@zbiotech.bsky.social
buy-side healthcare analyst, equity/debt and catalyst-driven focus...may have positions in names I discuss, opinions are my own
Reposted
"We need to stop trusting experts" has to rank at the top of the Top 10 stupidest statements in all of human history.
RFK Jr.: “We Need to Stop Trusting Experts:” so he used non-experts to present misinformation in his ACIP. open.substack.com/pub/pauloffi... via @pauloffit.bsky.social
RFK Jr.: “We Need to Stop Trusting Experts”
A recent recommendation by RFK Jr.’s vaccine advisory committee shows why trusting experts is still a good idea
open.substack.com
December 12, 2025 at 6:36 AM
"We need to stop trusting experts" has to rank at the top of the Top 10 stupidest statements in all of human history.
Reposted
I will never forget and never forgive these actions. And there are so many, with so many people carrying these orders out while others laugh and clap and post excited selfies about it all.
Justice has to be served.
Justice has to be served.
Read to the end. NPR asked why the Trump team ended a low-cost program that cured millions of tropical diseases w drugs donated by pharma. The spokesperson replied with an NPR headline—“Farewell to USAID”—and said: “What do you think farewell meant?” www.npr.org/sections/goa...
The fight to beat neglected tropical diseases was going well. 2025 could change that
The campaign to prevent and treat these diseases has seen great success thanks to a USAID program. Now that program is gone.
www.npr.org
December 11, 2025 at 9:38 PM
I will never forget and never forgive these actions. And there are so many, with so many people carrying these orders out while others laugh and clap and post excited selfies about it all.
Justice has to be served.
Justice has to be served.
Reposted
Yes, and what if your access to affordable healthcare was considered a right guaranteed to everyone by the government and not a bauble of certain types of employment or friggin club store membership? What then?
Rand Paul on his healthcare plan: "What if you could join Costco? Costco has 44m members and if one person negotiated for all 44 and they bought a group plan like Toyota or General Motors does, they would be the largest collective entity in the country. They would drive prices down by sheer might."
December 9, 2025 at 1:17 PM
Yes, and what if your access to affordable healthcare was considered a right guaranteed to everyone by the government and not a bauble of certain types of employment or friggin club store membership? What then?
Reposted
“Americans expect to dial back holiday spending significantly this year.”
(Per @gallup.com / Arbor Data)
(via Liz Ann Sonders)
(Per @gallup.com / Arbor Data)
(via Liz Ann Sonders)
December 9, 2025 at 12:15 PM
“Americans expect to dial back holiday spending significantly this year.”
(Per @gallup.com / Arbor Data)
(via Liz Ann Sonders)
(Per @gallup.com / Arbor Data)
(via Liz Ann Sonders)
Reposted
RFK's FDA is now scrutinizing the new-ish RSV antibodies:
Exclusive: US FDA launches fresh safety scrutiny of approved RSV therapies for infants
U.S. health regulators informed senior executives at Merck, Sanofi and AstraZeneca last week that their approved protective RSV treatments for infants would be subject to fresh safety scrutiny followi...
www.reuters.com
December 9, 2025 at 12:58 PM
RFK's FDA is now scrutinizing the new-ish RSV antibodies:
Reposted
The babies who will become infected as a result of this vote — and some will die prematurely of liver disease — will overwhelmingly be those born to marginalized, underserved families. This is a profound failure of evidence-based public health and a big step backwards. 2/2
December 5, 2025 at 4:13 PM
The babies who will become infected as a result of this vote — and some will die prematurely of liver disease — will overwhelmingly be those born to marginalized, underserved families. This is a profound failure of evidence-based public health and a big step backwards. 2/2
while siri's ACIP presentation was filled with pure anti-vax propoganda and 'junk science', as briefly and well articulated by Meissner, at least we could take solace in the fact that siri has no direct/active role in drug regulation or oversight
hoeg on the other hand...omg
CDER is big trouble
hoeg on the other hand...omg
CDER is big trouble
December 5, 2025 at 7:40 PM
while siri's ACIP presentation was filled with pure anti-vax propoganda and 'junk science', as briefly and well articulated by Meissner, at least we could take solace in the fact that siri has no direct/active role in drug regulation or oversight
hoeg on the other hand...omg
CDER is big trouble
hoeg on the other hand...omg
CDER is big trouble
Reposted
this shit is just beyond parody, man
December 5, 2025 at 5:33 PM
this shit is just beyond parody, man
cassidy best put out an APB for his integrity, it has been missing for quite some time
this isnt simply a 'mistake', but a direct consequence of rfk's personal agenda and perverse abuse of the system, enabled by cassidy
he has no shame, but what else is new?
www.cassidy.senate.gov/newsroom/pre...
this isnt simply a 'mistake', but a direct consequence of rfk's personal agenda and perverse abuse of the system, enabled by cassidy
he has no shame, but what else is new?
www.cassidy.senate.gov/newsroom/pre...
