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ybraegger.bsky.social
Yannick Brägger
@ybraegger.bsky.social
40 followers 100 following 1 posts
PhD Student at ETH Zürich
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ybraegger.bsky.social
Yannick Brägger @ybraegger.bsky.social · Mar 7
Check out the final version of our paper on nitrogen atom insertion into unactivated alkenes, out now in @science.org!

Many thanks to my amazing colleagues Ann-Sophie Paschke, Bence Béla Botlik, and former students Francesco Felician and Nima Nasiri!

www.science.org/doi/10.1126/...
Oxidative amination by nitrogen atom insertion into carbon-carbon double bonds
The synthesis of nitrogen-containing molecules through carbon–nitrogen (C–N) bond formation is critical for the discovery and preparation of medicines, agrochemicals, and materials. Here, we report th...
www.science.org
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Reposted by Yannick Brägger
morandilab.bsky.social
Morandi Research Group @morandilab.bsky.social · Sep 2
Congrats to Ann-Sophie Paschke, @ybraegger.bsky.social, Bence Botlik, Erich Staudinger, @origreen.bsky.social! "Carbon-to-nitrogen atom swap enables direct access to benzimidazoles from drug-like indoles". www.nature.com/articles/s41.... @natchem.nature.com.
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Reposted by Yannick Brägger
morandilab.bsky.social
Morandi Research Group @morandilab.bsky.social · Sep 2
Congrats to @fruepp.bsky.social, Vasily Grebennikov, Mykola Avramenko, Marc-Olivier Ebert "Kinetic, Spectroscopic, and Computational Investigation of Oxidative Aminative Alkene Cleavage Reveals an N-Iodonium-Iminoiodinane Pathway" now @chemrxiv.org - chemrxiv.org/engage/chemr...
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Reposted by Yannick Brägger
enirenberg.bsky.social
Edward Nirenberg @enirenberg.bsky.social · Mar 29
Peter Marks’s resignation letter. Everyone should read this.
Peter Marks, MD, PhD Director, Center for Biologics Evaluation and Research U.S. Food and Drug Administration 10903 New Hampshire Avenue Silver Spring, MD 20903 March 28, 2025 Sara Brenner, MD, MPH Acting Commissioner of Food and Drugs U.S. Food and Drug Administration 10903 New Hampshire Avenue Silver Spring, MD 20903 Dear Dr. Brenner: It is with a heavy heart that I have decided to resign from FDA and retire from federal service as Director of the Center for Biologics Evaluation and Research effective April 5, 2025. I leave behind a staff of professionals who are undoubtedly the most devoted to protecting and promoting the public health of any group of people that I have encountered during my four decades working in the public and private sectors. I have always done my best to advocate for their well-being and I would ask that you do the same during this very difficult time during which their critical importance to the safety and security of our nation may be underappreciated. Over the past years I have been involved in enhancing the safety of our nation's blood supply, in advancing the field of cell and gene therapy, and in responding to public health emergencies. In the last of these, during the COVID-19 pandemic I had the privilege of watching the vision that I conceived for Operation Warp Speed in March 2020 in collaboration with Dr. Robert Kadlec become a reality under the leadership of HHS Secretary Azar and President Trump due to the unwavering commitment of public servants at FDA and elsewhere across the government. At FDA, the tireless efforts of staff across the agency resulted in remarkably expediting the development of vaccines against the virus, meeting the standards for quality, safety, and effectiveness expected by the American public. The vaccines undoubtedly markedly reduced morbidity and mortality from COVID-19 in the United States and elsewhere. Many of these same individuals applied learnings from the pandemic during a flawless response helping… ongoing multistate measles outbreak that is particularly severe in Texas reminds us of what happens when confidence in well-established science underlying public health and well-being is undermined. Measles, which killed more than 100,000 unvaccinated children last year in Africa and Asia owing to pneumonitis and encephalitis caused by the virus, had been eliminated from our shores. The two-dose measles, mumps, rubella vaccine regimen (MMR) using over the past decades has a remarkably favorable benefit-risk profile. The MMR vaccine is 97% or more effective in preventing measles following the two-dose series, and its safety has been remarkably well studied. Though rarely followed by a single fever-related seizure, or very rarely by allergic reactions or blood clotting disorders, the vaccine very simply does not cause autism, nor is it associated with encephalitis or death. It does, however, protect against a potential devasting consequence of prior measles infection, subacute sclerosing panencephalitis (SSPE), which is an untreatable, relentlessly progressive neurologic disorder leading to death in about 1 in 10,000 individuals infected with measles. Undermining confidence in well-established vaccines that have met the high standards for quality, safety, and effectiveness that have been in place for decades at FDA is irresponsible, detrimental to public health, and a clear danger to our nation's health, safety. and security. In the years following the pandemic, at the Center for Biologics Evaluation and Research we have applied the same unwavering commitment to public health priorities to the development of cell and gene therapies to address both hereditary and acquired rare diseases. During my tenure as Center Director we have approved 22 gene therapies, including the first gene therapy ever to be approved in the United States. However, we know that we must do better to expedite the development of treatments for those individual suffering from any one of the thousan…
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Reposted by Yannick Brägger
morandilab.bsky.social
Morandi Research Group @morandilab.bsky.social · Mar 7
Many Congrats to @ybraegger.bsky.social,
Ann-Sophie Paschke, Nima Nasiri, Bence Botlik
and Francesco Felician for this masterpiece! Oxidative amination by nitrogen atom insertion into carbon-carbon double bonds in Science, @ethzurich.bsky.social.
www.science.org/doi/10.1126/...
Oxidative amination by nitrogen atom insertion into carbon-carbon double bonds
The synthesis of nitrogen-containing molecules through carbon–nitrogen (C–N) bond formation is critical for the discovery and preparation of medicines, agrochemicals, and materials. Here, we report th...
www.science.org
2 6 32
ybraegger.bsky.social
Yannick Brägger @ybraegger.bsky.social · Mar 7
Check out the final version of our paper on nitrogen atom insertion into unactivated alkenes, out now in @science.org!

