.ncbi.nlm.nih.gov/41174224/ #cryoem
November 2, 2025 at 7:40 PM
Structures of the sheathed flagellum reveal mechanisms of assembly and rotation in Vibrio cholerae pubmed.ncbi.nlm.nih.gov/41174224/ #cryoem
Reposted
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Quick Check Needed
mrc.tal.net
October 29, 2025 at 9:17 AM
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Reposted
Separation of halide oxidation and substrate halogenation chemistries rationalizes site-selective vanadium dependent haloperoxidase catalysis www.biorxiv.org/content/10.1101/2025.10.24.684477v1 #cryoem
October 26, 2025 at 11:46 AM
Separation of halide oxidation and substrate halogenation chemistries rationalizes site-selective vanadium dependent haloperoxidase catalysis www.biorxiv.org/content/10.1101/2025.10.24.684477v1 #cryoem
Reposted
Impurities in amyloid studies: The power of automated model building within a cautionary tale for structural biologists pubmed.ncbi.nlm.nih.gov/41123416/ #cryoem
October 23, 2025 at 11:06 PM
Impurities in amyloid studies: The power of automated model building within a cautionary tale for structural biologists pubmed.ncbi.nlm.nih.gov/41123416/ #cryoem
Reposted
A nice N&V article by Mike Dyall-Smith on our recent paper
( www.nature.com/articles/s41... ):
www.nature.com/articles/s41...
( www.nature.com/articles/s41... ):
www.nature.com/articles/s41...
Archaeal symbioses all the way down - Nature Microbiology
Ethiopian salt lakes feature unique microbial communities with nesting layers of symbioses, where haloarchaea and their ultra-small archaeal symbionts are prey to viruses, which are in turn hijacked b...
www.nature.com
October 20, 2025 at 11:51 AM
A nice N&V article by Mike Dyall-Smith on our recent paper
( www.nature.com/articles/s41... ):
www.nature.com/articles/s41...
( www.nature.com/articles/s41... ):
www.nature.com/articles/s41...
Reposted
Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency pubmed.ncbi.nlm.nih.gov/41107248/ #cryoem
October 18, 2025 at 3:24 PM
Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency pubmed.ncbi.nlm.nih.gov/41107248/ #cryoem
Reposted
Donor strand complementation and calcium ion coordination drive the chaperone-free polymerization of archaeal cannulae pubmed.ncbi.nlm.nih.gov/41083437/ #cryoem
October 14, 2025 at 12:29 PM
Donor strand complementation and calcium ion coordination drive the chaperone-free polymerization of archaeal cannulae pubmed.ncbi.nlm.nih.gov/41083437/ #cryoem
Cannulae paper published in final form. Thanks to the many collaborators and to the reviewers. @jerryknowsnothing.bsky.social @mikesleutel.bsky.social @vikramalva.bsky.social
rdcu.be/eKVlI
rdcu.be/eKVlI
Client Challenge
rdcu.be
October 14, 2025 at 10:57 AM
Cannulae paper published in final form. Thanks to the many collaborators and to the reviewers. @jerryknowsnothing.bsky.social @mikesleutel.bsky.social @vikramalva.bsky.social
rdcu.be/eKVlI
rdcu.be/eKVlI
Molecular Microbiology | Microbiology Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
Type IV Pili‐Associated Secretion of a Biofilm Matrix Protein From Clostridium perfringens That Forms Intermolecular Isopeptide Bonds
Clostridium perfringens produces and secretes a biofilm matrix protein, BsaA, which is in the same family as the Bacillus subtilis TasA matrix protein. In this report, we show that BsaA monomers, unl....
onlinelibrary.wiley.com
October 14, 2025 at 10:17 AM
Molecular Microbiology | Microbiology Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
Reposted
CryoSeek identification of glycofibrils with diverse compositions and structural assemblies www.biorxiv.org/content/10.1101/2025.09.30.679562v1 #cryoem
October 2, 2025 at 8:19 AM
CryoSeek identification of glycofibrils with diverse compositions and structural assemblies www.biorxiv.org/content/10.1101/2025.09.30.679562v1 #cryoem
Reposted
Absolute hand determination of glycofibrils from natural sources in cryo-EM www.biorxiv.org/content/10.1101/2025.09.30.679555v1 #cryoem
October 3, 2025 at 1:45 PM
Absolute hand determination of glycofibrils from natural sources in cryo-EM www.biorxiv.org/content/10.1101/2025.09.30.679555v1 #cryoem
Reposted
Look at this nice cover: beautiful archaella, image made by @sshamphavi.bsky.social !