December 5, 2025 at 5:15 PM
cassidy best put out an APB for his integrity, it has been missing for quite some time
this isnt simply a 'mistake', but a direct consequence of rfk's personal agenda and perverse abuse of the system, enabled by cassidy
he has no shame, but what else is new?
www.cassidy.senate.gov/newsroom/pre...
this isnt simply a 'mistake', but a direct consequence of rfk's personal agenda and perverse abuse of the system, enabled by cassidy
he has no shame, but what else is new?
www.cassidy.senate.gov/newsroom/pre...
"When a clown moves into a palace, he doesn't become a king. The palace becomes a circus."
The Ringling Brothers would be proud of this ACIP, what a travesty
The Ringling Brothers would be proud of this ACIP, what a travesty
A panel that advises #CDC on vaccine policy votes to do away with the recommendation all babies should be vaccinated against #hepatitisB at birth. "We are doing harm," said panel member Cody Meissner, who voted against this #ACIP recommendation. www.statnews.com/2025/12/05/c...
CDC panel recommends delaying birth dose of hepatitis B vaccine
The CDC's ACIP panel voted to recommend delaying the birth dose of the hepatitis B vaccine, ending a policy that has reined in the virus.
www.statnews.com
December 5, 2025 at 4:19 PM
"When a clown moves into a palace, he doesn't become a king. The palace becomes a circus."
The Ringling Brothers would be proud of this ACIP, what a travesty
The Ringling Brothers would be proud of this ACIP, what a travesty
god this ACIP is unbearable
December 5, 2025 at 2:27 PM
god this ACIP is unbearable
Reposted
Why are the richest people the biggest heartless dicks to the people in desperate circumstances?
You will have to face your creator someday who clearly said “what you do to the least of these you do to me”
I used to like Phil. Saudi sellout
You will have to face your creator someday who clearly said “what you do to the least of these you do to me”
I used to like Phil. Saudi sellout
December 5, 2025 at 3:09 AM
Why are the richest people the biggest heartless dicks to the people in desperate circumstances?
You will have to face your creator someday who clearly said “what you do to the least of these you do to me”
I used to like Phil. Saudi sellout
You will have to face your creator someday who clearly said “what you do to the least of these you do to me”
I used to like Phil. Saudi sellout
Reposted
A picture is worth a 1000 words. The birth dose of hepatitis B vaccines in the USA eliminated perinatally acquired hepatitis B infection from over 20,000 cases a year before the vaccine was introduced to <20 cases a year. The gaslighting by the current members ACIP is obscene, unethical and cruel.
December 4, 2025 at 5:28 PM
A picture is worth a 1000 words. The birth dose of hepatitis B vaccines in the USA eliminated perinatally acquired hepatitis B infection from over 20,000 cases a year before the vaccine was introduced to <20 cases a year. The gaslighting by the current members ACIP is obscene, unethical and cruel.
Reposted
This is extraordinary. Prasad's memo was something else, but to have 12 former FDA commissioners get together so quickly and say what a threat it is...just wow. www.nejm.org/doi/full/10.... #medsky #vaccine #fda
A Threat to Evidence-Based Vaccine Policy and Public Health Security at the FDA | NEJM
Twelve former commissioners of the FDA express concern that the agency’s recent moves will undermine a regulatory model designed to ensure vaccine safety, effectiveness, and availability.
www.nejm.org
December 3, 2025 at 10:44 PM
This is extraordinary. Prasad's memo was something else, but to have 12 former FDA commissioners get together so quickly and say what a threat it is...just wow. www.nejm.org/doi/full/10.... #medsky #vaccine #fda
if only bill could have helped prevent all the chaos that has delegitimized the ACIP…as well as the utter destruction of decades of expertise at the FDA
alas, there are no mirrors in his room, such a pathetic coward
alas, there are no mirrors in his room, such a pathetic coward
December 4, 2025 at 1:08 PM
if only bill could have helped prevent all the chaos that has delegitimized the ACIP…as well as the utter destruction of decades of expertise at the FDA
alas, there are no mirrors in his room, such a pathetic coward
alas, there are no mirrors in his room, such a pathetic coward
Reposted
Updated FDA org chart from BioSpace: nearly 90% of sr leaders who were at FDA a yr ago are gone. Most FDA employees are usually "career staff" who worked 4 multiple FDA commissioners & yrs of training 2b knowledgeable incl cell & gene therapies. Pazdur had worked 4 Bush, Obama,Trump & Biden #medsky
December 3, 2025 at 9:39 PM
Updated FDA org chart from BioSpace: nearly 90% of sr leaders who were at FDA a yr ago are gone. Most FDA employees are usually "career staff" who worked 4 multiple FDA commissioners & yrs of training 2b knowledgeable incl cell & gene therapies. Pazdur had worked 4 Bush, Obama,Trump & Biden #medsky
Reposted
"Credible sources suggest none—or very few—of the ACIP presentations will be delivered by CDC scientists or experts. Instead, external groups, including some with clear anti-vaccine track records, are slated to take the lead. This is highly unusual..."