Many thanks to my amazing colleagues Ann-Sophie Paschke, Bence Béla Botlik, and former students Francesco Felician and Nima Nasiri!

www.science.org/doi/10.1126/...
Oxidative amination by nitrogen atom insertion into carbon-carbon double bonds
The synthesis of nitrogen-containing molecules through carbon–nitrogen (C–N) bond formation is critical for the discovery and preparation of medicines, agrochemicals, and materials. Here, we report th...
www.science.org
1 3
Reposted by Yannick Brägger
jakeyeston.bsky.social
Jake Yeston @jakeyeston.bsky.social · Mar 6
Also in @science.org for chemsky this week, we have two methods of turning olefins into nitriles, respectively from Bill Morandi's group and Ning Jiao's group 🧪

www.science.org/doi/10.1126/...
Oxidative amination by nitrogen atom insertion into carbon-carbon double bonds
The synthesis of nitrogen-containing molecules through carbon–nitrogen (C–N) bond formation is critical for the discovery and preparation of medicines, agrochemicals, and materials. Here, we report th...
www.science.org
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Reposted by Yannick Brägger
spschmid.bsky.social
Stefan P. Schmid @spschmid.bsky.social · Mar 3
🚀 Looking for reaction conditions that work well for multiple substrates? CurryBO can help🍛

Now out on arXiv: arxiv.org/abs/2502.18966

A short explanation thread 👇
One Set to Rule Them All: How to Obtain General Chemical Conditions via Bayesian Optimization over Curried Functions
General parameters are highly desirable in the natural sciences - e.g., chemical reaction conditions that enable high yields across a range of related transformations. This has a significant practical...
arxiv.org
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