Thanks also to Marta Rodeiguez for keeping the EM im shape in @ottlab.bsky.social lab!
At @biologyunifreiburg.bsky.social at @uni-freiburg.de @sfb1381.bsky.social @cibss.bsky.social
Thanks also to Marta Rodeiguez for keeping the EM im shape in @ottlab.bsky.social lab!
At @biologyunifreiburg.bsky.social at @uni-freiburg.de @sfb1381.bsky.social @cibss.bsky.social
Some keen Observations in Our October issue!
🦠 Cancer microbiome
🌊 Marine microbes in warming oceans
🌐 broad-range phages
🧬 genetically minimised Salmonella
🔧 Viral infection mechanisms
🧪 Oxaloacetate antiviral defence
and more, here: www.nature.com/nmicrobiol/v...
🦠 Cancer microbiome
🌊 Marine microbes in warming oceans
🌐 broad-range phages
🧬 genetically minimised Salmonella
🔧 Viral infection mechanisms
🧪 Oxaloacetate antiviral defence
and more, here: www.nature.com/nmicrobiol/v...
October 2, 2025 at 8:28 AM
Look at this nice cover: beautiful archaella, image made by @sshamphavi.bsky.social !
Thanks also to Marta Rodeiguez for keeping the EM im shape in @ottlab.bsky.social lab!
At @biologyunifreiburg.bsky.social at @uni-freiburg.de @sfb1381.bsky.social @cibss.bsky.social
Thanks also to Marta Rodeiguez for keeping the EM im shape in @ottlab.bsky.social lab!
At @biologyunifreiburg.bsky.social at @uni-freiburg.de @sfb1381.bsky.social @cibss.bsky.social
Reposted
I’m thrilled to share my latest published manuscript, which summarizes my work in the exciting fields of structural biology and amyloid research. A huge thank you to @meytallandau.bsky.social and the team at @landaulabcssb.bsky.social for their shared efforts
doi.org/10.1002/advs...
doi.org/10.1002/advs...
Structural and Functional Versatility of the Amyloidogenic Non‐Amidated Variant of the Antimicrobial Peptide Citropin 1.3
Citropin 1.3 is an antimicrobial peptide derived from amphibians that forms amyloid structures. Here, the structural and functional properties of citropin 1.3 are characterized. Using high-resolution...
doi.org
September 29, 2025 at 7:02 AM
I’m thrilled to share my latest published manuscript, which summarizes my work in the exciting fields of structural biology and amyloid research. A huge thank you to @meytallandau.bsky.social and the team at @landaulabcssb.bsky.social for their shared efforts
doi.org/10.1002/advs...
doi.org/10.1002/advs...
Reposted
Structural and Functional Versatility of the Amyloidogenic Non-Amidated Variant of the Antimicrobial Peptide Citropin 1.3 pubmed.ncbi.nlm.nih.gov/41016026/ #cryoem
September 29, 2025 at 10:30 PM
Structural and Functional Versatility of the Amyloidogenic Non-Amidated Variant of the Antimicrobial Peptide Citropin 1.3 pubmed.ncbi.nlm.nih.gov/41016026/ #cryoem
Self‐Assembly of Off‐Target Peptide Sequences: Implications for the Design of Soft Materials - Wang - Small - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Self‐Assembly of Off‐Target Peptide Sequences: Implications for the Design of Soft Materials
For an ionic complementary peptide, both a truncated peptide and an epimerized peptide can still form gels. Mixing these peptides with the parent FEFEFKFK leads to the formation of new, but different...
onlinelibrary.wiley.com
September 28, 2025 at 1:01 PM
Self‐Assembly of Off‐Target Peptide Sequences: Implications for the Design of Soft Materials - Wang - Small - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Filamentous structure of the CotVW complex, the crust proteins of the Bacillus subtilis endospore - Journal of Biological Chemistry www.jbc.org/article/S002...
Spore protein assemblies are pretty wild. Nice inspiration for biomaterials design.
Spore protein assemblies are pretty wild. Nice inspiration for biomaterials design.
Filamentous structure of the CotVW complex, the crust proteins of the Bacillus subtilis endospore
The endospores of Bacillus subtilis are encased in a multilayered protective structure
comprising core, cortex, inner and outer coats, and an outermost crust. Among the
proteins required for crust for...
www.jbc.org
September 28, 2025 at 12:52 PM
Filamentous structure of the CotVW complex, the crust proteins of the Bacillus subtilis endospore - Journal of Biological Chemistry www.jbc.org/article/S002...
Spore protein assemblies are pretty wild. Nice inspiration for biomaterials design.
Spore protein assemblies are pretty wild. Nice inspiration for biomaterials design.