open.substack.com/pub/yourloca...
open.substack.com/pub/yourloca...
What to expect from this week's U.S. vaccine meeting
Hep B, routine vaccination schedule, and a firehose of falsehoods
open.substack.com
December 3, 2025 at 4:02 PM
"Credible sources suggest none—or very few—of the ACIP presentations will be delivered by CDC scientists or experts. Instead, external groups, including some with clear anti-vaccine track records, are slated to take the lead. This is highly unusual..."
open.substack.com/pub/yourloca...
open.substack.com/pub/yourloca...
so can your 'qualifications' to lead, marty
could you imagine how well biotech would be performing in the backdrop of a reasonably competent FDA which provided clear guidance? this administration is a disaster in every imaginable respect
could you imagine how well biotech would be performing in the backdrop of a reasonably competent FDA which provided clear guidance? this administration is a disaster in every imaginable respect
December 2, 2025 at 5:07 PM
so can your 'qualifications' to lead, marty
could you imagine how well biotech would be performing in the backdrop of a reasonably competent FDA which provided clear guidance? this administration is a disaster in every imaginable respect
could you imagine how well biotech would be performing in the backdrop of a reasonably competent FDA which provided clear guidance? this administration is a disaster in every imaginable respect
apparently pazdur didn't wanna be in the middle of an asshat sandwich after all
December 2, 2025 at 4:40 PM
apparently pazdur didn't wanna be in the middle of an asshat sandwich after all
Reposted
presented without comment
December 1, 2025 at 2:28 AM
presented without comment
i've lost track of how many times cassidy has humiliated himself
you'd think a guy who went to medical school would know what a spine is, but the deplorables et al keep finding new cringeworthy ways to debase themselves
www.statnews.com/2025/11/20/c...
you'd think a guy who went to medical school would know what a spine is, but the deplorables et al keep finding new cringeworthy ways to debase themselves
www.statnews.com/2025/11/20/c...
Cassidy and other Republicans have little to say about change to CDC’s position on vaccines and autism
RFK Jr. broke another promise to Sen. Bill Cassidy this week.
www.statnews.com
November 21, 2025 at 5:07 PM
i've lost track of how many times cassidy has humiliated himself
you'd think a guy who went to medical school would know what a spine is, but the deplorables et al keep finding new cringeworthy ways to debase themselves
www.statnews.com/2025/11/20/c...
you'd think a guy who went to medical school would know what a spine is, but the deplorables et al keep finding new cringeworthy ways to debase themselves
www.statnews.com/2025/11/20/c...
Reposted
My contempt for RFK Jr. is hard for me to put into words. And I am reasonably good at doing that under normal conditions. But. . .
CARTER: How could you possibly justify the decision to terminate HIV vaccines studies?
RFK JR: We've been promising an HIV vaccine since 1984 and every year Congress pours money into it
CARTER: Because they haven't come up with one, you then cut the forward motion by getting rid of NIH dollars?
RFK JR: We've been promising an HIV vaccine since 1984 and every year Congress pours money into it
CARTER: Because they haven't come up with one, you then cut the forward motion by getting rid of NIH dollars?
June 24, 2025 at 5:27 PM
My contempt for RFK Jr. is hard for me to put into words. And I am reasonably good at doing that under normal conditions. But. . .
ehhh…thanks for that vote bill, this is all on you…idiot
June 24, 2025 at 1:01 PM
ehhh…thanks for that vote bill, this is all on you…idiot
so who is bringing ivermectin to makary?
The FDA is launching a program to reward companies with accelerated drug review and speedy agency feedback, if their actions align with the agency’s national health priorities.
www.statnews.com/2025/06/17/f...
www.statnews.com/2025/06/17/f...
FDA announces a new priority review program in bid to further administration goals
The FDA is launching a program to reward companies with accelerated drug review and speedy agency feedback, if their actions align with the FDA's national health priorities.
www.statnews.com
June 17, 2025 at 5:03 PM
so who is bringing ivermectin to makary?